Incidental Mutation 'R7664:Mug1'
ID 591780
Institutional Source Beutler Lab
Gene Symbol Mug1
Ensembl Gene ENSMUSG00000059908
Gene Name murinoglobulin 1
Synonyms
MMRRC Submission 045704-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7664 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 121815500-121866016 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 121838179 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Asparagine at position 470 (H470N)
Ref Sequence ENSEMBL: ENSMUSP00000032228 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032228]
AlphaFold P28665
Predicted Effect possibly damaging
Transcript: ENSMUST00000032228
AA Change: H470N

PolyPhen 2 Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000032228
Gene: ENSMUSG00000059908
AA Change: H470N

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:A2M_N 128 221 5e-21 PFAM
A2M_N_2 449 599 2.55e-41 SMART
A2M 740 830 5.43e-36 SMART
Pfam:Thiol-ester_cl 963 992 1e-18 PFAM
Pfam:A2M_comp 1012 1268 5.4e-94 PFAM
A2M_recep 1378 1465 4.14e-41 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 99% (83/84)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele are viable, fertile and phenotypically normal under standard conditions but show increased mortality in response to diet-induced acute pancreatitis along with hepatic cell necrosis and inflammatory infiltration, andincreased plasma amylase and lipase levels. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 86 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca C T 11: 84,136,175 (GRCm39) T510I probably damaging Het
Akap12 G T 10: 4,303,748 (GRCm39) W291L probably damaging Het
Akip1 A T 7: 109,308,187 (GRCm39) I152F probably benign Het
Alpk2 T A 18: 65,440,073 (GRCm39) Y440F probably benign Het
Aox3 A G 1: 58,158,698 (GRCm39) T90A probably damaging Het
Arhgef18 A T 8: 3,436,390 (GRCm39) E228V probably damaging Het
B4galnt4 A G 7: 140,647,626 (GRCm39) K405E probably damaging Het
BC034090 T C 1: 155,117,377 (GRCm39) E247G probably damaging Het
Camkk2 A T 5: 122,894,645 (GRCm39) F216I unknown Het
Carm1 A C 9: 21,498,286 (GRCm39) K430T probably benign Het
Ccdc13 A G 9: 121,643,279 (GRCm39) V374A probably benign Het
Cdh26 T A 2: 178,111,835 (GRCm39) M465K probably benign Het
Ceacam10 A T 7: 24,477,757 (GRCm39) M91L probably benign Het
Chrnb1 T C 11: 69,677,850 (GRCm39) T301A possibly damaging Het
Clec4a3 A G 6: 122,943,381 (GRCm39) D101G probably benign Het
Cmss1 G A 16: 57,138,310 (GRCm39) P59S probably benign Het
Crhr1 T A 11: 104,059,968 (GRCm39) F138L probably benign Het
Cxcl5 A T 5: 90,907,890 (GRCm39) I107F probably damaging Het
Cxcr1 A G 1: 74,231,834 (GRCm39) S63P probably damaging Het
Cxcr5 A G 9: 44,424,607 (GRCm39) L350P probably benign Het
D5Ertd579e A T 5: 36,771,961 (GRCm39) H811Q probably benign Het
