Incidental Mutation 'R0153:Ttll5'
| ID |
22857 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ttll5
|
| Ensembl Gene |
ENSMUSG00000012609 |
| Gene Name |
tubulin tyrosine ligase-like family, member 5 |
| Synonyms |
1700048H13Rik, D630041K24Rik, STAMP, 2310009M18Rik, 4930556H18Rik |
| MMRRC Submission |
038436-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.716)
|
| Stock # |
R0153 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
(trace)
|
| Chromosome |
12 |
| Chromosomal Location |
85871417-86100534 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 85878740 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Asparagine
at position 49
(I49N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135139
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040179]
[ENSMUST00000040273]
[ENSMUST00000095536]
[ENSMUST00000110220]
[ENSMUST00000110224]
[ENSMUST00000142411]
[ENSMUST00000177114]
[ENSMUST00000153570]
[ENSMUST00000177188]
[ENSMUST00000176695]
[ENSMUST00000155448]
|
| AlphaFold |
Q8CHB8 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000040179
AA Change: I49N
PolyPhen 2
Score 0.478 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000048809
Gene: ENSMUSG00000012609
AA Change: I49N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TTL
|
110 |
407 |
1.9e-94 |
PFAM |
|
low complexity region
|
556 |
575 |
N/A |
INTRINSIC |
|
low complexity region
|
595 |
621 |
N/A |
INTRINSIC |
|
low complexity region
|
747 |
761 |
N/A |
INTRINSIC |
|
low complexity region
|
781 |
793 |
N/A |
INTRINSIC |
|
low complexity region
|
835 |
847 |
N/A |
INTRINSIC |
|
low complexity region
|
1167 |
1181 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000040273
AA Change: I49N
PolyPhen 2
Score 0.349 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000039939
Gene: ENSMUSG00000012609
AA Change: I49N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TTL
|
110 |
407 |
1e-94 |
PFAM |
|
low complexity region
|
556 |
575 |
N/A |
INTRINSIC |
|
low complexity region
|
595 |
621 |
N/A |
INTRINSIC |
|
low complexity region
|
747 |
761 |
N/A |
INTRINSIC |
|
low complexity region
|
781 |
793 |
N/A |
INTRINSIC |
|
low complexity region
|
835 |
847 |
N/A |
INTRINSIC |
|
low complexity region
|
1167 |
1181 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000095536
AA Change: I49N
PolyPhen 2
Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000093192
Gene: ENSMUSG00000012609
AA Change: I49N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TTL
|
110 |
407 |
2.2e-95 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110220
AA Change: I49N
PolyPhen 2
Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000105849
Gene: ENSMUSG00000012609
AA Change: I49N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TTL
|
110 |
348 |
3.5e-72 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000110224
AA Change: I49N
PolyPhen 2
Score 0.478 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000105853
Gene: ENSMUSG00000012609
AA Change: I49N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TTL
|
110 |
407 |
1e-94 |
PFAM |
|
low complexity region
|
543 |
562 |
N/A |
INTRINSIC |
|
low complexity region
|
582 |
608 |
N/A |
INTRINSIC |
|
low complexity region
|
734 |
748 |
N/A |
INTRINSIC |
|
low complexity region
|
768 |
780 |
N/A |
INTRINSIC |
|
low complexity region
|
822 |
834 |
N/A |
INTRINSIC |
|
low complexity region
|
1153 |
1167 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000124701
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000142411
AA Change: I49N
PolyPhen 2
Score 0.478 (Sensitivity: 0.89; Specificity: 0.90)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177114
