Mutagenetix > Incidental Mutation

Incidental Mutation 'R0423:Lilra6'

38582

Institutional Source

Beutler Lab

Gene Symbol

Lilra6

Ensembl Gene

ENSMUSG00000030427

Gene Name

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6

Synonyms

7M1, Pira3

MMRRC Submission

038625-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.086) question?

Stock #

R0423 (G1)

Quality Score

172

Status

Validated

Chromosome

Chromosomal Location

3911279-3918502 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 3917774 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000145890 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038176] [ENSMUST00000090689] [ENSMUST00000206077]

AlphaFold

A0A0B4J1F3

Predicted Effect

probably benign
Transcript: ENSMUST00000038176

SMART Domains

Protein: ENSMUSP00000042636
Gene: ENSMUSG00000030427

Domain	Start	End	E-Value	Type
low complexity region	8	17	N/A	INTRINSIC
IG_like	40	105	3.11e0	SMART
IG	129	315	4.53e-2	SMART
IG_like	237	302	1.54e-1	SMART
IG_like	328	415	1.79e1	SMART
IG_like	429	517	2.66e1	SMART
IG	529	618	8.59e-3	SMART
low complexity region	637	646	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000090689

SMART Domains

Protein: ENSMUSP00000088188
Gene: ENSMUSG00000030427

Domain	Start	End	E-Value	Type
low complexity region	8	17	N/A	INTRINSIC
IG_like	34	118	7.25e0	SMART
IG_like	129	220	1.62e2	SMART
IG_like	290	377	1.79e1	SMART
IG_like	391	479	2.66e1	SMART
IG	491	580	8.59e-3	SMART
low complexity region	599	608	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131255

Predicted Effect

probably benign
Transcript: ENSMUST00000206077

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206851

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.1%
10x: 95.9%
20x: 91.9%

Validation Efficiency

99% (84/85)

