Incidental Mutation 'R0153:Myo10'
| ID |
22866 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myo10
|
| Ensembl Gene |
ENSMUSG00000022272 |
| Gene Name |
myosin X |
| Synonyms |
myosin-X, D15Ertd600e |
| MMRRC Submission |
038436-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0153 (G1)
|
| Quality Score |
217 |
|
Status
|
Validated
(trace)
|
| Chromosome |
15 |
| Chromosomal Location |
25622636-25813759 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 25781324 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 194
(F194L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000022882
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022882]
[ENSMUST00000110457]
[ENSMUST00000124966]
[ENSMUST00000125667]
[ENSMUST00000135173]
[ENSMUST00000137601]
[ENSMUST00000151360]
|
| AlphaFold |
F8VQB6 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000022882
AA Change: F194L
PolyPhen 2
Score 0.840 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000022882
Gene: ENSMUSG00000022272
AA Change: F194L
| Domain | Start | End | E-Value | Type |
|---|
|
IQ
|
1 |
17 |
7.83e1 |
SMART |
|
IQ
|
18 |
40 |
1.06e0 |
SMART |
|
IQ
|
41 |
63 |
7.07e-2 |
SMART |
|
PDB:2LW9|B
|
136 |
171 |
7e-13 |
PDB |
|
low complexity region
|
172 |
186 |
N/A |
INTRINSIC |
|
low complexity region
|
213 |
235 |
N/A |
INTRINSIC |
|
low complexity region
|
344 |
356 |
N/A |
INTRINSIC |
|
low complexity region
|
401 |
419 |
N/A |
INTRINSIC |
|
PH
|
471 |
570 |
1.39e-21 |
SMART |
|
SCOP:d1faoa_
|
588 |
639 |
3e-6 |
SMART |
|
PH
|
651 |
757 |
6.76e-11 |
SMART |
|
MyTH4
|
805 |
953 |
4.12e-37 |
SMART |
|
B41
|
954 |
1216 |
1.72e-44 |
SMART |
|
Blast:B41
|
1218 |
1303 |
3e-45 |
BLAST |
|
low complexity region
|
1304 |
1316 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000110457
AA Change: F940L
PolyPhen 2
Score 0.609 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000106087
Gene: ENSMUSG00000022272
AA Change: F940L
| Domain | Start | End | E-Value | Type |
|---|
|
MYSc
|
57 |
740 |
N/A |
SMART |
|
IQ
|
741 |
763 |
1.27e-3 |
SMART |
|
IQ
|
764 |
786 |
1.06e0 |
SMART |
|
IQ
|
787 |
809 |
7.07e-2 |
SMART |
|
Pfam:MYO10_CC
|
881 |
932 |
4.2e-22 |
PFAM |
|
low complexity region
|
959 |
981 |
N/A |
INTRINSIC |
|
low complexity region
|
1090 |
1102 |
N/A |
INTRINSIC |
|
low complexity region
|
1147 |
1165 |
N/A |
INTRINSIC |
|
PH
|
1217 |
1316 |
1.39e-21 |
SMART |
|
PH
|
1397 |
1503 |
6.76e-11 |
SMART |
|
MyTH4
|
1551 |
1699 |
4.12e-37 |
SMART |
|
B41
|
1700 |
1962 |
1.72e-44 |
SMART |
|
low complexity region
|
2050 |
2062 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000124966
|
| SMART Domains |
Protein: ENSMUSP00000120817
Gene: ENSMUSG00000022272
| Domain | Start | End | E-Value | Type |
|---|
|
IQ
|
1 |
17 |
7.83e1 |
SMART |
|
IQ
|
18 |
40 |
1.06e0 |
SMART |
|
IQ
|
41 |
63 |
7.07e-2 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000125667
|
| SMART Domains |
Protein: ENSMUSP00000120566
Gene: ENSMUSG00000022272
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_head
|
1 |
85 |
5.8e-22 |
PFAM |
|
IQ
|
99 |
121 |
1.27e-3 |
SMART |
|
IQ
|
122 |
144 |
1.06e0 |
SMART |
|
IQ
|
145 |
167 |
7.07e-2 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000135173
|