AA Change: I49N
PolyPhen 2
Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000135395
Gene: ENSMUSG00000012609
AA Change: I49N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TTL
|
110 |
407 |
2.1e-95 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000153570
AA Change: I49N
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177188
AA Change: I49N
PolyPhen 2
Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000134928
Gene: ENSMUSG00000012609
AA Change: I49N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TTL
|
110 |
175 |
4.9e-14 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176695
AA Change: I49N
PolyPhen 2
Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000135852
Gene: ENSMUSG00000012609
AA Change: I49N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TTL
|
110 |
407 |
2.1e-95 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000155448
AA Change: I49N
PolyPhen 2
Score 0.478 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000134971
Gene: ENSMUSG00000012609
AA Change: I49N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TTL
|
110 |
407 |
6.4e-95 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176008
|
| Meta Mutation Damage Score |
0.6949 |
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 98.0%
- 10x: 95.5%
- 20x: 90.1%
|
| Validation Efficiency |
97% (99/102) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tubulin tyrosine ligase like protein family. This protein interacts with two glucocorticoid receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1. This protein may function as a coregulator of glucocorticoid receptor mediated gene induction and repression. This protein may also function as an alpha tubulin polyglutamylase.[provided by RefSeq, Feb 2010]
PHENOTYPE: Mice homozygous for a hypomorphic allele exhibit male infertility associated with abnormal sperm morphology and reduced tubulin polyglutamylation in the spermatozoa. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(7) : Targeted, other(3) Gene trapped(4) |
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb9 |
T |
C |
5: 124,218,119 (GRCm39) |
M406V |
probably benign |
Het |
| Adar |
T |
C |
3: 89,638,121 (GRCm39) |
S2P |
probably benign |
Het |
| Adgre1 |
T |
A |
17: 57,750,939 (GRCm39) |
S538T |
possibly damaging |
Het |
| Alms1 |
T |
A |
6: 85,618,363 (GRCm39) |
I2803N |
possibly damaging |
Het |
| Amn1 |
G |
T |
6: 149,090,091 (GRCm39) |
|
probably benign |
Het |
| Arid1b |
G |
A |
17: 5,393,207 (GRCm39) |
A2246T |
probably damaging |
Het |
| BC024139 |
T |
C |
15: 76,005,947 (GRCm39) |
E418G |
probably damaging |
Het |
| Bok |
A |
G |
1: 93,614,239 (GRCm39) |
D24G |
probably damaging |
Het |
| Cabp2 |
T |
C |
19: 4,134,913 (GRCm39) |
|
probably benign |
Het |
| Ccdc141 |
C |
A |
2: 76,995,582 (GRCm39) |
|
probably benign |
Het |
| Ccdc178 |
T |
C |
18: 22,283,492 (GRCm39) |
T13A |
probably benign |
Het |
| Ccdc42 |
G |
T |
11: 68,478,476 (GRCm39) |
V33F |
possibly damaging |
Het |
| Clcn7 |
G |
A |
17: 25,368,176 (GRCm39) |
|
probably benign |
Het |
| Cluh |
A |
G |
11: 74,548,176 (GRCm39) |
|
probably benign |
Het |
| Cr1l |
A |
T |
1: 194,797,164 (GRCm39) |
|
probably benign |
Het |
| Cracdl |
A |
G |
1: 37,663,720 (GRCm39) |
V726A |
probably benign |
Het |
| Csnk1g3 |
T |
A |
18: 54,051,861 (GRCm39) |
|
probably benign |
Het |
| Depdc5 |
T |
C |
5: 33,091,281 (GRCm39) |
|
probably benign |
Het |
| Dgkh |
A |
C |
14: 78,807,569 (GRCm39) |
Y1149* |
probably null |
Het |
| Dipk2a |
G |
T |
9: 94,406,533 (GRCm39) |
D291E |
probably benign |
Het |
| Dnai1 |
A |
G |
4: 41,635,162 (GRCm39) |
|
probably benign |
Het |
| Dync2i1 |
A |
G |
