|Institutional Source||Beutler Lab|
|Gene Name||golgi membrane protein 1|
|Synonyms||2310001L02Rik, GP73, PSEC0257, D030064E01Rik, Golph2|
|Essential gene?||Probably non essential (E-score: 0.056)|
|Stock #||R6993 (G1)|
|Chromosomal Location||59634626-59675811 bp(-) (GRCm38)|
|Type of Mutation||small deletion (1 aa in frame mutation)|
|DNA Base Change (assembly)||ACTTCTTCT to ACTTCT at 59649576 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000093410 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000022039] [ENSMUST00000095739]|
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||99% (66/67)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Sep 2009]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit increased premature lethality with kidney abnormalities and liver steatosis. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Golm1||
(F):5'- TCCATGTGAACATATGCATGC -3'
(R):5'- TCAAGGTGCAGGCTTCTGTG -3'
(F):5'- CCATGTGAACATATGCATGCATGTAC -3'
(R):5'- TCTGTAGACCGGACTAGGTTCAAC -3'