Mutagenetix > Incidental Mutations

Incidental Mutation 'R5190:Vmn1r195'

398070

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r195

Ensembl Gene

ENSMUSG00000069296

Gene Name

vomeronasal 1 receptor 195

Synonyms

V1ri6

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.050) question?

Stock #

R5190 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

22270522-22281230 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 22278386 bp

Zygosity

Heterozygous

Amino Acid Change

Arginine to Stop codon at position 9 (R9*)

Ref Sequence

ENSEMBL: ENSMUSP00000154274 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000091736] [ENSMUST00000228711]

Predicted Effect

probably null
Transcript: ENSMUST00000091736
AA Change: R9*

SMART Domains

Protein: ENSMUSP00000089330
Gene: ENSMUSG00000069296
AA Change: R9*

Domain	Start	End	E-Value	Type
transmembrane domain	10	32	N/A	INTRINSIC
Pfam:V1R	34	300	5.6e-41	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000121379

Predicted Effect

probably null
Transcript: ENSMUST00000228711
AA Change: R9*

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700049A03Rik	G	T	12: 71,164,546	E685*	probably null	Het
2700049A03Rik	A	T	12: 71,164,547	E685V	possibly damaging	Het
Abca7	T	C	10: 79,999,593		probably null	Het
Abca8a	C	T	11: 110,089,909		probably null	Het
Ablim3	A	G	18: 61,819,911	Y361H	probably benign	Het
Acan	C	T	7: 79,098,541	T1020I	probably benign	Het
Baat	A	G	4: 49,499,652	L218P	probably damaging	Het
Bcl11b	C	A	12: 107,989,716	C58F	probably damaging	Het
Cand2	G	T	6: 115,789,513	A360S	probably damaging	Het
Cdh2	A	G	18: 16,650,315	V62A	possibly damaging	Het
Cep44	C	T	8: 56,532,796	V354I	probably benign	Het
Col3a1	G	A	1: 45,329,084	R309Q	unknown	Het
Col3a1	G	A	1: 45,344,807		probably benign	Het
Coq5	A	G	5: 115,295,780		probably null	Het
Crtac1	A	G	19: 42,333,908	I131T	possibly damaging	Het
Decr1	C	T	4: 15,924,270	V217M	probably damaging	Het
Dnajc13	A	G	9: 104,174,525	V1706A	probably benign	Het
Dopey1	A	G	9: 86,487,304	I63M	probably damaging	Het
F830045P16Rik	T	C	2: 129,472,715	D214G	probably benign	Het
Fam216a	T	A	5: 122,367,521		probably null	Het
Fdxacb1	A	C	9: 50,772,087	H248P	possibly damaging	Het
Gnai1	A	T	5: 18,291,598	V109E	probably benign	Het
Helz2	A	T	2: 181,230,757		probably null	Het
Itgam	T	C	7: 128,116,317		probably null	Het
Kcnh1	A	G	1: 192,505,528	S766G	probably benign	Het
Klra1	C	A	6: 130,375,278	C167F	probably damaging	Het
Krtap9-3	T	A	11: 99,597,982	T25S	probably benign	Het
Mapk6	T	C	9: 75,388,344	Y624C	probably damaging	Het
Olfr1123	A	G	2: 87,418,843	Y263C	probably damaging	Het
Olfr1158	T	A	2: 87,990,763	Y217*	probably null	Het
Olfr1393	T	C	11: 49,280,382	V78A	probably damaging	Het
Olfr51	T	G	11: 51,007,554	I194S	probably damaging	Het
Olfr677	C	T	7: 105,056,453	S69L	probably damaging	Het
P3h2	A	G	16: 25,984,949	S356P	possibly damaging	Het
Pde12	C	T	14: 26,666,377		probably null	Het
Rln3	T	G	8: 84,043,237	K94N	probably damaging	Het
Skint5	T	C	4: 113,763,514	I668V	unknown	Het
Slitrk5	C	A	14: 111,679,420	Q159K	probably damaging	Het
Trim3	G	T	7: 105,619,509	N79K	probably damaging	Het
Tyw1	T	A	5: 130,267,915	C101*	probably null	Het
Ulk2	T	C	11: 61,781,711	T934A	probably benign	Het
Unc5b	T	C	10: 60,772,293	Y687C	probably benign	Het
Zfc3h1	T	G	10: 115,418,692	L1397R	probably damaging	Het
Zfp296	T	C	7: 19,577,407	V9A	probably benign	Het
Zfp423	T	A	8: 87,782,463	S397C	probably damaging	Het

Other mutations in Vmn1r195

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01751:Vmn1r195	APN	13	22279251	missense	probably benign	0.45
IGL01752:Vmn1r195	APN	13	22279251	missense	probably benign	0.45
IGL01780:Vmn1r195	APN	13	22279085	missense	probably benign	0.34
PIT4812001:Vmn1r195	UTSW	13	22278863	missense	probably benign	0.22
R0066:Vmn1r195	UTSW	13	22279239	missense	possibly damaging	0.94
R0066:Vmn1r195	UTSW	13	22279239	missense	possibly damaging	0.94
R0350:Vmn1r195	UTSW	13	22279233	missense	probably damaging	0.99
R0639:Vmn1r195	UTSW	13	22278941	missense	probably damaging	1.00
R0751:Vmn1r195	UTSW	13	22279011	missense	probably damaging	1.00
R1184:Vmn1r195	UTSW	13	22279011	missense	probably damaging	1.00
R1464:Vmn1r195	UTSW	13	22279178	missense	probably benign	0.01
R1464:Vmn1r195	UTSW	13	22279178	missense	probably benign	0.01
R1999:Vmn1r195	UTSW	13	22278764	missense	possibly damaging	0.83
R2150:Vmn1r195	UTSW	13	22278764	missense	possibly damaging	0.83
R4924:Vmn1r195	UTSW	13	22279019	missense	probably benign	0.03
R5522:Vmn1r195	UTSW	13	22278950	missense	probably damaging	1.00
R5621:Vmn1r195	UTSW	13	22278389	missense	probably benign	0.01
R6509:Vmn1r195	UTSW	13	22279109	missense	probably benign	0.45
R7288:Vmn1r195	UTSW	13	22279004	missense	probably damaging	1.00
R7291:Vmn1r195	UTSW	13	22278749	missense	probably damaging	1.00
R7428:Vmn1r195	UTSW	13	22278852	missense	probably benign	0.01
R7810:Vmn1r195	UTSW	13	22279074	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGCAAAGAATTCAATCAGGTGCATG -3'
(R):5'- TTTTACAGCCTGCAATGCCCAG -3'

Sequencing Primer
(F):5'- GTGCATGCTGTAAAAGAACCATGTAC -3'
(R):5'- GTGGCTACATATCTGATCCCCGAAG -3'

Posted On

2016-07-06