Mutagenetix > Incidental Mutation

Incidental Mutation 'R8939:Muc5ac'

680848

Institutional Source

Beutler Lab

Gene Symbol

Muc5ac

Ensembl Gene

ENSMUSG00000037974

Gene Name

mucin 5, subtypes A and C, tracheobronchial/gastric

Synonyms

MGM, 2210005L13Rik

MMRRC Submission

068712-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R8939 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

141342709-141372968 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 141347091 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Tyrosine at position 356 (N356Y)

Ref Sequence

ENSEMBL: ENSMUSP00000131681 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041924] [ENSMUST00000155534] [ENSMUST00000163321]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000041924
AA Change: N356Y

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000039699
Gene: ENSMUSG00000037974
AA Change: N356Y

Domain	Start	End	E-Value	Type
signal peptide	1	27	N/A	INTRINSIC
VWD	69	226	4.19e-30	SMART
C8	258	334	1.34e-11	SMART
Pfam:TIL	337	393	1.6e-14	PFAM
VWC	395	462	8.6e-18	SMART
VWD	421	585	1.55e-33	SMART
C8	622	696	8.42e-36	SMART
Pfam:TIL	702	759	6.1e-9	PFAM
VWC	761	825	6.75e-1	SMART
VWC	863	905	4.06e-1	SMART
VWD	890	1050	1.51e-45	SMART
C8	1086	1160	2.78e-36	SMART
low complexity region	1315	1330	N/A	INTRINSIC
low complexity region	1333	1366	N/A	INTRINSIC
low complexity region	1371	1387	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1394	1482	2.3e-25	PFAM
low complexity region	1521	1532	N/A	INTRINSIC
low complexity region	1536	1563	N/A	INTRINSIC
low complexity region	1578	1595	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1604	1692	2.2e-27	PFAM
Pfam:Mucin2_WxxW	1765	1857	8.6e-27	PFAM
low complexity region	1875	1895	N/A	INTRINSIC
low complexity region	1949	1968	N/A	INTRINSIC
VWD	2030	2199	4.17e-48	SMART
C8	2242	2311	3.95e-9	SMART
VWC	2376	2439	1.04e-11	SMART
VWC	2479	2543	9.31e-5	SMART
CT	2625	2711	3.43e-32	SMART
low complexity region	2720	2733	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000155534
AA Change: N356Y

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000122353
Gene: ENSMUSG00000037974
AA Change: N356Y

Domain	Start	End	E-Value	Type
signal peptide	1	27	N/A	INTRINSIC
VWD	69	226	4.19e-30	SMART
C8	258	334	1.34e-11	SMART
Pfam:TIL	337	393	9.6e-15	PFAM
VWC	395	437	3.54e-1	SMART
VWD	422	586	2.35e-33	SMART
C8	623	697	8.42e-36	SMART
Pfam:TIL	703	760	3.6e-9	PFAM
VWC	762	826	6.75e-1	SMART
VWC	864	906	4.06e-1	SMART
VWD	891	1051	1.51e-45	SMART
C8	1087	1161	2.78e-36	SMART
low complexity region	1316	1331	N/A	INTRINSIC
low complexity region	1334	1367	N/A	INTRINSIC
low complexity region	1372	1388	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1395	1483	1.3e-25	PFAM
low complexity region	1522	1533	N/A	INTRINSIC
low complexity region	1537	1564	N/A	INTRINSIC
low complexity region	1579	1596	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1605	1693	1.3e-27	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000163321
AA Change: N356Y

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000131681
Gene: ENSMUSG00000037974
AA Change: N356Y

