|Institutional Source||Beutler Lab|
|Gene Name||interferon induced transmembrane protein 3|
|Synonyms||mil-1, Fgls, 1110004C05Rik, fragilis, IP15|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R4991 (G1)|
|Chromosomal Location||141009586-141010770 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to T at 141010459 bp|
|Amino Acid Change||Phenylalanine to Isoleucine at position 63 (F63I)|
|Ref Sequence||ENSEMBL: ENSMUSP00000026565 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000026565]|
|Predicted Effect||probably damaging
AA Change: F63I
PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
AA Change: F63I
|Meta Mutation Damage Score||0.6514|
|Coding Region Coverage||
|Validation Efficiency||95% (73/77)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012]
PHENOTYPE: Mice homozygous for a reporter allele are viable and fertile with no detectable defects in embryogenesis or germ cell development but show increased susceptibility to respiratory syncytial virus and influenza A virus infection. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ifitm3||
(F):5'- CAGAGAGCCTTTAAGCCTACAC -3'
(R):5'- TCAAGCCTTCATCACCGCTG -3'
(F):5'- GAGCCTTTAAGCCTACACGTGTAC -3'
(R):5'- TCATCACCGCTGCCAGTG -3'