Incidental Mutation 'R8338:Arap3'
| ID |
644777 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arap3
|
| Ensembl Gene |
ENSMUSG00000024451 |
| Gene Name |
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 |
| Synonyms |
Centd3, E030006K04Rik, DRAG1 |
| MMRRC Submission |
067730-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.814)
|
| Stock # |
R8338 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
18 |
| Chromosomal Location |
38105681-38132022 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 38106683 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 1387
(S1387P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000035662
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000042944]
[ENSMUST00000043437]
[ENSMUST00000163131]
[ENSMUST00000164222]
[ENSMUST00000166148]
|
| AlphaFold |
Q8R5G7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000042944
AA Change: S1387P
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000035662
Gene: ENSMUSG00000024451
AA Change: S1387P
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
1 |
68 |
1.5e-7 |
SMART |
|
low complexity region
|
81 |
98 |
N/A |
INTRINSIC |
|
low complexity region
|
134 |
142 |
N/A |
INTRINSIC |
|
PH
|
283 |
376 |
3.4e-16 |
SMART |
|
PH
|
390 |
480 |
1.61e-8 |
SMART |
|
ArfGap
|
484 |
606 |
1.44e-25 |
SMART |
|
low complexity region
|
642 |
661 |
N/A |
INTRINSIC |
|
PH
|
671 |
785 |
2.86e1 |
SMART |
|
PH
|
795 |
901 |
6.87e-3 |
SMART |
|
RhoGAP
|
913 |
1089 |
2.11e-47 |
SMART |
|
Pfam:RA
|
1113 |
1206 |
6.2e-16 |
PFAM |
|
PH
|
1220 |
1323 |
3.46e-8 |
SMART |
|
low complexity region
|
1388 |
1407 |
N/A |
INTRINSIC |
|
low complexity region
|
1457 |
1469 |
N/A |
INTRINSIC |
|
low complexity region
|
1475 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1494 |
1529 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000043437
|
| SMART Domains |
Protein: ENSMUSP00000047878
Gene: ENSMUSG00000038524
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:FCH
|
21 |
100 |
1.6e-19 |
PFAM |
|
coiled coil region
|
188 |
209 |
N/A |
INTRINSIC |
|
low complexity region
|
346 |
357 |
N/A |
INTRINSIC |
|
SH3
|
469 |
526 |
1.34e-8 |
SMART |
|
SH3
|
547 |
606 |
1.94e-14 |
SMART |
|
low complexity region
|
622 |
634 |
N/A |
INTRINSIC |
|
low complexity region
|
657 |
686 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163131
|
| SMART Domains |
Protein: ENSMUSP00000133058
Gene: ENSMUSG00000038524
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:FCH
|
12 |
107 |
1.6e-18 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164222
|
| SMART Domains |
Protein: ENSMUSP00000128481
Gene: ENSMUSG00000038524
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:FCH
|
12 |
56 |
2.5e-11 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000166148
|
| SMART Domains |
Protein: ENSMUSP00000129825
Gene: ENSMUSG00000038524
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:FCH
|
12 |
93 |
1.6e-17 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
PHENOTYPE: Mice homozygous for a knock-out allele die around E11 exhibiting pallor, embryonic growth arrest, yolk sac and placental abnormalities, and an endothelial cell-autonomous defect in sprouting angiogenesis. Knock-in mice homozygous for a point mutation display similar angiogenesis defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(5) : Targeted(5)
|
