Mutagenetix > Incidental Mutation

Incidental Mutation 'R7574:Birc6'

586290

Institutional Source

Beutler Lab

Gene Symbol

Birc6

Ensembl Gene

ENSMUSG00000024073

Gene Name

baculoviral IAP repeat-containing 6

Synonyms

D630005A10Rik, apollon, Bruce, A430032G04Rik, A430040A19Rik

MMRRC Submission

045660-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R7574 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

74528295-74703356 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 74579884 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 736 (I736V)

Ref Sequence

ENSEMBL: ENSMUSP00000138333 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000180037] [ENSMUST00000182133] [ENSMUST00000182597] [ENSMUST00000182944] [ENSMUST00000183224]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000180037
AA Change: I736V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000136329
Gene: ENSMUSG00000024073
AA Change: I736V

Domain	Start	End	E-Value	Type
low complexity region	24	54	N/A	INTRINSIC
BIR	287	363	2.87e-24	SMART
low complexity region	472	493	N/A	INTRINSIC
low complexity region	624	635	N/A	INTRINSIC
low complexity region	674	685	N/A	INTRINSIC
low complexity region	769	781	N/A	INTRINSIC
low complexity region	1054	1071	N/A	INTRINSIC
low complexity region	1369	1380	N/A	INTRINSIC
coiled coil region	1620	1675	N/A	INTRINSIC
low complexity region	1709	1726	N/A	INTRINSIC
low complexity region	1993	1998	N/A	INTRINSIC
low complexity region	2044	2059	N/A	INTRINSIC
low complexity region	2142	2163	N/A	INTRINSIC
low complexity region	2253	2266	N/A	INTRINSIC
low complexity region	2491	2505	N/A	INTRINSIC
low complexity region	2671	2688	N/A	INTRINSIC
low complexity region	2893	2905	N/A	INTRINSIC
low complexity region	2958	2970	N/A	INTRINSIC
Pfam:DUF3643	3477	3632	1e-69	PFAM
low complexity region	3747	3772	N/A	INTRINSIC
low complexity region	3900	3919	N/A	INTRINSIC
low complexity region	3940	3958	N/A	INTRINSIC
low complexity region	3963	3972	N/A	INTRINSIC
low complexity region	4146	4157	N/A	INTRINSIC
low complexity region	4307	4318	N/A	INTRINSIC
low complexity region	4433	4444	N/A	INTRINSIC
UBCc	4592	4756	1.04e-25	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000182133
AA Change: I736V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000138693
Gene: ENSMUSG00000024073
AA Change: I736V

Domain	Start	End	E-Value	Type
low complexity region	24	54	N/A	INTRINSIC
BIR	287	363	2.87e-24	SMART
low complexity region	472	493	N/A	INTRINSIC
low complexity region	624	635	N/A	INTRINSIC
low complexity region	674	685	N/A	INTRINSIC
low complexity region	769	781	N/A	INTRINSIC
low complexity region	1054	1071	N/A	INTRINSIC
low complexity region	1369	1380	N/A	INTRINSIC
coiled coil region	1620	1675	N/A	INTRINSIC
low complexity region	1709	1726	N/A	INTRINSIC
low complexity region	1993	1998	N/A	INTRINSIC
low complexity region	2044	2055	N/A	INTRINSIC
low complexity region	2136	2157	N/A	INTRINSIC
low complexity region	2247	2260	N/A	INTRINSIC
low complexity region	2485	2499	N/A	INTRINSIC
low complexity region	2665	2682	N/A	INTRINSIC
low complexity region	2887	2899	N/A	INTRINSIC
low complexity region	2952	2964	N/A	INTRINSIC
Pfam:DUF3643	3470	3626	2.1e-71	PFAM
low complexity region	3741	3766	N/A	INTRINSIC
low complexity region	3894	3913	N/A	INTRINSIC
low complexity region	3934	3952	N/A	INTRINSIC
low complexity region	3957	3966	N/A	INTRINSIC
low complexity region	4140	4151	N/A	INTRINSIC
low complexity region	4301	4312	N/A	INTRINSIC
low complexity region	4427	4438	N/A	INTRINSIC
UBCc	4586	4750	1.04e-25	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000182597
AA Change: I736V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000138333
Gene: ENSMUSG00000024073
AA Change: I736V

