Incidental Mutation 'R9366:Parp14'
ID 709011
Institutional Source Beutler Lab
Gene Symbol Parp14
Ensembl Gene ENSMUSG00000034422
Gene Name poly (ADP-ribose) polymerase family, member 14
Synonyms CoaSt6, collaborator of Stat6, 1600029O10Rik
MMRRC Submission
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.493) question?
Stock # R9366 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 35653244-35691914 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to C at 35659630 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000037657 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042665]
AlphaFold Q2EMV9
PDB Structure Solution structure of WWE domain in Parp14 protein [SOLUTION NMR]
Predicted Effect probably null
Transcript: ENSMUST00000042665
SMART Domains Protein: ENSMUSP00000037657
Gene: ENSMUSG00000034422

DomainStartEndE-ValueType
low complexity region 38 49 N/A INTRINSIC
low complexity region 93 115 N/A INTRINSIC
RRM 228 297 4.71e-2 SMART
coiled coil region 443 468 N/A INTRINSIC
Blast:A1pp 693 746 6e-6 BLAST
low complexity region 771 795 N/A INTRINSIC
A1pp 814 948 7.62e-41 SMART
A1pp 1026 1160 5.88e-24 SMART
A1pp 1239 1358 6.82e-20 SMART
PDB:1X4R|A 1532 1619 9e-53 PDB
Pfam:PARP 1632 1817 2.5e-29 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit altered B cell subsets and inability to respond to the apoptosis protective affects of IL4. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd8 C T 8: 71,914,328 (GRCm39) R100Q probably benign Het
Acp5 C T 9: 22,039,224 (GRCm39) C163Y probably damaging Het
Ankrd17 C T 5: 90,416,508 (GRCm39) R1108Q probably damaging Het
Atp2b4 C A 1: 133,642,920 (GRCm39) G1062C probably damaging Het
Bicral A T 17: 47,117,558 (GRCm39) M788K possibly damaging Het
C1s2 C A 6: 124,602,694 (GRCm39) A506S probably benign Het
Capn9 C G 8: 125,332,280 (GRCm39) T417S probably benign Het
Cd109 T G 9: 78,622,275 (GRCm39) S1422A probably benign Het
Cd207 G T 6: 83,648,779 (GRCm39) N294K probably damaging Het
Cdc42bpa A G 1: 179,921,675 (GRCm39) E605G probably damaging Het
Cdhr1 C A 14: 36,811,463 (GRCm39) G216V possibly damaging Het
Ckap2 A T 8: 22,658,988 (GRCm39) M585K possibly damaging Het
Clp1 G T 2: 84,556,473 (GRCm39) S2R probably benign Het
Cngb3 G T 4: 19,395,983 (GRCm39) V342F probably benign Het
Col18a1 T C 10: 76,932,258 (GRCm39) D65G unknown Het
Col3a1 C T 1: 45,380,391 (GRCm39) P972S unknown Het
Cxcr5 C T 9: 44,424,730 (GRCm39) C309Y possibly damaging Het
Cyp2t4 G A 7: 26,854,717 (GRCm39) V66M possibly damaging Het
Dcc A T 18: 71,708,281 (GRCm39) N478K probably damaging Het
Emb G T 13: 117,357,096 (GRCm39) probably benign Het
Emsy A T 7: 98,290,860 (GRCm39) N101K probably benign Het
Epb41l5 A G 1: 119,548,448 (GRCm39) Y137H probably damaging Het
Etfdh C T 3: 79,519,271 (GRCm39) G354D probably benign Het
Fa2h A T 8: 112,076,006 (GRCm39) Y206N probably benign Het
Gabrr2 T C 4: 33,085,771 (GRCm39) V217A Het
Gimap4 A G 6: 48,668,037 (GRCm39) K264R probably benign Het
Gpr31b C A 17: 13,270,375 (GRCm39) D265Y probably damaging Het
Irx4 A G 13: 73,417,025 (GRCm39) T474A probably benign Het
Kif21a T C 15: 90,843,951 (GRCm39) E1096G probably damaging Het
Letm2 A T 8: 26,084,165 (GRCm39) V22E probably damaging Het
Lrrc45 A G 11: 120,611,552 (GRCm39) E642G probably damaging Het