Domain	Start	End	E-Value	Type
signal peptide	1	27	N/A	INTRINSIC
VWD	69	226	4.19e-30	SMART
C8	258	334	1.34e-11	SMART
Pfam:TIL	337	393	7.9e-15	PFAM
VWC	395	462	8.6e-18	SMART
VWD	421	585	1.55e-33	SMART
C8	622	696	8.42e-36	SMART
Pfam:TIL	702	759	1.9e-9	PFAM
VWC	761	825	6.75e-1	SMART
VWC	863	905	4.06e-1	SMART
VWD	890	1050	1.51e-45	SMART
C8	1086	1160	2.78e-36	SMART
low complexity region	1315	1330	N/A	INTRINSIC
low complexity region	1333	1366	N/A	INTRINSIC
low complexity region	1371	1387	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1394	1481	1.1e-23	PFAM
low complexity region	1521	1532	N/A	INTRINSIC
low complexity region	1536	1563	N/A	INTRINSIC
low complexity region	1578	1595	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1604	1691	1.1e-25	PFAM
Pfam:Mucin2_WxxW	1765	1856	6.3e-24	PFAM
low complexity region	1875	1895	N/A	INTRINSIC
low complexity region	1949	1968	N/A	INTRINSIC
VWD	2030	2199	4.17e-48	SMART
C8	2242	2311	3.95e-9	SMART
VWC	2376	2439	1.04e-11	SMART
VWC	2479	2543	9.31e-5	SMART
CT	2625	2711	3.43e-32	SMART
low complexity region	2720	2733	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

100% (71/71)

