Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01481:Vmn2r4'

278525

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r4

Ensembl Gene

ENSMUSG00000092049

Gene Name

vomeronasal 2, receptor 4

Synonyms

EG637053

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

IGL01481

Quality Score

Status

Chromosome

Chromosomal Location

64388621-64415296 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 64406395 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 388 (N388K)

Ref Sequence

ENSEMBL: ENSMUSP00000135228 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170280] [ENSMUST00000175724]

AlphaFold

K7N784

Predicted Effect

probably damaging
Transcript: ENSMUST00000170280
AA Change: N299K

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000127513
Gene: ENSMUSG00000092049
AA Change: N299K

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	1	416	2.7e-72	PFAM
Pfam:Peripla_BP_6	61	240	1.9e-9	PFAM
Pfam:NCD3G	458	511	1.1e-17	PFAM
Pfam:7tm_3	542	779	1.8e-75	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000175724
AA Change: N388K

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000135228
Gene: ENSMUSG00000092049
AA Change: N388K

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	88	505	2.3e-75	PFAM
Pfam:NCD3G	547	600	4.7e-17	PFAM
Pfam:7tm_3	633	867	8.2e-47	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930590J08Rik	A	T	6: 91,933,098	S523C	probably damaging	Het
Apaf1	A	T	10: 91,031,588	D798E	possibly damaging	Het
Arhgef7	G	T	8: 11,815,256	V410L	probably benign	Het
Capn7	T	C	14: 31,355,339	L338P	probably damaging	Het
Cldn17	A	G	16: 88,506,583	V86A	probably benign	Het
Clec4a2	A	G	6: 123,142,500	N237S	probably benign	Het
Cmtr1	T	G	17: 29,698,657	I654S	probably benign	Het
Cryzl2	G	A	1: 157,470,739		probably null	Het
Ctif	A	G	18: 75,611,784		probably benign	Het
Dcaf7	T	A	11: 106,054,746	I307N	probably damaging	Het
Drosha	A	T	15: 12,842,439	T399S	probably benign	Het
Eef2k	A	T	7: 120,895,218	Y35F	probably benign	Het
Emc1	T	C	4: 139,362,099	S193P	probably benign	Het
Fpr2	T	C	17: 17,892,763	I7T	probably benign	Het
Fras1	C	A	5: 96,657,241	N1247K	probably damaging	Het
Gipr	T	C	7: 19,159,506		probably benign	Het
Heatr5a	C	T	12: 51,955,425	G243S	probably damaging	Het
Hivep2	G	A	10: 14,149,237	R2265Q	probably benign	Het
Iars	T	C	13: 49,728,698	S1073P	probably benign	Het
Inpp4b	T	C	8: 81,997,380	S514P	probably damaging	Het
Inpp5b	T	A	4: 124,800,699		probably null	Het
Itga2	C	T	13: 114,859,632	V708I	possibly damaging	Het
Itih5	A	C	2: 10,190,289	Q164P	probably damaging	Het
Map3k19	T	A	1: 127,822,478	E1045D	probably damaging	Het
Mbd5	T	C	2: 49,278,939	V1374A	possibly damaging	Het
Mrps34	T	C	17: 24,897,336		probably benign	Het
Nadsyn1	T	C	7: 143,812,584	D191G	probably damaging	Het
Nlrc3	T	G	16: 3,963,905	N563H	probably damaging	Het
Nlrp4c	T	C	7: 6,100,784	C906R	possibly damaging	Het
Olfr1252	A	G	2: 89,721,526	L195P	probably damaging	Het
Olfr344	T	A	2: 36,568,742	L48H	probably damaging	Het
Olfr654	C	A	7: 104,587,860	P36T	probably damaging	Het
Olfr981	T	C	9: 40,023,278	M295T	possibly damaging	Het
Pdgfd	C	A	9: 6,337,271	T195K	probably null	Het
Ptprz1	C	A	6: 22,999,980	Q690K	probably benign	Het
Scfd1	T	A	12: 51,384,120	M23K	probably damaging	Het
Scn10a	G	A	9: 119,609,194	R1869C	probably damaging	Het
Scp2	T	C	4: 108,074,442		probably null	Het
Sec61a1	A	G	6: 88,506,847	V354A	probably benign	Het
Sgpp1	T	C	12: 75,722,657	I246V	probably benign	Het
Slco2a1	G	T	9: 103,070,251	D250Y	probably damaging	Het
Slit2	A	G	5: 48,302,931	N1435D	probably benign	Het
Sspo	A	G	6: 48,448,515	I23M	probably benign	Het
Steap4	A	T	5: 7,976,858	T274S	probably damaging	Het
Tbc1d22b	T	C	17: 29,568,598	L107P	possibly damaging	Het
Tiparp	G	T	3: 65,552,609	G442*	probably null	Het
Tmem45a2	T	A	16: 57,047,012	I109F	probably benign	Het
Top2a	A	T	11: 99,011,030	L458Q	probably damaging	Het
Tox	T	A	4: 6,842,396	T45S	probably damaging	Het
Wdr7	G	A	18: 63,739,179	D395N	probably damaging	Het

