|Institutional Source||Beutler Lab|
|Gene Name||somatostatin receptor 4|
|Is this an essential gene?||Possibly non essential (E-score: 0.261)|
|Stock #||R8939 (G1)|
|Chromosomal Location||148395344-148396767 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||C to A at 148396308 bp (GRCm38)|
|Amino Acid Change||Leucine to Methionine at position 280 (L280M)|
|Ref Sequence||ENSEMBL: ENSMUSP00000105588 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000109962]|
|AlphaFold||no structure available at present|
AA Change: L280M
PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
AA Change: L280M
|Coding Region Coverage||
|Validation Efficiency||100% (71/71)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygote null mice have increased susceptibility to inflammation, delayed type hypersensitivity, hyperalgesia and airway hypersensitivity. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Sstr4||
(F):5'- TGGCCATCGGATTATGCTAC -3'
(R):5'- AGAGGAGGGCATATGCATCC -3'
(F):5'- CTACCTGCTTATTGTGGGCAAG -3'
(R):5'- ATAGTAGTCCAGGGGCTCTTCC -3'