Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02957:Zfp735'

365187

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp735

Ensembl Gene

ENSMUSG00000060630

Gene Name

zinc finger protein 735

Synonyms

1700012C15Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

IGL02957

Quality Score

Status

Chromosome

Chromosomal Location

73579604-73604624 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 73601755 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 233 (Y233F)

Ref Sequence

ENSEMBL: ENSMUSP00000079269 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080407]

AlphaFold

B1ARH2

Predicted Effect

probably benign
Transcript: ENSMUST00000080407
AA Change: Y233F

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000079269
Gene: ENSMUSG00000060630
AA Change: Y233F

Domain	Start	End	E-Value	Type
KRAB	8	68	2.2e-34	SMART
ZnF_C2H2	483	505	4.38e1	SMART
ZnF_C2H2	511	533	2.67e-1	SMART
ZnF_C2H2	539	561	1.81e1	SMART
ZnF_C2H2	567	589	1.5e-4	SMART
ZnF_C2H2	595	617	4.87e-4	SMART
ZnF_C2H2	623	645	4.24e-4	SMART
ZnF_C2H2	651	673	2.27e-4	SMART
ZnF_C2H2	679	701	7.49e-5	SMART
ZnF_C2H2	707	729	4.87e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000145996

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000149560

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abi2	A	G	1: 60,509,945 (GRCm39)	D262G	probably damaging	Het
Abtb3	T	A	10: 85,469,701 (GRCm39)	M405K	probably damaging	Het
Abtb3	C	T	10: 85,467,150 (GRCm39)		probably benign	Het
Ahcyl1	G	T	3: 107,574,958 (GRCm39)	Q462K	probably damaging	Het
C8b	A	G	4: 104,623,652 (GRCm39)	T20A	probably benign	Het
Casd1	T	A	6: 4,634,068 (GRCm39)	Y594N	possibly damaging	Het
Crtc2	C	T	3: 90,169,840 (GRCm39)	P412L	probably damaging	Het
Cyp3a44	T	A	5: 145,716,472 (GRCm39)	R373*	probably null	Het
Dnah10	A	G	5: 124,840,197 (GRCm39)	D1277G	probably benign	Het
Dnah2	A	T	11: 69,339,333 (GRCm39)	V3058E	possibly damaging	Het
Eif3l	T	C	15: 78,974,028 (GRCm39)	L481P	probably benign	Het
Fbxw7	A	T	3: 84,883,544 (GRCm39)	T573S	probably benign	Het
Fcgbp	C	A	7: 27,791,272 (GRCm39)	Y844*	probably null	Het
Fcrl2	C	A	3: 87,169,501 (GRCm39)	V13F	possibly damaging	Het
Gbx2	T	G	1: 89,858,375 (GRCm39)	S35R	probably benign	Het
H2-M9	A	G	17: 36,953,049 (GRCm39)	L86S	probably benign	Het
Hebp1	C	T	6: 135,114,990 (GRCm39)	G157D	probably benign	Het
Igf2bp3	C	A	6: 49,064,338 (GRCm39)	V560L	probably benign	Het
Igsf10	A	G	3: 59,238,285 (GRCm39)	I632T	probably damaging	Het
Kcnab2	A	T	4: 152,520,326 (GRCm39)	S5T	possibly damaging	Het
Kcnh5	T	C	12: 75,054,439 (GRCm39)	S502G	probably benign	Het
Lpcat2	T	A	8: 93,602,212 (GRCm39)	Y224*	probably null	Het
Mcrip2	A	G	17: 26,087,499 (GRCm39)	V24A	probably damaging	Het
Mttp	T	C	3: 137,814,842 (GRCm39)	K493E	possibly damaging	Het
Myl7	A	G	11: 5,847,137 (GRCm39)	S139P	possibly damaging	Het
Npepps	C	T	11: 97,133,478 (GRCm39)	R268H	probably damaging	Het
Oas1c	C	T	5: 120,943,478 (GRCm39)	W18*	probably null	Het
Or10ak7	G	T	4: 118,791,316 (GRCm39)	T241N	probably damaging	Het
P4ha3	T	C	7: 99,968,112 (GRCm39)		probably benign	Het
Pate14	G	T	9: 36,549,146 (GRCm39)	T38K	probably benign	Het
Pkd1l2	G	A	8: 117,792,484 (GRCm39)	T436I	probably benign	Het
Pkhd1l1	T	A	15: 44,376,304 (GRCm39)	W989R	probably damaging	Het
Podxl	A	G	6: 31,505,384 (GRCm39)		probably benign	Het
Pot1b	T	C	17: 56,007,009 (GRCm39)	Y36C	probably damaging	Het
Ppme1	A	T	7: 99,987,647 (GRCm39)	I103K	possibly damaging	Het
Ppp1r12a	T	C	10: 108,034,779 (GRCm39)	I108T	probably damaging	Het
Pramel1	A	G	4: 143,124,168 (GRCm39)	H281R	probably benign	Het
Prep	T	C	10: 45,002,126 (GRCm39)	V427A	probably benign	Het
Prkce	A	G	17: 86,803,454 (GRCm39)	D451G	possibly damaging	Het
Prrc2c	A	G	1: 162,534,104 (GRCm39)		probably benign	Het
Ramacl	A	T	13: 67,056,277 (GRCm39)		probably benign	Het
Rrm2	A	G	12: 24,758,440 (GRCm39)	N32S	probably damaging	Het
Sema6a	A	G	18: 47,382,291 (GRCm39)	L752P	probably damaging	Het
Sik3	T	A	9: 46,107,143 (GRCm39)	I429N	possibly damaging	Het
Slc22a29	A	G	19: 8,147,354 (GRCm39)	L336P	probably benign	Het
Stk32a	A	T	18: 43,445,057 (GRCm39)	M284L	probably benign	Het
Syde2	T	C	3: 145,694,934 (GRCm39)		probably benign	Het
Tcta	G	A	9: 108,182,531 (GRCm39)	S91F	possibly damaging	Het
Traf3ip2	A	T	10: 39,530,406 (GRCm39)	T517S	probably damaging	Het
Trpv3	A	G	11: 73,176,698 (GRCm39)	Y359C	probably damaging	Het
Vmn1r66	A	G	7: 10,008,737 (GRCm39)	S99P	probably damaging	Het
Vmn2r8	G	A	5: 108,950,091 (GRCm39)	T252M	probably benign	Het
Wdr27	A	T	17: 15,130,372 (GRCm39)		probably benign	Het
Yipf1	A	G	4: 107,193,347 (GRCm39)	T78A	probably damaging	Het