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to T. muris infection with persistent worm burden, goblet cell hyperplasia, and increased serum IFN-gamma despite a normal TH2-type immune response. A portion of mice show corneal opacity and poor tear quality. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 72 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930578I06Rik	A	G	14: 64,225,162 (GRCm39)	V12A	probably benign	Het
Abcc12	A	G	8: 87,243,947 (GRCm39)	Y1069H	probably damaging	Het
Abcc9	T	C	6: 142,624,977 (GRCm39)	T473A	probably damaging	Het
Acsm1	A	T	7: 119,239,868 (GRCm39)	T271S	probably benign	Het
Adh6b	T	C	3: 138,055,397 (GRCm39)	I49T	probably benign	Het
Aff4	A	T	11: 53,263,231 (GRCm39)	T84S	probably benign	Het
Angptl7	G	A	4: 148,580,956 (GRCm39)	R280*	probably null	Het
Bhlhe23	T	A	2: 180,418,099 (GRCm39)	K146N	probably damaging	Het
Cacna1s	T	C	1: 136,014,544 (GRCm39)		probably null	Het
Cfap45	C	G	1: 172,372,834 (GRCm39)	R510G	probably damaging	Het
Chl1	A	G	6: 103,642,868 (GRCm39)	Y202C	probably damaging	Het
Chrna6	T	A	8: 27,896,870 (GRCm39)	T336S	probably benign	Het
Clpx	A	G	9: 65,231,519 (GRCm39)	K535E	probably benign	Het
Crybg3	T	C	16: 59,376,512 (GRCm39)	M1581V	probably benign	Het
Ddx4	A	T	13: 112,758,823 (GRCm39)	I246K	probably benign	Het
F7	G	T	8: 13,078,724 (GRCm39)	G52C	probably damaging	Het
Fam186b	T	C	15: 99,177,223 (GRCm39)	Q701R	probably benign	Het
Fign	T	A	2: 63,809,456 (GRCm39)	M605L	probably benign	Het
Fpr2	T	C	17: 18,113,883 (GRCm39)	F293S	probably damaging	Het
Gm40460	GCAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAG	GCAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAG	7: 141,794,171 (GRCm39)		probably benign	Het
Gria2	A	T	3: 80,618,170 (GRCm39)		probably benign	Het
Grid1	G	A	14: 35,043,664 (GRCm39)	D340N	probably damaging	Het
Gsto2	T	C	19: 47,873,203 (GRCm39)		probably null	Het
Hsd3b1	A	G	3: 98,760,299 (GRCm39)	W231R	probably damaging	Het
Igflr1	CAGAG	CAG	7: 30,266,888 (GRCm39)		probably null	Het
Ighv1-80	C	T	12: 115,876,113 (GRCm39)	G68R	probably damaging	Het
Il10ra	A	G	9: 45,177,802 (GRCm39)	V69A	unknown	Het
Klhdc1	C	T	12: 69,300,537 (GRCm39)	A159V	probably damaging	Het
Krtap4-6	A	G	11: 99,556,229 (GRCm39)	I166T	unknown	Het
Lce1h	A	T	3: 92,670,976 (GRCm39)	C59S	unknown	Het
Magi3	T	C	3: 103,996,748 (GRCm39)		probably benign	Het
Map3k1	G	T	13: 111,892,837 (GRCm39)	S806*	probably null	Het
