Mutagenetix > Incidental Mutation

Incidental Mutation 'R2857:Trank1'

252491

Institutional Source

Beutler Lab

Gene Symbol

Trank1

Ensembl Gene

ENSMUSG00000062296

Gene Name

tetratricopeptide repeat and ankyrin repeat containing 1

Synonyms

LOC235639, C030048J01Rik, A230061D21Rik, Lba1

MMRRC Submission

040447-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R2857 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

111140807-111224843 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 111196001 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 1342 (T1342S)

Ref Sequence

ENSEMBL: ENSMUSP00000077697 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078626]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000078626
AA Change: T1342S

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000077697
Gene: ENSMUSG00000062296
AA Change: T1342S

Domain	Start	End	E-Value	Type
low complexity region	4	30	N/A	INTRINSIC
low complexity region	34	52	N/A	INTRINSIC
low complexity region	113	129	N/A	INTRINSIC
Blast:TPR	144	177	1e-15	BLAST
Blast:TPR	178	209	8e-13	BLAST
Blast:ANK	332	361	1e-6	BLAST
ANK	369	405	5.29e0	SMART
ANK	538	567	2.11e2	SMART
ANK	572	609	7.29e2	SMART
ANK	621	652	1.21e2	SMART
low complexity region	887	895	N/A	INTRINSIC
low complexity region	1152	1172	N/A	INTRINSIC
Blast:AAA	1351	1569	1e-6	BLAST
low complexity region	2166	2177	N/A	INTRINSIC
low complexity region	2395	2411	N/A	INTRINSIC
low complexity region	2636	2649	N/A	INTRINSIC
low complexity region	2966	2983	N/A	INTRINSIC

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 93.6%

Validation Efficiency

Allele List at MGI

All alleles(2) : Targeted, other(2)

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A330087D11Rik	A	T	7: 29,273,303 (GRCm39)		noncoding transcript	Het
Amfr	A	T	8: 94,731,842 (GRCm39)	N11K	probably damaging	Het
Bpifa6	G	A	2: 153,831,194 (GRCm39)	M253I	probably benign	Het
C330018D20Rik	A	G	18: 57,095,531 (GRCm39)	L18P	probably benign	Het
Cd109	CATTTATTTATTTATTTATTTATTTATTTATTTAT	CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT	9: 78,619,782 (GRCm39)		probably benign	Het
Cdh23	C	T	10: 60,218,432 (GRCm39)		probably null	Het
Ceacam1	T	A	7: 25,173,442 (GRCm39)	I249F	probably damaging	Het
Cfap54	C	T	10: 92,881,144 (GRCm39)	R348Q	probably damaging	Het
Cfap91	A	C	16: 38,123,075 (GRCm39)	L651R	probably damaging	Het
Crygs	C	T	16: 22,624,301 (GRCm39)	G102D	possibly damaging	Het
Cuzd1	C	T	7: 130,917,863 (GRCm39)	V246M	probably damaging	Het
Ehd2	A	T	7: 15,698,054 (GRCm39)	V61E	probably damaging	Het
Erich5	C	T	15: 34,471,560 (GRCm39)	T263I	probably damaging	Het
Fbxo36	A	G	1: 84,874,316 (GRCm39)	K104R	probably benign	Het
Fibin	C	T	2: 110,192,542 (GRCm39)	R200H	probably damaging	Het
Gad2	A	C	2: 22,563,987 (GRCm39)	M397L	probably benign	Het
Garin3	T	C	11: 46,296,039 (GRCm39)	I137T	probably damaging	Het
Iqgap3	C	A	3: 88,014,903 (GRCm39)	S873*	probably null	Het
Kcnh8	A	G	17: 53,284,961 (GRCm39)	D977G	probably benign	Het
Mau2	T	C	8: 70,472,474 (GRCm39)	M570V	probably benign	Het
Mrgprb4	T	A	7: 47,848,084 (GRCm39)	R281S	possibly damaging	Het
Mthfd1	T	C	12: 76,335,699 (GRCm39)	Y258H	probably damaging	Het
Nexn	C	T	3: 151,953,680 (GRCm39)	E247K	probably damaging	Het
Or11g27	T	A	14: 50,770,897 (GRCm39)	N9K	probably benign	Het
Or3a10	C	T	11: 73,935,653 (GRCm39)	G149D	possibly damaging	Het
Or9e1	T	A	11: 58,732,708 (GRCm39)	V256E	probably benign	Het
Phrf1	T	A	7: 140,839,593 (GRCm39)		probably benign	Het
Prc1	A	G	7: 79,961,969 (GRCm39)	N52S	probably damaging	Het
Psd	G	C	19: 46,312,859 (GRCm39)	S170R	probably benign	Het
Riok1	T	C	13: 38,233,053 (GRCm39)	F229L	probably damaging	Het
Slco1a7	A	G	6: 141,690,264 (GRCm39)	V163A	probably benign	Het
Stat2	A	G	10: 128,112,770 (GRCm39)		probably null	Het
Sycp3	A	G	10: 88,303,234 (GRCm39)	E166G	probably damaging	Het
Szt2	G	A	4: 118,226,599 (GRCm39)	T510I	probably damaging	Het
Trav3-1	C	A	14: 52,818,515 (GRCm39)	A63E	probably benign	Het
Trim34b	A	T	7: 103,985,439 (GRCm39)	N358I	probably benign	Het
Trmt11	G	C	10: 30,423,744 (GRCm39)	P387R	probably damaging	Het
Vmn2r82	T	A	10: 79,217,090 (GRCm39)	I474N	probably damaging	Het
Vrk2	C	A	11: 26,433,324 (GRCm39)	S286I	possibly damaging	Het
Wdfy3	A	T	5: 102,023,796 (GRCm39)	I2451N	probably benign	Het
Zfp326	G	A	5: 106,036,395 (GRCm39)	R102H	probably benign	Het