| SMART Domains |
Protein: ENSMUSP00000118744
Gene: ENSMUSG00000022272
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_head
|
1 |
84 |
1.4e-21 |
PFAM |
|
IQ
|
98 |
120 |
1.27e-3 |
SMART |
|
IQ
|
121 |
143 |
1.06e0 |
SMART |
|
IQ
|
144 |
166 |
7.07e-2 |
SMART |
|
low complexity region
|
168 |
179 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000135981
|
| SMART Domains |
Protein: ENSMUSP00000123057
Gene: ENSMUSG00000022272
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:2DFS|M
|
2 |
38 |
6e-7 |
PDB |
|
Blast:MYSc
|
2 |
42 |
3e-19 |
BLAST |
|
IQ
|
59 |
81 |
1.27e-3 |
SMART |
|
IQ
|
82 |
104 |
1.06e0 |
SMART |
|
IQ
|
105 |
127 |
7.07e-2 |
SMART |
|
Pfam:MYO10_CC
|
199 |
242 |
1.7e-20 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000137601
|
| SMART Domains |
Protein: ENSMUSP00000118280
Gene: ENSMUSG00000022272
| Domain | Start | End | E-Value | Type |
|---|
|
MYSc
|
24 |
707 |
N/A |
SMART |
|
IQ
|
708 |
730 |
1.27e-3 |
SMART |
|
IQ
|
731 |
753 |
1.06e0 |
SMART |
|
IQ
|
754 |
776 |
7.07e-2 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000145587
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000151360
|
| SMART Domains |
Protein: ENSMUSP00000119367
Gene: ENSMUSG00000022272
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_head
|
1 |
51 |
7.1e-16 |
PFAM |
|
| Meta Mutation Damage Score |
0.0625 |
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 98.0%
- 10x: 95.5%
- 20x: 90.1%
|
| Validation Efficiency |
97% (99/102) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]
PHENOTYPE: Homozygous null mutations are semi-lethal with over half of homozygous embryos exhibiting exencephaly. Surviving mutants show decreased body weight, white spotting, syndactyly, persistence of hyaloid vascular system and other eye defects. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb9 |
T |
C |
5: 124,218,119 (GRCm39) |
M406V |
probably benign |
Het |
| Adar |
T |
C |
3: 89,638,121 (GRCm39) |
S2P |
probably benign |
Het |
| Adgre1 |
T |
A |
17: 57,750,939 (GRCm39) |
S538T |
possibly damaging |
Het |
| Alms1 |
T |
A |
6: 85,618,363 (GRCm39) |
I2803N |
possibly damaging |
Het |
| Amn1 |
G |
T |
6: 149,090,091 (GRCm39) |
|
probably benign |
Het |
| Arid1b |
G |
A |
17: 5,393,207 (GRCm39) |
A2246T |
probably damaging |
Het |
| BC024139 |
T |
C |
15: 76,005,947 (GRCm39) |
E418G |
probably damaging |
Het |
| Bok |
A |
G |
1: 93,614,239 (GRCm39) |
D24G |
probably damaging |
Het |
| Cabp2 |
T |
C |
19: 4,134,913 (GRCm39) |
|
probably benign |
Het |
| Ccdc141 |
C |
A |
2: 76,995,582 (GRCm39) |
|
probably benign |
Het |
| Ccdc178 |
T |
C |
18: 22,283,492 (GRCm39) |
T13A |
probably benign |
Het |
| Ccdc42 |
G |
T |
11: 68,478,476 (GRCm39) |
V33F |
possibly damaging |
Het |
| Clcn7 |
G |
A |
17: 25,368,176 (GRCm39) |
|
probably benign |
Het |
| Cluh |
A |
G |
11: 74,548,176 (GRCm39) |
|
probably benign |
Het |
| Cr1l |
A |
T |
1: 194,797,164 (GRCm39) |
|
probably benign |
Het |
| Cracdl |
A |
G |
1: 37,663,720 (GRCm39) |
V726A |
probably benign |
Het |
| Csnk1g3 |
T |
A |
18: 54,051,861 (GRCm39) |
|
probably benign |
Het |
| Depdc5 |
T |
C |
5: 33,091,281 (GRCm39) |
|
probably benign |
Het |
| Dgkh |
A |
C |
14: 78,807,569 (GRCm39) |
Y1149* |
