Mutagenetix > Incidental Mutations

Incidental Mutation 'R0423:Lilra6'

38582

Institutional Source

Beutler Lab

Gene Symbol

Lilra6

Ensembl Gene

ENSMUSG00000030427

Gene Name

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6

Synonyms

Pira3, 7M1

MMRRC Submission

038625-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

R0423 (G1)

Quality Score

172

Status

Validated

Chromosome

Chromosomal Location

3908280-3915503 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 3914775 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000145890 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038176] [ENSMUST00000090689] [ENSMUST00000206077]

AlphaFold

A0A0B4J1F3

Predicted Effect

probably benign
Transcript: ENSMUST00000038176

SMART Domains

Protein: ENSMUSP00000042636
Gene: ENSMUSG00000030427

Domain	Start	End	E-Value	Type
low complexity region	8	17	N/A	INTRINSIC
IG_like	40	105	3.11e0	SMART
IG	129	315	4.53e-2	SMART
IG_like	237	302	1.54e-1	SMART
IG_like	328	415	1.79e1	SMART
IG_like	429	517	2.66e1	SMART
IG	529	618	8.59e-3	SMART
low complexity region	637	646	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000090689

SMART Domains

Protein: ENSMUSP00000088188
Gene: ENSMUSG00000030427

Domain	Start	End	E-Value	Type
low complexity region	8	17	N/A	INTRINSIC
IG_like	34	118	7.25e0	SMART
IG_like	129	220	1.62e2	SMART
IG_like	290	377	1.79e1	SMART
IG_like	391	479	2.66e1	SMART
IG	491	580	8.59e-3	SMART
low complexity region	599	608	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131255

Predicted Effect

probably benign
Transcript: ENSMUST00000206077

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206851

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.1%
10x: 95.9%
20x: 91.9%

Validation Efficiency

99% (84/85)