Map3k6	T	A	4: 132,979,954 (GRCm39)		probably benign	Het
Mgam	G	A	6: 40,740,137 (GRCm39)		probably null	Het
Mtx1	A	G	3: 89,120,033 (GRCm39)	V207A	probably damaging	Het
Myo16	T	C	8: 10,524,679 (GRCm39)	F810S	probably damaging	Het
Nlrx1	A	G	9: 44,166,761 (GRCm39)	L774P	probably damaging	Het
Nr1i2	C	T	16: 38,086,382 (GRCm39)	V28I	probably benign	Het
Or10h28	A	G	17: 33,488,589 (GRCm39)	K297R	probably damaging	Het
Or5b122	A	C	19: 13,562,860 (GRCm39)	N64T	probably damaging	Het
Pcmtd2	T	C	2: 181,496,863 (GRCm39)		probably benign	Het
Pcnx3	A	G	19: 5,730,347 (GRCm39)	L102P	probably damaging	Het
Pnpla6	A	G	8: 3,571,319 (GRCm39)	E114G	possibly damaging	Het
Ppp4r1	T	C	17: 66,110,926 (GRCm39)	V70A	probably damaging	Het
Psd2	G	A	18: 36,121,292 (GRCm39)	V421M	probably damaging	Het
Qng1	C	T	13: 58,532,875 (GRCm39)	A32T	probably damaging	Het
Rbak	C	T	5: 143,160,025 (GRCm39)	E343K	possibly damaging	Het
Rhbdf1	G	A	11: 32,160,093 (GRCm39)	A136V	probably benign	Het
Rusc1	T	A	3: 88,995,337 (GRCm39)	E231D	probably benign	Het
Rxfp1	T	C	3: 79,552,231 (GRCm39)	E690G	probably damaging	Het
Sdr9c7	A	G	10: 127,734,776 (GRCm39)	E88G	probably benign	Het
Sec23b	T	C	2: 144,411,137 (GRCm39)		probably null	Het
Sgcb	A	T	5: 73,801,661 (GRCm39)	I68N	probably damaging	Het
Sh3pxd2b	T	C	11: 32,364,433 (GRCm39)		probably benign	Het
Slc25a48	C	T	13: 56,611,519 (GRCm39)	P209S	probably damaging	Het
Slc9a3	C	A	13: 74,311,895 (GRCm39)	H614Q	possibly damaging	Het
Slurp1	G	A	15: 74,598,763 (GRCm39)	S76L	probably damaging	Het
Spen	T	C	4: 141,202,969 (GRCm39)	E1886G	possibly damaging	Het
Sqor	C	T	2: 122,649,549 (GRCm39)	P151S	possibly damaging	Het
Sstr4	C	A	2: 148,238,228 (GRCm39)	L280M	probably damaging	Het
Stard10	A	G	7: 100,991,847 (GRCm39)	Y117C	probably damaging	Het
Stard13	A	T	5: 150,968,574 (GRCm39)		probably null	Het
Stim2	G	T	5: 54,262,673 (GRCm39)	R305L	possibly damaging	Het
Syt14	G	A	1: 192,612,896 (GRCm39)	R635C	probably damaging	Het
Tmcc3	A	T	10: 94,381,483 (GRCm39)		probably benign	Het
Ttn	T	C	2: 76,575,695 (GRCm39)	N23320S	possibly damaging	Het
Ubqln4	A	G	3: 88,473,023 (GRCm39)	T493A	probably benign	Het
Ugt2b34	A	G	5: 87,039,158 (GRCm39)	L501P	probably damaging	Het
Umod	T	C	7: 119,068,700 (GRCm39)	I449V	probably damaging	Het
Vmn2r51	C	A	7: 9,833,953 (GRCm39)	D362Y	possibly damaging	Het
Xirp2	A	C	2: 67,346,488 (GRCm39)	T2910P	probably benign	Het
Zscan20	A	G	4: 128,498,315 (GRCm39)	S28P	probably benign	Het

