Incidental Mutation 'R6173:Olfr1388'
ID489148
Institutional Source Beutler Lab
Gene Symbol Olfr1388
Ensembl Gene ENSMUSG00000047702
Gene Nameolfactory receptor 1388
SynonymsGA_x6K02T2QP88-5991012-5990077, MOR256-28
MMRRC Submission 044316-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.077) question?
Stock #R6173 (G1)
Quality Score225.009
Status Validated
Chromosome11
Chromosomal Location49436624-49446103 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 49444472 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 207 (V207A)
Ref Sequence ENSEMBL: ENSMUSP00000150160 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055584] [ENSMUST00000215226]
Predicted Effect probably benign
Transcript: ENSMUST00000055584
AA Change: V207A

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000053834
Gene: ENSMUSG00000047702
AA Change: V207A

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 3.7e-46 PFAM
Pfam:7TM_GPCR_Srsx 35 154 9.8e-7 PFAM
Pfam:7tm_1 41 289 7.6e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215226
AA Change: V207A

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.2%
Validation Efficiency 96% (52/54)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410141K09Rik T A 13: 66,431,549 T292S probably benign Het
Ank2 T C 3: 127,052,746 D219G probably damaging Het
Arap2 A T 5: 62,749,622 I18N probably damaging Het
Baz1b T C 5: 135,242,507 S1315P probably benign Het
Bbs7 A T 3: 36,592,374 C432* probably null Het
Bend3 A G 10: 43,509,868 T86A probably benign Het
Cadm2 C T 16: 66,882,841 V35I probably benign Het
Ch25h A G 19: 34,474,496 S211P probably damaging Het
Chd5 A T 4: 152,379,391 H1476L probably damaging Het
Chia1 T C 3: 106,129,022 probably null Het
Clpx C A 9: 65,301,879 S92* probably null Het
Dazl A T 17: 50,287,571 M152K probably benign Het
Dnah17 A G 11: 118,039,946 S3748P probably damaging Het
Dock2 T C 11: 34,262,388 K1251R probably null Het
Esr1 T C 10: 4,746,760 V203A probably damaging Het
F830045P16Rik A G 2: 129,463,668 I262T probably damaging Het
Foxp1 G A 6: 99,015,510 Q41* probably null Het
Foxp1 C A 6: 99,015,514 probably null Het
Fshb T C 2: 107,057,293 E127G possibly damaging Het
Galk2 A G 2: 125,859,217 probably benign Het
Gid4 A G 11: 60,432,415 D111G probably damaging Het
Gm14412 G A 2: 177,314,537 P522S probably damaging Het
K230010J24Rik A G 15: 76,045,388 E290G probably damaging Het
Mfap4 A G 11: 61,485,419 probably null Het
Mfsd2a A G 4: 122,951,246 V224A probably benign Het
Mocos A T 18: 24,676,582 Y414F probably benign Het
Mrto4 T C 4: 139,350,444 I27V probably benign Het
Muc4 A G 16: 32,736,140 probably benign Het
Mug1 T A 6: 121,863,793 I534N probably damaging Het
Mup20 A T 4: 62,054,030 L7Q unknown Het
Nlrp2 T C 7: 5,337,809 E2G probably damaging Het
Olfr1346 C T 7: 6,474,836 A242V probably damaging Het
Olfr360 A G 2: 37,069,079 Y258C possibly damaging Het
Olfr738 A G 14: 50,414,197 I218V possibly damaging Het
Parn T C 16: 13,651,811 T209A possibly damaging Het
Psip1 T A 4: 83,473,049 probably null Het
Ptprc A C 1: 138,067,890 C1157G probably damaging Het
Rad17 A C 13: 100,622,881 V546G probably benign Het
Rc3h2 GCC GCCC 2: 37,414,733 probably null Het
Safb A G 17: 56,597,798 E124G probably damaging Het
Sart3 C T 5: 113,743,206 A938T probably benign Het
Skint5 T C 4: 113,535,710 T1242A unknown Het
Slc13a5 C T 11: 72,253,197 E352K probably benign Het
Sohlh2 G T 3: 55,196,998 V263F probably benign Het
Strn A G 17: 78,700,869 Y107H probably damaging Het
Tbx15 G T 3: 99,253,887 E3* probably null Het
Tespa1 A G 10: 130,347,303 D39G probably benign Het
Trp73 A T 4: 154,104,341 D54E probably damaging Het
Ttll5 A T 12: 85,933,377 S912C probably damaging Het
Utp14b A T 1: 78,665,837 D484V probably benign Het
Utp14b A C 1: 78,665,840 N485T probably benign Het
Vmn2r29 T C 7: 7,231,370 E839G probably benign Het
Vmn2r6 G C 3: 64,559,755 P108A probably damaging Het
Vps8 T G 16: 21,495,932 probably null Het
Zfp36l1 A T 12: 80,109,546 probably null Het
Zp3r A T 1: 130,591,568 probably null Het
Other mutations in Olfr1388
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01015:Olfr1388 APN 11 49444374 missense probably damaging 1.00
IGL01346:Olfr1388 APN 11 49444768 missense probably benign 0.00
IGL01943:Olfr1388 APN 11 49444188 nonsense probably null
IGL03343:Olfr1388 APN 11 49444243 missense probably damaging 0.97
R1530:Olfr1388 UTSW 11 49443905 missense probably benign 0.27
R1699:Olfr1388 UTSW 11 49444289 missense possibly damaging 0.88
R2059:Olfr1388 UTSW 11 49444451 missense probably damaging 0.99
R2198:Olfr1388 UTSW 11 49443959 missense probably benign 0.01
R4782:Olfr1388 UTSW 11 49443869 missense probably benign 0.00
R4885:Olfr1388 UTSW 11 49444622 missense probably damaging 0.97
R4966:Olfr1388 UTSW 11 49444118 missense possibly damaging 0.94
R5165:Olfr1388 UTSW 11 49444376 missense probably damaging 1.00
R5173:Olfr1388 UTSW 11 49443886 missense probably benign 0.12
R5667:Olfr1388 UTSW 11 49444313 missense probably benign 0.00
R5671:Olfr1388 UTSW 11 49444313 missense probably benign 0.00
R5836:Olfr1388 UTSW 11 49444526 missense probably damaging 1.00
R6801:Olfr1388 UTSW 11 49444342 missense probably benign 0.10
R6864:Olfr1388 UTSW 11 49443940 missense probably benign
R6876:Olfr1388 UTSW 11 49444241 missense probably damaging 1.00
R7386:Olfr1388 UTSW 11 49444400 missense possibly damaging 0.95
R8119:Olfr1388 UTSW 11 49444126 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTCATACACTGGCCATCTC -3'
(R):5'- AGGGCAACAAACTTTCCCTC -3'

Sequencing Primer
(F):5'- TGGCCATCTCCTCCTGGGTAG -3'
(R):5'- CCCTCACTTTCAGAATAGGTGTGAG -3'
Posted On2017-10-10