Incidental Mutation 'R8769:Zfp735'
| ID |
664303 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp735
|
| Ensembl Gene |
ENSMUSG00000060630 |
| Gene Name |
zinc finger protein 735 |
| Synonyms |
1700012C15Rik |
| MMRRC Submission |
068624-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.074)
|
| Stock # |
R8769 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
73579604-73604624 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 73581127 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Lysine
at position 55
(E55K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000079269
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000080407]
|
| AlphaFold |
B1ARH2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000080407
AA Change: E55K
PolyPhen 2
Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000079269
Gene: ENSMUSG00000060630
AA Change: E55K
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
8 |
68 |
2.2e-34 |
SMART |
|
ZnF_C2H2
|
483 |
505 |
4.38e1 |
SMART |
|
ZnF_C2H2
|
511 |
533 |
2.67e-1 |
SMART |
|
ZnF_C2H2
|
539 |
561 |
1.81e1 |
SMART |
|
ZnF_C2H2
|
567 |
589 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
595 |
617 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
623 |
645 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
651 |
673 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
679 |
701 |
7.49e-5 |
SMART |
|
ZnF_C2H2
|
707 |
729 |
4.87e-4 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.6%
|
| Validation Efficiency |
97% (57/59) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 57 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933409G03Rik |
T |
A |
2: 68,446,589 (GRCm39) |
N289K |
unknown |
Het |
| Adgrl2 |
T |
C |
3: 148,522,917 (GRCm39) |
I436V |
|
Het |
| Agbl3 |
C |
T |
6: 34,834,549 (GRCm39) |
S911L |
probably damaging |
Het |
| Ampd2 |
C |
T |
3: 107,982,613 (GRCm39) |
M714I |
probably damaging |
Het |
| Asb6 |
T |
C |
2: 30,718,143 (GRCm39) |
D19G |
possibly damaging |
Het |
| Atosa |
C |
A |
9: 74,933,107 (GRCm39) |
L1025I |
probably damaging |
Het |
| Bbx |
T |
C |
16: 50,061,227 (GRCm39) |
Q298R |
probably damaging |
Het |
| Bcl9l |
T |
A |
9: 44,420,263 (GRCm39) |
M1223K |
probably benign |
Het |
| Ccr3 |
T |
A |
9: 123,829,096 (GRCm39) |
F144I |
possibly damaging |
Het |
| Cfap74 |
T |
A |
4: 155,503,105 (GRCm39) |
F32L |
|
Het |
| Clhc1 |
G |
A |
11: 29,511,401 (GRCm39) |
E293K |
probably damaging |
Het |
| Col22a1 |
A |
T |
15: 71,878,571 (GRCm39) |
D195E |
probably benign |
Het |
| Cttnbp2 |
T |
A |
6: 18,376,003 (GRCm39) |
D1512V |
probably damaging |
Het |
| Cul9 |
T |
C |
17: 46,832,828 (GRCm39) |
T1372A |
possibly damaging |
Het |
| Dyrk4 |
G |
T |
6: 126,857,208 (GRCm39) |
D490E |
possibly damaging |
Het |
| E4f1 |
C |
T |
17: 24,663,574 (GRCm39) |
V626M |
probably damaging |
Het |
| Edc3 |
C |
T |
9: 57,634,678 (GRCm39) |
R232C |
probably damaging |
Het |
| Eppk1 |
A |
G |
15: 75,994,895 (GRCm39) |
I662T |
probably benign |
Het |
| G3bp2 |
C |
T |
5: 92,231,356 (GRCm39) |
|
probably benign |
Het |
| Grik3 |
T |
C |
4: 125,550,166 (GRCm39) |
L397P |
probably damaging |
Het |
| Hectd4 |
A |
G |
5: 121,419,936 (GRCm39) |
N627S |
possibly damaging |
Het |
| Hecw2 |
C |
T |
1: 53,952,507 (GRCm39) |
V909I |
probably benign |
Het |
| Hsd17b12 |
A |
T |
2: 93,945,397 (GRCm39) |
M75K |
probably damaging |
Het |
| Htt |
C |
T |
5: 34,977,633 (GRCm39) |
T809I |
probably benign |
Het |
| Itih1 |
A |
G |
14: 30,655,381 (GRCm39) |
S609P |
probably damaging |
Het |
| Klk1b9 |
T |
A |
7: 43,629,666 (GRCm39) |
C234S |
probably damaging |
Het |
| Lrrc37a |
A |
G |
11: 103,389,536 (GRCm39) |
L1963P |
probably benign |
Het |
| Lypd3 |
C |
A |
7: 24,337,932 (GRCm39) |
H99Q |
probably damaging |
Het |
| Mdn1 |
C |
A |
4: 32,751,390 (GRCm39) |
H4593Q |
probably damaging |
Het |
| Mroh1 |
A |
G |
15: 76,297,126 (GRCm39) |
S325G |
probably benign |
Het |
| Muc5ac |
G |
A |
7: 141,372,609 (GRCm39) |
G3452R |
probably damaging |
Het |
| Myrfl |
A |
T |
10: 116,612,696 (GRCm39) |
D884E |
probably damaging |
Het |
| Nbeal1 |
T |
A |
1: 60,274,370 (GRCm39) |
H260Q |
probably damaging |
Het |
| Ngef |
A |
G |
1: 87,408,883 (GRCm39) |
L519P |
probably damaging |
Het |
| Or5ac20 |
A |
G |
16: 59,104,194 (GRCm39) |
L222P |