12: 116,196,256 (GRCm39) |
V497A |
probably benign |
Het |
| Efcab2 |
A |
G |
1: 178,302,451 (GRCm39) |
E65G |
possibly damaging |
Het |
| Eif4a3l1 |
A |
T |
6: 136,305,842 (GRCm39) |
D101V |
probably damaging |
Het |
| Eno1b |
T |
C |
18: 48,180,806 (GRCm39) |
I328T |
probably benign |
Het |
| Fgfr4 |
A |
G |
13: 55,309,198 (GRCm39) |
|
probably benign |
Het |
| Garin5b |
A |
T |
7: 4,773,286 (GRCm39) |
L177Q |
probably damaging |
Het |
| Gm10720 |
A |
C |
9: 3,015,787 (GRCm39) |
S44R |
probably null |
Het |
| Gm17535 |
T |
A |
9: 3,035,786 (GRCm39) |
L218H |
probably benign |
Het |
| Gm6471 |
A |
T |
7: 142,385,368 (GRCm39) |
|
noncoding transcript |
Het |
| Hnrnpm |
C |
T |
17: 33,865,489 (GRCm39) |
R724Q |
probably damaging |
Het |
| Homer1 |
C |
T |
13: 93,528,254 (GRCm39) |
T117I |
possibly damaging |
Het |
| Hoxd4 |
A |
T |
2: 74,557,801 (GRCm39) |
Q60L |
probably damaging |
Het |
| Ift172 |
T |
C |
5: 31,417,968 (GRCm39) |
R1274G |
probably benign |
Het |
| Ino80d |
A |
G |
1: 63,097,477 (GRCm39) |
S806P |
probably damaging |
Het |
| Itga10 |
T |
C |
3: 96,561,016 (GRCm39) |
V627A |
probably benign |
Het |
| Itgb2l |
A |
G |
16: 96,238,569 (GRCm39) |
Y77H |
possibly damaging |
Het |
| Kel |
A |
T |
6: 41,678,877 (GRCm39) |
H195Q |
probably benign |
Het |
| Klhdc7a |
A |
G |
4: 139,694,582 (GRCm39) |
S122P |
possibly damaging |
Het |
| Krt71 |
T |
A |
15: 101,643,141 (GRCm39) |
I456F |
possibly damaging |
Het |
| Lats1 |
T |
A |
10: 7,567,339 (GRCm39) |
S37T |
probably damaging |
Het |
| Lrp1b |
T |
A |
2: 41,013,031 (GRCm39) |
H1858L |
possibly damaging |
Het |
| Matk |
A |
T |
10: 81,098,676 (GRCm39) |
T461S |
probably benign |
Het |
| Meikin |
A |
G |
11: 54,300,468 (GRCm39) |
|
probably benign |
Het |
| Muc6 |
T |
C |
7: 141,214,029 (GRCm39) |
Q2832R |
possibly damaging |
Het |
| Myo10 |
T |
C |
15: 25,781,324 (GRCm39) |
F194L |
possibly damaging |
Het |
| Nbas |
G |
A |
12: 13,323,877 (GRCm39) |
|
probably benign |
Het |
| Nme4 |
A |
G |
17: 26,312,831 (GRCm39) |
|
probably null |
Het |
| Or13p8 |
A |
T |
4: 118,583,530 (GRCm39) |
I29F |
possibly damaging |
Het |
| Or4c112 |
T |
A |
2: 88,853,540 (GRCm39) |
N269I |
probably benign |
Het |
| Or5w13 |
A |
G |
2: 87,523,948 (GRCm39) |
S93P |
probably benign |
Het |
| Or7g32 |
T |
A |
9: 19,408,233 (GRCm39) |
L63H |
probably damaging |
Het |
| Or8g34 |
T |
C |
9: 39,372,967 (GRCm39) |
V80A |
probably damaging |
Het |
| Pacsin2 |
T |
C |
15: 83,261,862 (GRCm39) |
Q473R |
probably benign |
Het |
| Patz1 |
A |
G |
11: 3,243,288 (GRCm39) |
H427R |
probably damaging |
Het |
| Pkp3 |
A |
G |
7: 140,663,256 (GRCm39) |
Y367C |
probably damaging |
Het |
| Prdm2 |
G |
A |
4: 142,860,338 (GRCm39) |
P984L |
possibly damaging |
Het |
| Rev3l |
T |
A |
10: 39,750,124 (GRCm39) |
C3091* |
probably null |
Het |
| Rims4 |
C |
T |
2: 163,705,849 (GRCm39) |
V262M |
possibly damaging |
Het |
| Rpl5 |
T |
C |
5: 108,052,623 (GRCm39) |
F140L |
probably benign |
Het |
| Sec24a |
A |
C |
11: 51,591,653 (GRCm39) |
I1014M |
probably benign |
Het |
| Serpinb11 |
A |
G |
1: 107,299,933 (GRCm39) |
H93R |
probably benign |
Het |
| Shank2 |
C |
A |
7: 143,623,872 (GRCm39) |
H286N |
probably benign |
Het |
| Sipa1l2 |
G |
T |
8: 126,148,637 (GRCm39) |
Q1651K |
probably damaging |
Het |
| Slc17a3 |
C |
T |
13: 24,039,841 (GRCm39) |
S293F |
probably damaging |
Het |
| Slc30a5 |
A |
T |
13: 100,963,002 (GRCm39) |
F75L |
possibly damaging |
Het |
| Slco1a1 |
G |
T |
6: 141,856,427 (GRCm39) |
|
probably benign |
Het |
| Smg5 |
C |
T |
3: 88,261,179 (GRCm39) |
|
probably benign |
Het |
| Snapc1 |
C |
T |
12: 74,021,806 (GRCm39) |
R81C |
probably damaging |
Het |