Other mutations in Trank1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00234:Trank1	APN	9	111,221,677 (GRCm39)	missense	probably damaging	1.00
IGL00467:Trank1	APN	9	111,193,734 (GRCm39)	splice site	probably benign
IGL00569:Trank1	APN	9	111,174,579 (GRCm39)	missense	possibly damaging	0.69
IGL00585:Trank1	APN	9	111,178,358 (GRCm39)	missense	possibly damaging	0.82
IGL01070:Trank1	APN	9	111,195,861 (GRCm39)	missense	probably damaging	1.00
IGL01134:Trank1	APN	9	111,220,849 (GRCm39)	missense	probably benign
IGL01154:Trank1	APN	9	111,215,468 (GRCm39)	missense	probably benign	0.00
IGL01355:Trank1	APN	9	111,194,588 (GRCm39)	missense	possibly damaging	0.94
IGL01407:Trank1	APN	9	111,193,790 (GRCm39)	missense	probably damaging	0.99
IGL01410:Trank1	APN	9	111,194,117 (GRCm39)	missense	probably benign	0.00
IGL01410:Trank1	APN	9	111,194,327 (GRCm39)	missense	probably benign	0.00
IGL01504:Trank1	APN	9	111,202,612 (GRCm39)	missense	probably damaging	1.00
IGL01744:Trank1	APN	9	111,178,431 (GRCm39)	missense	probably damaging	1.00
IGL02043:Trank1	APN	9	111,193,028 (GRCm39)	missense	probably damaging	0.98
IGL02104:Trank1	APN	9	111,219,780 (GRCm39)	missense	possibly damaging	0.85
IGL02193:Trank1	APN	9	111,196,344 (GRCm39)	missense	probably benign	0.43
IGL02581:Trank1	APN	9	111,212,193 (GRCm39)	missense	probably benign	0.00
IGL02630:Trank1	APN	9	111,202,143 (GRCm39)	missense	possibly damaging	0.70
IGL02839:Trank1	APN	9	111,193,824 (GRCm39)	missense	probably damaging	1.00
IGL02897:Trank1	APN	9	111,196,585 (GRCm39)	missense	probably damaging	0.99
IGL03065:Trank1	APN	9	111,219,361 (GRCm39)	missense	possibly damaging	0.64
IGL03123:Trank1	APN	9	111,196,475 (GRCm39)	missense	probably damaging	1.00
IGL03143:Trank1	APN	9	111,195,155 (GRCm39)	missense	probably damaging	1.00
IGL03323:Trank1	APN	9	111,181,184 (GRCm39)	missense	probably damaging	1.00
1mM(1):Trank1	UTSW	9	111,222,049 (GRCm39)	missense	probably damaging	1.00
PIT4486001:Trank1	UTSW	9	111,219,175 (GRCm39)	missense	probably damaging	1.00
PIT4812001:Trank1	UTSW	9	111,176,980 (GRCm39)	missense	probably damaging	1.00
R0035:Trank1	UTSW	9	111,195,844 (GRCm39)	missense	probably benign	0.00
R0064:Trank1	UTSW	9	111,172,263 (GRCm39)	missense	probably damaging	1.00
R0064:Trank1	UTSW	9	111,172,263 (GRCm39)	missense	probably damaging	1.00
R0089:Trank1	UTSW	9	111,221,978 (GRCm39)	missense	probably benign	0.00
R0207:Trank1	UTSW	9	111,195,321 (GRCm39)	missense	probably damaging	1.00