| Other mutations in this stock |
Total: 76 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ache |
T |
C |
5: 137,290,006 (GRCm39) |
L445P |
probably damaging |
Het |
| Agrn |
G |
A |
4: 156,253,018 (GRCm39) |
T1773I |
probably benign |
Het |
| Bcl11a |
G |
C |
11: 24,114,578 (GRCm39) |
K640N |
probably damaging |
Het |
| Bicd1 |
G |
A |
6: 149,414,621 (GRCm39) |
V445I |
probably benign |
Het |
| Bltp3a |
A |
G |
17: 28,095,669 (GRCm39) |
N26S |
probably damaging |
Het |
| C2cd6 |
A |
C |
1: 59,099,734 (GRCm39) |
N402K |
probably benign |
Het |
| Celsr3 |
C |
T |
9: 108,704,539 (GRCm39) |
Q341* |
probably null |
Het |
| Cers1 |
A |
G |
8: 70,783,772 (GRCm39) |
E240G |
possibly damaging |
Het |
| Cfap157 |
G |
T |
2: 32,668,018 (GRCm39) |
T441N |
possibly damaging |
Het |
| Cfap44 |
G |
A |
16: 44,239,698 (GRCm39) |
|
probably null |
Het |
| Chd1 |
A |
G |
17: 15,990,242 (GRCm39) |
Y1598C |
probably damaging |
Het |
| Ckap2l |
T |
G |
2: 129,126,939 (GRCm39) |
Q413P |
probably damaging |
Het |
| Cobl |
T |
C |
11: 12,203,696 (GRCm39) |
E1002G |
probably benign |
Het |
| Cryge |
G |
A |
1: 65,087,933 (GRCm39) |
T156M |
unknown |
Het |
| Cubn |
A |
C |
2: 13,435,658 (GRCm39) |
F1099L |
probably benign |
Het |
| Cyp7b1 |
T |
C |
3: 18,151,730 (GRCm39) |
E161G |
probably benign |
Het |
| Dnah10 |
A |
G |
5: 124,909,566 (GRCm39) |
E4452G |
probably damaging |
Het |
| Dnah2 |
C |
T |
11: 69,378,122 (GRCm39) |
R1273Q |
probably damaging |
Het |
| Dnah3 |
T |
C |
7: 119,671,104 (GRCm39) |
E593G |
probably benign |
Het |
| Dnah9 |
C |
A |
11: 65,732,067 (GRCm39) |
|
probably null |
Het |
| Dnajc22 |
C |
A |
15: 98,999,022 (GRCm39) |
P69Q |
probably benign |
Het |
| Fam171a2 |
T |
A |
11: 102,329,172 (GRCm39) |
D529V |
probably benign |
Het |
| Fbxl17 |
T |
C |
17: 63,663,753 (GRCm39) |
I579V |
possibly damaging |
Het |
| Fry |
C |
T |
5: 150,282,516 (GRCm39) |
T347M |
probably damaging |
Het |
| Gm13272 |
A |
C |
4: 88,698,364 (GRCm39) |
D93A |
probably benign |
Het |
| Grm4 |
A |
T |
17: 27,653,977 (GRCm39) |
F658I |
probably damaging |
Het |
| Hmcn1 |
G |
A |
1: 150,614,485 (GRCm39) |
T1307I |
probably benign |
Het |
| Igkv12-98 |
G |
A |
6: 68,548,159 (GRCm39) |
S96N |
probably benign |
Het |
| Il2ra |
A |
T |
2: 11,687,885 (GRCm39) |
T222S |
probably benign |
Het |
| Il5ra |
G |
T |
6: 106,689,350 (GRCm39) |
T414K |
probably benign |
Het |
| Isg15 |
T |
A |
4: 156,284,088 (GRCm39) |
I147F |
probably benign |
Het |
| Kif14 |
C |
A |
1: 136,422,416 (GRCm39) |
A902E |
probably damaging |
Het |
| Lcat |
G |
A |
8: 106,666,719 (GRCm39) |
R268C |
probably damaging |
Het |
| Lipa |
T |
C |
19: 34,471,477 (GRCm39) |
N366S |
probably benign |
Het |
| Lrp4 |
A |
G |
2: 91,322,713 (GRCm39) |
T1101A |
probably benign |
Het |
| Man1a |
T |
A |
10: 53,801,643 (GRCm39) |
|
probably null |
Het |
| Mib1 |
A |
G |
18: 10,726,372 (GRCm39) |
D23G |
probably benign |
Het |
| Morc2b |
A |
T |
17: 33,355,387 (GRCm39) |
M795K |
probably benign |
Het |
| Msantd5f1 |
T |
A |
4: 73,605,435 (GRCm39) |
M282K |
possibly damaging |
Het |
| Mycbp2 |
T |
A |
14: 103,372,701 (GRCm39) |
E4048D |
probably damaging |
Het |
| Myo7b |
A |
G |
18: 32,104,408 (GRCm39) |
S1447P |
probably damaging |
Het |
| Myt1 |
A |
T |
2: 181,443,655 (GRCm39) |
T536S |
possibly damaging |
Het |
| Nod1 |
A |
T |
6: 54,920,956 (GRCm39) |
L454Q |
probably damaging |
Het |
