Incidental Mutation 'R3236:Vmn2r24'
| ID |
259028 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r24
|
| Ensembl Gene |
ENSMUSG00000072780 |
| Gene Name |
vomeronasal 2, receptor 24 |
| Synonyms |
EG243628 |
| MMRRC Submission |
040618-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
R3236 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
123755930-123793239 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to T
at 123755984 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 19
(Q19*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000074602
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000075095]
|
| AlphaFold |
D3YUI0 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000075095
AA Change: Q19*
|
| SMART Domains |
Protein: ENSMUSP00000074602
Gene: ENSMUSG00000072780
AA Change: Q19*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
469 |
1.6e-32 |
PFAM |
|
Pfam:NCD3G
|
518 |
571 |
1.1e-22 |
PFAM |
|
Pfam:7tm_3
|
602 |
839 |
1.1e-54 |
PFAM |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 97.1%
- 20x: 94.4%
|
| Validation Efficiency |
98% (64/65) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 63 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700049A03Rik |
G |
T |
12: 71,211,320 (GRCm39) |
E685* |
probably null |
Het |
| 2700049A03Rik |
A |
T |
12: 71,211,321 (GRCm39) |
E685V |
possibly damaging |
Het |
| 5730455P16Rik |
G |
A |
11: 80,258,996 (GRCm39) |
L255F |
probably damaging |
Het |
| Aff2 |
T |
A |
X: 68,907,543 (GRCm39) |
V1175E |
possibly damaging |
Het |
| Agbl3 |
A |
G |
6: 34,800,022 (GRCm39) |
|
probably null |
Het |
| Armh3 |
A |
T |
19: 45,963,722 (GRCm39) |
|
probably benign |
Het |
| Atm |
T |
A |
9: 53,391,048 (GRCm39) |
D1842V |
probably benign |
Het |
| Bcar3 |
C |
A |
3: 122,318,645 (GRCm39) |
Q678K |
probably benign |
Het |
| Ccdc88a |
A |
G |
11: 29,397,995 (GRCm39) |
T243A |
possibly damaging |
Het |
| Col5a3 |
G |
T |
9: 20,718,949 (GRCm39) |
N268K |
unknown |
Het |
| Col6a1 |
G |
A |
10: 76,547,154 (GRCm39) |
T737M |
unknown |
Het |
| Cyp3a25 |
T |
C |
5: 145,939,938 (GRCm39) |
|
probably benign |
Het |
| Dnah17 |
T |
C |
11: 117,985,680 (GRCm39) |
T1466A |
probably benign |
Het |
| Dnah9 |
G |
A |
11: 65,845,815 (GRCm39) |
T3023I |
probably benign |
Het |
| Ecm1 |
G |
T |
3: 95,642,158 (GRCm39) |
Q476K |
possibly damaging |
Het |
| Eml6 |
A |
G |
11: 29,781,097 (GRCm39) |
|
probably null |
Het |
| Fbh1 |
T |
C |
2: 11,774,637 (GRCm39) |
D36G |
probably damaging |
Het |
| Fyb1 |
A |
C |
15: 6,659,597 (GRCm39) |
D434A |
probably damaging |
Het |
| Gm5478 |
A |
G |
15: 101,552,738 (GRCm39) |
Y398H |
probably damaging |
Het |
| H2-Q6 |
C |
A |
17: 35,644,676 (GRCm39) |
T155K |
probably damaging |
Het |
| Hk1 |
T |
C |
10: 62,131,798 (GRCm39) |
|
probably null |
Het |
| Kdm6b |
A |
G |
11: 69,297,192 (GRCm39) |
Y387H |
probably damaging |
Het |
| Lipn |
A |
G |
19: 34,046,138 (GRCm39) |
N37S |
probably benign |
Het |
| Lrig3 |
G |
A |
10: 125,833,056 (GRCm39) |
C310Y |
probably damaging |
Het |
| Map6 |
T |
A |
7: 98,986,031 (GRCm39) |
V645E |
probably damaging |
Het |
| Memo1 |
A |
T |
17: 74,509,347 (GRCm39) |
I224K |
probably damaging |
Het |
| Morc2a |
T |
C |
11: 3,633,612 (GRCm39) |
I602T |
probably benign |
Het |
| N4bp3 |
A |
T |
11: 51,536,761 (GRCm39) |
F104Y |
probably damaging |
Het |
| Ndrg3 |
T |
A |
2: 156,785,957 (GRCm39) |
I161F |
probably damaging |
Het |
| Notch3 |
T |
C |
17: 32,377,435 (GRCm39) |
R214G |
probably damaging |
Het |
| Obscn |
T |
C |
11: 59,022,472 (GRCm39) |
R758G |
possibly damaging |
Het |
| Or14j10 |
T |
C |
17: 37,935,127 (GRCm39) |
E133G |
possibly damaging |
Het |
| Or4p7 |
T |
C |
2: 88,221,750 (GRCm39) |
I53T |
probably benign |
Het |
| Pdgfra |
T |
C |
5: 75,328,597 (GRCm39) |
V243A |
probably damaging |
Het |
| Piwil4 |
A |
G |
9: 14,611,544 (GRCm39) |
|
probably benign |
Het |
| Plxna2 |
C |
T |
1: 194,431,625 (GRCm39) |
S538F |
probably damaging |
Het |
| Pon2 |
A |
T |
6: 5,266,986 (GRCm39) |
N252K |
possibly damaging |
Het |
| Ptf1a |
T |
C |
2: 19,450,718 (GRCm39) |
F16S |
probably damaging |
Het |
| Rasgrp1 |
A |
G |
2: 117,122,293 (GRCm39) |
Y366H |