Ddx46 T G 13: 55,806,864 (GRCm39) I499S probably damaging Het
Ddx51 T G 5: 110,804,785 (GRCm39) probably null Het
Dnaja1 C T 4: 40,724,090 (GRCm39) P84S probably benign Het
Dnajc27 A G 12: 4,153,132 (GRCm39) K203E possibly damaging Het
Fam107b T A 2: 3,571,747 (GRCm39) C24S probably damaging Het
Fancg T C 4: 43,010,066 (GRCm39) K11R probably benign Het
Fnip1 T C 11: 54,356,951 (GRCm39) L44P probably damaging Het
Fthl17b C T X: 8,829,043 (GRCm39) R9Q possibly damaging Het
Fthl17b C T X: 8,829,047 (GRCm39) V8M possibly damaging Het
Heca A T 10: 17,778,118 (GRCm39) L493Q probably damaging Het
Hrh2 C T 13: 54,368,875 (GRCm39) P284S probably damaging Het
Ifnar1 C G 16: 91,292,082 (GRCm39) A141G probably damaging Het
Igkv6-32 T A 6: 70,051,282 (GRCm39) T25S probably damaging Het
Inppl1 T C 7: 101,479,304 (GRCm39) H525R probably damaging Het
Itga2b A G 11: 102,351,666 (GRCm39) L553P probably damaging Het
Itgbl1 A G 14: 124,083,962 (GRCm39) Y280C probably damaging Het
Kap T C 6: 133,828,920 (GRCm39) I54V probably benign Het
Kcnh4 G T 11: 100,641,148 (GRCm39) L434M probably damaging Het
Klhl14 T C 18: 21,687,706 (GRCm39) D572G probably damaging Het
Klhl41 T A 2: 69,501,061 (GRCm39) L174Q probably damaging Het
Lrp2 T G 2: 69,337,076 (GRCm39) H1232P probably damaging Het
Lyar A G 5: 38,388,161 (GRCm39) E229G probably benign Het
Mark4 A T 7: 19,177,151 (GRCm39) L226Q probably damaging Het
Mcm8 A G 2: 132,685,453 (GRCm39) K823R probably damaging Het
Mfsd6 A T 1: 52,748,212 (GRCm39) S218T probably benign Het
Mlip A T 9: 77,045,828 (GRCm39) I884N possibly damaging Het
Mmrn1 A G 6: 60,953,689 (GRCm39) T657A probably benign Het
Morc2b A G 17: 33,355,376 (GRCm39) Y799H probably benign Het
Muc16 A T 9: 18,519,018 (GRCm39) I6304N probably benign Het
Naaladl2 T C 3: 24,112,303 (GRCm39) Y593C probably damaging Het
Ncor1 T C 11: 62,289,154 (GRCm39) E341G probably damaging Het
Nrg1 G T 8: 32,499,169 (GRCm39) probably null Het
Nudt3 A G 17: 27,842,149 (GRCm39) L4P probably benign Het
Odf2l T A 3: 144,854,345 (GRCm39) H493Q probably benign Het
Ost4 A C 5: 31,065,007 (GRCm39) probably null Het
Patj A T 4: 98,385,187 (GRCm39) Q840L possibly damaging Het
Pcdh20 T A 14: 88,706,803 (GRCm39) T166S probably benign Het
Pcdhb4 T A 18: 37,442,293 (GRCm39) D534E probably damaging Het
Pik3ap1 T C 19: 41,310,069 (GRCm39) D417G possibly damaging Het
Ppwd1 A T 13: 104,356,798 (GRCm39) V239E probably damaging Het
Prdm9 T A 17: 15,775,833 (GRCm39) Y206F probably damaging Het
Ranbp6 A G 19: 29,789,476 (GRCm39) V292A possibly damaging Het
Rgs21 T A 1: 144,416,987 (GRCm39) M22L probably benign Het
Rnf17 A T 14: 56,676,335 (GRCm39) I399F probably damaging Het
Rph3a T A 5: 121,099,339 (GRCm39) Q184L probably benign Het
Scrn3 T C 2: 73,149,714 (GRCm39) Y137H possibly damaging Het
