Mutagenetix > Incidental Mutation

Incidental Mutation 'R9175:Ank2'

696608

Institutional Source

Beutler Lab

Gene Symbol

Ank2

Ensembl Gene

ENSMUSG00000032826

Gene Name

ankyrin 2, brain

Synonyms

Gm4392, Ank-2, ankyrin B, Ankyrin-B, Ankyrin-2

MMRRC Submission

068948-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R9175 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

126715261-127292999 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 126722402 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 1017 (T1017I)

Ref Sequence

ENSEMBL: ENSMUSP00000043765 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000044443] [ENSMUST00000182064] [ENSMUST00000182078]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000044443
AA Change: T1017I

PolyPhen 2 Score 0.523 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000043765
Gene: ENSMUSG00000032826
AA Change: T1017I

Domain	Start	End	E-Value	Type
low complexity region	9	22	N/A	INTRINSIC
low complexity region	57	69	N/A	INTRINSIC
ZU5	128	232	4.13e-61	SMART
Pfam:ZU5	289	374	2.8e-8	PFAM
low complexity region	587	597	N/A	INTRINSIC
DEATH	603	697	1.52e-27	SMART
low complexity region	732	748	N/A	INTRINSIC
low complexity region	860	873	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000182064

SMART Domains

Protein: ENSMUSP00000138620
Gene: ENSMUSG00000032826

Domain	Start	End	E-Value	Type
ANK	9	38	1e1	SMART
ANK	42	71	8.9e-7	SMART
ANK	75	104	4.4e-9	SMART
ANK	108	137	2.8e-9	SMART
ANK	141	169	5.3e-1	SMART
ANK	170	199	7.3e-1	SMART
ANK	211	240	1.1e-7	SMART
ANK	244	273	4.4e-9	SMART
ANK	277	306	9.3e-8	SMART
ANK	310	339	2.1e-8	SMART
ANK	343	372	1.3e-7	SMART
ANK	376	405	6.2e-9	SMART
ANK	409	438	1.1e-7	SMART
ANK	442	471	2.9e-8	SMART
ANK	475	504	1.1e-5	SMART
ANK	508	537	6.5e-6	SMART
ANK	541	570	2.3e-7	SMART
ANK	574	603	2.4e-7	SMART
ANK	607	636	3.2e-9	SMART
ANK	640	669	5.5e-5	SMART
ANK	673	702	1.9e-8	SMART
ANK	706	735	3.3e-9	SMART
low complexity region	755	775	N/A	INTRINSIC
low complexity region	793	806	N/A	INTRINSIC
low complexity region	841	853	N/A	INTRINSIC
ZU5	912	1016	2e-63	SMART
low complexity region	1371	1381	N/A	INTRINSIC
low complexity region	1448	1463	N/A	INTRINSIC
low complexity region	1490	1503	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000182078
AA Change: T3867I

SMART Domains

Protein: ENSMUSP00000138753
Gene: ENSMUSG00000032826
AA Change: T3867I

Domain	Start	End	E-Value	Type
low complexity region	7	18	N/A	INTRINSIC
low complexity region	114	125	N/A	INTRINSIC
low complexity region	191	209	N/A	INTRINSIC
low complexity region	304	312	N/A	INTRINSIC
low complexity region	478	493	N/A	INTRINSIC
low complexity region	527	544	N/A	INTRINSIC
DEATH	591	685	1e-29	SMART
low complexity region	720	736	N/A	INTRINSIC
low complexity region	848	861	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000182118