Other mutations in Zfp735

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00492:Zfp735	APN	11	73,602,192 (GRCm39)	missense	possibly damaging	0.86
IGL00798:Zfp735	APN	11	73,602,386 (GRCm39)	missense	possibly damaging	0.72
IGL01642:Zfp735	APN	11	73,601,305 (GRCm39)	missense	possibly damaging	0.73
IGL01684:Zfp735	APN	11	73,581,191 (GRCm39)	missense	possibly damaging	0.86
IGL02096:Zfp735	APN	11	73,602,254 (GRCm39)	missense	probably benign	0.01
IGL02238:Zfp735	APN	11	73,601,319 (GRCm39)	missense	probably benign	0.00
IGL02505:Zfp735	APN	11	73,580,626 (GRCm39)	missense	probably benign	0.03
IGL02740:Zfp735	APN	11	73,601,412 (GRCm39)	missense	possibly damaging	0.53
bananaquit	UTSW	11	73,601,412 (GRCm39)	nonsense	probably null
bescher	UTSW	11	73,602,979 (GRCm39)	missense	possibly damaging	0.93
Galvanic	UTSW	11	73,602,504 (GRCm39)	nonsense	probably null
grassquit	UTSW	11	73,603,029 (GRCm39)	missense	possibly damaging	0.66
R0114:Zfp735	UTSW	11	73,601,488 (GRCm39)	missense	probably benign	0.33
R0217:Zfp735	UTSW	11	73,602,112 (GRCm39)	missense	possibly damaging	0.73
R0943:Zfp735	UTSW	11	73,602,909 (GRCm39)	missense	probably benign	0.04
R1421:Zfp735	UTSW	11	73,601,523 (GRCm39)	missense	probably benign
R1460:Zfp735	UTSW	11	73,603,159 (GRCm39)	missense	possibly damaging	0.73
R1493:Zfp735	UTSW	11	73,601,305 (GRCm39)	missense	possibly damaging	0.73
R1517:Zfp735	UTSW	11	73,601,470 (GRCm39)	missense	probably benign
R1676:Zfp735	UTSW	11	73,602,301 (GRCm39)	missense	possibly damaging	0.53
R1709:Zfp735	UTSW	11	73,602,589 (GRCm39)	missense	probably benign	0.01
R1871:Zfp735	UTSW	11	73,601,412 (GRCm39)	nonsense	probably null
R1931:Zfp735	UTSW	11	73,602,677 (GRCm39)	missense	possibly damaging	0.69
R2219:Zfp735	UTSW	11	73,601,851 (GRCm39)	missense	possibly damaging	0.53
R2227:Zfp735	UTSW	11	73,602,223 (GRCm39)	nonsense	probably null
R2227:Zfp735	UTSW	11	73,602,222 (GRCm39)	missense	possibly damaging	0.53
R3552:Zfp735	UTSW	11	73,602,067 (GRCm39)	nonsense	probably null
R3856:Zfp735	UTSW	11	73,602,282 (GRCm39)	missense	probably benign	0.01
R3925:Zfp735	UTSW	11	73,601,950 (GRCm39)	missense	probably benign	0.33
R4572:Zfp735	UTSW	11	73,580,611 (GRCm39)	missense	probably benign	0.02
R4585:Zfp735	UTSW	11	73,580,550 (GRCm39)	missense	possibly damaging	0.51
R4586:Zfp735	UTSW	11	73,580,550 (GRCm39)	missense	possibly damaging	0.51
R4619:Zfp735	UTSW	11	73,602,031 (GRCm39)	missense	probably damaging	0.98
R4687:Zfp735	UTSW	11	73,602,682 (GRCm39)	missense	probably damaging	0.98
R4687:Zfp735	UTSW	11	73,602,681 (GRCm39)	missense	probably damaging	0.98
R5435:Zfp735	UTSW	11	73,602,939 (GRCm39)	missense	possibly damaging	0.72
R5489:Zfp735	UTSW	11	73,601,419 (GRCm39)	nonsense	probably null