Sec14l4 C A 11: 3,994,178 (GRCm39) Y342* probably null Het
Serpinb11 G A 1: 107,307,718 (GRCm39) G383D probably damaging Het
Sf3b1 A G 1: 55,026,626 (GRCm39) V1261A probably damaging Het
Sh3tc2 C T 18: 62,148,042 (GRCm39) Q1251* probably null Het
Skor1 A T 9: 63,049,045 (GRCm39) D845E probably benign Het
Slc39a7 A G 17: 34,248,551 (GRCm39) L364P probably damaging Het
Snrpn T C 7: 59,637,239 (GRCm39) I26V probably benign Het
Snx5 A T 2: 144,099,924 (GRCm39) probably null Het
Spag9 T C 11: 93,992,986 (GRCm39) probably null Het
Srrm2 T C 17: 24,039,955 (GRCm39) S2200P probably damaging Het
Stx11 T C 10: 12,817,070 (GRCm39) E218G probably damaging Het
Tmem151b T C 17: 45,856,861 (GRCm39) N193S probably damaging Het
Tmem87b A T 2: 128,690,974 (GRCm39) D525V possibly damaging Het
Ubtfl1 A T 9: 18,320,782 (GRCm39) R103S possibly damaging Het
Vmn1r196 T A 13: 22,477,932 (GRCm39) D190E probably damaging Het
Vmn2r67 T A 7: 84,805,019 (GRCm39) D31V probably benign Het
Zbtb22 T A 17: 34,137,553 (GRCm39) M566K probably benign Het
Zfp568 A T 7: 29,721,715 (GRCm39) H220L probably benign Het
Zfp974 A T 7: 27,610,137 (GRCm39) S529R possibly damaging Het
Other mutations in Mug1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00158:Mug1 APN 6 121,842,768 (GRCm39) missense probably damaging 1.00
IGL00485:Mug1 APN 6 121,864,375 (GRCm39) missense probably benign 0.17
IGL00816:Mug1 APN 6 121,859,597 (GRCm39) missense probably damaging 0.99
IGL01140:Mug1 APN 6 121,859,693 (GRCm39) missense probably benign 0.01
IGL01141:Mug1 APN 6 121,847,458 (GRCm39) missense probably benign 0.08
IGL01384:Mug1 APN 6 121,826,433 (GRCm39) splice site probably benign
IGL01659:Mug1 APN 6 121,847,619 (GRCm39) splice site probably benign
IGL02049:Mug1 APN 6 121,848,295 (GRCm39) missense probably benign
IGL02151:Mug1 APN 6 121,861,649 (GRCm39) critical splice donor site probably null
IGL02315:Mug1 APN 6 121,817,126 (GRCm39) missense probably benign
IGL02629:Mug1 APN 6 121,817,024 (GRCm39) missense possibly damaging 0.62
IGL02642:Mug1 APN 6 121,859,544 (GRCm39) missense probably benign 0.14
IGL02807:Mug1 APN 6 121,863,531 (GRCm39) missense probably damaging 0.96
IGL02932:Mug1 APN 6 121,864,386 (GRCm39) missense probably benign 0.35
IGL03232:Mug1 APN 6 121,855,494 (GRCm39) missense probably benign 0.00
R1462_Mug1_304 UTSW 6 121,859,588 (GRCm39) missense probably benign 0.41
R2341_Mug1_749 UTSW 6 121,861,588 (GRCm39) missense probably benign 0.06
R4261_Mug1_652 UTSW 6 121,850,693 (GRCm39) missense probably benign
R6173_mug1_139 UTSW 6 121,840,752 (GRCm39) missense probably damaging 0.99
IGL03050:Mug1 UTSW 6 121,857,530 (GRCm39) missense possibly damaging 0.90
R0101:Mug1 UTSW 6 121,861,206 (GRCm39) missense possibly damaging 0.59
R0194:Mug1 UTSW 6 121,817,066 (GRCm39) missense probably damaging 0.98