Predicted Effect

probably damaging
Transcript: ENSMUST00000182571
AA Change: T62I

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.2%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous mutation of this gene results in death by postnatal day 8, although some animals survive to P20. Mutant animals display reduced body size, impaired balance and locomotion, brain structure dysmorphologies, abnormal lens, and optic nerve degeneration. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2900092C05Rik	G	A	7: 12,249,412 (GRCm39)	D82N	probably benign	Het
Abca13	A	G	11: 9,531,593 (GRCm39)	K4607E	probably damaging	Het
Agpat4	G	C	17: 12,417,669 (GRCm39)	G70A	probably damaging	Het
C2cd2	T	C	16: 97,678,421 (GRCm39)	I339V	probably benign	Het
Cacna1a	A	T	8: 85,296,644 (GRCm39)	N1221Y	probably damaging	Het
Cacna1e	A	G	1: 154,274,314 (GRCm39)	V2197A	probably damaging	Het
Ccdc74a	T	C	16: 17,468,042 (GRCm39)	S101P	probably benign	Het
Cdh13	A	T	8: 119,968,968 (GRCm39)	I442F	probably damaging	Het
Cnot2	A	T	10: 116,334,051 (GRCm39)	M373K	possibly damaging	Het
Coch	C	A	12: 51,645,060 (GRCm39)	H205N	possibly damaging	Het
Col6a4	A	G	9: 105,957,560 (GRCm39)	V88A	probably benign	Het
Erich3	A	G	3: 154,419,601 (GRCm39)	T35A	probably benign	Het
Gm28360	A	T	1: 117,781,328 (GRCm39)	K106N	possibly damaging	Het
Hps4	G	A	5: 112,525,905 (GRCm39)	S642N	possibly damaging	Het
Hspg2	T	C	4: 137,256,657 (GRCm39)	F1467L	probably damaging	Het
Ighg2c	T	C	12: 113,252,499 (GRCm39)	T18A		Het
Iqcm	A	G	8: 76,710,867 (GRCm39)	K472E	possibly damaging	Het
Kcnk5	A	T	14: 20,192,117 (GRCm39)	V348D	probably benign	Het
Kcns3	C	T	12: 11,169,801 (GRCm39)		probably benign	Het
Klk15	C	T	7: 43,587,790 (GRCm39)	H73Y	possibly damaging	Het
Muc5ac	A	G	7: 141,366,093 (GRCm39)	D2787G	possibly damaging	Het
Nasp	A	G	4: 116,471,576 (GRCm39)	C84R	probably damaging	Het
Nfia	G	A	4: 97,671,362 (GRCm39)	R24H	probably damaging	Het
Opa3	C	T	7: 18,989,466 (GRCm39)	R110C	probably damaging	Het
Or2t48	T	C	11: 58,420,590 (GRCm39)	D74G	probably damaging	Het
Or8k25	A	G	2: 86,244,099 (GRCm39)	I99T	probably benign	Het
Pdia4	A	C	6: 47,775,417 (GRCm39)	S464R	possibly damaging	Het
Rab3gap2	A	G	1: 185,009,360 (GRCm39)	D1092G	probably damaging	Het
Rev3l	A	G	10: 39,730,764 (GRCm39)	K2763E	possibly damaging	Het
Sanbr	A	T	11: 23,534,518 (GRCm39)		probably null	Het
Sorbs1	A	T	19: 40,315,018 (GRCm39)	L598Q	probably damaging	Het
Sppl2b	A	T	10: 80,698,807 (GRCm39)	M154L	probably benign	Het
Stk33	A	G	7: 108,920,724 (GRCm39)	I331T	probably damaging	Het
Strip2	A	G	6: 29,933,035 (GRCm39)	E494G	probably benign	Het
Supt6	C	T	11: 78,112,052 (GRCm39)	R1010Q	possibly damaging	Het
Tada1	G	A	1: 166,210,005 (GRCm39)	R69H	probably damaging	Het
Tent4a	A	G	13: 69,663,915 (GRCm39)	L268P	probably damaging	Het
Tmco1	C	T	1: 167,136,132 (GRCm39)		probably benign	Het
Tomm34	A	G	2: 163,912,385 (GRCm39)		probably null	Het
Tpi1	T	C	6: 124,788,871 (GRCm39)	T223A	probably damaging	Het
Trpc3	T	A	3: 36,709,279 (GRCm39)	N399I	probably benign	Het
Vgll2	A	G	10: 51,903,635 (GRCm39)	H166R	probably damaging	Het
Vmn2r107	A	T	17: 20,577,051 (GRCm39)	I350F	possibly damaging	Het
Vmn2r114	T	A	17: 23,527,212 (GRCm39)	K440M	probably damaging	Het
Vmn2r55	T	C	7: 12,385,793 (GRCm39)	Y729C	possibly damaging	Het
Zfp106	G	T	2: 120,353,197 (GRCm39)	A1554E	probably damaging	Het
Zfyve27	A	G	19: 42,169,997 (GRCm39)	Y176C	probably damaging	Het
Zswim5	T	A	4: 116,822,941 (GRCm39)	N470K	probably benign	Het