Other mutations in Muc5ac

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00899:Muc5ac	APN	7	141,366,440 (GRCm39)	missense	possibly damaging	0.93
IGL01064:Muc5ac	APN	7	141,361,210 (GRCm39)	missense	probably benign	0.12
IGL01155:Muc5ac	APN	7	141,360,680 (GRCm39)	splice site	probably benign
IGL01452:Muc5ac	APN	7	141,371,292 (GRCm39)	missense	probably benign	0.00
IGL01590:Muc5ac	APN	7	141,352,630 (GRCm39)	missense	probably benign	0.02
IGL02104:Muc5ac	APN	7	141,364,815 (GRCm39)	missense	probably damaging	0.98
IGL02152:Muc5ac	APN	7	141,353,914 (GRCm39)	missense	possibly damaging	0.86
IGL02153:Muc5ac	APN	7	141,372,537 (GRCm39)	nonsense	probably null
IGL02178:Muc5ac	APN	7	141,359,184 (GRCm39)	splice site	probably benign
IGL02403:Muc5ac	APN	7	141,357,187 (GRCm39)	missense	possibly damaging	0.71
IGL02576:Muc5ac	APN	7	141,370,781 (GRCm39)	missense	probably benign	0.01
IGL02665:Muc5ac	APN	7	141,344,823 (GRCm39)	missense	possibly damaging	0.71
IGL02704:Muc5ac	APN	7	141,349,000 (GRCm39)	missense	possibly damaging	0.71
IGL02808:Muc5ac	APN	7	141,359,512 (GRCm39)	missense	possibly damaging	0.72
IGL03283:Muc5ac	APN	7	141,367,518 (GRCm39)	missense	probably benign	0.34
IGL03384:Muc5ac	APN	7	141,366,140 (GRCm39)	missense	possibly damaging	0.71
IGL03046:Muc5ac	UTSW	7	141,348,950 (GRCm39)	missense	probably benign	0.27
PIT4515001:Muc5ac	UTSW	7	141,361,153 (GRCm39)	missense	probably damaging	0.99
R0092:Muc5ac	UTSW	7	141,372,367 (GRCm39)	missense	possibly damaging	0.72
R0145:Muc5ac	UTSW	7	141,349,012 (GRCm39)	missense	possibly damaging	0.71
R0147:Muc5ac	UTSW	7	141,364,776 (GRCm39)	missense	probably benign	0.08
R0363:Muc5ac	UTSW	7	141,354,697 (GRCm39)	missense	probably benign	0.01
R0384:Muc5ac	UTSW	7	141,365,988 (GRCm39)	missense	possibly damaging	0.71
R0440:Muc5ac	UTSW	7	141,345,771 (GRCm39)	nonsense	probably null
R0583:Muc5ac	UTSW	7	141,361,345 (GRCm39)	missense	probably damaging	0.99
R0616:Muc5ac	UTSW	7	141,349,981 (GRCm39)	missense	probably benign	0.02
R0682:Muc5ac	UTSW	7	141,359,406 (GRCm39)	missense	possibly damaging	0.53
R0685:Muc5ac	UTSW	7	141,361,446 (GRCm39)	missense	probably benign	0.03
R0883:Muc5ac	UTSW	7	141,350,002 (GRCm39)	missense	possibly damaging	0.71
R0924:Muc5ac	UTSW	7	141,361,252 (GRCm39)	missense	possibly damaging	0.68
R1300:Muc5ac	UTSW	7	141,370,666 (GRCm39)	missense	possibly damaging	0.73
R1315:Muc5ac	UTSW	7	141,361,060 (GRCm39)	missense	probably damaging	0.99
R1354:Muc5ac	UTSW	7	141,361,114 (GRCm39)	missense	probably damaging	0.99
R1484:Muc5ac	UTSW	7	141,367,629 (GRCm39)	splice site	probably null
R1599:Muc5ac	UTSW	7	141,352,640 (GRCm39)	missense	possibly damaging	0.52
R1758:Muc5ac	UTSW	7	141,355,268 (GRCm39)	missense	possibly damaging	0.86
R1837:Muc5ac	UTSW	7	141,360,823 (GRCm39)	missense	probably benign	0.00
R1911:Muc5ac	UTSW	7	141,350,041 (GRCm39)	missense	probably benign	0.18
R1922:Muc5ac	UTSW	7	141,347,426 (GRCm39)	missense	probably benign	0.03
R1966:Muc5ac	UTSW	7	141,357,113 (GRCm39)	missense	possibly damaging	0.92
R1994:Muc5ac	UTSW	7	141,366,889 (GRCm39)	missense	possibly damaging	0.93
R2056:Muc5ac	UTSW	7	141,345,772 (GRCm39)	missense	probably benign	0.01
R2126:Muc5ac	UTSW	7	141,364,479 (GRCm39)	missense	possibly damaging	0.84
R2170:Muc5ac	UTSW	7	141,366,084 (GRCm39)	missense	possibly damaging	0.93
R2258:Muc5ac	UTSW	7	141,344,745 (GRCm39)	missense	probably benign	0.41