Allele List at MGI

Other mutations in this stock

Total: 71 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930432E11Rik	A	T	7: 29,261,825 (GRCm39)		noncoding transcript	Het
A630001G21Rik	A	G	1: 85,654,187 (GRCm39)	I50T	probably benign	Het
Abhd12	T	C	2: 150,680,312 (GRCm39)	T264A	possibly damaging	Het
Acsm3	T	C	7: 119,376,382 (GRCm39)	Y370H	probably damaging	Het
Ank2	G	T	3: 126,723,509 (GRCm39)	Y3789*	probably null	Het
Anxa4	C	T	6: 86,737,719 (GRCm39)	A1T	probably damaging	Het
Apba1	T	A	19: 23,922,362 (GRCm39)	V810D	probably damaging	Het
Bank1	A	G	3: 135,989,778 (GRCm39)	I104T	possibly damaging	Het
Birc6	T	C	17: 75,003,292 (GRCm39)	Y4721H	probably damaging	Het
Bmpr2	A	G	1: 59,907,669 (GRCm39)	T921A	probably benign	Het
Ccdc102a	A	C	8: 95,632,554 (GRCm39)		probably benign	Het
Ccdc141	C	A	2: 76,869,794 (GRCm39)	D904Y	probably damaging	Het
Ccdc96	A	G	5: 36,642,591 (GRCm39)	K199R	probably benign	Het
Cdh10	G	A	15: 18,986,965 (GRCm39)	V399I	probably benign	Het
Cenpk	A	G	13: 104,370,733 (GRCm39)	T85A	probably benign	Het
Col6a2	A	C	10: 76,450,751 (GRCm39)	V60G	possibly damaging	Het
Cops7b	A	G	1: 86,526,753 (GRCm39)	D119G	probably benign	Het
Cstf2t	A	G	19: 31,061,676 (GRCm39)	E404G	possibly damaging	Het
Ctnna2	A	T	6: 77,630,052 (GRCm39)	V134E	probably damaging	Het
Cwh43	A	C	5: 73,574,085 (GRCm39)	M250L	probably benign	Het
Daam2	T	A	17: 49,776,449 (GRCm39)	K813*	probably null	Het
Dhcr24	G	A	4: 106,443,733 (GRCm39)		probably benign	Het
Dnah8	G	T	17: 30,920,955 (GRCm39)	R1182L	probably benign	Het
Doc2a	C	T	7: 126,447,830 (GRCm39)	P25S	probably damaging	Het
Dst	A	G	1: 34,317,116 (GRCm39)	S6823G	possibly damaging	Het
Espl1	T	A	15: 102,212,421 (GRCm39)	L509*	probably null	Het
Fbxw19	C	T	9: 109,315,134 (GRCm39)	V143I	probably benign	Het
Fbxw5	A	G	2: 25,394,538 (GRCm39)	T171A	possibly damaging	Het
Gfra2	C	T	14: 71,133,521 (GRCm39)	T117M	probably damaging	Het
Gm454	T	A	5: 138,202,403 (GRCm39)		noncoding transcript	Het
Ilrun	A	C	17: 28,005,207 (GRCm39)	Y117D	probably damaging	Het
Kcnq4	A	G	4: 120,574,705 (GRCm39)	S120P	probably damaging	Het
Krt84	A	T	15: 101,437,155 (GRCm39)	L336Q	probably damaging	Het
Mbnl2	G	A	14: 120,562,736 (GRCm39)	R29H	probably damaging	Het
Mcm3ap	G	A	10: 76,338,539 (GRCm39)	G1389D	probably benign	Het
Mettl13	A	T	1: 162,371,954 (GRCm39)	I305N	probably damaging	Het
Muc6	A	G	7: 141,238,548 (GRCm39)	S30P	probably benign	Het
Myh7	T	A	14: 55,216,646 (GRCm39)	Q1237L	probably benign	Het
Myo9a	T	G	9: 59,802,619 (GRCm39)	D2035E	probably damaging	Het
Nat10	A	G	2: 103,578,572 (GRCm39)	S211P	probably damaging	Het
Ntm	T	C	9: 29,090,395 (GRCm39)	Y108C	probably damaging	Het
Or14c39	T	C	7: 86,344,434 (GRCm39)	Y257H	possibly damaging	Het
Or7g25	A	T	9: 19,160,248 (GRCm39)	L149*	probably null	Het
Pcdhb16	A	G	18: 37,613,422 (GRCm39)	D794G	probably benign	Het
Phlpp1	A	G	1: 106,267,345 (GRCm39)	T753A	probably benign	Het
Pierce1	T	C	2: 28,356,036 (GRCm39)		probably benign	Het
Pnldc1	T	C	17: 13,108,963 (GRCm39)	Q511R	possibly damaging	Het
Ppip5k2	A	G	1: 97,689,152 (GRCm39)	S38P	possibly damaging	Het
Pygb	A	G	2: 150,665,904 (GRCm39)	K593E	probably benign	Het
Rangap1	A	T	15: 81,589,664 (GRCm39)	F564I	probably damaging	Het
Rictor	A	T	15: 6,803,381 (GRCm39)	I498F	possibly damaging	Het
Rnase12	A	T	14: 51,294,613 (GRCm39)	V22D	probably benign	Het
Rpl7l1	T	A	17: 47,091,324 (GRCm39)	M93L	probably benign	Het
Smg1	T	C	7: 117,776,103 (GRCm39)	R1396G	possibly damaging	Het
Snx19	C	A	9: 30,347,133 (GRCm39)	T692N	probably damaging	Het
Spag6	A	G	2: 18,715,404 (GRCm39)	D61G	probably benign	Het
Spen	T	A	4: 141,206,647 (GRCm39)	N660I	unknown	Het
Sptan1	T	G	2: 29,918,684 (GRCm39)	C2246G	probably null	Het
Svopl	A	G	6: 38,013,642 (GRCm39)		probably benign	Het
Taf2	A	T	15: 54,928,078 (GRCm39)	N108K	probably benign	Het
Thbs4	T	C	13: 92,893,079 (GRCm39)	D703G	probably damaging	Het
Tle6	G	T	10: 81,434,457 (GRCm39)	N47K	possibly damaging	Het
Usp48	G	T	4: 137,343,722 (GRCm39)	V452L	probably benign	Het
Ust	A	T	10: 8,173,912 (GRCm39)	S198T	probably damaging	Het
Wnk2	T	A	13: 49,248,894 (GRCm39)	M386L	possibly damaging	Het
Ywhaq	T	C	12: 21,441,382 (GRCm39)		probably benign	Het
Zfp11	C	T	5: 129,735,302 (GRCm39)	G53E	possibly damaging	Het
Zfp316	A	G	5: 143,238,993 (GRCm39)	S1009P	probably damaging	Het
Zfp963	A	G	8: 70,197,156 (GRCm39)	Y29H	probably damaging	Het
Zmym4	A	G	4: 126,776,112 (GRCm39)		probably benign	Het
Zranb3	A	G	1: 128,019,607 (GRCm39)	I45T	probably damaging	Het

