Mutagenetix > Incidental Mutation

Incidental Mutation 'R6630:Vmn2r24'

525049

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r24

Ensembl Gene

ENSMUSG00000072780

Gene Name

vomeronasal 2, receptor 24

Synonyms

EG243628

MMRRC Submission

044752-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

R6630 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

123755930-123793239 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 123763981 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 286 (I286N)

Ref Sequence

ENSEMBL: ENSMUSP00000074602 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075095]

AlphaFold

D3YUI0

Predicted Effect

probably benign
Transcript: ENSMUST00000075095
AA Change: I286N

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000074602
Gene: ENSMUSG00000072780
AA Change: I286N

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	1.6e-32	PFAM
Pfam:NCD3G	518	571	1.1e-22	PFAM
Pfam:7tm_3	602	839	1.1e-54	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 97.7%
20x: 92.7%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A4gnt	A	G	9: 99,495,971 (GRCm39)	T136A	probably benign	Het
Calb1	T	A	4: 15,885,637 (GRCm39)	D69E	probably benign	Het
Cecr2	A	T	6: 120,739,139 (GRCm39)	N1261Y	probably damaging	Het
Cemip2	A	G	19: 21,829,593 (GRCm39)	N1234S	probably damaging	Het
Cenpo	G	A	12: 4,267,236 (GRCm39)		probably benign	Het
Cep131	A	G	11: 119,964,641 (GRCm39)	W272R	probably damaging	Het
Cnr1	T	A	4: 33,944,659 (GRCm39)	I349N	probably damaging	Het
Dcst1	A	T	3: 89,271,633 (GRCm39)	I50K	possibly damaging	Het
Defa40	T	A	8: 21,739,904 (GRCm39)	S43T	probably damaging	Het
Dhh	C	T	15: 98,792,247 (GRCm39)	V254M	possibly damaging	Het
Dhrs9	G	T	2: 69,228,067 (GRCm39)	W227L	possibly damaging	Het
Heca	G	A	10: 17,783,856 (GRCm39)	R104*	probably null	Het
Irx4	G	T	13: 73,416,545 (GRCm39)	A314S	probably benign	Het
Map1s	T	C	8: 71,366,442 (GRCm39)	V449A	probably damaging	Het
Mapk1	A	G	16: 16,844,249 (GRCm39)	D7G	probably damaging	Het
Mapre3	G	T	5: 31,019,886 (GRCm39)	V56F	probably damaging	Het
Mepce	G	A	5: 137,783,183 (GRCm39)	T381I	probably benign	Het
Mga	T	A	2: 119,754,140 (GRCm39)	V804E	probably damaging	Het
Myh6	T	C	14: 55,179,458 (GRCm39)	K157E	probably benign	Het
Or1e33	T	A	11: 73,738,702 (GRCm39)	H83L	probably benign	Het
Palb2	A	T	7: 121,723,752 (GRCm39)	S303T	probably damaging	Het
Phc2	C	A	4: 128,617,423 (GRCm39)	P483Q	probably damaging	Het
Polr2a	A	G	11: 69,626,339 (GRCm39)	S1604P	possibly damaging	Het
Ppp4r3a	A	G	12: 101,016,035 (GRCm39)	L39S	probably damaging	Het
Samsn1	G	A	16: 75,676,092 (GRCm39)	A101V	probably benign	Het
Spata31h1	A	T	10: 82,122,906 (GRCm39)	M3368K	possibly damaging	Het
Trbv3	T	A	6: 41,025,506 (GRCm39)	I32K	possibly damaging	Het
Trpm3	A	T	19: 22,965,347 (GRCm39)	N1614I	probably benign	Het
Ubr2	T	C	17: 47,262,910 (GRCm39)	R1234G	possibly damaging	Het
Usp24	T	C	4: 106,245,032 (GRCm39)	S1291P	possibly damaging	Het
Vmn1r81	A	T	7: 11,994,584 (GRCm39)	L8*	probably null	Het