Allele List at MGI

Other mutations in this stock

Total: 71 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700007K13Rik	T	C	2: 28,466,024		probably benign	Het
4930432E11Rik	A	T	7: 29,562,400		noncoding transcript	Het
A630001G21Rik	A	G	1: 85,726,466	I50T	probably benign	Het
Abhd12	T	C	2: 150,838,392	T264A	possibly damaging	Het
Acsm3	T	C	7: 119,777,159	Y370H	probably damaging	Het
Ank2	G	T	3: 126,929,860	Y3789*	probably null	Het
Anxa4	C	T	6: 86,760,737	A1T	probably damaging	Het
Apba1	T	A	19: 23,944,998	V810D	probably damaging	Het
Bank1	A	G	3: 136,284,017	I104T	possibly damaging	Het
Birc6	T	C	17: 74,696,297	Y4721H	probably damaging	Het
Bmpr2	A	G	1: 59,868,510	T921A	probably benign	Het
Ccdc102a	A	C	8: 94,905,926		probably benign	Het
Ccdc141	C	A	2: 77,039,450	D904Y	probably damaging	Het
Ccdc96	A	G	5: 36,485,247	K199R	probably benign	Het
Cdh10	G	A	15: 18,986,879	V399I	probably benign	Het
Cenpk	A	G	13: 104,234,225	T85A	probably benign	Het
Col6a2	A	C	10: 76,614,917	V60G	possibly damaging	Het
Cops7b	A	G	1: 86,599,031	D119G	probably benign	Het
Cstf2t	A	G	19: 31,084,276	E404G	possibly damaging	Het
Ctnna2	A	T	6: 77,653,069	V134E	probably damaging	Het
Cwh43	A	C	5: 73,416,742	M250L	probably benign	Het
D17Wsu92e	A	C	17: 27,786,233	Y117D	probably damaging	Het
Daam2	T	A	17: 49,469,421	K813*	probably null	Het
Dhcr24	G	A	4: 106,586,536		probably benign	Het
Dnah8	G	T	17: 30,701,981	R1182L	probably benign	Het
Doc2a	C	T	7: 126,848,658	P25S	probably damaging	Het
Dst	A	G	1: 34,278,035	S6823G	possibly damaging	Het
Espl1	T	A	15: 102,303,986	L509*	probably null	Het
Fbxw19	C	T	9: 109,486,066	V143I	probably benign	Het
Fbxw5	A	G	2: 25,504,526	T171A	possibly damaging	Het
Gfra2	C	T	14: 70,896,081	T117M	probably damaging	Het
Gm454	T	A	5: 138,204,141		noncoding transcript	Het
Kcnq4	A	G	4: 120,717,508	S120P	probably damaging	Het
Krt84	A	T	15: 101,528,720	L336Q	probably damaging	Het
Mbnl2	G	A	14: 120,325,324	R29H	probably damaging	Het
Mcm3ap	G	A	10: 76,502,705	G1389D	probably benign	Het
Mettl13	A	T	1: 162,544,385	I305N	probably damaging	Het
Muc6	A	G	7: 141,652,283	S30P	probably benign	Het
Myh7	T	A	14: 54,979,189	Q1237L	probably benign	Het
Myo9a	T	G	9: 59,895,336	D2035E	probably damaging	Het
Nat10	A	G	2: 103,748,227	S211P	probably damaging	Het
Ntm	T	C	9: 29,179,099	Y108C	probably damaging	Het
Olfr292	T	C	7: 86,695,226	Y257H	possibly damaging	Het
Olfr843	A	T	9: 19,248,952	L149*	probably null	Het
Pcdhb16	A	G	18: 37,480,369	D794G	probably benign	Het
Phlpp1	A	G	1: 106,339,615	T753A	probably benign	Het
Pnldc1	T	C	17: 12,890,076	Q511R	possibly damaging	Het
Ppip5k2	A	G	1: 97,761,427	S38P	possibly damaging	Het
Pygb	A	G	2: 150,823,984	K593E	probably benign	Het
Rangap1	A	T	15: 81,705,463	F564I	probably damaging	Het
Rictor	A	T	15: 6,773,900	I498F	possibly damaging	Het
Rnase12	A	T	14: 51,057,156	V22D	probably benign	Het
Rpl7l1	T	A	17: 46,780,398	M93L	probably benign	Het
Smg1	T	C	7: 118,176,880	R1396G	possibly damaging	Het
Snx19	C	A	9: 30,435,837	T692N	probably damaging	Het
Spag6	A	G	2: 18,710,593	D61G	probably benign	Het
Spen	T	A	4: 141,479,336	N660I	unknown	Het
Sptan1	T	G	2: 30,028,672	C2246G	probably null	Het
Svopl	A	G	6: 38,036,707		probably benign	Het
Taf2	A	T	15: 55,064,682	N108K	probably benign	Het
Thbs4	T	C	13: 92,756,571	D703G	probably damaging	Het
Tle6	G	T	10: 81,598,623	N47K	possibly damaging	Het
Usp48	G	T	4: 137,616,411	V452L	probably benign	Het
Ust	A	T	10: 8,298,148	S198T	probably damaging	Het
Wnk2	T	A	13: 49,095,418	M386L	possibly damaging	Het
Ywhaq	T	C	12: 21,391,381		probably benign	Het
Zfp11	C	T	5: 129,658,238	G53E	possibly damaging	Het
Zfp316	A	G	5: 143,253,238	S1009P	probably damaging	Het
Zfp963	A	G	8: 69,744,506	Y29H	probably damaging	Het
Zmym4	A	G	4: 126,882,319		probably benign	Het
Zranb3	A	G	1: 128,091,870	I45T	probably damaging	Het