Other mutations in Ank2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01298:Ank2	APN	3	126,753,369 (GRCm39)	missense	possibly damaging	0.80
IGL01652:Ank2	APN	3	126,726,690 (GRCm39)	missense	probably benign	0.00
IGL01969:Ank2	APN	3	126,746,872 (GRCm39)	missense	possibly damaging	0.47
IGL02122:Ank2	APN	3	126,731,523 (GRCm39)	splice site	probably benign
IGL02537:Ank2	APN	3	126,749,565 (GRCm39)	missense	probably damaging	1.00
IGL02858:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL02981:Ank2	APN	3	126,728,211 (GRCm39)	missense	possibly damaging	0.58
IGL02981:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03024:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03074:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03111:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03129:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03174:Ank2	APN	3	126,733,744 (GRCm39)	missense	probably damaging	0.98
IGL03177:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03185:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03188:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03242:Ank2	APN	3	126,722,454 (GRCm39)	missense	possibly damaging	0.90
IGL03244:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03248:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03285:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03304:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03358:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03380:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03389:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03400:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03409:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
ballast	UTSW	3	126,736,782 (GRCm39)	missense	unknown
Chain	UTSW	3	126,740,587 (GRCm39)	intron	probably benign
Deadman	UTSW	3	126,723,471 (GRCm39)	missense	probably benign	0.19
drag	UTSW	3	126,797,631 (GRCm39)	missense	probably damaging	1.00
mooring	UTSW	3	126,728,226 (GRCm39)	missense	possibly damaging	0.73
Treasure	UTSW	3	126,740,398 (GRCm39)	missense	unknown
Windlass	UTSW	3	126,739,798 (GRCm39)	missense	probably benign
R0033:Ank2	UTSW	3	126,898,397 (GRCm39)	splice site	probably benign
R0042:Ank2	UTSW	3	126,730,280 (GRCm39)	missense	probably damaging	0.99
R0042:Ank2	UTSW	3	126,730,280 (GRCm39)	missense	probably damaging	0.99
R0079:Ank2	UTSW	3	126,728,264 (GRCm39)	missense	probably benign	0.01
R0423:Ank2	UTSW	3	126,723,509 (GRCm39)	nonsense	probably null
R0699:Ank2	UTSW	3	126,723,478 (GRCm39)	missense	probably benign	0.00
R0724:Ank2	UTSW	3	126,755,986 (GRCm39)	missense	probably damaging	1.00
R0990:Ank2	UTSW	3	126,728,315 (GRCm39)	missense	possibly damaging	0.64
R1450:Ank2	UTSW	3	126,750,951 (GRCm39)	missense	possibly damaging	0.94
R1500:Ank2	UTSW	3	126,726,631 (GRCm39)	missense	probably benign
R1702:Ank2	UTSW	3	126,749,548 (GRCm39)	missense	probably benign	0.00
