Mutagenetix > Incidental Mutations

Incidental Mutation 'R1715:Hdac10'

190965

Institutional Source

Beutler Lab

Gene Symbol

Hdac10

Ensembl Gene

ENSMUSG00000062906

Gene Name

histone deacetylase 10

Synonyms

MMRRC Submission

039748-MU

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1715 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

89123307-89128700 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

G to T at 89126709 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000104971 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041656] [ENSMUST00000082197] [ENSMUST00000088827] [ENSMUST00000109347] [ENSMUST00000109347] [ENSMUST00000109353]

Predicted Effect

probably benign
Transcript: ENSMUST00000041656

SMART Domains

Protein: ENSMUSP00000040132
Gene: ENSMUSG00000051786

Domain	Start	End	E-Value	Type
Pfam:Spc97_Spc98	355	1667	3.3e-119	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000082197

SMART Domains

Protein: ENSMUSP00000080832
Gene: ENSMUSG00000062906

Domain	Start	End	E-Value	Type
Pfam:Hist_deacetyl	13	322	2.1e-85	PFAM
low complexity region	478	489	N/A	INTRINSIC
low complexity region	583	595	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000088827

SMART Domains

Protein: ENSMUSP00000086207
Gene: ENSMUSG00000022610

Domain	Start	End	E-Value	Type
S_TKc	27	311	1.63e-96	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000109347

SMART Domains

Protein: ENSMUSP00000104971
Gene: ENSMUSG00000062906

Domain	Start	End	E-Value	Type
Pfam:Hist_deacetyl	13	251	6.1e-66	PFAM
low complexity region	270	282	N/A	INTRINSIC
low complexity region	398	409	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000109347

SMART Domains

Protein: ENSMUSP00000104971
Gene: ENSMUSG00000062906

Domain	Start	End	E-Value	Type
Pfam:Hist_deacetyl	13	251	6.1e-66	PFAM
low complexity region	270	282	N/A	INTRINSIC
low complexity region	398	409	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000109353

SMART Domains

Protein: ENSMUSP00000104977
Gene: ENSMUSG00000051786

Domain	Start	End	E-Value	Type
Pfam:Spc97_Spc98	355	1675	2.8e-94	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000128908

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129398

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134111

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138245

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000143465

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153195

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000231014

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000230266

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000231098

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000230509

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000230352

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.8%
20x: 94.1%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700023F06Rik	T	C	11: 103,199,824		probably null	Het
2210010C04Rik	A	G	6: 41,032,936		probably null	Het
2410089E03Rik	T	A	15: 8,226,900		probably null	Het
Abca8a	G	A	11: 110,091,580	T12M	probably damaging	Het
Alms1	T	A	6: 85,629,052	Y2561*	probably null	Het
Atp10a	G	A	7: 58,786,505	V348I	probably damaging	Het
Best2	T	C	8: 85,011,223	Y181C	probably benign	Het
Btaf1	T	A	19: 36,969,121	D442E	probably damaging	Het
C330027C09Rik	C	T	16: 49,005,719	T383I	probably benign	Het
Carmil3	T	G	14: 55,504,532	V1153G	probably benign	Het
Cc2d2a	A	G	5: 43,718,661	I993M	probably damaging	Het
Ccng1	G	A	11: 40,752,114	P169S	probably benign	Het
Cmtr2	T	C	8: 110,222,798	L580P	probably damaging	Het
Col22a1	T	C	15: 72,006,981	E109G	possibly damaging	Het
Crispld2	G	T	8: 120,023,649	W264L	possibly damaging	Het
Cyp2c38	T	C	19: 39,404,795	H276R	probably benign	Het
Dag1	A	T	9: 108,208,715	V409E	possibly damaging	Het
Emc8	T	C	8: 120,658,555	N146S	probably benign	Het
Glt8d1	T	C	14: 31,011,521	V321A	possibly damaging	Het
Gm5174	C	T	10: 86,656,912		noncoding transcript	Het
Hectd4	A	G	5: 121,344,818	D3144G	possibly damaging	Het
Ifna11	C	T	4: 88,820,236	S93L	probably damaging	Het
Il16	T	C	7: 83,648,728	N431S	probably benign	Het
Irf8	A	T	8: 120,754,388	E237V	probably damaging	Het
Lrp1b	A	G	2: 41,185,981	Y1769H	probably damaging	Het
Lrrc9	A	G	12: 72,477,299	N761D	probably damaging	Het
Mbtps1	T	C	8: 119,542,730	Y207C	probably benign	Het
Myo9a	A	G	9: 59,832,300	E765G	probably damaging	Het
Nlrp3	A	G	11: 59,543,351	D80G	probably damaging	Het
Olfr361	G	A	2: 37,085,176	P191S	probably damaging	Het
Olfr697	G	C	7: 106,741,548	P129A	probably damaging	Het
Olfr830	A	T	9: 18,875,794	I156F	probably benign	Het
Pcyt2	T	A	11: 120,615,851		probably null	Het
Plxnd1	T	C	6: 115,968,681	T944A	probably benign	Het
Psd4	A	T	2: 24,405,332	I833F	probably damaging	Het
Psmd7	A	G	8: 107,581,185	I222T	probably benign	Het
Rap2b	A	G	3: 61,365,190	E45G	probably damaging	Het
Rbm22	T	C	18: 60,560,844	S7P	possibly damaging	Het
Rbpms2	ACTGCTGCTGCTGCTGC	ACTGCTGCTGCTGCTGCTGC	9: 65,651,666		probably benign	Het
Rfx4	A	G	10: 84,844,280	N107S	probably damaging	Het
Ripk2	T	A	4: 16,155,192		probably null	Het
Rpgrip1	T	A	14: 52,140,691	C499S	possibly damaging	Het
Scarf1	T	C	11: 75,524,044	S515P	probably damaging	Het
Sgip1	T	C	4: 102,915,059	V215A	probably benign	Het
Sis	T	C	3: 72,889,010	I1813V	possibly damaging	Het
Slc17a3	A	T	13: 23,856,741	T317S	probably benign	Het
Slc35e1	T	C	8: 72,483,977	N340S	probably benign	Het
Smg6	A	G	11: 74,929,430	I176V	probably benign	Het
Smim17	T	C	7: 6,429,326	L89S	probably damaging	Het
Synm	T	C	7: 67,736,303	N95S	probably damaging	Het
Tdrd9	A	G	12: 112,036,439	K841E	possibly damaging	Het
Tep1	G	T	14: 50,854,567	F570L	possibly damaging	Het
Tgm3	G	A	2: 130,026,814		probably null	Het
Tra2b	T	C	16: 22,252,746	Y128C	possibly damaging	Het
Vmn2r17	T	C	5: 109,428,244	V327A	probably benign	Het
Wdr20rt	A	T	12: 65,227,314	D344V	probably damaging	Het
Zfp940	A	G	7: 29,844,938	C515R	probably damaging	Het

