Incidental Mutation 'R7646:Vmn2r24'
| ID |
590529 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r24
|
| Ensembl Gene |
ENSMUSG00000072780 |
| Gene Name |
vomeronasal 2, receptor 24 |
| Synonyms |
EG243628 |
| MMRRC Submission |
045724-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
R7646 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
123755930-123793239 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 123793169 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 832
(M832K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000074602
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000075095]
|
| AlphaFold |
D3YUI0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000075095
AA Change: M832K
PolyPhen 2
Score 0.196 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000074602
Gene: ENSMUSG00000072780
AA Change: M832K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
469 |
1.6e-32 |
PFAM |
|
Pfam:NCD3G
|
518 |
571 |
1.1e-22 |
PFAM |
|
Pfam:7tm_3
|
602 |
839 |
1.1e-54 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.9%
|
| Validation Efficiency |
100% (64/64) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 64 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca16 |
A |
G |
7: 120,113,937 (GRCm39) |
H936R |
probably benign |
Het |
| Afg3l1 |
C |
A |
8: 124,219,766 (GRCm39) |
D431E |
possibly damaging |
Het |
| Agrn |
T |
C |
4: 156,279,811 (GRCm39) |
N120S |
probably damaging |
Het |
| Apob |
A |
G |
12: 8,059,189 (GRCm39) |
D2557G |
probably damaging |
Het |
| Atl2 |
A |
G |
17: 80,162,036 (GRCm39) |
Y359H |
probably damaging |
Het |
| Banp |
T |
C |
8: 122,750,775 (GRCm39) |
S489P |
possibly damaging |
Het |
| Cage1 |
A |
G |
13: 38,206,823 (GRCm39) |
C341R |
probably damaging |
Het |
| Cdh23 |
T |
C |
10: 60,140,931 (GRCm39) |
N3139S |
possibly damaging |
Het |
| Chd2 |
G |
T |
7: 73,085,521 (GRCm39) |
S1704R |
possibly damaging |
Het |
| Col4a2 |
T |
A |
8: 11,495,086 (GRCm39) |
F1515I |
probably benign |
Het |
| Crocc |
T |
A |
4: 140,748,966 (GRCm39) |
Q1613L |
probably null |
Het |
| Cttnbp2 |
A |
T |
6: 18,375,939 (GRCm39) |
S1533R |
probably damaging |
Het |
| Dlgap5 |
C |
T |
14: 47,636,976 (GRCm39) |
|
probably null |
Het |
| Dnah8 |
G |
A |
17: 30,868,651 (GRCm39) |
D362N |
probably benign |
Het |
| Elf5 |
G |
T |
2: 103,269,588 (GRCm39) |
K56N |
probably benign |
Het |
| Emsy |
G |
A |
7: 98,268,560 (GRCm39) |
P508S |
probably damaging |
Het |
| Fam135a |
T |
C |
1: 24,067,704 (GRCm39) |
H1055R |
probably benign |
Het |
| Fh1 |
C |
T |
1: 175,442,479 (GRCm39) |
V124I |
probably benign |
Het |
| Gbf1 |
T |
A |
19: 46,272,111 (GRCm39) |
D1610E |
probably damaging |
Het |
| Glp1r |
A |
G |
17: 31,155,257 (GRCm39) |
K415E |
probably benign |
Het |
| Glyr1 |
T |
C |
16: 4,836,361 (GRCm39) |
D496G |
probably damaging |
Het |
| Herc2 |
A |
G |
7: 55,784,361 (GRCm39) |
I1342V |
probably benign |
Het |
| Hoxa7 |
A |
G |
6: 52,192,699 (GRCm39) |
*230Q |
probably null |
Het |
| Ice1 |
A |
G |
13: 70,737,916 (GRCm39) |
V2177A |
possibly damaging |
Het |
| Ildr1 |
T |
A |
16: 36,542,281 (GRCm39) |
M271K |
possibly damaging |
Het |
| Klk1b22 |
T |
G |
7: 43,765,542 (GRCm39) |
|
probably null |
Het |
| Lig3 |
T |
A |
11: 82,674,304 (GRCm39) |
N43K |
probably benign |
Het |
| Mcmdc2 |
A |
G |
1: 9,982,360 (GRCm39) |
T83A |
possibly damaging |
Het |
| Megf10 |
GGCAGCAACAGCACCAGCAGCAACAGCACCAGCAGCA |
GGCAGCAACAGCACCAGCAGCA |
18: 57,427,071 (GRCm39) |
|
probably benign |
Het |
| Mki67 |
A |
T |
7: 135,298,498 (GRCm39) |
S2179T |
possibly damaging |
Het |
| Mrpl38 |
G |
A |
11: 116,023,593 (GRCm39) |
S282L |
probably damaging |
Het |
| Ndst2 |
A |
G |
14: 20,774,527 (GRCm39) |
|
probably null |
Het |
| Nlrp4a |
C |
G |
7: 26,148,987 (GRCm39) |
A198G |
probably damaging |
Het |
| Nup98 |
A |
C |
7: 101,803,242 (GRCm39) |
S653A |
probably benign |
Het |
| Or12e8 |
A |
G |
2: 87,188,102 (GRCm39) |
I105V |
probably benign |
Het |
| Or13a27 |
A |
G |
7: 139,925,864 (GRCm39) |
F13L |
probably damaging |
Het |
| Or14j10 |
G |
T |
17: 37,935,295 (GRCm39) |
T77K |
probably damaging |
Het |
| Or51ai2 |
G |
A |
7: 103,587,504 (GRCm39) |
A306T |
probably damaging |
Het |
| Or8k37 |
C |
A |