| Nrf1 |
T |
A |
6: 30,140,247 (GRCm39) |
W199R |
|
Het |
| Or10w1 |
T |
A |
19: 13,632,216 (GRCm39) |
M141K |
possibly damaging |
Het |
| Or13a27 |
T |
A |
7: 139,925,306 (GRCm39) |
M199L |
probably benign |
Het |
| Or14c44 |
T |
C |
7: 86,061,702 (GRCm39) |
I44T |
probably benign |
Het |
| Or8k27 |
A |
T |
2: 86,275,729 (GRCm39) |
M199K |
probably benign |
Het |
| Or9a4 |
T |
C |
6: 40,548,910 (GRCm39) |
F197L |
probably benign |
Het |
| Ostn |
G |
T |
16: 27,143,285 (GRCm39) |
A38S |
probably benign |
Het |
| Paxbp1 |
A |
T |
16: 90,833,435 (GRCm39) |
D266E |
probably damaging |
Het |
| Pcdhb14 |
G |
T |
18: 37,582,175 (GRCm39) |
G427V |
probably damaging |
Het |
| Pdzrn3 |
A |
T |
6: 101,127,783 (GRCm39) |
M961K |
probably benign |
Het |
| Peg10 |
CCACATCAGGATCCACATCAGGATGCACATCAGCATCAGGATCCCCATCAGGATGCACATCAGGATCCACATCAGGATGCACATCAG |
CCACATCAGGATCCACATCAGGATGCACATCAG |
6: 4,756,398 (GRCm39) |
|
probably benign |
Het |
| Prdx5 |
T |
C |
19: 6,884,632 (GRCm39) |
D148G |
probably damaging |
Het |
| Ptprj |
A |
T |
2: 90,301,481 (GRCm39) |
I217N |
possibly damaging |
Het |
| Rccd1 |
A |
T |
7: 79,970,618 (GRCm39) |
L54Q |
possibly damaging |
Het |
| Rfx6 |
T |
A |
10: 51,594,190 (GRCm39) |
V370E |
probably damaging |
Het |
| Sdr16c6 |
C |
T |
4: 4,076,620 (GRCm39) |
C93Y |
probably damaging |
Het |
| Shroom1 |
A |
G |
11: 53,354,107 (GRCm39) |
D9G |
probably benign |
Het |
| Snrpe |
A |
G |
1: 133,536,681 (GRCm39) |
V33A |
probably benign |
Het |
| Spats2 |
T |
A |
15: 99,076,340 (GRCm39) |
D139E |
probably damaging |
Het |
| Spopfm1 |
A |
G |
3: 94,173,285 (GRCm39) |
I94V |
possibly damaging |
Het |
| St18 |
A |
G |
1: 6,879,516 (GRCm39) |
E405G |
probably damaging |
Het |
| Strap |
A |
T |
6: 137,718,976 (GRCm39) |
E176V |
possibly damaging |
Het |
| Stxbp5l |
G |
T |
16: 36,994,718 (GRCm39) |
T729K |
probably damaging |
Het |
| Synj2bp |
G |
A |
12: 81,551,326 (GRCm39) |
Q97* |
probably null |
Het |
| Tbc1d32 |
T |
A |
10: 55,904,173 (GRCm39) |
Q1198L |
possibly damaging |
Het |
| Tmem98 |
T |
C |
11: 80,712,135 (GRCm39) |
S191P |
probably benign |
Het |
| Tnn |
C |
T |
1: 159,946,053 (GRCm39) |
G922R |
probably damaging |
Het |
| Treh |
A |
G |
9: 44,595,808 (GRCm39) |
N366S |
probably benign |
Het |
| Ttn |
T |
G |
2: 76,750,136 (GRCm39) |
S3638R |
probably benign |
Het |
| Uggt1 |
A |
G |
1: 36,266,602 (GRCm39) |
L124P |
probably damaging |
Het |
| V1rd19 |
A |
T |
7: 23,702,674 (GRCm39) |
K47* |
probably null |
Het |
| Wdhd1 |
T |
C |
14: 47,506,120 (GRCm39) |
M265V |
probably benign |
Het |
| Wsb1 |
T |
C |
11: 79,137,103 (GRCm39) |
D168G |
probably damaging |
Het |
|
| Other mutations in Arap3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00515:Arap3
|
APN |
18 |
38,108,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01145:Arap3
|
APN |
18 |
38,122,232 (GRCm39) |
missense |
probably benign |
|
|
IGL01154:Arap3
|
APN |
18 |
38,129,787 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL01305:Arap3
|
APN |
18 |
38,124,380 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01542:Arap3
|
APN |
18 |
38,123,889 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01543:Arap3
|
APN |
18 |
38,123,889 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01544:Arap3
|
APN |
18 |
38,123,889 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01545:Arap3
|
APN |
18 |