R1703:Ank2	UTSW	3	126,723,415 (GRCm39)	missense	probably damaging	1.00
R1710:Ank2	UTSW	3	126,726,709 (GRCm39)	nonsense	probably null
R1743:Ank2	UTSW	3	126,722,324 (GRCm39)	missense	probably damaging	0.99
R1775:Ank2	UTSW	3	126,728,196 (GRCm39)	missense	probably benign	0.00
R1852:Ank2	UTSW	3	126,791,500 (GRCm39)	critical splice donor site	probably null
R2198:Ank2	UTSW	3	126,728,226 (GRCm39)	missense	possibly damaging	0.73
R2892:Ank2	UTSW	3	127,041,892 (GRCm39)	splice site	probably null
R2893:Ank2	UTSW	3	127,041,892 (GRCm39)	splice site	probably null
R2894:Ank2	UTSW	3	127,041,892 (GRCm39)	splice site	probably null
R3148:Ank2	UTSW	3	126,726,724 (GRCm39)	missense	probably benign	0.00
R3776:Ank2	UTSW	3	126,735,911 (GRCm39)	intron	probably benign
R3784:Ank2	UTSW	3	126,746,842 (GRCm39)	missense	probably damaging	1.00
R3856:Ank2	UTSW	3	126,723,493 (GRCm39)	missense	probably benign	0.00
R3906:Ank2	UTSW	3	126,810,547 (GRCm39)	missense	probably damaging	1.00
R3907:Ank2	UTSW	3	126,810,547 (GRCm39)	missense	probably damaging	1.00
R3953:Ank2	UTSW	3	126,781,809 (GRCm39)	missense	probably damaging	1.00
R3963:Ank2	UTSW	3	126,728,245 (GRCm39)	missense	probably benign
R4367:Ank2	UTSW	3	126,739,798 (GRCm39)	missense	probably benign
R4414:Ank2	UTSW	3	127,019,411 (GRCm39)	critical splice donor site	probably null
R4432:Ank2	UTSW	3	126,741,455 (GRCm39)	intron	probably benign
R4433:Ank2	UTSW	3	126,741,455 (GRCm39)	intron	probably benign
R4579:Ank2	UTSW	3	126,752,612 (GRCm39)	missense	probably damaging	1.00
R4597:Ank2	UTSW	3	126,781,800 (GRCm39)	missense	probably damaging	1.00
R4603:Ank2	UTSW	3	126,825,665 (GRCm39)	missense	probably benign	0.00
R4729:Ank2	UTSW	3	126,770,545 (GRCm39)	nonsense	probably null
R4815:Ank2	UTSW	3	126,730,410 (GRCm39)	missense	probably benign
R4826:Ank2	UTSW	3	126,749,650 (GRCm39)	missense	probably benign	0.35
R4871:Ank2	UTSW	3	126,753,444 (GRCm39)	missense	probably damaging	1.00
R4880:Ank2	UTSW	3	126,840,475 (GRCm39)	splice site	probably null
R4915:Ank2	UTSW	3	126,736,320 (GRCm39)	intron	probably benign
R4935:Ank2	UTSW	3	126,749,713 (GRCm39)	missense	probably damaging	1.00
R4936:Ank2	UTSW	3	126,748,688 (GRCm39)	missense	possibly damaging	0.94
R4937:Ank2	UTSW	3	126,756,050 (GRCm39)	missense	probably damaging	1.00
R4946:Ank2	UTSW	3	126,735,589 (GRCm39)	intron	probably benign
R4963:Ank2	UTSW	3	126,825,745 (GRCm39)	missense	probably benign	0.01
R4989:Ank2	UTSW	3	126,757,094 (GRCm39)	missense	possibly damaging	0.94
R5023:Ank2	UTSW	3	126,735,520 (GRCm39)	intron	probably benign
R5060:Ank2	UTSW	3	126,739,570 (GRCm39)	intron	probably benign
R5078:Ank2	UTSW	3	126,736,002 (GRCm39)	intron	probably benign
R5086:Ank2	UTSW	3	126,740,997 (GRCm39)	intron	probably benign
R5134:Ank2	UTSW	3	126,757,094 (GRCm39)	missense	possibly damaging	0.94
R5148:Ank2	UTSW	3	126,819,285 (GRCm39)	splice site	probably null
R5175:Ank2	UTSW	3	126,797,673 (GRCm39)	missense	probably damaging	1.00