| Taf8 |
A |
T |
17: 47,809,177 (GRCm39) |
|
probably benign |
Het |
| Tars3 |
A |
G |
7: 65,333,829 (GRCm39) |
D617G |
probably damaging |
Het |
| Tbc1d5 |
A |
T |
17: 51,291,715 (GRCm39) |
|
probably benign |
Het |
| Tfcp2 |
C |
G |
15: 100,412,708 (GRCm39) |
E315Q |
probably damaging |
Het |
| Tmf1 |
A |
T |
6: 97,147,345 (GRCm39) |
S540R |
probably damaging |
Het |
| Tmprss4 |
T |
C |
9: 45,095,634 (GRCm39) |
Q70R |
probably benign |
Het |
| Trip13 |
G |
T |
13: 74,068,183 (GRCm39) |
A266E |
possibly damaging |
Het |
| Ttc24 |
T |
A |
3: 87,982,234 (GRCm39) |
|
probably benign |
Het |
| Tut7 |
G |
A |
13: 59,930,150 (GRCm39) |
R962* |
probably null |
Het |
| Ube2ql1 |
A |
T |
13: 69,886,711 (GRCm39) |
M250K |
possibly damaging |
Het |
| Vmn1r87 |
A |
T |
7: 12,866,211 (GRCm39) |
D25E |
probably damaging |
Het |
| Vmn2r84 |
A |
G |
10: 130,227,877 (GRCm39) |
Y120H |
probably benign |
Het |
| Wdr6 |
G |
A |
9: 108,452,441 (GRCm39) |
R481C |
probably damaging |
Het |
| Zdhhc17 |
A |
T |
10: 110,790,955 (GRCm39) |
Y371* |
probably null |
Het |
| Zfp292 |
T |
C |
4: 34,811,185 (GRCm39) |
N620D |
probably benign |
Het |
| Zfp932 |
T |
A |
5: 110,154,834 (GRCm39) |
Y11N |
probably benign |
Het |
|
| Other mutations in Ttll5 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00844:Ttll5
|
APN |
12 |
85,890,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00932:Ttll5
|
APN |
12 |
85,976,681 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00964:Ttll5
|
APN |
12 |
85,896,057 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL00978:Ttll5
|
APN |
12 |
85,980,256 (GRCm39) |
nonsense |
probably null |
|
|
IGL00990:Ttll5
|
APN |
12 |
85,923,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01726:Ttll5
|
APN |
12 |
85,965,708 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL01797:Ttll5
|
APN |
12 |
86,003,371 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL02008:Ttll5
|
APN |
12 |
85,980,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02210:Ttll5
|
APN |
12 |
85,959,319 (GRCm39) |
intron |
probably benign |
|
|
IGL02979:Ttll5
|
APN |
12 |
85,873,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03079:Ttll5
|
APN |
12 |
85,923,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03149:Ttll5
|
APN |
12 |
85,965,758 (GRCm39) |
missense |
probably damaging |
0.98 |
|
G4846:Ttll5
|
UTSW |
12 |
86,071,018 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4812001:Ttll5
|
UTSW |
12 |
85,973,635 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0045:Ttll5
|
UTSW |
12 |
85,926,133 (GRCm39) |
splice site |
probably benign |
|
|
R0282:Ttll5
|
UTSW |
12 |
86,042,827 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0318:Ttll5
|
UTSW |
12 |
85,923,368 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0465:Ttll5
|
UTSW |
12 |
85,980,100 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0540:Ttll5
|
UTSW |
12 |
85,980,450 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1086:Ttll5
|
UTSW |
12 |
85,937,853 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R1467:Ttll5
|
UTSW |
12 |
85,965,736 (GRCm39) |
splice site |
probably null |
|
|
R1470:Ttll5
|
UTSW |
12 |
85,926,168 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R1470:Ttll5
|
UTSW |
12 |
85,926,168 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R1505:Ttll5
|
UTSW |
12 |
85,926,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1524:Ttll5
|
UTSW |
12 |
85,911,342 (GRCm39) |
nonsense |
probably null |
|
|
R1540:Ttll5
|
UTSW |
12 |
85,938,982 (GRCm39) |
nonsense |
probably null |
|
|
R1598:Ttll5
|
UTSW |
12 |
85,910,372 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1649:Ttll5
|