Domain	Start	End	E-Value	Type
low complexity region	24	54	N/A	INTRINSIC
BIR	287	363	2.87e-24	SMART
low complexity region	472	493	N/A	INTRINSIC
low complexity region	624	635	N/A	INTRINSIC
low complexity region	674	685	N/A	INTRINSIC
low complexity region	769	781	N/A	INTRINSIC
low complexity region	1054	1071	N/A	INTRINSIC
low complexity region	1369	1380	N/A	INTRINSIC
coiled coil region	1620	1675	N/A	INTRINSIC
low complexity region	1709	1726	N/A	INTRINSIC
low complexity region	1993	1998	N/A	INTRINSIC
low complexity region	2044	2059	N/A	INTRINSIC
low complexity region	2142	2163	N/A	INTRINSIC
low complexity region	2262	2275	N/A	INTRINSIC
low complexity region	2500	2514	N/A	INTRINSIC
low complexity region	2680	2697	N/A	INTRINSIC
low complexity region	2902	2914	N/A	INTRINSIC
low complexity region	2967	2979	N/A	INTRINSIC
Pfam:DUF3643	3485	3641	2.2e-71	PFAM
low complexity region	3756	3781	N/A	INTRINSIC
low complexity region	3909	3928	N/A	INTRINSIC
low complexity region	3949	3967	N/A	INTRINSIC
low complexity region	3972	3981	N/A	INTRINSIC
low complexity region	4155	4166	N/A	INTRINSIC
low complexity region	4316	4327	N/A	INTRINSIC
low complexity region	4442	4453	N/A	INTRINSIC
UBCc	4601	4765	1.04e-25	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000182944
AA Change: I736V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000138732
Gene: ENSMUSG00000024073
AA Change: I736V

Domain	Start	End	E-Value	Type
low complexity region	24	54	N/A	INTRINSIC
BIR	287	363	2.87e-24	SMART
low complexity region	472	493	N/A	INTRINSIC
low complexity region	624	635	N/A	INTRINSIC
low complexity region	674	685	N/A	INTRINSIC
low complexity region	769	781	N/A	INTRINSIC
low complexity region	1054	1071	N/A	INTRINSIC
low complexity region	1369	1380	N/A	INTRINSIC
coiled coil region	1616	1671	N/A	INTRINSIC
low complexity region	1705	1722	N/A	INTRINSIC
low complexity region	1989	1994	N/A	INTRINSIC
low complexity region	2040	2055	N/A	INTRINSIC
low complexity region	2138	2159	N/A	INTRINSIC
low complexity region	2249	2262	N/A	INTRINSIC
low complexity region	2487	2501	N/A	INTRINSIC
low complexity region	2667	2684	N/A	INTRINSIC
low complexity region	2889	2901	N/A	INTRINSIC
low complexity region	2954	2966	N/A	INTRINSIC
Pfam:DUF3643	3472	3628	3.2e-71	PFAM
low complexity region	3743	3768	N/A	INTRINSIC
low complexity region	3896	3915	N/A	INTRINSIC
low complexity region	3936	3954	N/A	INTRINSIC
low complexity region	3959	3968	N/A	INTRINSIC
low complexity region	4142	4153	N/A	INTRINSIC
low complexity region	4303	4314	N/A	INTRINSIC
low complexity region	4429	4440	N/A	INTRINSIC
UBCc	4588	4752	1.04e-25	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000183224
AA Change: I708V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000138270
Gene: ENSMUSG00000024073
AA Change: I708V