Mark1 A T 1: 184,653,792 (GRCm39) V170E probably damaging Het
Mbd6 G A 10: 127,122,304 (GRCm39) Q175* probably null Het
Mrc1 T A 2: 14,321,709 (GRCm39) D1067E probably damaging Het
Muc5b A G 7: 141,417,041 (GRCm39) H3329R probably benign Het
Myh1 A T 11: 67,110,114 (GRCm39) D1434V probably damaging Het
Myo5a T A 9: 75,124,800 (GRCm39) L1785Q probably damaging Het
Myrfl A G 10: 116,670,358 (GRCm39) I295T possibly damaging Het
Nav3 C A 10: 109,659,364 (GRCm39) R751L probably damaging Het
Neb T C 2: 52,172,699 (GRCm39) K1536R probably benign Het
Nynrin T G 14: 56,100,587 (GRCm39) S126A probably damaging Het
Or13p3 A T 4: 118,566,831 (GRCm39) T76S probably damaging Het
Or5m8 A G 2: 85,822,731 (GRCm39) D190G possibly damaging Het
Or6c69c A T 10: 129,911,067 (GRCm39) K263* probably null Het
Phldb1 G T 9: 44,622,546 (GRCm39) L36M possibly damaging Het
Pin1 C A 9: 20,566,841 (GRCm39) T81N probably damaging Het
Pkhd1l1 T C 15: 44,410,308 (GRCm39) I2605T probably benign Het
Plcb3 A G 19: 6,937,658 (GRCm39) probably null Het
Proser3 G A 7: 30,248,478 (GRCm39) S72L probably damaging Het
Pum2 T A 12: 8,783,344 (GRCm39) S598T probably benign Het
Pwp1 T A 10: 85,717,870 (GRCm39) N269K probably damaging Het
Qsox1 A G 1: 155,665,162 (GRCm39) S260P probably benign Het
Ric3 A G 7: 108,653,644 (GRCm39) L149P probably damaging Het
Rif1 A G 2: 52,010,356 (GRCm39) T707A Het
Rnf213 A C 11: 119,327,057 (GRCm39) R1682S Het
Rpgrip1l G T 8: 91,996,809 (GRCm39) Y690* probably null Het
Slc29a2 A G 19: 5,074,609 (GRCm39) T34A probably damaging Het
Slc6a1 A G 6: 114,280,974 (GRCm39) N176S possibly damaging Het
Slco1b2 T A 6: 141,602,552 (GRCm39) Y168* probably null Het
Snca C A 6: 60,792,675 (GRCm39) A78S probably benign Het
Snrnp200 T A 2: 127,058,010 (GRCm39) D257E probably benign Het
Srebf2 T C 15: 82,083,837 (GRCm39) V959A probably benign Het
Stk3 A C 15: 35,072,634 (GRCm39) I209S probably damaging Het
Thsd7a A T 6: 12,555,480 (GRCm39) C135S Het
Tlnrd1 G T 7: 83,531,582 (GRCm39) A283E probably benign Het
Tomm70a A T 16: 56,970,259 (GRCm39) K546* probably null Het
Trak1 C T 9: 121,301,578 (GRCm39) T778I probably damaging Het
Trappc9 T C 15: 72,808,937 (GRCm39) I709V probably benign Het
Trgc3 A G 13: 19,446,825 (GRCm39) T115A probably benign Het
Trp53rkb T C 2: 166,637,700 (GRCm39) S219P possibly damaging Het
Ubqlnl G C 7: 103,798,592 (GRCm39) L302V possibly damaging Het
Uqcc1 C A 2: 155,771,995 (GRCm39) probably benign Het
Vps13a G A 19: 16,672,894 (GRCm39) R1293W probably damaging Het
Vps9d1 G T 8: 123,974,486 (GRCm39) S267* probably null Het
Vwa5b1 A T 4: 138,318,229 (GRCm39) I546N probably damaging Het
Zbtb8b A T 4: 129,326,151 (GRCm39) M338K probably benign Het
Zfp652 C T 11: 95,643,833 (GRCm39) R344* probably null Het
Other mutations in Parp14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00337:Parp14 APN 16 35,661,445 (GRCm39) missense probably benign 0.00
IGL00497:Parp14 APN 16 35,655,206 (GRCm39) missense probably damaging 1.00
IGL00754:Parp14 APN 16 35,659,741 (GRCm39) missense probably benign 0.15
IGL00960:Parp14 APN 16 35,661,589 (GRCm39) missense probably benign 0.20
IGL01321:Parp14 APN 16 35,676,929 (GRCm39) missense probably benign
IGL01397:Parp14 APN 16 35,679,098 (GRCm39) missense probably benign 0.19