Other mutations in Vmn2r4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01310:Vmn2r4	APN	3	64409779	splice site	probably null
IGL01448:Vmn2r4	APN	3	64406395	missense	probably damaging	0.99
IGL01452:Vmn2r4	APN	3	64406395	missense	probably damaging	0.99
IGL01454:Vmn2r4	APN	3	64406395	missense	probably damaging	0.99
IGL01456:Vmn2r4	APN	3	64406395	missense	probably damaging	0.99
IGL01463:Vmn2r4	APN	3	64406395	missense	probably damaging	0.99
IGL01467:Vmn2r4	APN	3	64406395	missense	probably damaging	0.99
IGL01468:Vmn2r4	APN	3	64406395	missense	probably damaging	0.99
IGL01470:Vmn2r4	APN	3	64406395	missense	probably damaging	0.99
IGL01476:Vmn2r4	APN	3	64406395	missense	probably damaging	0.99
IGL01534:Vmn2r4	APN	3	64406423	missense	probably damaging	1.00
IGL01636:Vmn2r4	APN	3	64406236	missense	probably benign	0.21
IGL01879:Vmn2r4	APN	3	64391010	missense	probably damaging	1.00
IGL02147:Vmn2r4	APN	3	64398361	splice site	probably benign
IGL02276:Vmn2r4	APN	3	64406456	missense	possibly damaging	0.95
IGL02432:Vmn2r4	APN	3	64406400	missense	probably benign	0.38
IGL02533:Vmn2r4	APN	3	64398419	nonsense	probably null
IGL02655:Vmn2r4	APN	3	64398465	missense	probably damaging	0.97
IGL02666:Vmn2r4	APN	3	64389012	missense	probably benign	0.10
IGL02902:Vmn2r4	APN	3	64406916	missense	probably benign	0.22
IGL03189:Vmn2r4	APN	3	64389168	missense	possibly damaging	0.89
IGL03250:Vmn2r4	APN	3	64406642	missense	probably damaging	1.00
IGL03271:Vmn2r4	APN	3	64398429	missense	probably benign	0.01
R0310:Vmn2r4	UTSW	3	64389434	nonsense	probably null
R0504:Vmn2r4	UTSW	3	64389363	missense	probably damaging	1.00
R1546:Vmn2r4	UTSW	3	64406888	missense	probably damaging	1.00
R1562:Vmn2r4	UTSW	3	64389444	missense	probably damaging	0.98
R1863:Vmn2r4	UTSW	3	64406989	missense	probably benign	0.33
R1873:Vmn2r4	UTSW	3	64391058	missense	possibly damaging	0.93
R1939:Vmn2r4	UTSW	3	64398555	missense	probably benign	0.00
R2103:Vmn2r4	UTSW	3	64415283	missense	possibly damaging	0.48
R3083:Vmn2r4	UTSW	3	64389367	missense	probably damaging	1.00
R3687:Vmn2r4	UTSW	3	64389475	missense	possibly damaging	0.93
R3707:Vmn2r4	UTSW	3	64389474	missense	probably damaging	0.99
R3963:Vmn2r4	UTSW	3	64415151	missense	probably damaging	0.99
R4428:Vmn2r4	UTSW	3	64415169	missense	probably damaging	1.00