Other mutations in Vmn2r24

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00954:Vmn2r24	APN	6	123,792,596 (GRCm39)	missense	probably damaging	1.00
IGL01382:Vmn2r24	APN	6	123,763,938 (GRCm39)	missense	possibly damaging	0.62
IGL01592:Vmn2r24	APN	6	123,764,445 (GRCm39)	missense	probably benign	0.30
IGL01754:Vmn2r24	APN	6	123,781,120 (GRCm39)	missense	probably damaging	1.00
IGL01939:Vmn2r24	APN	6	123,764,404 (GRCm39)	missense	probably benign
IGL02140:Vmn2r24	APN	6	123,757,631 (GRCm39)	missense	probably damaging	0.98
IGL02272:Vmn2r24	APN	6	123,763,843 (GRCm39)	missense	possibly damaging	0.94
IGL02568:Vmn2r24	APN	6	123,792,812 (GRCm39)	missense	probably benign	0.36
IGL02748:Vmn2r24	APN	6	123,793,057 (GRCm39)	missense	possibly damaging	0.90
IGL03022:Vmn2r24	APN	6	123,755,967 (GRCm39)	missense	probably damaging	0.99
IGL03343:Vmn2r24	APN	6	123,793,070 (GRCm39)	missense	probably damaging	1.00
R0357:Vmn2r24	UTSW	6	123,792,369 (GRCm39)	frame shift	probably null
R0453:Vmn2r24	UTSW	6	123,757,350 (GRCm39)	critical splice acceptor site	probably null
R0538:Vmn2r24	UTSW	6	123,793,012 (GRCm39)	missense	probably benign	0.32
R0607:Vmn2r24	UTSW	6	123,763,893 (GRCm39)	missense	probably benign
R1381:Vmn2r24	UTSW	6	123,763,692 (GRCm39)	missense	probably damaging	1.00
R1589:Vmn2r24	UTSW	6	123,783,479 (GRCm39)	splice site	probably benign
R1848:Vmn2r24	UTSW	6	123,793,183 (GRCm39)	missense	probably damaging	1.00
R2035:Vmn2r24	UTSW	6	123,793,019 (GRCm39)	missense	probably damaging	1.00
R2077:Vmn2r24	UTSW	6	123,792,358 (GRCm39)	missense	probably damaging	1.00
R2122:Vmn2r24	UTSW	6	123,792,353 (GRCm39)	missense	possibly damaging	0.81
R2145:Vmn2r24	UTSW	6	123,755,972 (GRCm39)	missense	probably benign
R2483:Vmn2r24	UTSW	6	123,792,997 (GRCm39)	missense	probably damaging	1.00
R2512:Vmn2r24	UTSW	6	123,763,985 (GRCm39)	missense	probably benign	0.01
R3001:Vmn2r24	UTSW	6	123,781,231 (GRCm39)	missense	probably benign	0.00
R3002:Vmn2r24	UTSW	6	123,781,231 (GRCm39)	missense	probably benign	0.00
R3236:Vmn2r24	UTSW	6	123,755,984 (GRCm39)	nonsense	probably null
R3623:Vmn2r24	UTSW	6	123,792,997 (GRCm39)	missense	probably damaging	1.00
R3624:Vmn2r24	UTSW	6	123,792,997 (GRCm39)	missense	probably damaging	1.00
R3835:Vmn2r24	UTSW	6	123,764,412 (GRCm39)	missense	probably benign	0.33
R4074:Vmn2r24	UTSW	6	123,764,374 (GRCm39)	missense	possibly damaging	0.92
R4075:Vmn2r24	UTSW	6	123,764,374 (GRCm39)	missense	possibly damaging	0.92
R4812:Vmn2r24	UTSW	6	123,756,144 (GRCm39)	missense	probably benign	0.00
R4825:Vmn2r24	UTSW	6	123,792,739 (GRCm39)	missense	probably benign	0.02
R5351:Vmn2r24	UTSW	6	123,793,223 (GRCm39)	missense	possibly damaging	0.80
