Incidental Mutation 'R8833:Fam135b'
ID 674000
Institutional Source Beutler Lab
Gene Symbol Fam135b
Ensembl Gene ENSMUSG00000036800
Gene Name family with sequence similarity 135, member B
Synonyms 1700010C24Rik, A830008O07Rik
MMRRC Submission 068661-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8833 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 71310800-71600282 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 71334783 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 804 (N804D)
Ref Sequence ENSEMBL: ENSMUSP00000022953 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022953]
AlphaFold Q9DAI6
Predicted Effect probably benign
Transcript: ENSMUST00000022953
AA Change: N804D

PolyPhen 2 Score 0.039 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000022953
Gene: ENSMUSG00000036800
AA Change: N804D

DomainStartEndE-ValueType
Pfam:DUF3657 111 172 1.9e-19 PFAM
low complexity region 744 757 N/A INTRINSIC
low complexity region 1124 1130 N/A INTRINSIC
Pfam:DUF676 1132 1328 2.7e-60 PFAM
Pfam:PGAP1 1135 1309 3.2e-9 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.5%
Validation Efficiency 100% (53/53)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1c6 T A 13: 4,496,377 (GRCm39) D132E possibly damaging Het
Armh4 C T 14: 50,011,318 (GRCm39) V130I probably benign Het
Atp10b A G 11: 43,112,986 (GRCm39) E844G probably damaging Het
Bbx T A 16: 50,045,629 (GRCm39) M311L probably benign Het
Bzw2 A T 12: 36,169,069 (GRCm39) M153K probably benign Het
C1qtnf6 G T 15: 78,409,574 (GRCm39) T91K probably benign Het
Cdh4 A G 2: 179,535,828 (GRCm39) D793G possibly damaging Het
Ces4a A G 8: 105,858,614 (GRCm39) I11V probably benign Het
Cpne9 T C 6: 113,281,473 (GRCm39) L518P probably damaging Het
Dip2c T A 13: 9,625,519 (GRCm39) probably null Het
Frem3 G A 8: 81,339,401 (GRCm39) D565N probably benign Het
Fscb T A 12: 64,519,997 (GRCm39) T490S unknown Het
Fuca1 A G 4: 135,648,206 (GRCm39) D31G probably damaging Het
Gbp8 G T 5: 105,166,668 (GRCm39) N220K possibly damaging Het
Gfra2 T C 14: 71,163,337 (GRCm39) F207L probably damaging Het
Grap2 A G 15: 80,522,684 (GRCm39) N70S probably benign Het
Ifna13 C A 4: 88,562,157 (GRCm39) E156* probably null Het
Jmjd1c G A 10: 67,054,162 (GRCm39) R22H probably benign Het
Macf1 A G 4: 123,365,134 (GRCm39) V3209A probably benign Het
Muc5b A G 7: 141,412,105 (GRCm39) T1684A unknown Het
Naip5 T A 13: 100,359,442 (GRCm39) E598V probably damaging Het
Niban1 T A 1: 151,520,681 (GRCm39) V125E probably damaging Het
Notch1 G A 2: 26,371,615 (GRCm39) T278I probably damaging Het
Or4d10c A G 19: 12,065,643 (GRCm39) V171A possibly damaging Het
Or4k5 A T 14: 50,385,823 (GRCm39) C169* probably null Het
Or52z13 T G 7: 103,247,444 (GRCm39) F307C possibly damaging Het
Or5k14 A T 16: 58,692,959 (GRCm39) Y185N probably damaging Het
Orm1 A T 4: 63,262,938 (GRCm39) E35V probably damaging Het
Pak1 T A 7: 97,503,839 (GRCm39) I58N possibly damaging Het
Pard3b A G 1: 62,384,158 (GRCm39) E841G probably benign Het
Pcdhb9 G T 18: 37,534,468 (GRCm39) R154I probably benign Het
Pdpr G A 8: 111,852,312 (GRCm39) V560I probably damaging Het
Pkdcc T C 17: 83,531,355 (GRCm39) F455L probably damaging Het
Potefam3c A T 8: 69,881,982 (GRCm39) D331E probably benign Het
Pus7l A T 15: 94,438,143 (GRCm39) F234Y probably damaging Het
Rab3gap2 T A 1: 184,990,722 (GRCm39) L632Q probably damaging Het
Rarb T A 14: 16,819,015 (GRCm38) probably benign Het
Ro60 T A 1: 143,641,517 (GRCm39) K315* probably null Het
Rom1 A T 19: 8,905,471 (GRCm39) H236Q possibly damaging Het
Secisbp2 T C 13: 51,819,352 (GRCm39) S311P probably benign Het
Slc26a1 T C 5: 108,820,182 (GRCm39) D355G probably benign Het