38,123,889 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01677:Arap3
|
APN |
18 |
38,129,700 (GRCm39) |
missense |
probably benign |
|
|
IGL01925:Arap3
|
APN |
18 |
38,117,299 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL01933:Arap3
|
APN |
18 |
38,111,506 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02048:Arap3
|
APN |
18 |
38,130,032 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL02064:Arap3
|
APN |
18 |
38,124,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02207:Arap3
|
APN |
18 |
38,120,906 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02376:Arap3
|
APN |
18 |
38,111,506 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02531:Arap3
|
APN |
18 |
38,122,804 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02568:Arap3
|
APN |
18 |
38,129,711 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL02640:Arap3
|
APN |
18 |
38,120,855 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02658:Arap3
|
APN |
18 |
38,124,047 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03090:Arap3
|
APN |
18 |
38,122,165 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03352:Arap3
|
APN |
18 |
38,114,355 (GRCm39) |
splice site |
probably benign |
|
|
ANU22:Arap3
|
UTSW |
18 |
38,124,380 (GRCm39) |
critical splice donor site |
probably null |
|
|
P0016:Arap3
|
UTSW |
18 |
38,117,401 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4260001:Arap3
|
UTSW |
18 |
38,129,948 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0066:Arap3
|
UTSW |
18 |
38,129,760 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0324:Arap3
|
UTSW |
18 |
38,106,278 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0562:Arap3
|
UTSW |
18 |
38,108,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1289:Arap3
|
UTSW |
18 |
38,115,026 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1346:Arap3
|
UTSW |
18 |
38,108,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1419:Arap3
|
UTSW |
18 |
38,111,485 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R1470:Arap3
|
UTSW |
18 |
38,122,249 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1470:Arap3
|
UTSW |
18 |
38,122,249 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1537:Arap3
|
UTSW |
18 |
38,122,737 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1644:Arap3
|
UTSW |
18 |
38,117,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1731:Arap3
|
UTSW |
18 |
38,122,965 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1758:Arap3
|
UTSW |
18 |
38,122,965 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1843:Arap3
|
UTSW |
18 |
38,108,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1907:Arap3
|
UTSW |
18 |
38,129,724 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1954:Arap3
|
UTSW |
18 |
38,115,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2124:Arap3
|
UTSW |
18 |
38,106,403 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2135:Arap3
|
UTSW |
18 |
38,107,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2172:Arap3
|
UTSW |
18 |
38,123,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2418:Arap3
|
UTSW |
18 |
38,122,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2419:Arap3
|
UTSW |
18 |
38,122,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2907:Arap3
|
UTSW |
18 |
38,123,580 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4425:Arap3
|
UTSW |
18 |
38,111,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4669:Arap3