R0255:Trank1	UTSW	9	111,195,092 (GRCm39)	missense	possibly damaging	0.92
R0334:Trank1	UTSW	9	111,222,008 (GRCm39)	missense	probably damaging	1.00
R0334:Trank1	UTSW	9	111,194,421 (GRCm39)	missense	probably benign	0.00
R0383:Trank1	UTSW	9	111,220,545 (GRCm39)	missense	probably benign	0.08
R0421:Trank1	UTSW	9	111,220,907 (GRCm39)	missense	probably damaging	1.00
R0494:Trank1	UTSW	9	111,220,361 (GRCm39)	missense	probably benign	0.19
R0518:Trank1	UTSW	9	111,162,876 (GRCm39)	missense	probably damaging	1.00
R0560:Trank1	UTSW	9	111,220,154 (GRCm39)	missense	possibly damaging	0.88
R0637:Trank1	UTSW	9	111,219,509 (GRCm39)	missense	probably damaging	1.00
R0731:Trank1	UTSW	9	111,194,556 (GRCm39)	missense	probably damaging	1.00
R0761:Trank1	UTSW	9	111,195,681 (GRCm39)	missense	probably damaging	1.00
R0766:Trank1	UTSW	9	111,176,537 (GRCm39)	missense	probably benign	0.45
R0827:Trank1	UTSW	9	111,178,485 (GRCm39)	unclassified	probably benign
R1005:Trank1	UTSW	9	111,162,789 (GRCm39)	missense	probably benign	0.13
R1108:Trank1	UTSW	9	111,194,375 (GRCm39)	missense	probably benign	0.00
R1155:Trank1	UTSW	9	111,196,038 (GRCm39)	missense	possibly damaging	0.95
R1470:Trank1	UTSW	9	111,172,300 (GRCm39)	missense	possibly damaging	0.91
R1470:Trank1	UTSW	9	111,172,300 (GRCm39)	missense	possibly damaging	0.91
R1596:Trank1	UTSW	9	111,195,358 (GRCm39)	missense	possibly damaging	0.93
R1601:Trank1	UTSW	9	111,202,545 (GRCm39)	missense	probably damaging	1.00
R1751:Trank1	UTSW	9	111,220,547 (GRCm39)	missense	probably benign
R1754:Trank1	UTSW	9	111,221,939 (GRCm39)	missense	probably benign	0.00
R1767:Trank1	UTSW	9	111,220,547 (GRCm39)	missense	probably benign
R1768:Trank1	UTSW	9	111,221,995 (GRCm39)	missense	probably damaging	0.96
R1809:Trank1	UTSW	9	111,221,893 (GRCm39)	missense	probably benign	0.34
R1912:Trank1	UTSW	9	111,219,777 (GRCm39)	missense	probably benign	0.00
R1920:Trank1	UTSW	9	111,176,996 (GRCm39)	critical splice donor site	probably null
R1960:Trank1	UTSW	9	111,220,696 (GRCm39)	missense	probably damaging	1.00
R1993:Trank1	UTSW	9	111,207,900 (GRCm39)	missense	probably benign	0.20
R2012:Trank1	UTSW	9	111,194,096 (GRCm39)	missense	probably benign
R2025:Trank1	UTSW	9	111,221,107 (GRCm39)	missense	probably benign	0.01
R2050:Trank1	UTSW	9	111,193,856 (GRCm39)	missense	probably damaging	1.00
R2912:Trank1	UTSW	9	111,221,551 (GRCm39)	missense	probably damaging	0.98
R2962:Trank1	UTSW	9	111,181,148 (GRCm39)	missense	probably damaging	1.00
R3030:Trank1	UTSW	9	111,220,598 (GRCm39)	missense	possibly damaging	0.63