Other mutations in Lilra6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00508:Lilra6	APN	7	3911554	missense	probably benign	0.04
IGL00569:Lilra6	APN	7	3914589	missense	probably damaging	0.99
IGL00899:Lilra6	APN	7	3913057	missense	probably damaging	1.00
IGL00955:Lilra6	APN	7	3911404	splice site	probably benign
IGL01585:Lilra6	APN	7	3914499	missense	probably benign	0.01
IGL02195:Lilra6	APN	7	3914550	missense	probably benign	0.00
IGL02586:Lilra6	APN	7	3908820	missense	probably benign	0.36
IGL02719:Lilra6	APN	7	3912992	missense	possibly damaging	0.96
IGL03166:Lilra6	APN	7	3912627	missense	possibly damaging	0.69
IGL03329:Lilra6	APN	7	3914648	splice site	probably benign
R0233:Lilra6	UTSW	7	3914936	missense	possibly damaging	0.69
R0233:Lilra6	UTSW	7	3914936	missense	possibly damaging	0.69
R0483:Lilra6	UTSW	7	3913139	missense	probably benign	0.02
R0511:Lilra6	UTSW	7	3912785	missense	possibly damaging	0.77
R1472:Lilra6	UTSW	7	3912719	missense	probably damaging	1.00
R1560:Lilra6	UTSW	7	3911408	critical splice donor site	probably null
R1584:Lilra6	UTSW	7	3912662	missense	probably damaging	1.00
R1781:Lilra6	UTSW	7	3915067	missense	probably benign	0.28
R2411:Lilra6	UTSW	7	3911454	missense	probably damaging	1.00
R2420:Lilra6	UTSW	7	3914858	missense	probably damaging	1.00
R4021:Lilra6	UTSW	7	3911418	missense	probably benign	0.20
R4074:Lilra6	UTSW	7	3914890	missense	probably benign	0.23
R4284:Lilra6	UTSW	7	3908804	missense	possibly damaging	0.76
R4508:Lilra6	UTSW	7	3912029	nonsense	probably null
R4894:Lilra6	UTSW	7	3912531	missense	probably benign	0.01
R4977:Lilra6	UTSW	7	3914383	missense	probably benign	0.01
R5048:Lilra6	UTSW	7	3915441	critical splice donor site	probably null
R5164:Lilra6	UTSW	7	3914881	missense	probably damaging	1.00
R5185:Lilra6	UTSW	7	3914636	missense	probably benign	0.00
R5527:Lilra6	UTSW	7	3914587	start gained	probably benign
R6281:Lilra6	UTSW	7	3911973	missense	probably damaging	1.00
R6480:Lilra6	UTSW	7	3912933	missense	probably damaging	1.00
R6512:Lilra6	UTSW	7	3914388	missense	probably benign	0.06
R6565:Lilra6	UTSW	7	3915020	missense	probably benign
R7017:Lilra6	UTSW	7	3908708	missense	possibly damaging	0.93
R7095:Lilra6	UTSW	7	3913197	missense	probably damaging	1.00
R7747:Lilra6	UTSW	7	3912996	missense	probably benign	0.16
R8056:Lilra6	UTSW	7	3912552	missense	probably damaging	1.00
R8280:Lilra6	UTSW	7	3913047	missense	probably benign	0.01
R9197:Lilra6	UTSW	7	3912717	missense	possibly damaging	0.94
R9354:Lilra6	UTSW	7	3911629	missense	probably damaging	1.00
R9379:Lilra6	UTSW	7	3913167	missense	probably damaging	1.00
R9406:Lilra6	UTSW	7	3914854
Z1176:Lilra6	UTSW	7	3915074	critical splice acceptor site	probably null
Z1177:Lilra6	UTSW	7	3912581	missense	possibly damaging	0.48

Predicted Primers

PCR Primer
(F):5'- TGGAGAGTGACATACCCTCCTGAAG -3'
(R):5'- ATTGGAGCCAATGAGTACCGCC -3'

Sequencing Primer
(F):5'- TCCTGAAGTTACCACAGGGC -3'
(R):5'- TGAGTACCGCCTCTATAAAGATGG -3'

Posted On

2013-05-23