probably null |
Het |
| Dipk2a |
G |
T |
9: 94,406,533 (GRCm39) |
D291E |
probably benign |
Het |
| Dnai1 |
A |
G |
4: 41,635,162 (GRCm39) |
|
probably benign |
Het |
| Dync2i1 |
A |
G |
12: 116,196,256 (GRCm39) |
V497A |
probably benign |
Het |
| Efcab2 |
A |
G |
1: 178,302,451 (GRCm39) |
E65G |
possibly damaging |
Het |
| Eif4a3l1 |
A |
T |
6: 136,305,842 (GRCm39) |
D101V |
probably damaging |
Het |
| Eno1b |
T |
C |
18: 48,180,806 (GRCm39) |
I328T |
probably benign |
Het |
| Fgfr4 |
A |
G |
13: 55,309,198 (GRCm39) |
|
probably benign |
Het |
| Garin5b |
A |
T |
7: 4,773,286 (GRCm39) |
L177Q |
probably damaging |
Het |
| Gm10720 |
A |
C |
9: 3,015,787 (GRCm39) |
S44R |
probably null |
Het |
| Gm17535 |
T |
A |
9: 3,035,786 (GRCm39) |
L218H |
probably benign |
Het |
| Gm6471 |
A |
T |
7: 142,385,368 (GRCm39) |
|
noncoding transcript |
Het |
| Hnrnpm |
C |
T |
17: 33,865,489 (GRCm39) |
R724Q |
probably damaging |
Het |
| Homer1 |
C |
T |
13: 93,528,254 (GRCm39) |
T117I |
possibly damaging |
Het |
| Hoxd4 |
A |
T |
2: 74,557,801 (GRCm39) |
Q60L |
probably damaging |
Het |
| Ift172 |
T |
C |
5: 31,417,968 (GRCm39) |
R1274G |
probably benign |
Het |
| Ino80d |
A |
G |
1: 63,097,477 (GRCm39) |
S806P |
probably damaging |
Het |
| Itga10 |
T |
C |
3: 96,561,016 (GRCm39) |
V627A |
probably benign |
Het |
| Itgb2l |
A |
G |
16: 96,238,569 (GRCm39) |
Y77H |
possibly damaging |
Het |
| Kel |
A |
T |
6: 41,678,877 (GRCm39) |
H195Q |
probably benign |
Het |
| Klhdc7a |
A |
G |
4: 139,694,582 (GRCm39) |
S122P |
possibly damaging |
Het |
| Krt71 |
T |
A |
15: 101,643,141 (GRCm39) |
I456F |
possibly damaging |
Het |
| Lats1 |
T |
A |
10: 7,567,339 (GRCm39) |
S37T |
probably damaging |
Het |
| Lrp1b |
T |
A |
2: 41,013,031 (GRCm39) |
H1858L |
possibly damaging |
Het |
| Matk |
A |
T |
10: 81,098,676 (GRCm39) |
T461S |
probably benign |
Het |
| Meikin |
A |
G |
11: 54,300,468 (GRCm39) |
|
probably benign |
Het |
| Muc6 |
T |
C |
7: 141,214,029 (GRCm39) |
Q2832R |
possibly damaging |
Het |
| Nbas |
G |
A |
12: 13,323,877 (GRCm39) |
|
probably benign |
Het |
| Nme4 |
A |
G |
17: 26,312,831 (GRCm39) |
|
probably null |
Het |
| Or13p8 |
A |
T |
4: 118,583,530 (GRCm39) |
I29F |
possibly damaging |
Het |
| Or4c112 |
T |
A |
2: 88,853,540 (GRCm39) |
N269I |
probably benign |
Het |
| Or5w13 |
A |
G |
2: 87,523,948 (GRCm39) |
S93P |
probably benign |
Het |
| Or7g32 |
T |
A |
9: 19,408,233 (GRCm39) |
L63H |
probably damaging |
Het |
| Or8g34 |
T |
C |
9: 39,372,967 (GRCm39) |
V80A |
probably damaging |
Het |
| Pacsin2 |
T |
C |
15: 83,261,862 (GRCm39) |
Q473R |
probably benign |
Het |
| Patz1 |
A |
G |
11: 3,243,288 (GRCm39) |
H427R |
probably damaging |
Het |
| Pkp3 |
A |
G |
7: 140,663,256 (GRCm39) |
Y367C |
probably damaging |
Het |
| Prdm2 |
G |
A |
4: 142,860,338 (GRCm39) |
P984L |
possibly damaging |
Het |
| Rev3l |
T |
A |
10: 39,750,124 (GRCm39) |
C3091* |
probably null |
Het |
| Rims4 |
C |
T |
2: 163,705,849 (GRCm39) |
V262M |
possibly damaging |
Het |
| Rpl5 |
T |
C |
5: 108,052,623 (GRCm39) |
F140L |
probably benign |
Het |
| Sec24a |
A |
C |
11: 51,591,653 (GRCm39) |
I1014M |
probably benign |
Het |
| Serpinb11 |
A |
G |
1: 107,299,933 (GRCm39) |
H93R |
probably benign |