R5516:Zfp735	UTSW	11	73,601,640 (GRCm39)	missense	probably benign
R5654:Zfp735	UTSW	11	73,602,964 (GRCm39)	missense	possibly damaging	0.71
R5990:Zfp735	UTSW	11	73,581,174 (GRCm39)	missense	possibly damaging	0.70
R6332:Zfp735	UTSW	11	73,602,504 (GRCm39)	nonsense	probably null
R6427:Zfp735	UTSW	11	73,581,140 (GRCm39)	missense	possibly damaging	0.73
R6460:Zfp735	UTSW	11	73,602,478 (GRCm39)	missense	probably benign	0.33
R6820:Zfp735	UTSW	11	73,579,783 (GRCm39)	start codon destroyed	probably null	0.01
R6831:Zfp735	UTSW	11	73,601,434 (GRCm39)	missense	probably damaging	1.00
R6833:Zfp735	UTSW	11	73,601,434 (GRCm39)	missense	probably damaging	1.00
R6834:Zfp735	UTSW	11	73,601,434 (GRCm39)	missense	probably damaging	1.00
R6897:Zfp735	UTSW	11	73,601,880 (GRCm39)	missense	probably benign	0.08
R6941:Zfp735	UTSW	11	73,581,159 (GRCm39)	missense	probably benign	0.33
R7335:Zfp735	UTSW	11	73,602,379 (GRCm39)	missense	possibly damaging	0.47
R7366:Zfp735	UTSW	11	73,602,979 (GRCm39)	missense	possibly damaging	0.93
R7474:Zfp735	UTSW	11	73,602,002 (GRCm39)	missense	possibly damaging	0.72
R7487:Zfp735	UTSW	11	73,581,154 (GRCm39)	missense	possibly damaging	0.53
R7583:Zfp735	UTSW	11	73,601,933 (GRCm39)	missense	possibly damaging	0.86
R7866:Zfp735	UTSW	11	73,601,629 (GRCm39)	missense	probably benign	0.00
R8005:Zfp735	UTSW	11	73,603,140 (GRCm39)	nonsense	probably null
R8500:Zfp735	UTSW	11	73,601,811 (GRCm39)	missense	possibly damaging	0.53
R8551:Zfp735	UTSW	11	73,603,122 (GRCm39)	missense	probably benign	0.06
R8754:Zfp735	UTSW	11	73,603,000 (GRCm39)	missense	possibly damaging	0.85
R8769:Zfp735	UTSW	11	73,581,127 (GRCm39)	missense	possibly damaging	0.53
R8794:Zfp735	UTSW	11	73,603,029 (GRCm39)	missense	possibly damaging	0.66
R8835:Zfp735	UTSW	11	73,601,692 (GRCm39)	missense	possibly damaging	0.53
R8869:Zfp735	UTSW	11	73,602,510 (GRCm39)	missense	possibly damaging	0.53
R8969:Zfp735	UTSW	11	73,602,699 (GRCm39)	missense	possibly damaging	0.83
R9072:Zfp735	UTSW	11	73,603,060 (GRCm39)	missense	probably benign	0.21
R9073:Zfp735	UTSW	11	73,603,060 (GRCm39)	missense	probably benign	0.21
R9193:Zfp735	UTSW	11	73,580,600 (GRCm39)	missense	possibly damaging	0.71
R9355:Zfp735	UTSW	11	73,602,362 (GRCm39)	missense	probably benign	0.01
R9414:Zfp735	UTSW	11	73,602,023 (GRCm39)	nonsense	probably null
R9456:Zfp735	UTSW	11	73,602,403 (GRCm39)	missense	possibly damaging	0.53
R9573:Zfp735	UTSW	11	73,602,936 (GRCm39)	missense	possibly damaging	0.67
R9647:Zfp735	UTSW	11	73,580,600 (GRCm39)	missense	probably damaging	0.98
R9710:Zfp735	UTSW	11	73,601,806 (GRCm39)	missense	possibly damaging	0.86
Z1176:Zfp735	UTSW	11	73,601,641 (GRCm39)	missense	probably benign	0.02

Posted On

2015-12-18