R3821:Trank1	UTSW	9	111,207,887 (GRCm39)	missense	probably damaging	1.00
R3822:Trank1	UTSW	9	111,207,887 (GRCm39)	missense	probably damaging	1.00
R3892:Trank1	UTSW	9	111,193,827 (GRCm39)	missense	probably benign	0.03
R4105:Trank1	UTSW	9	111,181,265 (GRCm39)	missense	probably damaging	1.00
R4166:Trank1	UTSW	9	111,202,592 (GRCm39)	nonsense	probably null
R4237:Trank1	UTSW	9	111,196,103 (GRCm39)	missense	probably benign	0.04
R4239:Trank1	UTSW	9	111,196,103 (GRCm39)	missense	probably benign	0.04
R4394:Trank1	UTSW	9	111,194,265 (GRCm39)	missense	possibly damaging	0.86
R4417:Trank1	UTSW	9	111,195,036 (GRCm39)	missense	probably benign	0.17
R4611:Trank1	UTSW	9	111,191,329 (GRCm39)	missense	probably damaging	1.00
R4694:Trank1	UTSW	9	111,221,129 (GRCm39)	missense	probably benign	0.40
R4731:Trank1	UTSW	9	111,219,478 (GRCm39)	missense	probably damaging	1.00
R4843:Trank1	UTSW	9	111,195,146 (GRCm39)	missense	probably benign	0.00
R4852:Trank1	UTSW	9	111,220,963 (GRCm39)	missense	possibly damaging	0.68
R4859:Trank1	UTSW	9	111,194,078 (GRCm39)	missense	probably benign	0.17
R4868:Trank1	UTSW	9	111,194,709 (GRCm39)	missense	probably damaging	1.00
R5080:Trank1	UTSW	9	111,218,289 (GRCm39)	missense	probably damaging	0.99
R5156:Trank1	UTSW	9	111,219,762 (GRCm39)	missense	probably damaging	1.00
R5174:Trank1	UTSW	9	111,194,627 (GRCm39)	missense	probably benign	0.00
R5234:Trank1	UTSW	9	111,215,535 (GRCm39)	missense	probably damaging	1.00
R5386:Trank1	UTSW	9	111,191,470 (GRCm39)	missense	probably benign	0.12
R5419:Trank1	UTSW	9	111,220,369 (GRCm39)	missense	probably damaging	1.00
R5435:Trank1	UTSW	9	111,220,958 (GRCm39)	missense	probably benign	0.00
R5444:Trank1	UTSW	9	111,222,026 (GRCm39)	missense	probably benign	0.04
R5543:Trank1	UTSW	9	111,195,180 (GRCm39)	missense	probably damaging	0.97
R5560:Trank1	UTSW	9	111,219,635 (GRCm39)	missense	probably damaging	1.00
R5772:Trank1	UTSW	9	111,195,744 (GRCm39)	missense	possibly damaging	0.86
R5774:Trank1	UTSW	9	111,220,294 (GRCm39)	missense	probably damaging	1.00
R5843:Trank1	UTSW	9	111,194,928 (GRCm39)	missense	possibly damaging	0.59
R5858:Trank1	UTSW	9	111,221,604 (GRCm39)	missense	probably benign
R5878:Trank1	UTSW	9	111,195,753 (GRCm39)	missense	possibly damaging	0.93
R5900:Trank1	UTSW	9	111,220,784 (GRCm39)	missense	probably damaging	1.00
R5917:Trank1	UTSW	9	111,191,485 (GRCm39)	missense	probably benign	0.38
R5954:Trank1	UTSW	9	111,194,201 (GRCm39)	missense	probably benign	0.13