Het |
| Shank2 |
C |
A |
7: 143,623,872 (GRCm39) |
H286N |
probably benign |
Het |
| Sipa1l2 |
G |
T |
8: 126,148,637 (GRCm39) |
Q1651K |
probably damaging |
Het |
| Slc17a3 |
C |
T |
13: 24,039,841 (GRCm39) |
S293F |
probably damaging |
Het |
| Slc30a5 |
A |
T |
13: 100,963,002 (GRCm39) |
F75L |
possibly damaging |
Het |
| Slco1a1 |
G |
T |
6: 141,856,427 (GRCm39) |
|
probably benign |
Het |
| Smg5 |
C |
T |
3: 88,261,179 (GRCm39) |
|
probably benign |
Het |
| Snapc1 |
C |
T |
12: 74,021,806 (GRCm39) |
R81C |
probably damaging |
Het |
| Taf8 |
A |
T |
17: 47,809,177 (GRCm39) |
|
probably benign |
Het |
| Tars3 |
A |
G |
7: 65,333,829 (GRCm39) |
D617G |
probably damaging |
Het |
| Tbc1d5 |
A |
T |
17: 51,291,715 (GRCm39) |
|
probably benign |
Het |
| Tfcp2 |
C |
G |
15: 100,412,708 (GRCm39) |
E315Q |
probably damaging |
Het |
| Tmf1 |
A |
T |
6: 97,147,345 (GRCm39) |
S540R |
probably damaging |
Het |
| Tmprss4 |
T |
C |
9: 45,095,634 (GRCm39) |
Q70R |
probably benign |
Het |
| Trip13 |
G |
T |
13: 74,068,183 (GRCm39) |
A266E |
possibly damaging |
Het |
| Ttc24 |
T |
A |
3: 87,982,234 (GRCm39) |
|
probably benign |
Het |
| Ttll5 |
T |
A |
12: 85,878,740 (GRCm39) |
I49N |
probably damaging |
Het |
| Tut7 |
G |
A |
13: 59,930,150 (GRCm39) |
R962* |
probably null |
Het |
| Ube2ql1 |
A |
T |
13: 69,886,711 (GRCm39) |
M250K |
possibly damaging |
Het |
| Vmn1r87 |
A |
T |
7: 12,866,211 (GRCm39) |
D25E |
probably damaging |
Het |
| Vmn2r84 |
A |
G |
10: 130,227,877 (GRCm39) |
Y120H |
probably benign |
Het |
| Wdr6 |
G |
A |
9: 108,452,441 (GRCm39) |
R481C |
probably damaging |
Het |
| Zdhhc17 |
A |
T |
10: 110,790,955 (GRCm39) |
Y371* |
probably null |
Het |
| Zfp292 |
T |
C |
4: 34,811,185 (GRCm39) |
N620D |
probably benign |
Het |
| Zfp932 |
T |
A |
5: 110,154,834 (GRCm39) |
Y11N |
probably benign |
Het |
|
| Other mutations in Myo10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00557:Myo10
|
APN |
15 |
25,776,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01068:Myo10
|
APN |
15 |
25,739,395 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01352:Myo10
|
APN |
15 |
25,701,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01388:Myo10
|
APN |
15 |
25,736,703 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL01460:Myo10
|
APN |
15 |
25,714,194 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01553:Myo10
|
APN |
15 |
25,776,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01732:Myo10
|
APN |
15 |
25,732,149 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL01992:Myo10
|
APN |
15 |
25,799,634 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02000:Myo10
|
APN |
15 |
25,808,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02045:Myo10
|
APN |
15 |
25,726,574 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02307:Myo10
|
APN |
15 |
25,776,401 (GRCm39) |
splice site |
probably benign |
|
|
IGL02511:Myo10
|
APN |
15 |
25,723,975 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03240:Myo10
|
APN |
15 |
25,701,688 (GRCm39) |
missense |
probably damaging |
1.00 |
|
least
|
UTSW |
15 |
25,726,561 (GRCm39) |
nonsense |
probably null |
|
|
R0037:Myo10
|
UTSW |
15 |
25,666,618 (GRCm39) |
intron |
probably benign |
|
|