R4710:Vmn2r4	UTSW	3	64409780	critical splice donor site	probably null
R4737:Vmn2r4	UTSW	3	64409963	missense	probably damaging	1.00
R4767:Vmn2r4	UTSW	3	64390976	missense	probably damaging	0.99
R4776:Vmn2r4	UTSW	3	64388661	missense	probably damaging	0.96
R4834:Vmn2r4	UTSW	3	64410063	missense	probably benign	0.40
R4893:Vmn2r4	UTSW	3	64406255	missense	probably damaging	0.96
R4908:Vmn2r4	UTSW	3	64389055	missense	possibly damaging	0.59
R5049:Vmn2r4	UTSW	3	64398598	splice site	probably null
R5092:Vmn2r4	UTSW	3	64390952	missense	probably benign	0.01
R5234:Vmn2r4	UTSW	3	64398457	missense	possibly damaging	0.88
R5240:Vmn2r4	UTSW	3	64406937	missense	possibly damaging	0.53
R5704:Vmn2r4	UTSW	3	64409949	missense	probably benign	0.03
R5897:Vmn2r4	UTSW	3	64415266	nonsense	probably null
R5907:Vmn2r4	UTSW	3	64391066	missense	probably damaging	0.99
R5924:Vmn2r4	UTSW	3	64389264	missense	probably damaging	1.00
R6145:Vmn2r4	UTSW	3	64406943	missense	probably benign	0.00
R6191:Vmn2r4	UTSW	3	64415281	missense	probably benign	0.34
R6192:Vmn2r4	UTSW	3	64415278	missense	probably benign	0.00
R6207:Vmn2r4	UTSW	3	64406505	missense	probably damaging	1.00
R6457:Vmn2r4	UTSW	3	64409957	missense	probably damaging	1.00
R6533:Vmn2r4	UTSW	3	64415098	missense	probably benign
R6545:Vmn2r4	UTSW	3	64406356	missense	possibly damaging	0.50
R6594:Vmn2r4	UTSW	3	64389310	missense	probably damaging	1.00
R7049:Vmn2r4	UTSW	3	64389129	missense	probably benign	0.14
R7150:Vmn2r4	UTSW	3	64398477	missense	probably benign	0.01
R7187:Vmn2r4	UTSW	3	64415260	missense	probably benign	0.00
R7363:Vmn2r4	UTSW	3	64407011	missense	probably damaging	1.00
R7477:Vmn2r4	UTSW	3	64398429	missense	probably benign	0.01
R7675:Vmn2r4	UTSW	3	64415236	missense	probably benign	0.01
R7858:Vmn2r4	UTSW	3	64409805	missense	probably benign	0.00
R7888:Vmn2r4	UTSW	3	64406522	missense	probably damaging	0.99
R8678:Vmn2r4	UTSW	3	64406970	missense	probably benign
R8743:Vmn2r4	UTSW	3	64409826	missense	possibly damaging	0.95
R8841:Vmn2r4	UTSW	3	64406637	missense	probably damaging	0.97
R9671:Vmn2r4	UTSW	3	64409850	missense	probably benign	0.00
R9778:Vmn2r4	UTSW	3	64415076	missense	probably benign	0.15
X0019:Vmn2r4	UTSW	3	64406636	missense	probably damaging	0.99

Posted On

2015-04-16