R5665:Vmn2r24	UTSW	6	123,763,938 (GRCm39)	missense	possibly damaging	0.62
R5790:Vmn2r24	UTSW	6	123,792,499 (GRCm39)	missense	probably benign
R5808:Vmn2r24	UTSW	6	123,792,597 (GRCm39)	nonsense	probably null
R5879:Vmn2r24	UTSW	6	123,764,226 (GRCm39)	missense	possibly damaging	0.89
R5923:Vmn2r24	UTSW	6	123,792,751 (GRCm39)	missense	probably damaging	0.96
R5969:Vmn2r24	UTSW	6	123,755,981 (GRCm39)	missense	probably benign	0.00
R6050:Vmn2r24	UTSW	6	123,792,691 (GRCm39)	missense	probably damaging	1.00
R6171:Vmn2r24	UTSW	6	123,764,205 (GRCm39)	missense	probably damaging	0.98
R6174:Vmn2r24	UTSW	6	123,793,236 (GRCm39)	missense	probably benign	0.00
R6356:Vmn2r24	UTSW	6	123,783,368 (GRCm39)	missense	possibly damaging	0.93
R6562:Vmn2r24	UTSW	6	123,757,386 (GRCm39)	missense	probably benign	0.01
R6563:Vmn2r24	UTSW	6	123,781,137 (GRCm39)	missense	possibly damaging	0.86
R6584:Vmn2r24	UTSW	6	123,792,764 (GRCm39)	missense	possibly damaging	0.53
R6803:Vmn2r24	UTSW	6	123,755,960 (GRCm39)	missense	possibly damaging	0.64
R6864:Vmn2r24	UTSW	6	123,756,117 (GRCm39)	missense	possibly damaging	0.89
R7252:Vmn2r24	UTSW	6	123,764,191 (GRCm39)	missense	possibly damaging	0.90
R7369:Vmn2r24	UTSW	6	123,792,638 (GRCm39)	missense	probably damaging	0.99
R7646:Vmn2r24	UTSW	6	123,793,169 (GRCm39)	missense	probably benign	0.20
R7799:Vmn2r24	UTSW	6	123,757,422 (GRCm39)	missense	probably benign	0.00
R7803:Vmn2r24	UTSW	6	123,757,438 (GRCm39)	missense	probably benign	0.00
R7959:Vmn2r24	UTSW	6	123,755,949 (GRCm39)	missense	possibly damaging	0.86
R8215:Vmn2r24	UTSW	6	123,756,077 (GRCm39)	missense	probably benign	0.10
R8796:Vmn2r24	UTSW	6	123,757,500 (GRCm39)	missense	probably benign
R9172:Vmn2r24	UTSW	6	123,783,432 (GRCm39)	missense	probably damaging	1.00
R9300:Vmn2r24	UTSW	6	123,793,030 (GRCm39)	missense	possibly damaging	0.46
R9369:Vmn2r24	UTSW	6	123,792,357 (GRCm39)	missense	probably damaging	1.00
R9375:Vmn2r24	UTSW	6	123,792,542 (GRCm39)	missense	probably damaging	1.00
R9523:Vmn2r24	UTSW	6	123,763,950 (GRCm39)	missense	possibly damaging	0.89
R9546:Vmn2r24	UTSW	6	123,764,266 (GRCm39)	missense	probably damaging	0.98
RF006:Vmn2r24	UTSW	6	123,783,378 (GRCm39)	missense	probably damaging	1.00
RF016:Vmn2r24	UTSW	6	123,781,174 (GRCm39)	missense	probably benign	0.04
X0023:Vmn2r24	UTSW	6	123,764,359 (GRCm39)	missense	probably damaging	0.99
Z1088:Vmn2r24	UTSW	6	123,781,155 (GRCm39)	missense	probably benign	0.00
Z1177:Vmn2r24	UTSW	6	123,763,719 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TCTTCCTTAGGGACATCACAGAG -3'
(R):5'- ATGGACCACACATCCTGGATAAAG -3'

Sequencing Primer
(F):5'- GGAGATGACAAATCATGGACTTTGTG -3'
(R):5'- GGTTGAACACTTCTGAGAAAATCC -3'

Posted On

2018-06-22