|
UTSW |
18 |
38,129,307 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4734:Arap3
|
UTSW |
18 |
38,129,328 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4815:Arap3
|
UTSW |
18 |
38,106,296 (GRCm39) |
missense |
probably benign |
|
|
R5328:Arap3
|
UTSW |
18 |
38,124,740 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5350:Arap3
|
UTSW |
18 |
38,115,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5466:Arap3
|
UTSW |
18 |
38,129,789 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5482:Arap3
|
UTSW |
18 |
38,107,727 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5572:Arap3
|
UTSW |
18 |
38,124,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5779:Arap3
|
UTSW |
18 |
38,117,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6053:Arap3
|
UTSW |
18 |
38,123,824 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6144:Arap3
|
UTSW |
18 |
38,118,486 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6166:Arap3
|
UTSW |
18 |
38,107,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6248:Arap3
|
UTSW |
18 |
38,124,407 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6266:Arap3
|
UTSW |
18 |
38,123,844 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6385:Arap3
|
UTSW |
18 |
38,130,084 (GRCm39) |
nonsense |
probably null |
|
|
R6694:Arap3
|
UTSW |
18 |
38,124,590 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6856:Arap3
|
UTSW |
18 |
38,112,916 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7073:Arap3
|
UTSW |
18 |
38,107,495 (GRCm39) |
nonsense |
probably null |
|
|
R7297:Arap3
|
UTSW |
18 |
38,106,616 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7352:Arap3
|
UTSW |
18 |
38,106,331 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7652:Arap3
|
UTSW |
18 |
38,111,505 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7726:Arap3
|
UTSW |
18 |
38,122,520 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7747:Arap3
|
UTSW |
18 |
38,121,941 (GRCm39) |
splice site |
probably null |
|
|
R7944:Arap3
|
UTSW |
18 |
38,122,232 (GRCm39) |
missense |
probably benign |
|
|
R8152:Arap3
|
UTSW |
18 |
38,124,410 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R8549:Arap3
|
UTSW |
18 |
38,106,365 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8793:Arap3
|
UTSW |
18 |
38,107,492 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8876:Arap3
|
UTSW |
18 |
38,130,077 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9142:Arap3
|
UTSW |
18 |
38,112,934 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9237:Arap3
|
UTSW |
18 |
38,112,934 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9583:Arap3
|
UTSW |
18 |
38,109,096 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9696:Arap3
|
UTSW |
18 |
38,112,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0011:Arap3
|
UTSW |
18 |
38,107,154 (GRCm39) |
critical splice donor site |
probably null |
|
|
X0026:Arap3
|
UTSW |
18 |
38,118,364 (GRCm39) |
critical splice donor site |
probably null |
|
|
X0027:Arap3
|
UTSW |
18 |
38,106,538 (GRCm39) |
splice site |
probably null |
|
|
X0066:Arap3
|
UTSW |
18 |
38,124,699 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GGGTTGATCAAAGGACCTCTG -3'
(R):5'- TCTGAGTTCAAGCCTCACCAAC -3'
Sequencing Primer
(F):5'- TGATCAAAGGACCTCTGGCTGG -3'
(R):5'- GTCCAGGGCATCTTGACTC -3'
|
| Posted On |
2020-09-02 |
Incidental Mutation