R2259:Muc5ac	UTSW	7	141,344,745 (GRCm39)	missense	probably benign	0.41
R2293:Muc5ac	UTSW	7	141,360,936 (GRCm39)	missense	probably damaging	0.99
R2435:Muc5ac	UTSW	7	141,371,841 (GRCm39)	missense	possibly damaging	0.53
R2895:Muc5ac	UTSW	7	141,344,877 (GRCm39)	missense	possibly damaging	0.92
R2910:Muc5ac	UTSW	7	141,361,378 (GRCm39)	missense	probably damaging	0.99
R3154:Muc5ac	UTSW	7	141,346,473 (GRCm39)	splice site	probably null
R3762:Muc5ac	UTSW	7	141,361,212 (GRCm39)	missense	possibly damaging	0.53
R3791:Muc5ac	UTSW	7	141,352,238 (GRCm39)	missense	probably benign	0.32
R3806:Muc5ac	UTSW	7	141,367,471 (GRCm39)	missense	possibly damaging	0.91
R3825:Muc5ac	UTSW	7	141,368,460 (GRCm39)	missense	possibly damaging	0.92
R3888:Muc5ac	UTSW	7	141,344,961 (GRCm39)	missense	possibly damaging	0.51
R3929:Muc5ac	UTSW	7	141,356,629 (GRCm39)	missense	probably benign
R3981:Muc5ac	UTSW	7	141,367,512 (GRCm39)	missense	possibly damaging	0.86
R4034:Muc5ac	UTSW	7	141,353,581 (GRCm39)	critical splice donor site	probably null
R4043:Muc5ac	UTSW	7	141,361,215 (GRCm39)	missense	possibly damaging	0.53
R4061:Muc5ac	UTSW	7	141,364,867 (GRCm39)	missense	possibly damaging	0.85
R4106:Muc5ac	UTSW	7	141,356,572 (GRCm39)	missense	possibly damaging	0.86
R4206:Muc5ac	UTSW	7	141,370,847 (GRCm39)	missense	possibly damaging	0.73
R4613:Muc5ac	UTSW	7	141,344,840 (GRCm39)	missense	possibly damaging	0.93
R4719:Muc5ac	UTSW	7	141,343,500 (GRCm39)	missense	possibly damaging	0.83
R4751:Muc5ac	UTSW	7	141,371,338 (GRCm39)	missense	probably benign	0.00
R4789:Muc5ac	UTSW	7	141,352,619 (GRCm39)	missense	possibly damaging	0.86
R4928:Muc5ac	UTSW	7	141,371,639 (GRCm39)	nonsense	probably null
R4971:Muc5ac	UTSW	7	141,370,015 (GRCm39)	missense	possibly damaging	0.68
R4982:Muc5ac	UTSW	7	141,363,193 (GRCm39)	intron	probably benign
R5088:Muc5ac	UTSW	7	141,350,056 (GRCm39)	missense	possibly damaging	0.53
R5141:Muc5ac	UTSW	7	141,368,479 (GRCm39)	missense	possibly damaging	0.72
R5224:Muc5ac	UTSW	7	141,347,708 (GRCm39)	missense	probably benign	0.32
R5366:Muc5ac	UTSW	7	141,361,287 (GRCm39)	missense	probably benign	0.01
R5497:Muc5ac	UTSW	7	141,361,380 (GRCm39)	missense	probably damaging	0.99
R5507:Muc5ac	UTSW	7	141,361,569 (GRCm39)	missense	possibly damaging	0.72
R5643:Muc5ac	UTSW	7	141,347,452 (GRCm39)	critical splice donor site	probably null
R5811:Muc5ac	UTSW	7	141,352,721 (GRCm39)	missense	possibly damaging	0.51
R5946:Muc5ac	UTSW	7	141,371,644 (GRCm39)	missense	possibly damaging	0.73
R5970:Muc5ac	UTSW	7	141,344,406 (GRCm39)	nonsense	probably null
R5977:Muc5ac	UTSW	7	141,350,104 (GRCm39)	missense	possibly damaging	0.73
R6051:Muc5ac	UTSW	7	141,365,594 (GRCm39)	missense	possibly damaging	0.53
R6126:Muc5ac	UTSW	7	141,354,969 (GRCm39)	missense	possibly damaging	0.71
R6159:Muc5ac	UTSW	7	141,369,323 (GRCm39)	missense	possibly damaging	0.53
R6256:Muc5ac	UTSW	7	141,343,532 (GRCm39)	missense	possibly damaging	0.53
R6283:Muc5ac	UTSW	7	141,370,601 (GRCm39)	nonsense	probably null
R6341:Muc5ac	UTSW	7	141,355,229 (GRCm39)	missense	probably damaging	0.99
R6356:Muc5ac	UTSW	7	141,366,416 (GRCm39)	missense	probably benign	0.05
R6481:Muc5ac	UTSW	7	141,362,808 (GRCm39)	intron	probably benign
R6483:Muc5ac	UTSW	7	141,356,591 (GRCm39)	missense	probably benign	0.18
R6627:Muc5ac	UTSW	7	141,362,427 (GRCm39)	intron	probably benign
R6636:Muc5ac	UTSW	7	141,372,342 (GRCm39)	missense	possibly damaging	0.86
R6637:Muc5ac	UTSW	7	141,372,342 (GRCm39)	missense	possibly damaging	0.86