R0196:Mug1 UTSW 6 121,815,684 (GRCm39) critical splice donor site probably null
R0325:Mug1 UTSW 6 121,826,801 (GRCm39) missense probably benign
R0332:Mug1 UTSW 6 121,826,856 (GRCm39) splice site probably null
R0377:Mug1 UTSW 6 121,834,320 (GRCm39) missense probably benign 0.02
R0393:Mug1 UTSW 6 121,826,809 (GRCm39) missense possibly damaging 0.64
R0414:Mug1 UTSW 6 121,833,513 (GRCm39) missense probably benign 0.00
R0457:Mug1 UTSW 6 121,838,514 (GRCm39) missense probably benign 0.06
R0479:Mug1 UTSW 6 121,817,186 (GRCm39) missense probably benign
R0519:Mug1 UTSW 6 121,828,383 (GRCm39) missense possibly damaging 0.83
R0535:Mug1 UTSW 6 121,828,413 (GRCm39) missense probably benign
R0745:Mug1 UTSW 6 121,864,386 (GRCm39) missense probably benign 0.35
R0939:Mug1 UTSW 6 121,861,308 (GRCm39) missense possibly damaging 0.95
R0975:Mug1 UTSW 6 121,855,498 (GRCm39) missense probably damaging 0.99
R1033:Mug1 UTSW 6 121,857,510 (GRCm39) missense probably damaging 0.99
R1086:Mug1 UTSW 6 121,862,813 (GRCm39) missense probably damaging 1.00
R1116:Mug1 UTSW 6 121,847,604 (GRCm39) missense probably benign
R1131:Mug1 UTSW 6 121,838,144 (GRCm39) missense probably benign 0.18
R1249:Mug1 UTSW 6 121,826,420 (GRCm39) missense probably benign 0.07
R1364:Mug1 UTSW 6 121,858,672 (GRCm39) missense probably damaging 1.00
R1418:Mug1 UTSW 6 121,815,635 (GRCm39) missense probably benign 0.00
R1462:Mug1 UTSW 6 121,859,588 (GRCm39) missense probably benign 0.41
R1462:Mug1 UTSW 6 121,859,588 (GRCm39) missense probably benign 0.41
R1494:Mug1 UTSW 6 121,856,259 (GRCm39) missense probably damaging 1.00
R1639:Mug1 UTSW 6 121,857,530 (GRCm39) missense probably damaging 1.00
R1901:Mug1 UTSW 6 121,858,780 (GRCm39) missense probably benign
R1902:Mug1 UTSW 6 121,858,780 (GRCm39) missense probably benign
R2087:Mug1 UTSW 6 121,833,250 (GRCm39) missense probably benign 0.00
R2168:Mug1 UTSW 6 121,847,458 (GRCm39) missense probably benign 0.08
R2249:Mug1 UTSW 6 121,847,469 (GRCm39) missense probably benign
R2341:Mug1 UTSW 6 121,861,588 (GRCm39) missense probably benign 0.06
R2888:Mug1 UTSW 6 121,858,802 (GRCm39) missense probably benign 0.44
R2892:Mug1 UTSW 6 121,817,029 (GRCm39) missense possibly damaging 0.91
R3703:Mug1 UTSW 6 121,865,515 (GRCm39) splice site probably benign
R3789:Mug1 UTSW 6 121,861,587 (GRCm39) missense probably benign 0.03
R3790:Mug1 UTSW 6 121,861,587 (GRCm39) missense probably benign 0.03
R3950:Mug1 UTSW 6 121,855,489 (GRCm39) missense probably damaging 1.00
R4261:Mug1 UTSW 6 121,850,693 (GRCm39) missense probably benign
R4402:Mug1 UTSW 6 121,856,311 (GRCm39) missense probably damaging 1.00
R4589:Mug1 UTSW 6 121,834,310 (GRCm39) missense probably benign 0.19
R4707:Mug1 UTSW 6 121,861,600 (GRCm39) missense probably damaging 1.00