probably damaging |
Het |
| Or5b102 |
T |
A |
19: 13,041,307 (GRCm39) |
C177* |
probably null |
Het |
| Or5w1b |
A |
T |
2: 87,475,960 (GRCm39) |
F169Y |
probably damaging |
Het |
| Pcca |
A |
G |
14: 122,854,260 (GRCm39) |
K184R |
probably benign |
Het |
| Pkd1l3 |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
8: 110,350,827 (GRCm39) |
|
probably benign |
Het |
| Ppp6r1 |
A |
T |
7: 4,644,289 (GRCm39) |
V379E |
probably benign |
Het |
| Prkca |
A |
T |
11: 107,842,286 (GRCm39) |
|
probably benign |
Het |
| Prune2 |
A |
G |
19: 17,100,442 (GRCm39) |
E1982G |
probably damaging |
Het |
| Rad21l |
T |
C |
2: 151,509,838 (GRCm39) |
T88A |
probably benign |
Het |
| Rpgrip1l |
T |
C |
8: 91,979,212 (GRCm39) |
|
probably benign |
Het |
| Sec62 |
T |
C |
3: 30,864,177 (GRCm39) |
|
probably null |
Het |
| Slc22a19 |
C |
T |
19: 7,670,086 (GRCm39) |
R256Q |
possibly damaging |
Het |
| Slc43a2 |
G |
T |
11: 75,434,192 (GRCm39) |
|
probably null |
Het |
| Smarcd3 |
T |
C |
5: 24,803,792 (GRCm39) |
M30V |
probably benign |
Het |
| Tes3-ps |
T |
A |
13: 49,647,356 (GRCm39) |
D77E |
probably benign |
Het |
| Thbs3 |
G |
A |
3: 89,131,937 (GRCm39) |
|
probably benign |
Het |
| Trpm2 |
A |
T |
10: 77,768,128 (GRCm39) |
N790K |
probably benign |
Het |
| Ttc13 |
A |
T |
8: 125,405,816 (GRCm39) |
N492K |
possibly damaging |
Het |
| Ttc39c |
T |
C |
18: 12,828,545 (GRCm39) |
L235P |
probably damaging |
Het |
| Tyms |
T |
C |
5: 30,278,360 (GRCm39) |
|
probably benign |
Het |
| Whamm |
A |
T |
7: 81,234,933 (GRCm39) |
K333* |
probably null |
Het |
| Ydjc |
A |
G |
16: 16,968,732 (GRCm39) |
I224V |
probably benign |
Het |
| Zc3hav1 |
C |
T |
6: 38,313,416 (GRCm39) |
D210N |
possibly damaging |
Het |
|
| Other mutations in Zfp735 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00492:Zfp735
|
APN |
11 |
73,602,192 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL00798:Zfp735
|
APN |
11 |
73,602,386 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL01642:Zfp735
|
APN |
11 |
73,601,305 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL01684:Zfp735
|
APN |
11 |
73,581,191 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02096:Zfp735
|
APN |
11 |
73,602,254 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02238:Zfp735
|
APN |
11 |
73,601,319 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02505:Zfp735
|
APN |
11 |
73,580,626 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02740:Zfp735
|
APN |
11 |
73,601,412 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL02957:Zfp735
|
APN |
11 |
73,601,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
bananaquit
|
UTSW |
11 |
73,601,412 (GRCm39) |
nonsense |
probably null |
|
|
bescher
|
UTSW |
11 |
73,602,979 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
Galvanic
|
UTSW |
11 |
73,602,504 (GRCm39) |
nonsense |
probably null |
|
|
grassquit
|
UTSW |
11 |
73,603,029 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0114:Zfp735
|
UTSW |
11 |
73,601,488 (GRCm39) |
missense |
probably benign |
0.33 |
|
R0217:Zfp735
|
UTSW |
11 |
73,602,112 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0943:Zfp735
|
UTSW |
11 |
73,602,909 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1421:Zfp735
|
UTSW |
11 |
73,601,523 (GRCm39) |
missense |
probably benign |
|
|
R1460:Zfp735
|
UTSW |
11 |
73,603,159 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1493:Zfp735
|
UTSW |
11 |
73,601,305 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1517:Zfp735
|
UTSW |
11 |
73,601,470 (GRCm39) |
missense |
probably benign |
|
|
R1676:Zfp735
|
UTSW |
11 |
73,602,301 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1709:Zfp735
|
UTSW |
11 |
73,602,589 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1871:Zfp735
|
UTSW |
11 |
73,601,412 (GRCm39) |
nonsense |
probably null |
|
|
R1931:Zfp735
|
UTSW |
11 |
73,602,677 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R2219:Zfp735
|
UTSW |
11 |
73,601,851 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2227:Zfp735
|
UTSW |
11 |
73,602,223 (GRCm39) |
nonsense |
probably null |
|
|
R2227:Zfp735
|
UTSW |
11 |
73,602,222 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3552:Zfp735
|
UTSW |
11 |
73,602,067 (GRCm39) |
nonsense |
probably null |
|
|
R3856:Zfp735
|
UTSW |
11 |