Slc28a3 C T 13: 58,707,077 (GRCm39) A574T probably damaging Het
Sox11 A G 12: 27,392,313 (GRCm39) V32A possibly damaging Het
Spata17 T C 1: 186,915,436 (GRCm39) Y107C probably damaging Het
Speer1a C A 5: 11,394,205 (GRCm39) Y104* probably null Het
Stxbp5l T C 16: 37,024,814 (GRCm39) T595A probably benign Het
Syt11 T C 3: 88,655,149 (GRCm39) D78G probably damaging Het
Tatdn2 T G 6: 113,684,348 (GRCm39) I674S probably damaging Het
Tex14 T A 11: 87,383,878 (GRCm39) S189R probably benign Het
Tln2 C A 9: 67,128,693 (GRCm39) E1465D possibly damaging Het
Tor3a T C 1: 156,483,373 (GRCm39) T350A probably benign Het
Ttr T G 18: 20,799,550 (GRCm39) V36G probably damaging Het
Vmn1r129 A T 7: 21,095,205 (GRCm39) H4Q probably null Het
Vmn1r32 A G 6: 66,530,623 (GRCm39) M51T possibly damaging Het
Zfp141 T C 7: 42,125,687 (GRCm39) T262A possibly damaging Het
Zfp980 T A 4: 145,427,596 (GRCm39) N108K probably benign Het
Other mutations in Fam135b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Fam135b APN 15 71,322,343 (GRCm39) missense probably damaging 1.00
IGL00565:Fam135b APN 15 71,343,361 (GRCm39) missense probably benign
IGL00645:Fam135b APN 15 71,334,395 (GRCm39) missense probably damaging 1.00
IGL00686:Fam135b APN 15 71,334,168 (GRCm39) missense probably benign 0.00
IGL00857:Fam135b APN 15 71,335,465 (GRCm39) missense probably benign 0.16
IGL01443:Fam135b APN 15 71,335,213 (GRCm39) missense probably benign 0.02
IGL01690:Fam135b APN 15 71,328,784 (GRCm39) missense probably benign 0.19
IGL01920:Fam135b APN 15 71,493,885 (GRCm39) missense possibly damaging 0.94
IGL01987:Fam135b APN 15 71,333,964 (GRCm39) missense probably benign
IGL02154:Fam135b APN 15 71,320,559 (GRCm39) missense probably benign 0.12
IGL03107:Fam135b APN 15 71,335,410 (GRCm39) missense probably benign
IGL03264:Fam135b APN 15 71,334,637 (GRCm39) missense probably benign
IGL03055:Fam135b UTSW 15 71,493,883 (GRCm39) missense possibly damaging 0.51
R0010:Fam135b UTSW 15 71,493,881 (GRCm39) missense probably damaging 1.00
R0010:Fam135b UTSW 15 71,493,881 (GRCm39) missense probably damaging 1.00
R0230:Fam135b UTSW 15 71,317,886 (GRCm39) missense probably benign 0.02
R0413:Fam135b UTSW 15 71,335,670 (GRCm39) missense probably benign 0.45
R0524:Fam135b UTSW 15 71,334,133 (GRCm39) missense probably benign 0.00
R0565:Fam135b UTSW 15 71,362,686 (GRCm39) missense possibly damaging 0.88
R0628:Fam135b UTSW 15 71,320,505 (GRCm39) splice site probably benign
R1415:Fam135b UTSW 15 71,328,777 (GRCm39) missense probably damaging 0.99
R1462:Fam135b UTSW 15 71,493,845 (GRCm39) splice site probably benign
R1701:Fam135b UTSW 15 71,331,578 (GRCm39) missense probably damaging 1.00
R1797:Fam135b UTSW 15 71,324,290 (GRCm39) missense probably benign 0.41
R1807:Fam135b UTSW 15 71,335,761 (GRCm39) missense probably benign
R1835:Fam135b UTSW 15 71,362,560 (GRCm39) missense probably damaging 1.00
R1905:Fam135b UTSW 15 71,404,836 (GRCm39) missense probably damaging 1.00
R1937:Fam135b UTSW 15 71,493,863 (GRCm39) missense probably damaging 1.00
R1998:Fam135b UTSW 15 71,324,253 (GRCm39) missense probably damaging 0.98
R2076:Fam135b UTSW 15 71,350,092 (GRCm39) missense probably damaging 0.99
R2518:Fam135b UTSW 15 71,335,760 (GRCm39) missense probably benign 0.00
R3110:Fam135b UTSW 15 71,335,879 (GRCm39) missense probably benign 0.05
R3112:Fam135b UTSW 15 71,335,879 (GRCm39) missense probably benign 0.05
R3932:Fam135b UTSW 15 71,322,280 (GRCm39) missense probably benign 0.29
R4361:Fam135b UTSW 15 71,362,676 (GRCm39) missense probably damaging 1.00
R4397:Fam135b UTSW 15 71,320,525 (GRCm39) missense probably benign 0.17
R4435:Fam135b UTSW 15 71,320,588 (GRCm39) missense probably damaging 1.00