R5275:Ank2	UTSW	3	126,825,832 (GRCm39)	missense	probably damaging	1.00
R5295:Ank2	UTSW	3	126,825,832 (GRCm39)	missense	probably damaging	1.00
R5303:Ank2	UTSW	3	126,739,453 (GRCm39)	intron	probably benign
R5309:Ank2	UTSW	3	126,753,417 (GRCm39)	missense	probably damaging	0.99
R5312:Ank2	UTSW	3	126,753,417 (GRCm39)	missense	probably damaging	0.99
R5352:Ank2	UTSW	3	127,292,640 (GRCm39)	utr 5 prime	probably benign
R5355:Ank2	UTSW	3	126,737,698 (GRCm39)	intron	probably benign
R5386:Ank2	UTSW	3	126,775,582 (GRCm39)	missense	probably benign	0.01
R5396:Ank2	UTSW	3	126,746,875 (GRCm39)	missense	probably damaging	1.00
R5518:Ank2	UTSW	3	126,753,348 (GRCm39)	missense	probably damaging	0.98
R5534:Ank2	UTSW	3	126,740,947 (GRCm39)	intron	probably benign
R5554:Ank2	UTSW	3	126,792,622 (GRCm39)	missense	possibly damaging	0.78
R5582:Ank2	UTSW	3	126,739,954 (GRCm39)	intron	probably benign
R5747:Ank2	UTSW	3	126,735,400 (GRCm39)	intron	probably benign
R5794:Ank2	UTSW	3	126,723,669 (GRCm39)	missense	probably benign	0.00
R5831:Ank2	UTSW	3	127,132,808 (GRCm39)	start gained	probably benign
R5925:Ank2	UTSW	3	126,726,612 (GRCm39)	missense	probably benign	0.18
R5954:Ank2	UTSW	3	126,791,510 (GRCm39)	missense	probably benign	0.34
R5956:Ank2	UTSW	3	126,736,337 (GRCm39)	intron	probably benign
R5986:Ank2	UTSW	3	126,806,335 (GRCm39)	missense	possibly damaging	0.94
R5992:Ank2	UTSW	3	126,753,300 (GRCm39)	critical splice donor site	probably null
R6020:Ank2	UTSW	3	126,740,470 (GRCm39)	intron	probably benign
R6027:Ank2	UTSW	3	126,791,528 (GRCm39)	missense	possibly damaging	0.92
R6049:Ank2	UTSW	3	126,736,669 (GRCm39)	missense	possibly damaging	0.95
R6060:Ank2	UTSW	3	126,749,601 (GRCm39)	missense	probably damaging	1.00
R6114:Ank2	UTSW	3	126,804,700 (GRCm39)	missense	probably damaging	1.00
R6124:Ank2	UTSW	3	127,041,800 (GRCm39)	missense	probably benign	0.31
R6156:Ank2	UTSW	3	126,737,886 (GRCm39)	missense	probably damaging	1.00
R6173:Ank2	UTSW	3	126,846,395 (GRCm39)	missense	probably damaging	1.00
R6176:Ank2	UTSW	3	126,739,120 (GRCm39)	missense	probably benign	0.05
R6184:Ank2	UTSW	3	126,756,047 (GRCm39)	missense	probably damaging	1.00
R6199:Ank2	UTSW	3	126,797,655 (GRCm39)	missense	probably damaging	1.00
R6241:Ank2	UTSW	3	126,846,397 (GRCm39)	missense	probably damaging	1.00
R6254:Ank2	UTSW	3	126,735,453 (GRCm39)	intron	probably benign
R6259:Ank2	UTSW	3	126,810,635 (GRCm39)	missense	probably benign	0.28
R6260:Ank2	UTSW	3	126,737,206 (GRCm39)	missense	probably benign
R6321:Ank2	UTSW	3	126,740,587 (GRCm39)	intron	probably benign
R6393:Ank2	UTSW	3	126,723,406 (GRCm39)	missense	probably damaging	1.00
R6406:Ank2	UTSW	3	126,825,874 (GRCm39)	missense	probably damaging	1.00
R6544:Ank2	UTSW	3	126,726,871 (GRCm39)	missense	probably damaging	0.99
R6583:Ank2	UTSW	3	126,810,613 (GRCm39)	missense	probably damaging	1.00
R6739:Ank2	UTSW	3	126,873,643 (GRCm39)	missense	probably damaging	1.00