IGL01591:Parp14 APN 16 35,678,877 (GRCm39) missense possibly damaging 0.71
IGL01728:Parp14 APN 16 35,677,805 (GRCm39) missense probably damaging 1.00
IGL01734:Parp14 APN 16 35,678,970 (GRCm39) missense probably benign 0.00
IGL02156:Parp14 APN 16 35,678,967 (GRCm39) missense probably benign 0.13
IGL02951:Parp14 APN 16 35,678,903 (GRCm39) missense probably benign 0.06
IGL03067:Parp14 APN 16 35,676,878 (GRCm39) missense probably benign 0.10
IGL03135:Parp14 APN 16 35,678,381 (GRCm39) missense probably damaging 1.00
IGL03141:Parp14 APN 16 35,659,663 (GRCm39) missense probably benign 0.00
IGL03146:Parp14 APN 16 35,678,823 (GRCm39) nonsense probably null
IGL03333:Parp14 APN 16 35,661,800 (GRCm39) missense probably benign 0.08
IGL03391:Parp14 APN 16 35,678,640 (GRCm39) missense probably benign
thurston UTSW 16 35,664,785 (GRCm39) splice site probably benign
PIT4585001:Parp14 UTSW 16 35,678,975 (GRCm39) missense probably benign 0.03
R0306:Parp14 UTSW 16 35,676,944 (GRCm39) missense probably benign
R0506:Parp14 UTSW 16 35,661,779 (GRCm39) missense possibly damaging 0.70
R0586:Parp14 UTSW 16 35,661,382 (GRCm39) missense probably benign 0.00
R0606:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R0612:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R0699:Parp14 UTSW 16 35,680,955 (GRCm39) missense probably damaging 1.00
R0786:Parp14 UTSW 16 35,661,172 (GRCm39) missense possibly damaging 0.86
R0883:Parp14 UTSW 16 35,678,888 (GRCm39) missense probably benign 0.03
R0900:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1087:Parp14 UTSW 16 35,678,658 (GRCm39) missense probably damaging 1.00
R1104:Parp14 UTSW 16 35,664,785 (GRCm39) splice site probably benign
R1120:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1134:Parp14 UTSW 16 35,655,272 (GRCm39) missense probably damaging 1.00
R1153:Parp14 UTSW 16 35,678,041 (GRCm39) missense possibly damaging 0.49
R1159:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1160:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1237:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1238:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1239:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1423:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1511:Parp14 UTSW 16 35,677,594 (GRCm39) missense probably benign 0.00
R1518:Parp14 UTSW 16 35,677,008 (GRCm39) missense possibly damaging 0.79
R1619:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1707:Parp14 UTSW 16 35,678,219 (GRCm39) missense probably damaging 1.00
R1792:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1831:Parp14 UTSW 16 35,678,958 (GRCm39) missense possibly damaging 0.77
R1840:Parp14 UTSW 16 35,683,819 (GRCm39) missense probably damaging 1.00
R1889:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1902:Parp14 UTSW 16 35,673,888 (GRCm39) critical splice donor site probably null
R1943:Parp14 UTSW 16 35,656,499 (GRCm39) missense probably damaging 1.00
R1954:Parp14 UTSW 16 35,678,671 (GRCm39) missense probably benign 0.08
R2115:Parp14 UTSW 16 35,678,904 (GRCm39) missense probably benign 0.16
R2216:Parp14 UTSW 16 35,677,575 (GRCm39) missense probably benign 0.00
R2519:Parp14 UTSW 16 35,678,573 (GRCm39) missense possibly damaging 0.95
R3851:Parp14 UTSW 16 35,674,118 (GRCm39) missense possibly damaging 0.92