UTSW |
12 |
85,969,788 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Ttll5
|
UTSW |
12 |
85,980,176 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2340:Ttll5
|
UTSW |
12 |
85,938,922 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4049:Ttll5
|
UTSW |
12 |
86,059,573 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4094:Ttll5
|
UTSW |
12 |
86,003,376 (GRCm39) |
nonsense |
probably null |
|
|
R4095:Ttll5
|
UTSW |
12 |
86,003,376 (GRCm39) |
nonsense |
probably null |
|
|
R4908:Ttll5
|
UTSW |
12 |
85,965,948 (GRCm39) |
missense |
probably benign |
0.31 |
|
R5012:Ttll5
|
UTSW |
12 |
85,973,618 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5137:Ttll5
|
UTSW |
12 |
85,969,819 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5416:Ttll5
|
UTSW |
12 |
86,059,602 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R5773:Ttll5
|
UTSW |
12 |
85,980,329 (GRCm39) |
frame shift |
probably null |
|
|
R5774:Ttll5
|
UTSW |
12 |
85,980,329 (GRCm39) |
frame shift |
probably null |
|
|
R6039:Ttll5
|
UTSW |
12 |
85,878,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6039:Ttll5
|
UTSW |
12 |
85,878,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6173:Ttll5
|
UTSW |
12 |
85,980,151 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6343:Ttll5
|
UTSW |
12 |
86,003,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6449:Ttll5
|
UTSW |
12 |
86,071,050 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6750:Ttll5
|
UTSW |
12 |
86,003,384 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6802:Ttll5
|
UTSW |
12 |
85,926,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6825:Ttll5
|
UTSW |
12 |
85,930,102 (GRCm39) |
splice site |
probably null |
|
|
R6955:Ttll5
|
UTSW |
12 |
85,911,353 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7098:Ttll5
|
UTSW |
12 |
85,964,447 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7154:Ttll5
|
UTSW |
12 |
85,972,538 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7215:Ttll5
|
UTSW |
12 |
85,980,170 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7339:Ttll5
|
UTSW |
12 |
85,904,238 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7520:Ttll5
|
UTSW |
12 |
85,946,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7728:Ttll5
|
UTSW |
12 |
86,003,406 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7894:Ttll5
|
UTSW |
12 |
85,935,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8119:Ttll5
|
UTSW |
12 |
86,067,322 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8129:Ttll5
|
UTSW |
12 |
85,937,858 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8200:Ttll5
|
UTSW |
12 |
85,926,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8357:Ttll5
|
UTSW |
12 |
85,923,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8413:Ttll5
|
UTSW |
12 |
85,965,895 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8457:Ttll5
|
UTSW |
12 |
85,923,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9086:Ttll5
|
UTSW |
12 |
86,071,107 (GRCm39) |
missense |
probably benign |
|
|
R9086:Ttll5
|
UTSW |
12 |
85,964,516 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9265:Ttll5
|
UTSW |
12 |
85,937,795 (GRCm39) |
nonsense |
probably null |
|
|
R9293:Ttll5
|
UTSW |
12 |
85,937,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9302:Ttll5
|
UTSW |
12 |
85,873,338 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R9621:Ttll5
|
UTSW |
12 |
85,938,896 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCAAGTATGAGGTAGGGACAAGCCATAG -3'
(R):5'- GGACTctctcagaactcaatgaccacaa -3'
Sequencing Primer
(F):5'- AAGCCATAGTCATCTGCTTCAG -3'
(R):5'- tggcagtatagagaggaggg -3'
|
| Posted On |
2013-04-16 |
Incidental Mutation