R6754:Ank2	UTSW	3	126,890,488 (GRCm39)	intron	probably benign
R6786:Ank2	UTSW	3	126,752,581 (GRCm39)	missense	probably damaging	0.99
R6798:Ank2	UTSW	3	126,737,913 (GRCm39)	intron	probably benign
R6882:Ank2	UTSW	3	126,739,406 (GRCm39)	intron	probably benign
R6940:Ank2	UTSW	3	126,735,621 (GRCm39)	intron	probably benign
R6949:Ank2	UTSW	3	126,804,533 (GRCm39)	missense	probably benign	0.00
R7001:Ank2	UTSW	3	126,871,230 (GRCm39)	missense	probably damaging	1.00
R7033:Ank2	UTSW	3	126,738,499 (GRCm39)	nonsense	probably null
R7036:Ank2	UTSW	3	126,740,041 (GRCm39)	intron	probably benign
R7045:Ank2	UTSW	3	126,806,393 (GRCm39)	missense	probably damaging	1.00
R7048:Ank2	UTSW	3	126,819,267 (GRCm39)	missense	probably benign	0.03
R7054:Ank2	UTSW	3	126,736,952 (GRCm39)	intron	probably benign
R7069:Ank2	UTSW	3	126,739,947 (GRCm39)	intron	probably benign
R7091:Ank2	UTSW	3	126,817,000 (GRCm39)	missense	probably damaging	0.98
R7107:Ank2	UTSW	3	126,797,631 (GRCm39)	missense	probably damaging	1.00
R7175:Ank2	UTSW	3	126,740,590 (GRCm39)	missense	unknown
R7191:Ank2	UTSW	3	126,740,041 (GRCm39)	missense	unknown
R7272:Ank2	UTSW	3	126,736,782 (GRCm39)	missense	unknown
R7381:Ank2	UTSW	3	126,730,277 (GRCm39)	missense	possibly damaging	0.46
R7394:Ank2	UTSW	3	126,730,302 (GRCm39)	missense	possibly damaging	0.77
R7462:Ank2	UTSW	3	126,736,683 (GRCm39)	missense	unknown
R7490:Ank2	UTSW	3	126,752,538 (GRCm39)	missense	probably damaging	0.99
R7514:Ank2	UTSW	3	126,819,252 (GRCm39)	missense	probably benign	0.06
R7534:Ank2	UTSW	3	126,727,982 (GRCm39)	splice site	probably null
R7540:Ank2	UTSW	3	126,781,808 (GRCm39)	missense	possibly damaging	0.94
R7547:Ank2	UTSW	3	126,738,852 (GRCm39)	missense	unknown
R7579:Ank2	UTSW	3	126,740,047 (GRCm39)	missense	unknown
R7584:Ank2	UTSW	3	126,739,777 (GRCm39)	nonsense	probably null
R7625:Ank2	UTSW	3	126,846,449 (GRCm39)	missense	probably damaging	1.00
R7698:Ank2	UTSW	3	126,825,860 (GRCm39)	missense	probably benign	0.35
R7716:Ank2	UTSW	3	126,736,815 (GRCm39)	missense	unknown
R7718:Ank2	UTSW	3	126,758,662 (GRCm39)	missense	possibly damaging	0.88
R7722:Ank2	UTSW	3	126,822,951 (GRCm39)	missense	probably benign	0.01
R7738:Ank2	UTSW	3	126,741,271 (GRCm39)	missense
R7977:Ank2	UTSW	3	126,739,356 (GRCm39)	missense	unknown
R7987:Ank2	UTSW	3	126,739,356 (GRCm39)	missense	unknown
R8007:Ank2	UTSW	3	126,730,096 (GRCm39)	intron	probably benign
R8150:Ank2	UTSW	3	126,741,162 (GRCm39)	missense
R8161:Ank2	UTSW	3	126,825,778 (GRCm39)	missense
R8196:Ank2	UTSW	3	126,723,532 (GRCm39)	missense	probably damaging	0.99
R8248:Ank2	UTSW	3	126,731,434 (GRCm39)	missense	possibly damaging	0.78
R8255:Ank2	UTSW	3	126,740,398 (GRCm39)	missense	unknown
R8279:Ank2	UTSW	3	126,726,820 (GRCm39)	missense	probably benign	0.04
R8300:Ank2	UTSW	3	126,804,555 (GRCm39)	missense
R8716:Ank2	UTSW	3	126,736,488 (GRCm39)	nonsense	probably null
R8724:Ank2	UTSW	3	126,737,405 (GRCm39)	missense	unknown