R0282:Myo10
|
UTSW |
15 |
25,793,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0360:Myo10
|
UTSW |
15 |
25,804,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0585:Myo10
|
UTSW |
15 |
25,736,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0617:Myo10
|
UTSW |
15 |
25,738,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0729:Myo10
|
UTSW |
15 |
25,722,243 (GRCm39) |
splice site |
probably benign |
|
|
R0771:Myo10
|
UTSW |
15 |
25,778,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0960:Myo10
|
UTSW |
15 |
25,801,275 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1562:Myo10
|
UTSW |
15 |
25,780,497 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1651:Myo10
|
UTSW |
15 |
25,742,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1789:Myo10
|
UTSW |
15 |
25,726,611 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1816:Myo10
|
UTSW |
15 |
25,800,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1835:Myo10
|
UTSW |
15 |
25,805,673 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1908:Myo10
|
UTSW |
15 |
25,801,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2082:Myo10
|
UTSW |
15 |
25,786,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2101:Myo10
|
UTSW |
15 |
25,722,345 (GRCm39) |
missense |
probably benign |
0.26 |
|
R2129:Myo10
|
UTSW |
15 |
25,781,885 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2141:Myo10
|
UTSW |
15 |
25,714,194 (GRCm39) |
missense |
probably benign |
|
|
R2142:Myo10
|
UTSW |
15 |
25,714,194 (GRCm39) |
missense |
probably benign |
|
|
R2920:Myo10
|
UTSW |
15 |
25,801,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2938:Myo10
|
UTSW |
15 |
25,795,803 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3723:Myo10
|
UTSW |
15 |
25,803,374 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3852:Myo10
|
UTSW |
15 |
25,779,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4162:Myo10
|
UTSW |
15 |
25,726,501 (GRCm39) |
splice site |
probably null |
|
|
R4163:Myo10
|
UTSW |
15 |
25,726,501 (GRCm39) |
splice site |
probably null |
|
|
R4164:Myo10
|
UTSW |
15 |
25,726,501 (GRCm39) |
splice site |
probably null |
|
|
R4177:Myo10
|
UTSW |
15 |
25,734,137 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4409:Myo10
|
UTSW |
15 |
25,807,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4667:Myo10
|
UTSW |
15 |
25,793,239 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4905:Myo10
|
UTSW |
15 |
25,800,298 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4933:Myo10
|
UTSW |
15 |
25,781,204 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4968:Myo10
|
UTSW |
15 |
25,808,270 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5081:Myo10
|
UTSW |
15 |
25,786,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5123:Myo10
|
UTSW |
15 |
25,726,569 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5310:Myo10
|
UTSW |
15 |
25,778,164 (GRCm39) |
splice site |
probably null |
|
|
R6073:Myo10
|
UTSW |
15 |
25,736,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6117:Myo10
|
UTSW |
15 |
25,805,745 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6185:Myo10
|
UTSW |
15 |
25,726,596 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6749:Myo10
|
UTSW |
15 |