Domain	Start	End	E-Value	Type
low complexity region	2	26	N/A	INTRINSIC
BIR	259	335	2.87e-24	SMART
low complexity region	444	465	N/A	INTRINSIC
low complexity region	596	607	N/A	INTRINSIC
low complexity region	646	657	N/A	INTRINSIC
low complexity region	741	753	N/A	INTRINSIC
low complexity region	1026	1043	N/A	INTRINSIC
low complexity region	1355	1366	N/A	INTRINSIC
coiled coil region	1606	1661	N/A	INTRINSIC
low complexity region	1695	1712	N/A	INTRINSIC
low complexity region	1979	1984	N/A	INTRINSIC
low complexity region	2030	2041	N/A	INTRINSIC
low complexity region	2122	2143	N/A	INTRINSIC
low complexity region	2233	2246	N/A	INTRINSIC
low complexity region	2471	2485	N/A	INTRINSIC
low complexity region	2651	2668	N/A	INTRINSIC
low complexity region	2873	2885	N/A	INTRINSIC
low complexity region	2938	2950	N/A	INTRINSIC
Pfam:DUF3643	3456	3612	3.2e-71	PFAM
low complexity region	3727	3752	N/A	INTRINSIC
low complexity region	3880	3899	N/A	INTRINSIC
low complexity region	3920	3938	N/A	INTRINSIC
low complexity region	3943	3952	N/A	INTRINSIC
low complexity region	4126	4137	N/A	INTRINSIC
low complexity region	4287	4298	N/A	INTRINSIC
low complexity region	4413	4424	N/A	INTRINSIC
UBCc	4572	4736	1.04e-25	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.1%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mice exhibit perinatal lethality and exhibit placental defects. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 98 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4833420G17Rik	T	C	13: 119,469,942 (GRCm38)	V240A	probably damaging	Het
A930009A15Rik	C	T	10: 115,570,114 (GRCm38)		probably benign	Het
Aarsd1	A	G	11: 101,411,144 (GRCm38)	I201T	probably damaging	Het
Acaca	T	A	11: 84,261,588 (GRCm38)	Y854N	probably benign	Het
Adra2c	T	C	5: 35,280,415 (GRCm38)	L177P	probably damaging	Het
Akr1c12	A	T	13: 4,279,310 (GRCm38)	I16N	probably damaging	Het
Aldh8a1	A	T	10: 21,380,830 (GRCm38)	I47F	possibly damaging	Het
Bmp2	A	T	2: 133,560,897 (GRCm38)	M123L	probably benign	Het
C1ql1	T	C	11: 102,945,986 (GRCm38)	Y159C	probably damaging	Het
Ccdc148	T	C	2: 58,823,633 (GRCm38)	Y502C	probably damaging	Het
Ccdc155	A	T	7: 45,204,611 (GRCm38)	H31Q	possibly damaging	Het
Cenpf	A	T	1: 189,658,667 (GRCm38)	N989K	probably damaging	Het
Ciz1	A	G	2: 32,367,368 (GRCm38)	M142V	probably benign	Het
Cnot4	T	C	6: 35,053,004 (GRCm38)	R320G	possibly damaging	Het
Cyth1	G	T	11: 118,182,863 (GRCm38)	H215N	probably damaging	Het
Dapk1	G	A	13: 60,761,173 (GRCm38)	G1200D	probably damaging	Het
Dhps	A	G	8: 85,072,552 (GRCm38)	Y103C	probably damaging	Het