probably benign |
Het |
| Rbfox1 |
G |
A |
16: 7,225,892 (GRCm39) |
V353I |
possibly damaging |
Het |
| Rrh |
T |
C |
3: 129,605,360 (GRCm39) |
Y110C |
probably damaging |
Het |
| Rufy4 |
T |
C |
1: 74,186,822 (GRCm39) |
C537R |
probably damaging |
Het |
| Scaf4 |
T |
A |
16: 90,057,105 (GRCm39) |
D82V |
unknown |
Het |
| Serhl |
C |
A |
15: 82,988,604 (GRCm39) |
P177Q |
probably damaging |
Het |
| Setdb1 |
A |
G |
3: 95,246,065 (GRCm39) |
V619A |
probably damaging |
Het |
| Sf3b3 |
A |
G |
8: 111,538,652 (GRCm39) |
S1123P |
probably damaging |
Het |
| Slc1a3 |
T |
C |
15: 8,668,607 (GRCm39) |
I453V |
probably damaging |
Het |
| Slf2 |
A |
G |
19: 44,930,773 (GRCm39) |
I617V |
probably benign |
Het |
| Snrnp200 |
T |
A |
2: 127,063,802 (GRCm39) |
D660E |
probably damaging |
Het |
| Spata22 |
T |
A |
11: 73,236,713 (GRCm39) |
F340I |
probably damaging |
Het |
| Speer4e1 |
T |
A |
5: 14,984,939 (GRCm39) |
E206D |
possibly damaging |
Het |
| Stard6 |
T |
A |
18: 70,633,557 (GRCm39) |
M188K |
probably damaging |
Het |
| Stat6 |
G |
A |
10: 127,488,091 (GRCm39) |
V282I |
possibly damaging |
Het |
| Supt20 |
T |
C |
3: 54,616,501 (GRCm39) |
S253P |
possibly damaging |
Het |
| Szt2 |
A |
C |
4: 118,240,231 (GRCm39) |
|
probably null |
Het |
| Thsd4 |
C |
A |
9: 60,301,670 (GRCm39) |
K208N |
probably benign |
Het |
| Thsd7b |
C |
T |
1: 130,145,855 (GRCm39) |
Q1588* |
probably null |
Het |
| Tmem167 |
C |
T |
13: 90,252,499 (GRCm39) |
R52C |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,729,753 (GRCm39) |
|
probably benign |
Het |
| Usp39 |
G |
A |
6: 72,315,372 (GRCm39) |
|
probably benign |
Het |
| Vmn2r112 |
T |
A |
17: 22,822,096 (GRCm39) |
V258E |
probably damaging |
Het |
| Vps13b |
G |
A |
15: 35,910,450 (GRCm39) |
E3405K |
probably benign |
Het |
| Zgrf1 |
A |
G |
3: 127,407,024 (GRCm39) |
D1597G |
probably damaging |
Het |
|
| Other mutations in Vmn2r24 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00954:Vmn2r24
|
APN |
6 |
123,792,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01382:Vmn2r24
|
APN |
6 |
123,763,938 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
IGL01592:Vmn2r24
|
APN |
6 |
123,764,445 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL01754:Vmn2r24
|
APN |
6 |
123,781,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01939:Vmn2r24
|
APN |
6 |
123,764,404 (GRCm39) |
missense |
probably benign |
|
|
IGL02140:Vmn2r24
|
APN |
6 |
123,757,631 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02272:Vmn2r24
|
APN |
6 |
123,763,843 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02568:Vmn2r24
|
APN |
6 |
123,792,812 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL02748:Vmn2r24
|
APN |
6 |
123,793,057 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03022:Vmn2r24
|
APN |
6 |
123,755,967 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03343:Vmn2r24
|
APN |
6 |
123,793,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0357:Vmn2r24
|
UTSW |
6 |
123,792,369 (GRCm39) |
frame shift |
probably null |
|
|
R0453:Vmn2r24
|
UTSW |
6 |
123,757,350 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0538:Vmn2r24
|
UTSW |
6 |
123,793,012 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0607:Vmn2r24
|
UTSW |
6 |
123,763,893 (GRCm39) |
missense |
probably benign |
|
|
R1381:Vmn2r24
|
UTSW |
6 |
123,763,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1589:Vmn2r24
|
UTSW |
6 |
123,783,479 (GRCm39) |
splice site |
probably benign |
|
|
R1848:Vmn2r24
|
UTSW |
6 |
123,793,183 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2035:Vmn2r24
|
UTSW |
6 |
123,793,019 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2077:Vmn2r24
|
UTSW |
6 |
123,792,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2122:Vmn2r24
|
UTSW |
6 |
123,792,353 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R2145:Vmn2r24
|
UTSW |
6 |
123,755,972 (GRCm39) |
missense |
probably benign |
|
|
R2483:Vmn2r24
|
UTSW |
6 |
123,792,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2512:Vmn2r24
|
UTSW |
6 |
123,763,985 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3001:Vmn2r24
|
UTSW |
6 |
123,781,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3002:Vmn2r24