R8765:Ank2	UTSW	3	126,850,731 (GRCm39)	missense	possibly damaging	0.94
R8779:Ank2	UTSW	3	126,758,751 (GRCm39)	missense	probably damaging	0.99
R8783:Ank2	UTSW	3	126,846,455 (GRCm39)	missense	probably damaging	1.00
R8785:Ank2	UTSW	3	126,791,570 (GRCm39)	missense	probably damaging	1.00
R8826:Ank2	UTSW	3	126,740,951 (GRCm39)	missense	unknown
R8872:Ank2	UTSW	3	126,791,525 (GRCm39)	missense	possibly damaging	0.88
R8903:Ank2	UTSW	3	126,840,431 (GRCm39)	missense	probably damaging	1.00
R8906:Ank2	UTSW	3	126,726,720 (GRCm39)	missense	probably benign	0.00
R8918:Ank2	UTSW	3	126,737,380 (GRCm39)	missense	unknown
R8947:Ank2	UTSW	3	126,736,396 (GRCm39)	intron	probably benign
R8977:Ank2	UTSW	3	126,738,575 (GRCm39)	missense	unknown
R8990:Ank2	UTSW	3	126,841,829 (GRCm39)	critical splice donor site	probably null
R8994:Ank2	UTSW	3	126,723,471 (GRCm39)	missense	probably benign	0.19
R9009:Ank2	UTSW	3	126,728,025 (GRCm39)	unclassified	probably benign
R9123:Ank2	UTSW	3	126,733,744 (GRCm39)	missense	probably damaging	1.00
R9125:Ank2	UTSW	3	126,733,744 (GRCm39)	missense	probably damaging	1.00
R9130:Ank2	UTSW	3	126,810,565 (GRCm39)	missense
R9220:Ank2	UTSW	3	126,737,086 (GRCm39)	missense	unknown
R9225:Ank2	UTSW	3	126,736,111 (GRCm39)	missense	unknown
R9286:Ank2	UTSW	3	126,846,381 (GRCm39)	missense	probably damaging	0.99
R9325:Ank2	UTSW	3	126,775,504 (GRCm39)	missense	probably damaging	0.98
R9367:Ank2	UTSW	3	126,738,678 (GRCm39)	missense	unknown
R9385:Ank2	UTSW	3	126,753,366 (GRCm39)	missense	probably benign	0.00
R9391:Ank2	UTSW	3	126,731,394 (GRCm39)	missense	probably damaging	0.99
R9422:Ank2	UTSW	3	126,890,505 (GRCm39)	missense	unknown
R9536:Ank2	UTSW	3	126,736,031 (GRCm39)	missense	unknown
R9647:Ank2	UTSW	3	126,792,623 (GRCm39)	missense	possibly damaging	0.93
R9650:Ank2	UTSW	3	126,735,829 (GRCm39)	missense	unknown
R9666:Ank2	UTSW	3	126,726,838 (GRCm39)	nonsense	probably null
R9686:Ank2	UTSW	3	126,740,550 (GRCm39)	missense	unknown
R9730:Ank2	UTSW	3	127,019,493 (GRCm39)	missense
R9738:Ank2	UTSW	3	126,737,121 (GRCm39)	missense	unknown
R9743:Ank2	UTSW	3	126,733,794 (GRCm39)	missense	possibly damaging	0.81
R9747:Ank2	UTSW	3	126,752,667 (GRCm39)	missense	probably damaging	1.00
R9800:Ank2	UTSW	3	126,740,149 (GRCm39)	missense	unknown
R9803:Ank2	UTSW	3	126,752,726 (GRCm39)	missense	possibly damaging	0.64
RF020:Ank2	UTSW	3	126,739,125 (GRCm39)	missense	unknown
Z1088:Ank2	UTSW	3	126,823,158 (GRCm39)	missense	possibly damaging	0.45
Z1177:Ank2	UTSW	3	126,738,006 (GRCm39)	missense	unknown
Z1187:Ank2	UTSW	3	126,749,601 (GRCm39)	missense	probably damaging	1.00
Z1190:Ank2	UTSW	3	126,749,601 (GRCm39)	missense	probably damaging	1.00
Z1192:Ank2	UTSW	3	126,749,601 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCTGTGCATAAAAGAAGCAGTG -3'
(R):5'- TTTCACAGCACAGAAAATGGC -3'

Sequencing Primer
(F):5'- GACAAAGGATTCTCTTTCTGAACCC -3'
(R):5'- CACAGAAAATGGCATCGTTTGTTCC -3'

Posted On

2022-02-07