R6656:Muc5ac	UTSW	7	141,357,065 (GRCm39)	missense	probably damaging	0.98
R6721:Muc5ac	UTSW	7	141,352,729 (GRCm39)	missense	possibly damaging	0.71
R6794:Muc5ac	UTSW	7	141,363,289 (GRCm39)	intron	probably benign
R6844:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6847:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6852:Muc5ac	UTSW	7	141,370,644 (GRCm39)	missense	probably benign	0.03
R6862:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6863:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6864:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6865:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6874:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6875:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6876:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6877:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6889:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6920:Muc5ac	UTSW	7	141,347,035 (GRCm39)	missense	possibly damaging	0.86
R6998:Muc5ac	UTSW	7	141,372,451 (GRCm39)	missense	possibly damaging	0.92
R7017:Muc5ac	UTSW	7	141,363,424 (GRCm39)	intron	probably benign
R7091:Muc5ac	UTSW	7	141,363,424 (GRCm39)	intron	probably benign
R7092:Muc5ac	UTSW	7	141,363,424 (GRCm39)	intron	probably benign
R7092:Muc5ac	UTSW	7	141,363,385 (GRCm39)	intron	probably benign
R7110:Muc5ac	UTSW	7	141,353,559 (GRCm39)	missense	possibly damaging	0.95
R7117:Muc5ac	UTSW	7	141,367,559 (GRCm39)	nonsense	probably null
R7238:Muc5ac	UTSW	7	141,363,424 (GRCm39)	intron	probably benign
R7238:Muc5ac	UTSW	7	141,363,254 (GRCm39)	missense	unknown
R7396:Muc5ac	UTSW	7	141,362,152 (GRCm39)	missense	unknown
R7456:Muc5ac	UTSW	7	141,346,904 (GRCm39)	missense	probably benign	0.32
R7477:Muc5ac	UTSW	7	141,370,019 (GRCm39)	missense	possibly damaging	0.72
R7530:Muc5ac	UTSW	7	141,367,536 (GRCm39)	missense	possibly damaging	0.51
R7545:Muc5ac	UTSW	7	141,362,405 (GRCm39)	missense	unknown
R7604:Muc5ac	UTSW	7	141,363,446 (GRCm39)	missense	unknown
R7635:Muc5ac	UTSW	7	141,359,413 (GRCm39)	missense	probably damaging	0.98
R7635:Muc5ac	UTSW	7	141,359,490 (GRCm39)	missense	possibly damaging	0.53
R7650:Muc5ac	UTSW	7	141,363,159 (GRCm39)	missense	unknown
R7651:Muc5ac	UTSW	7	141,349,991 (GRCm39)	missense	possibly damaging	0.92
R7685:Muc5ac	UTSW	7	141,363,120 (GRCm39)	missense	unknown
R7720:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7749:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7750:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7751:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7754:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7798:Muc5ac	UTSW	7	141,347,778 (GRCm39)	critical splice donor site	probably null
R7835:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7837:Muc5ac	UTSW	7	141,369,700 (GRCm39)	missense	possibly damaging	0.53
R7858:Muc5ac	UTSW	7	141,357,166 (GRCm39)	missense	possibly damaging	0.51
R7866:Muc5ac	UTSW	7	141,349,589 (GRCm39)	missense	probably benign	0.00
R7874:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7876:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7877:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7881:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7884:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7921:Muc5ac	UTSW	7	141,363,424 (GRCm39)	intron	probably benign
R7976:Muc5ac	UTSW	7	141,363,528 (GRCm39)	missense	unknown