Other mutations in Lilra6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00508:Lilra6	APN	7	3,914,553 (GRCm39)	missense	probably benign	0.04
IGL00569:Lilra6	APN	7	3,917,588 (GRCm39)	missense	probably damaging	0.99
IGL00899:Lilra6	APN	7	3,916,056 (GRCm39)	missense	probably damaging	1.00
IGL00955:Lilra6	APN	7	3,914,403 (GRCm39)	splice site	probably benign
IGL01585:Lilra6	APN	7	3,917,498 (GRCm39)	missense	probably benign	0.01
IGL02195:Lilra6	APN	7	3,917,549 (GRCm39)	missense	probably benign	0.00
IGL02586:Lilra6	APN	7	3,911,819 (GRCm39)	missense	probably benign	0.36
IGL02719:Lilra6	APN	7	3,915,991 (GRCm39)	missense	possibly damaging	0.96
IGL03166:Lilra6	APN	7	3,915,626 (GRCm39)	missense	possibly damaging	0.69
IGL03329:Lilra6	APN	7	3,917,647 (GRCm39)	splice site	probably benign
R0233:Lilra6	UTSW	7	3,917,935 (GRCm39)	missense	possibly damaging	0.69
R0233:Lilra6	UTSW	7	3,917,935 (GRCm39)	missense	possibly damaging	0.69
R0483:Lilra6	UTSW	7	3,916,138 (GRCm39)	missense	probably benign	0.02
R0511:Lilra6	UTSW	7	3,915,784 (GRCm39)	missense	possibly damaging	0.77
R1472:Lilra6	UTSW	7	3,915,718 (GRCm39)	missense	probably damaging	1.00
R1560:Lilra6	UTSW	7	3,914,407 (GRCm39)	critical splice donor site	probably null
R1584:Lilra6	UTSW	7	3,915,661 (GRCm39)	missense	probably damaging	1.00
R1781:Lilra6	UTSW	7	3,918,066 (GRCm39)	missense	probably benign	0.28
R2411:Lilra6	UTSW	7	3,914,453 (GRCm39)	missense	probably damaging	1.00
R2420:Lilra6	UTSW	7	3,917,857 (GRCm39)	missense	probably damaging	1.00
R4021:Lilra6	UTSW	7	3,914,417 (GRCm39)	missense	probably benign	0.20
R4074:Lilra6	UTSW	7	3,917,889 (GRCm39)	missense	probably benign	0.23
R4284:Lilra6	UTSW	7	3,911,803 (GRCm39)	missense	possibly damaging	0.76
R4508:Lilra6	UTSW	7	3,915,028 (GRCm39)	nonsense	probably null
R4894:Lilra6	UTSW	7	3,915,530 (GRCm39)	missense	probably benign	0.01
R4977:Lilra6	UTSW	7	3,917,382 (GRCm39)	missense	probably benign	0.01
R5048:Lilra6	UTSW	7	3,918,440 (GRCm39)	critical splice donor site	probably null
R5164:Lilra6	UTSW	7	3,917,880 (GRCm39)	missense	probably damaging	1.00
R5185:Lilra6	UTSW	7	3,917,635 (GRCm39)	missense	probably benign	0.00
R5527:Lilra6	UTSW	7	3,917,586 (GRCm39)	start gained	probably benign
R6281:Lilra6	UTSW	7	3,914,972 (GRCm39)	missense	probably damaging	1.00
R6480:Lilra6	UTSW	7	3,915,932 (GRCm39)	missense	probably damaging	1.00
R6512:Lilra6	UTSW	7	3,917,387 (GRCm39)	missense	probably benign	0.06
R6565:Lilra6	UTSW	7	3,918,019 (GRCm39)	missense	probably benign
R7017:Lilra6	UTSW	7	3,911,707 (GRCm39)	missense	possibly damaging	0.93
R7095:Lilra6	UTSW	7	3,916,196 (GRCm39)	missense	probably damaging	1.00
R7747:Lilra6	UTSW	7	3,915,995 (GRCm39)	missense	probably benign	0.16
R8056:Lilra6	UTSW	7	3,915,551 (GRCm39)	missense	probably damaging	1.00
R8280:Lilra6	UTSW	7	3,916,046 (GRCm39)	missense	probably benign	0.01
R9197:Lilra6	UTSW	7	3,915,716 (GRCm39)	missense	possibly damaging	0.94
R9354:Lilra6	UTSW	7	3,914,628 (GRCm39)	missense	probably damaging	1.00
R9379:Lilra6	UTSW	7	3,916,166 (GRCm39)	missense	probably damaging	1.00
R9406:Lilra6	UTSW	7	3,917,853 (GRCm39)	missense	probably benign
R9462:Lilra6	UTSW	7	3,914,994 (GRCm39)	missense	probably damaging	0.97
R9649:Lilra6	UTSW	7	3,917,521 (GRCm39)	missense	possibly damaging	0.47
Z1176:Lilra6	UTSW	7	3,918,073 (GRCm39)	critical splice acceptor site	probably null
Z1177:Lilra6	UTSW	7	3,915,580 (GRCm39)	missense	possibly damaging	0.48

Predicted Primers

PCR Primer
(F):5'- TGGAGAGTGACATACCCTCCTGAAG -3'
(R):5'- ATTGGAGCCAATGAGTACCGCC -3'

Sequencing Primer
(F):5'- TCCTGAAGTTACCACAGGGC -3'
(R):5'- TGAGTACCGCCTCTATAAAGATGG -3'

Posted On

2013-05-23