R6041:Trank1	UTSW	9	111,206,864 (GRCm39)	missense	possibly damaging	0.94
R6112:Trank1	UTSW	9	111,220,805 (GRCm39)	missense	probably damaging	1.00
R6165:Trank1	UTSW	9	111,220,940 (GRCm39)	missense	probably benign	0.00
R6255:Trank1	UTSW	9	111,181,314 (GRCm39)	critical splice donor site	probably null
R6395:Trank1	UTSW	9	111,196,268 (GRCm39)	missense	probably damaging	1.00
R6567:Trank1	UTSW	9	111,176,589 (GRCm39)	missense	probably benign	0.02
R6644:Trank1	UTSW	9	111,193,902 (GRCm39)	missense	possibly damaging	0.85
R6724:Trank1	UTSW	9	111,194,984 (GRCm39)	missense	probably damaging	1.00
R6788:Trank1	UTSW	9	111,219,747 (GRCm39)	missense	probably damaging	1.00
R6831:Trank1	UTSW	9	111,206,967 (GRCm39)	missense	probably benign	0.00
R6934:Trank1	UTSW	9	111,202,158 (GRCm39)	missense	probably damaging	0.99
R7127:Trank1	UTSW	9	111,194,864 (GRCm39)	missense	possibly damaging	0.85
R7206:Trank1	UTSW	9	111,174,583 (GRCm39)	critical splice donor site	probably null
R7236:Trank1	UTSW	9	111,202,142 (GRCm39)	missense	possibly damaging	0.93
R7247:Trank1	UTSW	9	111,196,580 (GRCm39)	missense	probably damaging	1.00
R7292:Trank1	UTSW	9	111,206,938 (GRCm39)	missense	probably benign	0.02
R7310:Trank1	UTSW	9	111,196,194 (GRCm39)	missense	probably damaging	1.00
R7431:Trank1	UTSW	9	111,191,470 (GRCm39)	missense	probably benign	0.12
R7448:Trank1	UTSW	9	111,195,417 (GRCm39)	missense	probably benign	0.01
R7477:Trank1	UTSW	9	111,194,025 (GRCm39)	missense	probably benign	0.00
R7514:Trank1	UTSW	9	111,193,824 (GRCm39)	missense	probably damaging	1.00
R7595:Trank1	UTSW	9	111,195,059 (GRCm39)	missense	probably damaging	1.00
R7637:Trank1	UTSW	9	111,194,364 (GRCm39)	missense	possibly damaging	0.71
R7648:Trank1	UTSW	9	111,220,753 (GRCm39)	missense	probably benign
R7737:Trank1	UTSW	9	111,195,080 (GRCm39)	nonsense	probably null
R7784:Trank1	UTSW	9	111,193,171 (GRCm39)	missense	probably damaging	1.00
R7884:Trank1	UTSW	9	111,221,584 (GRCm39)	missense	probably benign
R7912:Trank1	UTSW	9	111,220,596 (GRCm39)	missense	probably benign	0.04
R7938:Trank1	UTSW	9	111,194,096 (GRCm39)	missense	probably benign
R7979:Trank1	UTSW	9	111,206,967 (GRCm39)	missense	probably benign	0.00
R8064:Trank1	UTSW	9	111,181,144 (GRCm39)	nonsense	probably null
R8100:Trank1	UTSW	9	111,221,861 (GRCm39)	missense	probably damaging	1.00
R8124:Trank1	UTSW	9	111,207,995 (GRCm39)	missense	probably benign	0.31
R8198:Trank1	UTSW	9	111,219,880 (GRCm39)	missense	probably benign	0.09
R8219:Trank1	UTSW	9	111,193,977 (GRCm39)	missense	probably damaging	1.00