R4766:Mug1 UTSW 6 121,861,213 (GRCm39) missense probably benign 0.01
R4840:Mug1 UTSW 6 121,862,813 (GRCm39) missense probably damaging 1.00
R4984:Mug1 UTSW 6 121,815,576 (GRCm39) utr 5 prime probably benign
R4999:Mug1 UTSW 6 121,855,902 (GRCm39) nonsense probably null
R5198:Mug1 UTSW 6 121,851,521 (GRCm39) missense probably damaging 1.00
R5220:Mug1 UTSW 6 121,838,092 (GRCm39) missense probably benign 0.03
R5253:Mug1 UTSW 6 121,865,872 (GRCm39) missense probably benign 0.03
R5273:Mug1 UTSW 6 121,850,748 (GRCm39) missense probably damaging 0.99
R5285:Mug1 UTSW 6 121,818,066 (GRCm39) missense probably benign 0.45
R5387:Mug1 UTSW 6 121,861,353 (GRCm39) missense probably damaging 0.99
R5560:Mug1 UTSW 6 121,838,032 (GRCm39) missense probably damaging 0.96
R5652:Mug1 UTSW 6 121,817,140 (GRCm39) missense probably benign
R5704:Mug1 UTSW 6 121,828,392 (GRCm39) missense possibly damaging 0.63
R5732:Mug1 UTSW 6 121,855,452 (GRCm39) missense probably benign 0.00
R6053:Mug1 UTSW 6 121,842,697 (GRCm39) missense probably benign 0.00
R6173:Mug1 UTSW 6 121,840,752 (GRCm39) missense probably damaging 0.99
R6578:Mug1 UTSW 6 121,864,411 (GRCm39) missense probably benign 0.00
R6647:Mug1 UTSW 6 121,817,200 (GRCm39) missense probably benign 0.02
R6681:Mug1 UTSW 6 121,815,683 (GRCm39) missense possibly damaging 0.75
R6925:Mug1 UTSW 6 121,858,746 (GRCm39) missense probably damaging 1.00
R7014:Mug1 UTSW 6 121,838,084 (GRCm39) missense probably benign 0.22
R7031:Mug1 UTSW 6 121,815,673 (GRCm39) missense probably benign 0.00
R7034:Mug1 UTSW 6 121,850,603 (GRCm39) missense probably benign 0.00
R7156:Mug1 UTSW 6 121,861,302 (GRCm39) missense probably damaging 1.00
R7156:Mug1 UTSW 6 121,857,864 (GRCm39) missense probably damaging 1.00
R7179:Mug1 UTSW 6 121,834,379 (GRCm39) missense probably benign 0.00
R7211:Mug1 UTSW 6 121,857,498 (GRCm39) missense possibly damaging 0.52
R7318:Mug1 UTSW 6 121,847,611 (GRCm39) critical splice donor site probably null
R7462:Mug1 UTSW 6 121,852,399 (GRCm39) missense probably benign 0.00
R7479:Mug1 UTSW 6 121,855,467 (GRCm39) missense possibly damaging 0.83
R7588:Mug1 UTSW 6 121,852,476 (GRCm39) missense probably damaging 1.00
R7611:Mug1 UTSW 6 121,852,387 (GRCm39) critical splice acceptor site probably null
R7659:Mug1 UTSW 6 121,838,179 (GRCm39) missense possibly damaging 0.95
R7660:Mug1 UTSW 6 121,838,179 (GRCm39) missense possibly damaging 0.95
R7661:Mug1 UTSW 6 121,838,179 (GRCm39) missense possibly damaging 0.95
R7663:Mug1 UTSW 6 121,838,179 (GRCm39) missense possibly damaging 0.95
R7666:Mug1 UTSW 6 121,838,179 (GRCm39) missense possibly damaging 0.95
R7788:Mug1 UTSW 6 121,838,179 (GRCm39) missense possibly damaging 0.95
R7789:Mug1 UTSW 6 121,838,179 (GRCm39) missense possibly damaging 0.95
R7794:Mug1 UTSW 6 121,833,247 (GRCm39) missense possibly damaging 0.93