R4645:Fam135b UTSW 15 71,334,189 (GRCm39) missense probably benign
R4740:Fam135b UTSW 15 71,335,920 (GRCm39) missense probably benign 0.01
R4748:Fam135b UTSW 15 71,335,904 (GRCm39) missense probably benign 0.00
R4754:Fam135b UTSW 15 71,334,800 (GRCm39) missense probably benign 0.01
R5044:Fam135b UTSW 15 71,334,560 (GRCm39) missense probably benign 0.02
R5469:Fam135b UTSW 15 71,317,892 (GRCm39) missense probably benign 0.16
R5617:Fam135b UTSW 15 71,493,865 (GRCm39) missense probably damaging 1.00
R5642:Fam135b UTSW 15 71,333,985 (GRCm39) missense probably damaging 1.00
R5778:Fam135b UTSW 15 71,350,881 (GRCm39) missense probably damaging 1.00
R5891:Fam135b UTSW 15 71,397,652 (GRCm39) missense probably damaging 1.00
R5958:Fam135b UTSW 15 71,334,744 (GRCm39) missense
R5982:Fam135b UTSW 15 71,320,518 (GRCm39) critical splice donor site probably null
R5987:Fam135b UTSW 15 71,362,697 (GRCm39) missense probably benign 0.00
R6535:Fam135b UTSW 15 71,493,924 (GRCm39) missense probably damaging 0.99
R6734:Fam135b UTSW 15 71,334,629 (GRCm39) missense probably benign 0.02
R6887:Fam135b UTSW 15 71,335,164 (GRCm39) missense probably damaging 1.00
R7028:Fam135b UTSW 15 71,343,412 (GRCm39) missense probably damaging 1.00
R7035:Fam135b UTSW 15 71,334,102 (GRCm39) missense possibly damaging 0.77
R7097:Fam135b UTSW 15 71,493,917 (GRCm39) missense possibly damaging 0.92
R7143:Fam135b UTSW 15 71,351,000 (GRCm39) missense probably benign 0.44
R7414:Fam135b UTSW 15 71,350,105 (GRCm39) missense probably damaging 0.97
R7439:Fam135b UTSW 15 71,335,529 (GRCm39) missense probably damaging 0.98
R7441:Fam135b UTSW 15 71,335,529 (GRCm39) missense probably damaging 0.98
R7545:Fam135b UTSW 15 71,322,359 (GRCm39) missense possibly damaging 0.95
R7615:Fam135b UTSW 15 71,335,172 (GRCm39) missense probably damaging 1.00
R7642:Fam135b UTSW 15 71,350,991 (GRCm39) missense possibly damaging 0.51
R7649:Fam135b UTSW 15 71,334,429 (GRCm39) missense probably benign 0.00
R7686:Fam135b UTSW 15 71,335,233 (GRCm39) missense possibly damaging 0.68
R7866:Fam135b UTSW 15 71,333,925 (GRCm39) missense probably benign 0.00
R8006:Fam135b UTSW 15 71,334,183 (GRCm39) missense probably benign 0.00
R8068:Fam135b UTSW 15 71,404,827 (GRCm39) missense probably damaging 1.00
R8167:Fam135b UTSW 15 71,404,840 (GRCm39) missense probably null 1.00
R8252:Fam135b UTSW 15 71,404,872 (GRCm39) missense probably benign 0.10
R8548:Fam135b UTSW 15 71,334,659 (GRCm39) missense probably damaging 0.99
R8955:Fam135b UTSW 15 71,334,063 (GRCm39) missense possibly damaging 0.85
R8961:Fam135b UTSW 15 71,404,812 (GRCm39) missense probably damaging 1.00
R8987:Fam135b UTSW 15 71,334,189 (GRCm39) missense probably benign 0.00
R9149:Fam135b UTSW 15 71,334,744 (GRCm39) missense
R9161:Fam135b UTSW 15 71,334,417 (GRCm39) missense possibly damaging 0.91
R9227:Fam135b UTSW 15 71,335,856 (GRCm39) missense probably benign 0.28
R9230:Fam135b UTSW 15 71,335,856 (GRCm39) missense probably benign 0.28
R9365:Fam135b UTSW 15 71,334,813 (GRCm39) missense probably benign 0.00
R9622:Fam135b UTSW 15 71,397,686 (GRCm39) missense probably damaging 0.98
R9758:Fam135b UTSW 15 71,324,199 (GRCm39) missense probably benign 0.28
R9759:Fam135b UTSW 15 71,335,689 (GRCm39) missense probably benign 0.44
T0722:Fam135b UTSW 15 71,335,734 (GRCm39) missense probably damaging 1.00
T0975:Fam135b UTSW 15 71,335,734 (GRCm39) missense probably damaging 1.00
Z1177:Fam135b UTSW 15 71,493,925 (GRCm39) start codon destroyed probably null 0.06
Predicted Primers PCR Primer
(F):5'- CAACATGTAGTGGGGTCTCAGC -3'
(R):5'- CAGTGGCATTCAGGCTTCTC -3'

Sequencing Primer
(F):5'- CCATCCAGACAACAGGGTTCTTG -3'
(R):5'- GTGGCATTCAGGCTTCTCTTTCC -3'
Posted On 2021-07-15