|
UTSW |
6 |
123,781,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3623:Vmn2r24
|
UTSW |
6 |
123,792,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3624:Vmn2r24
|
UTSW |
6 |
123,792,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3835:Vmn2r24
|
UTSW |
6 |
123,764,412 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4074:Vmn2r24
|
UTSW |
6 |
123,764,374 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4075:Vmn2r24
|
UTSW |
6 |
123,764,374 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4812:Vmn2r24
|
UTSW |
6 |
123,756,144 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4825:Vmn2r24
|
UTSW |
6 |
123,792,739 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5351:Vmn2r24
|
UTSW |
6 |
123,793,223 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5665:Vmn2r24
|
UTSW |
6 |
123,763,938 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R5790:Vmn2r24
|
UTSW |
6 |
123,792,499 (GRCm39) |
missense |
probably benign |
|
|
R5808:Vmn2r24
|
UTSW |
6 |
123,792,597 (GRCm39) |
nonsense |
probably null |
|
|
R5879:Vmn2r24
|
UTSW |
6 |
123,764,226 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5923:Vmn2r24
|
UTSW |
6 |
123,792,751 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5969:Vmn2r24
|
UTSW |
6 |
123,755,981 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6050:Vmn2r24
|
UTSW |
6 |
123,792,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6171:Vmn2r24
|
UTSW |
6 |
123,764,205 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6174:Vmn2r24
|
UTSW |
6 |
123,793,236 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6356:Vmn2r24
|
UTSW |
6 |
123,783,368 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6562:Vmn2r24
|
UTSW |
6 |
123,757,386 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6563:Vmn2r24
|
UTSW |
6 |
123,781,137 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6584:Vmn2r24
|
UTSW |
6 |
123,792,764 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6630:Vmn2r24
|
UTSW |
6 |
123,763,981 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6803:Vmn2r24
|
UTSW |
6 |
123,755,960 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6864:Vmn2r24
|
UTSW |
6 |
123,756,117 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7252:Vmn2r24
|
UTSW |
6 |
123,764,191 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7369:Vmn2r24
|
UTSW |
6 |
123,792,638 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7646:Vmn2r24
|
UTSW |
6 |
123,793,169 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7799:Vmn2r24
|
UTSW |
6 |
123,757,422 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7803:Vmn2r24
|
UTSW |
6 |
123,757,438 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7959:Vmn2r24
|
UTSW |
6 |
123,755,949 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8215:Vmn2r24
|
UTSW |
6 |
123,756,077 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8796:Vmn2r24
|
UTSW |
6 |
123,757,500 (GRCm39) |
missense |
probably benign |
|
|
R9172:Vmn2r24
|
UTSW |
6 |
123,783,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9300:Vmn2r24
|
UTSW |
6 |
123,793,030 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9369:Vmn2r24
|
UTSW |
6 |
123,792,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9375:Vmn2r24
|
UTSW |
6 |
123,792,542 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9523:Vmn2r24
|
UTSW |
6 |
123,763,950 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9546:Vmn2r24
|
UTSW |
6 |
123,764,266 (GRCm39) |
missense |
probably damaging |
0.98 |
|
RF006:Vmn2r24
|
UTSW |
6 |
123,783,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF016:Vmn2r24
|
UTSW |
6 |
123,781,174 (GRCm39) |
missense |
probably benign |
0.04 |
|
X0023:Vmn2r24
|
UTSW |
6 |
123,764,359 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Vmn2r24
|
UTSW |
6 |
123,781,155 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Vmn2r24
|
UTSW |
6 |
123,763,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TACTGGTGGGCATGGATCAG -3'
(R):5'- TAGAGAAGCCAAGCACTTACACATG -3'
Sequencing Primer
(F):5'- TATAATCTCATCCTTACTGACCAGAC -3'
(R):5'- TGAACAACATCCAGTGTATCCG -3'
|
| Posted On |
2015-01-23 |
Incidental Mutation