73,602,282 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3925:Zfp735
|
UTSW |
11 |
73,601,950 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4572:Zfp735
|
UTSW |
11 |
73,580,611 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4585:Zfp735
|
UTSW |
11 |
73,580,550 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R4586:Zfp735
|
UTSW |
11 |
73,580,550 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R4619:Zfp735
|
UTSW |
11 |
73,602,031 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4687:Zfp735
|
UTSW |
11 |
73,602,682 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4687:Zfp735
|
UTSW |
11 |
73,602,681 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5435:Zfp735
|
UTSW |
11 |
73,602,939 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R5489:Zfp735
|
UTSW |
11 |
73,601,419 (GRCm39) |
nonsense |
probably null |
|
|
R5516:Zfp735
|
UTSW |
11 |
73,601,640 (GRCm39) |
missense |
probably benign |
|
|
R5654:Zfp735
|
UTSW |
11 |
73,602,964 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5990:Zfp735
|
UTSW |
11 |
73,581,174 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R6332:Zfp735
|
UTSW |
11 |
73,602,504 (GRCm39) |
nonsense |
probably null |
|
|
R6427:Zfp735
|
UTSW |
11 |
73,581,140 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R6460:Zfp735
|
UTSW |
11 |
73,602,478 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6820:Zfp735
|
UTSW |
11 |
73,579,783 (GRCm39) |
start codon destroyed |
probably null |
0.01 |
|
R6831:Zfp735
|
UTSW |
11 |
73,601,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6833:Zfp735
|
UTSW |
11 |
73,601,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6834:Zfp735
|
UTSW |
11 |
73,601,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6897:Zfp735
|
UTSW |
11 |
73,601,880 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6941:Zfp735
|
UTSW |
11 |
73,581,159 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7335:Zfp735
|
UTSW |
11 |
73,602,379 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7366:Zfp735
|
UTSW |
11 |
73,602,979 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7474:Zfp735
|
UTSW |
11 |
73,602,002 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7487:Zfp735
|
UTSW |
11 |
73,581,154 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7583:Zfp735
|
UTSW |
11 |
73,601,933 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7866:Zfp735
|
UTSW |
11 |
73,601,629 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8005:Zfp735
|
UTSW |
11 |
73,603,140 (GRCm39) |
nonsense |
probably null |
|
|
R8500:Zfp735
|
UTSW |
11 |
73,601,811 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8551:Zfp735
|
UTSW |
11 |
73,603,122 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8754:Zfp735
|
UTSW |
11 |
73,603,000 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8794:Zfp735
|
UTSW |
11 |
73,603,029 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8835:Zfp735
|
UTSW |
11 |
73,601,692 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8869:Zfp735
|
UTSW |
11 |
73,602,510 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8969:Zfp735
|
UTSW |
11 |
73,602,699 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9072:Zfp735
|
UTSW |
11 |
73,603,060 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9073:Zfp735
|
UTSW |
11 |
73,603,060 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9193:Zfp735
|
UTSW |
11 |
73,580,600 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9355:Zfp735
|
UTSW |
11 |
73,602,362 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9414:Zfp735
|
UTSW |
11 |
73,602,023 (GRCm39) |
nonsense |
probably null |
|
|
R9456:Zfp735
|
UTSW |
11 |
73,602,403 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9573:Zfp735
|
UTSW |
11 |
73,602,936 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9647:Zfp735
|
UTSW |
11 |
73,580,600 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9710:Zfp735
|
UTSW |
11 |
73,601,806 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
Z1176:Zfp735
|
UTSW |
11 |
73,601,641 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGGTCAGACCTTCATTAATTAGTCC -3'
(R):5'- CCAAGGTGTGCTATTTCTCTGG -3'
Sequencing Primer
(F):5'- CCACAGTTGTCTTATTTCTAATGTGG -3'
(R):5'- CTCTGGTACATTACTCTGAACAAC -3'
|
| Posted On |
2021-03-08 |
Incidental Mutation