R4052:Parp14 UTSW 16 35,678,771 (GRCm39) missense probably benign 0.05
R4671:Parp14 UTSW 16 35,678,691 (GRCm39) missense probably benign 0.00
R4867:Parp14 UTSW 16 35,677,697 (GRCm39) missense probably benign 0.01
R4941:Parp14 UTSW 16 35,666,403 (GRCm39) missense probably benign
R4992:Parp14 UTSW 16 35,661,512 (GRCm39) missense probably benign 0.05
R5055:Parp14 UTSW 16 35,664,733 (GRCm39) missense probably benign 0.00
R5073:Parp14 UTSW 16 35,655,077 (GRCm39) missense probably damaging 0.99
R5170:Parp14 UTSW 16 35,677,649 (GRCm39) missense probably benign 0.21
R5422:Parp14 UTSW 16 35,686,545 (GRCm39) missense probably benign 0.01
R5543:Parp14 UTSW 16 35,655,137 (GRCm39) missense probably benign 0.00
R5549:Parp14 UTSW 16 35,661,505 (GRCm39) missense probably benign 0.00
R5553:Parp14 UTSW 16 35,677,306 (GRCm39) missense probably benign 0.01
R5691:Parp14 UTSW 16 35,683,909 (GRCm39) missense probably benign 0.12
R5774:Parp14 UTSW 16 35,678,780 (GRCm39) missense probably damaging 1.00
R5855:Parp14 UTSW 16 35,661,297 (GRCm39) nonsense probably null
R5942:Parp14 UTSW 16 35,659,737 (GRCm39) missense probably damaging 0.98
R5990:Parp14 UTSW 16 35,661,827 (GRCm39) missense probably benign 0.14
R5991:Parp14 UTSW 16 35,661,827 (GRCm39) missense probably benign 0.14
R6018:Parp14 UTSW 16 35,661,827 (GRCm39) missense probably benign 0.14
R6022:Parp14 UTSW 16 35,661,827 (GRCm39) missense probably benign 0.14
R6075:Parp14 UTSW 16 35,677,389 (GRCm39) missense probably damaging 0.99
R6395:Parp14 UTSW 16 35,676,918 (GRCm39) missense probably benign 0.00
R6525:Parp14 UTSW 16 35,680,811 (GRCm39) missense probably benign 0.05
R6683:Parp14 UTSW 16 35,655,047 (GRCm39) missense probably damaging 1.00
R7525:Parp14 UTSW 16 35,677,861 (GRCm39) missense probably benign 0.00
R8011:Parp14 UTSW 16 35,677,004 (GRCm39) missense probably benign 0.00
R8192:Parp14 UTSW 16 35,691,584 (GRCm39) missense probably benign 0.01
R8367:Parp14 UTSW 16 35,678,124 (GRCm39) missense probably benign 0.36
R8526:Parp14 UTSW 16 35,661,307 (GRCm39) missense possibly damaging 0.87
R8751:Parp14 UTSW 16 35,677,181 (GRCm39) missense probably benign 0.32
R8962:Parp14 UTSW 16 35,677,187 (GRCm39) missense probably damaging 1.00
R9231:Parp14 UTSW 16 35,661,583 (GRCm39) missense probably damaging 0.98
R9363:Parp14 UTSW 16 35,678,586 (GRCm39) missense possibly damaging 0.90
R9379:Parp14 UTSW 16 35,680,853 (GRCm39) missense probably benign 0.08
R9562:Parp14 UTSW 16 35,677,775 (GRCm39) missense probably benign 0.16
R9565:Parp14 UTSW 16 35,677,775 (GRCm39) missense probably benign 0.16
R9696:Parp14 UTSW 16 35,661,252 (GRCm39) missense probably damaging 0.96
R9696:Parp14 UTSW 16 35,661,251 (GRCm39) missense possibly damaging 0.67
X0026:Parp14 UTSW 16 35,677,527 (GRCm39) nonsense probably null
X0060:Parp14 UTSW 16 35,655,077 (GRCm39) missense probably damaging 0.99
Z1088:Parp14 UTSW 16 35,661,956 (GRCm39) missense probably damaging 1.00
Z1177:Parp14 UTSW 16 35,665,708 (GRCm39) missense probably damaging 1.00
Z1177:Parp14 UTSW 16 35,691,573 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- GGCCTTGTCATGCATCAATAAGAG -3'
(R):5'- CTACATGGGAGCCCTTCATG -3'

Sequencing Primer
(F):5'- GTCCTGTGAAGGCTCAATTCCAG -3'
(R):5'- ACATGGGAGCCCTTCATGTCTAC -3'
Posted On 2022-04-18