R7809:Mug1 UTSW 6 121,855,944 (GRCm39) missense possibly damaging 0.79
R7836:Mug1 UTSW 6 121,847,611 (GRCm39) critical splice donor site probably null
R7867:Mug1 UTSW 6 121,850,593 (GRCm39) missense probably benign
R7904:Mug1 UTSW 6 121,828,424 (GRCm39) missense probably benign
R7937:Mug1 UTSW 6 121,838,128 (GRCm39) missense probably benign 0.00
R7981:Mug1 UTSW 6 121,858,723 (GRCm39) missense probably damaging 1.00
R7999:Mug1 UTSW 6 121,857,855 (GRCm39) missense possibly damaging 0.90
R8070:Mug1 UTSW 6 121,852,838 (GRCm39) missense probably benign 0.26
R8071:Mug1 UTSW 6 121,850,631 (GRCm39) missense probably benign
R8151:Mug1 UTSW 6 121,818,117 (GRCm39) missense probably benign 0.01
R8491:Mug1 UTSW 6 121,859,688 (GRCm39) missense probably damaging 1.00
R8714:Mug1 UTSW 6 121,859,681 (GRCm39) missense probably benign 0.01
R8734:Mug1 UTSW 6 121,848,340 (GRCm39) missense probably benign 0.00
R8738:Mug1 UTSW 6 121,817,208 (GRCm39) splice site probably benign
R8807:Mug1 UTSW 6 121,851,434 (GRCm39) missense probably benign 0.27
R8931:Mug1 UTSW 6 121,861,296 (GRCm39) missense probably benign
R8940:Mug1 UTSW 6 121,858,642 (GRCm39) missense
R9156:Mug1 UTSW 6 121,851,390 (GRCm39) missense probably damaging 0.99
R9314:Mug1 UTSW 6 121,834,296 (GRCm39) missense probably damaging 0.97
R9315:Mug1 UTSW 6 121,850,730 (GRCm39) missense possibly damaging 0.95
R9330:Mug1 UTSW 6 121,859,723 (GRCm39) missense probably benign 0.14
R9334:Mug1 UTSW 6 121,838,490 (GRCm39) missense probably benign 0.01
R9357:Mug1 UTSW 6 121,852,450 (GRCm39) missense probably benign 0.02
R9515:Mug1 UTSW 6 121,861,635 (GRCm39) missense probably damaging 1.00
R9549:Mug1 UTSW 6 121,858,762 (GRCm39) missense probably damaging 1.00
R9564:Mug1 UTSW 6 121,861,587 (GRCm39) missense probably benign 0.03
R9663:Mug1 UTSW 6 121,859,699 (GRCm39) missense probably benign 0.03
R9663:Mug1 UTSW 6 121,857,463 (GRCm39) missense probably benign 0.08
R9681:Mug1 UTSW 6 121,833,254 (GRCm39) missense probably benign 0.01
R9777:Mug1 UTSW 6 121,857,864 (GRCm39) missense probably damaging 1.00
RF017:Mug1 UTSW 6 121,861,533 (GRCm39) missense probably damaging 1.00
X0064:Mug1 UTSW 6 121,838,174 (GRCm39) missense possibly damaging 0.48
Z1176:Mug1 UTSW 6 121,857,452 (GRCm39) missense probably damaging 1.00
Z1176:Mug1 UTSW 6 121,818,253 (GRCm39) missense probably benign 0.32
Z1177:Mug1 UTSW 6 121,856,258 (GRCm39) critical splice acceptor site probably null
Z1177:Mug1 UTSW 6 121,840,767 (GRCm39) missense probably damaging 0.99
Z1177:Mug1 UTSW 6 121,863,527 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TATTCTGTCTGCTAGGCAATCTG -3'
(R):5'- CCCAGATAGAACCCAATGTGTAAAG -3'

Sequencing Primer
(F):5'- TCTGCTAGGCAATCTGCAGCATAG -3'
(R):5'- CCCAATGTGTAAAGAGAGACATGGTC -3'
Posted On 2019-11-12