2: 86,469,513 (GRCm39) |
D180Y |
probably damaging |
Het |
| Pclo |
A |
T |
5: 14,570,909 (GRCm39) |
D98V |
probably damaging |
Het |
| Peg3 |
A |
T |
7: 6,712,221 (GRCm39) |
D1000E |
probably benign |
Het |
| Polr3h |
A |
G |
15: 81,801,571 (GRCm39) |
Y131H |
probably damaging |
Het |
| Rapgef6 |
A |
G |
11: 54,516,780 (GRCm39) |
I346V |
probably benign |
Het |
| Rufy1 |
T |
A |
11: 50,301,436 (GRCm39) |
K332M |
probably damaging |
Het |
| Scn1a |
T |
C |
2: 66,118,102 (GRCm39) |
M404V |
possibly damaging |
Het |
| Septin8 |
T |
A |
11: 53,428,744 (GRCm39) |
|
probably null |
Het |
| Sesn3 |
A |
G |
9: 14,219,911 (GRCm39) |
D100G |
probably damaging |
Het |
| Setx |
A |
G |
2: 29,067,561 (GRCm39) |
I2388V |
possibly damaging |
Het |
| Skint5 |
T |
A |
4: 113,620,739 (GRCm39) |
|
probably null |
Het |
| Slc25a23 |
C |
T |
17: 57,366,759 (GRCm39) |
|
probably benign |
Het |
| Slc4a7 |
G |
A |
14: 14,773,348 (GRCm38) |
E773K |
probably benign |
Het |
| Slco3a1 |
G |
A |
7: 74,154,344 (GRCm39) |
A76V |
probably damaging |
Het |
| Stradb |
A |
T |
1: 59,033,567 (GRCm39) |
D410V |
probably benign |
Het |
| Syne1 |
T |
C |
10: 5,122,949 (GRCm39) |
D329G |
probably damaging |
Het |
| Syt4 |
A |
C |
18: 31,574,658 (GRCm39) |
S320A |
possibly damaging |
Het |
| Tnfsf4 |
A |
G |
1: 161,244,733 (GRCm39) |
T141A |
possibly damaging |
Het |
| Trim34b |
G |
A |
7: 103,984,559 (GRCm39) |
A279T |
probably damaging |
Het |
| Trpm6 |
A |
T |
19: 18,845,325 (GRCm39) |
D1675V |
probably benign |
Het |
| Wdr90 |
A |
G |
17: 26,079,104 (GRCm39) |
V246A |
probably benign |
Het |
| Xkr6 |
G |
T |
14: 63,844,423 (GRCm39) |
D149Y |
probably damaging |
Het |
| Zfp108 |
A |
G |
7: 23,960,840 (GRCm39) |
Y477C |
probably damaging |
Het |
| Zfp37 |
T |
G |
4: 62,109,532 (GRCm39) |
I552L |
probably damaging |
Het |
| Zfp426 |
A |
T |
9: 20,381,320 (GRCm39) |
S556T |
probably damaging |
Het |
| Zfp954 |
G |
A |
7: 7,118,720 (GRCm39) |
L275F |
possibly damaging |
Het |
|
| Other mutations in Vmn2r24 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00954:Vmn2r24
|
APN |
6 |
123,792,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01382:Vmn2r24
|
APN |
6 |
123,763,938 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
IGL01592:Vmn2r24
|
APN |
6 |
123,764,445 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL01754:Vmn2r24
|
APN |
6 |
123,781,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01939:Vmn2r24
|
APN |
6 |
123,764,404 (GRCm39) |
missense |
probably benign |
|
|
IGL02140:Vmn2r24
|
APN |
6 |
123,757,631 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02272:Vmn2r24
|
APN |
6 |
123,763,843 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02568:Vmn2r24
|
APN |
6 |
123,792,812 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL02748:Vmn2r24
|
APN |
6 |
123,793,057 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03022:Vmn2r24
|
APN |
6 |
123,755,967 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03343:Vmn2r24
|
APN |
6 |
123,793,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0357:Vmn2r24
|
UTSW |
6 |
123,792,369 (GRCm39) |
frame shift |
probably null |
|
|
R0453:Vmn2r24
|
UTSW |
6 |
123,757,350 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0538:Vmn2r24
|
UTSW |
6 |
123,793,012 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0607:Vmn2r24
|
UTSW |
6 |
123,763,893 (GRCm39) |
missense |
probably benign |
|
|
R1381:Vmn2r24
|
UTSW |
6 |
123,763,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1589:Vmn2r24
|
UTSW |
6 |
123,783,479 (GRCm39) |
splice site |
probably benign |
|
|
R1848:Vmn2r24
|
UTSW |
6 |
123,793,183 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2035:Vmn2r24
|
UTSW |
6 |
123,793,019 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2077:Vmn2r24
|
UTSW |
6 |
123,792,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2122:Vmn2r24
|
UTSW |
6 |
123,792,353 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R2145:Vmn2r24
|
UTSW |
6 |
123,755,972 (GRCm39) |
missense |
probably benign |
|
|
R2483:Vmn2r24
|
UTSW |
6 |
123,792,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2512:Vmn2r24
|
UTSW |
6 |
123,763,985 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3001:Vmn2r24