25,714,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6819:Myo10
|
UTSW |
15 |
25,781,496 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6875:Myo10
|
UTSW |
15 |
25,805,745 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6908:Myo10
|
UTSW |
15 |
25,804,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6963:Myo10
|
UTSW |
15 |
25,734,149 (GRCm39) |
missense |
probably benign |
0.31 |
|
R7144:Myo10
|
UTSW |
15 |
25,724,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7266:Myo10
|
UTSW |
15 |
25,783,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7380:Myo10
|
UTSW |
15 |
25,779,706 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7460:Myo10
|
UTSW |
15 |
25,807,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7614:Myo10
|
UTSW |
15 |
25,701,709 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7618:Myo10
|
UTSW |
15 |
25,726,561 (GRCm39) |
nonsense |
probably null |
|
|
R7717:Myo10
|
UTSW |
15 |
25,732,056 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7811:Myo10
|
UTSW |
15 |
25,804,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7830:Myo10
|
UTSW |
15 |
25,738,057 (GRCm39) |
nonsense |
probably null |
|
|
R7862:Myo10
|
UTSW |
15 |
25,666,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8232:Myo10
|
UTSW |
15 |
25,804,400 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8264:Myo10
|
UTSW |
15 |
25,800,195 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8377:Myo10
|
UTSW |
15 |
25,804,481 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8385:Myo10
|
UTSW |
15 |
25,804,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8426:Myo10
|
UTSW |
15 |
25,799,576 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8439:Myo10
|
UTSW |
15 |
25,725,158 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8696:Myo10
|
UTSW |
15 |
25,799,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8775:Myo10
|
UTSW |
15 |
25,800,145 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8775-TAIL:Myo10
|
UTSW |
15 |
25,800,145 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8970:Myo10
|
UTSW |
15 |
25,803,467 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9024:Myo10
|
UTSW |
15 |
25,793,295 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9196:Myo10
|
UTSW |
15 |
25,805,716 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9224:Myo10
|
UTSW |
15 |
25,808,081 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9308:Myo10
|
UTSW |
15 |
25,781,862 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9358:Myo10
|
UTSW |
15 |
25,781,520 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R9606:Myo10
|
UTSW |
15 |
25,776,401 (GRCm39) |
frame shift |
probably null |
|
|
R9722:Myo10
|
UTSW |
15 |
25,801,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF013:Myo10
|
UTSW |
15 |
25,799,565 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Myo10
|
UTSW |
15 |
25,799,640 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Myo10
|
UTSW |
15 |
25,781,487 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATCCTCCGCCTGGAGAAGGAAATC -3'
(R):5'- GGCACCACCGTGTAGTTCATGTAAG -3'
Sequencing Primer
(F):5'- CTGGAGAAGGAAATCGAGGATCTG -3'
(R):5'- TTGAAGGCGTCGTCATCC -3'
|
| Posted On |
2013-04-16 |
Incidental Mutation