Other mutations in Hdac10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00229:Hdac10	APN	15	89128442	missense	probably damaging	1.00
IGL01063:Hdac10	APN	15	89123868	missense	possibly damaging	0.68
IGL01577:Hdac10	APN	15	89126213	missense	possibly damaging	0.90
IGL01690:Hdac10	APN	15	89125991	missense	probably benign	0.00
IGL01724:Hdac10	APN	15	89124709	unclassified	probably benign
IGL01866:Hdac10	APN	15	89124533	missense	probably damaging	1.00
IGL01989:Hdac10	APN	15	89125343	missense	probably damaging	1.00
IGL01995:Hdac10	APN	15	89127598	missense	probably damaging	1.00
IGL02256:Hdac10	APN	15	89125894	unclassified	probably benign
IGL02668:Hdac10	APN	15	89125644	missense	probably benign	0.10
R0240:Hdac10	UTSW	15	89125882	missense	possibly damaging	0.65
R0240:Hdac10	UTSW	15	89125882	missense	possibly damaging	0.65
R0454:Hdac10	UTSW	15	89125758	splice site	probably null
R0723:Hdac10	UTSW	15	89126418	missense	probably damaging	1.00
R0924:Hdac10	UTSW	15	89125862	missense	probably benign
R1553:Hdac10	UTSW	15	89125515	missense	possibly damaging	0.51
R1608:Hdac10	UTSW	15	89125318	missense	probably benign	0.04
R1619:Hdac10	UTSW	15	89126675	missense	probably damaging	1.00
R2284:Hdac10	UTSW	15	89127404	missense	probably benign	0.00
R2872:Hdac10	UTSW	15	89125856	missense	possibly damaging	0.46
R2872:Hdac10	UTSW	15	89125856	missense	possibly damaging	0.46
R3688:Hdac10	UTSW	15	89123564	critical splice donor site	probably null
R4283:Hdac10	UTSW	15	89125623	missense	possibly damaging	0.94
R4604:Hdac10	UTSW	15	89125397	critical splice acceptor site	probably null
R4654:Hdac10	UTSW	15	89126833	unclassified	probably benign
R4898:Hdac10	UTSW	15	89128447	start codon destroyed	probably null	1.00
R4998:Hdac10	UTSW	15	89123940	missense	possibly damaging	0.94
R5393:Hdac10	UTSW	15	89126684	missense	probably damaging	1.00
R5769:Hdac10	UTSW	15	89123616	missense	probably benign	0.00
R5785:Hdac10	UTSW	15	89126945	missense	probably benign
R6992:Hdac10	UTSW	15	89125331	missense	probably benign	0.01
R7149:Hdac10	UTSW	15	89127449	missense	probably damaging	1.00
R7237:Hdac10	UTSW	15	89125377	missense	probably benign
R7276:Hdac10	UTSW	15	89128285	missense	probably benign	0.01
R7395:Hdac10	UTSW	15	89128284	missense	probably benign	0.14

Predicted Primers

PCR Primer
(F):5'- CGATAGCAGAGTCAAATCCAGCCG -3'
(R):5'- CCAAGGTTTCACTGTCAATTTGCCC -3'

Sequencing Primer
(F):5'- AGGTTAGACTTTCTGAGACACC -3'
(R):5'- ACTGTCAATTTGCCCTGGAAC -3'

Posted On

2014-05-14