|
UTSW |
6 |
123,781,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3002:Vmn2r24
|
UTSW |
6 |
123,781,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3236:Vmn2r24
|
UTSW |
6 |
123,755,984 (GRCm39) |
nonsense |
probably null |
|
|
R3623:Vmn2r24
|
UTSW |
6 |
123,792,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3624:Vmn2r24
|
UTSW |
6 |
123,792,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3835:Vmn2r24
|
UTSW |
6 |
123,764,412 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4074:Vmn2r24
|
UTSW |
6 |
123,764,374 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4075:Vmn2r24
|
UTSW |
6 |
123,764,374 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4812:Vmn2r24
|
UTSW |
6 |
123,756,144 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4825:Vmn2r24
|
UTSW |
6 |
123,792,739 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5351:Vmn2r24
|
UTSW |
6 |
123,793,223 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5665:Vmn2r24
|
UTSW |
6 |
123,763,938 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R5790:Vmn2r24
|
UTSW |
6 |
123,792,499 (GRCm39) |
missense |
probably benign |
|
|
R5808:Vmn2r24
|
UTSW |
6 |
123,792,597 (GRCm39) |
nonsense |
probably null |
|
|
R5879:Vmn2r24
|
UTSW |
6 |
123,764,226 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5923:Vmn2r24
|
UTSW |
6 |
123,792,751 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5969:Vmn2r24
|
UTSW |
6 |
123,755,981 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6050:Vmn2r24
|
UTSW |
6 |
123,792,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6171:Vmn2r24
|
UTSW |
6 |
123,764,205 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6174:Vmn2r24
|
UTSW |
6 |
123,793,236 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6356:Vmn2r24
|
UTSW |
6 |
123,783,368 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6562:Vmn2r24
|
UTSW |
6 |
123,757,386 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6563:Vmn2r24
|
UTSW |
6 |
123,781,137 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6584:Vmn2r24
|
UTSW |
6 |
123,792,764 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6630:Vmn2r24
|
UTSW |
6 |
123,763,981 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6803:Vmn2r24
|
UTSW |
6 |
123,755,960 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6864:Vmn2r24
|
UTSW |
6 |
123,756,117 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7252:Vmn2r24
|
UTSW |
6 |
123,764,191 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7369:Vmn2r24
|
UTSW |
6 |
123,792,638 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7799:Vmn2r24
|
UTSW |
6 |
123,757,422 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7803:Vmn2r24
|
UTSW |
6 |
123,757,438 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7959:Vmn2r24
|
UTSW |
6 |
123,755,949 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8215:Vmn2r24
|
UTSW |
6 |
123,756,077 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8796:Vmn2r24
|
UTSW |
6 |
123,757,500 (GRCm39) |
missense |
probably benign |
|
|
R9172:Vmn2r24
|
UTSW |
6 |
123,783,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9300:Vmn2r24
|
UTSW |
6 |
123,793,030 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9369:Vmn2r24
|
UTSW |
6 |
123,792,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9375:Vmn2r24
|
UTSW |
6 |
123,792,542 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9523:Vmn2r24
|
UTSW |
6 |
123,763,950 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9546:Vmn2r24
|
UTSW |
6 |
123,764,266 (GRCm39) |
missense |
probably damaging |
0.98 |
|
RF006:Vmn2r24
|
UTSW |
6 |
123,783,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF016:Vmn2r24
|
UTSW |
6 |
123,781,174 (GRCm39) |
missense |
probably benign |
0.04 |
|
X0023:Vmn2r24
|
UTSW |
6 |
123,764,359 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Vmn2r24
|
UTSW |
6 |
123,781,155 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Vmn2r24
|
UTSW |
6 |
123,763,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTGGTGAGAAGGTTACCTGACAG -3'
(R):5'- TGTCTAGTTGACTACAAGGATAGCC -3'
Sequencing Primer
(F):5'- ACCTGACAGTTTCAATGAGGC -3'
(R):5'- ACTGCAGAAGCCATTGTTTG -3'
|
| Posted On |
2019-10-24 |
Incidental Mutation