R8104:Muc5ac	UTSW	7	141,358,520 (GRCm39)	missense	possibly damaging	0.96
R8177:Muc5ac	UTSW	7	141,361,068 (GRCm39)	missense	probably damaging	1.00
R8214:Muc5ac	UTSW	7	141,356,685 (GRCm39)	missense	possibly damaging	0.53
R8292:Muc5ac	UTSW	7	141,363,000 (GRCm39)	missense	unknown
R8386:Muc5ac	UTSW	7	141,361,371 (GRCm39)	missense	possibly damaging	0.93
R8400:Muc5ac	UTSW	7	141,364,213 (GRCm39)	missense	probably damaging	0.99
R8504:Muc5ac	UTSW	7	141,360,892 (GRCm39)	missense	probably damaging	1.00
R8709:Muc5ac	UTSW	7	141,370,663 (GRCm39)	missense	possibly damaging	0.96
R8725:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R8727:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R8754:Muc5ac	UTSW	7	141,354,008 (GRCm39)	missense	possibly damaging	0.85
R8769:Muc5ac	UTSW	7	141,372,609 (GRCm39)	missense	probably damaging	1.00
R8933:Muc5ac	UTSW	7	141,343,493 (GRCm39)	missense	possibly damaging	0.59
R9049:Muc5ac	UTSW	7	141,362,712 (GRCm39)	missense	unknown
R9124:Muc5ac	UTSW	7	141,363,529 (GRCm39)	missense	unknown
R9131:Muc5ac	UTSW	7	141,363,529 (GRCm39)	missense	unknown
R9132:Muc5ac	UTSW	7	141,363,529 (GRCm39)	missense	unknown
R9135:Muc5ac	UTSW	7	141,352,218 (GRCm39)	missense	probably damaging	0.99
R9156:Muc5ac	UTSW	7	141,363,529 (GRCm39)	missense	unknown
R9157:Muc5ac	UTSW	7	141,363,529 (GRCm39)	missense	unknown
R9159:Muc5ac	UTSW	7	141,363,529 (GRCm39)	missense	unknown
R9160:Muc5ac	UTSW	7	141,363,529 (GRCm39)	missense	unknown
R9161:Muc5ac	UTSW	7	141,353,026 (GRCm39)	missense	possibly damaging	0.53
R9175:Muc5ac	UTSW	7	141,366,093 (GRCm39)	missense	possibly damaging	0.92
R9183:Muc5ac	UTSW	7	141,352,637 (GRCm39)	missense	possibly damaging	0.71
R9218:Muc5ac	UTSW	7	141,361,098 (GRCm39)	missense	probably damaging	0.99
R9219:Muc5ac	UTSW	7	141,370,800 (GRCm39)	nonsense	probably null
R9239:Muc5ac	UTSW	7	141,353,954 (GRCm39)	missense	probably damaging	0.99
R9246:Muc5ac	UTSW	7	141,364,215 (GRCm39)	missense	probably benign	0.11
R9287:Muc5ac	UTSW	7	141,361,626 (GRCm39)	missense	probably damaging	0.99
R9320:Muc5ac	UTSW	7	141,369,255 (GRCm39)	missense	probably benign	0.01
R9327:Muc5ac	UTSW	7	141,365,429 (GRCm39)	missense	possibly damaging	0.86
R9428:Muc5ac	UTSW	7	141,362,559 (GRCm39)	missense	unknown
R9430:Muc5ac	UTSW	7	141,362,569 (GRCm39)	missense	unknown
R9454:Muc5ac	UTSW	7	141,362,431 (GRCm39)	missense	unknown
R9483:Muc5ac	UTSW	7	141,365,465 (GRCm39)	nonsense	probably null
R9581:Muc5ac	UTSW	7	141,363,799 (GRCm39)	missense	unknown
R9610:Muc5ac	UTSW	7	141,350,078 (GRCm39)	missense	possibly damaging	0.86
R9642:Muc5ac	UTSW	7	141,349,601 (GRCm39)	missense	possibly damaging	0.71
R9684:Muc5ac	UTSW	7	141,364,798 (GRCm39)	missense	probably benign	0.41
R9760:Muc5ac	UTSW	7	141,360,985 (GRCm39)	missense	probably benign	0.05
R9778:Muc5ac	UTSW	7	141,349,021 (GRCm39)	nonsense	probably null
X0060:Muc5ac	UTSW	7	141,357,070 (GRCm39)	missense	possibly damaging	0.71
Z1088:Muc5ac	UTSW	7	141,365,429 (GRCm39)	missense	possibly damaging	0.86
Z1088:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
Z1177:Muc5ac	UTSW	7	141,371,777 (GRCm39)	missense	probably benign	0.33
Z1177:Muc5ac	UTSW	7	141,362,961 (GRCm39)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- CGTCTGACTGCATCTGCCATAC -3'
(R):5'- ACTTTGGGCCAGGGTCATAG -3'

Sequencing Primer
(F):5'- CAGTGTGCACATGCTGGAG -3'
(R):5'- GGTCATAGGGATCTCTCACCAAG -3'

Posted On

2021-08-31