R8223:Trank1	UTSW	9	111,194,957 (GRCm39)	missense	probably damaging	1.00
R8316:Trank1	UTSW	9	111,178,370 (GRCm39)	missense	probably benign	0.38
R8347:Trank1	UTSW	9	111,196,317 (GRCm39)	missense	probably damaging	1.00
R8436:Trank1	UTSW	9	111,220,450 (GRCm39)	missense	possibly damaging	0.86
R8489:Trank1	UTSW	9	111,219,343 (GRCm39)	missense	probably benign	0.01
R8682:Trank1	UTSW	9	111,194,412 (GRCm39)	missense	probably benign	0.01
R8768:Trank1	UTSW	9	111,218,344 (GRCm39)	missense	probably benign	0.00
R8770:Trank1	UTSW	9	111,219,892 (GRCm39)	missense	probably benign	0.00
R8829:Trank1	UTSW	9	111,176,591 (GRCm39)	missense	probably benign
R8838:Trank1	UTSW	9	111,193,973 (GRCm39)	missense	probably benign	0.03
R8855:Trank1	UTSW	9	111,141,289 (GRCm39)	missense	unknown
R8929:Trank1	UTSW	9	111,208,003 (GRCm39)	missense	possibly damaging	0.93
R9047:Trank1	UTSW	9	111,191,500 (GRCm39)	missense	probably damaging	0.99
R9090:Trank1	UTSW	9	111,174,547 (GRCm39)	missense	probably damaging	1.00
R9114:Trank1	UTSW	9	111,162,843 (GRCm39)	missense	probably damaging	1.00
R9133:Trank1	UTSW	9	111,220,770 (GRCm39)	missense	possibly damaging	0.93
R9177:Trank1	UTSW	9	111,221,579 (GRCm39)	missense	probably benign	0.00
R9178:Trank1	UTSW	9	111,196,268 (GRCm39)	missense	probably damaging	1.00
R9271:Trank1	UTSW	9	111,174,547 (GRCm39)	missense	probably damaging	1.00
R9314:Trank1	UTSW	9	111,195,049 (GRCm39)	missense	probably damaging	1.00
R9373:Trank1	UTSW	9	111,194,259 (GRCm39)	missense	probably benign	0.25
R9380:Trank1	UTSW	9	111,221,738 (GRCm39)	missense	probably benign	0.07
R9435:Trank1	UTSW	9	111,193,890 (GRCm39)	missense	probably benign	0.04
R9501:Trank1	UTSW	9	111,176,943 (GRCm39)	missense	probably benign	0.00
R9593:Trank1	UTSW	9	111,191,365 (GRCm39)	missense	probably benign	0.30
R9601:Trank1	UTSW	9	111,202,193 (GRCm39)	missense	probably benign	0.18
R9729:Trank1	UTSW	9	111,220,537 (GRCm39)	missense	probably damaging	1.00
X0064:Trank1	UTSW	9	111,172,304 (GRCm39)	missense	possibly damaging	0.57
Z1088:Trank1	UTSW	9	111,193,778 (GRCm39)	missense	probably damaging	0.99
Z1177:Trank1	UTSW	9	111,221,938 (GRCm39)	missense	possibly damaging	0.47
Z1177:Trank1	UTSW	9	111,196,445 (GRCm39)	missense	possibly damaging	0.83
Z1177:Trank1	UTSW	9	111,140,970 (GRCm39)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- GACCTGAGGGATGAAAACTTCC -3'
(R):5'- TCTCCCATGGGGACAACTAAG -3'

Sequencing Primer
(F):5'- GGATGAAAACTTCCCTCTGTTTG -3'
(R):5'- TGGGGACAACTAAGAGCCTC -3'

Posted On

2014-12-04