Dnah1	T	A	14: 31,319,908 (GRCm38)	E35D	probably benign	Het
Dnajb9	A	T	12: 44,207,386 (GRCm38)	D79E	probably damaging	Het
Eif4a2	T	C	16: 23,110,127 (GRCm38)	F164S	probably benign	Het
Enpp2	T	C	15: 54,851,417 (GRCm38)	T595A	probably benign	Het
Exoc6b	T	A	6: 84,791,384 (GRCm38)		probably null	Het
Fam171a1	T	C	2: 3,220,354 (GRCm38)	S286P	probably damaging	Het
Fam35a	C	T	14: 34,237,466 (GRCm38)	S853N	probably damaging	Het
Fermt2	T	A	14: 45,469,325 (GRCm38)	N338I	probably damaging	Het
Fhdc1	A	G	3: 84,446,131 (GRCm38)	F596L	probably benign	Het
Fry	T	C	5: 150,380,894 (GRCm38)	V583A	probably benign	Het
Gbp10	G	A	5: 105,236,149 (GRCm38)		probably benign	Het
Gdap1	T	A	1: 17,161,441 (GRCm38)	F337I	possibly damaging	Het
Git2	C	T	5: 114,766,489 (GRCm38)	R123H	probably damaging	Het
Gm14085	A	T	2: 122,522,844 (GRCm38)	I502F	not run	Het
Gm35339	T	A	15: 76,357,749 (GRCm38)	Y747*	probably null	Het
Gm8251	A	T	1: 44,059,433 (GRCm38)	V835E	possibly damaging	Het
Gpr6	A	T	10: 41,070,656 (GRCm38)	I310N	possibly damaging	Het
Gpsm2	G	A	3: 108,700,745 (GRCm38)	A239V	probably damaging	Het
Hexa	T	C	9: 59,563,984 (GRCm38)	V507A	probably benign	Het
Hmcn2	A	T	2: 31,455,519 (GRCm38)	H4718L	possibly damaging	Het
Hrh4	T	C	18: 13,021,913 (GRCm38)	F170L	possibly damaging	Het
Ica1	T	C	6: 8,658,266 (GRCm38)	T284A	probably benign	Het
Itga5	T	C	15: 103,350,449 (GRCm38)	N774S	probably damaging	Het
Itgb2	T	C	10: 77,560,158 (GRCm38)	S556P	probably benign	Het
Kcnq4	A	G	4: 120,711,368 (GRCm38)	F384L	probably benign	Het
Lama2	A	T	10: 27,006,730 (GRCm38)	N2612K	probably benign	Het
Lnx1	T	C	5: 74,685,438 (GRCm38)	E117G	probably benign	Het
Lrrc14b	G	T	13: 74,360,773 (GRCm38)	A505E	probably damaging	Het
Ly6g	T	C	15: 75,158,564 (GRCm38)	I77T	probably benign	Het
Mmp1a	TG	TGG	9: 7,465,083 (GRCm38)		probably null	Het
Mrgpre	C	T	7: 143,781,350 (GRCm38)	V139M	probably damaging	Het
Muc4	T	A	16: 32,753,411 (GRCm38)	S1096T	probably benign	Het
Myrfl	G	A	10: 116,831,525 (GRCm38)	R337*	probably null	Het
Ndufa4	C	T	6: 11,906,093 (GRCm38)	V20I	probably benign	Het
Nf1	A	G	11: 79,408,769 (GRCm38)	D241G	probably null	Het
Nid1	A	G	13: 13,468,443 (GRCm38)	D322G	probably benign	Het
Nova1	A	T	12: 46,700,761 (GRCm38)	D244E	unknown	Het
Olfr1022	A	G	2: 85,869,006 (GRCm38)	K138R	probably benign	Het
Olfr1240	T	C	2: 89,439,401 (GRCm38)	K293E	possibly damaging	Het
Olfr743	T	A	14: 50,534,313 (GRCm38)	D300E	probably benign	Het
Padi2	C	A	4: 140,949,337 (GRCm38)	N595K	possibly damaging	Het
Pag1	A	G	3: 9,693,891 (GRCm38)	I389T	probably damaging	Het
Pcdh10	G	T	3: 45,381,375 (GRCm38)	G708V	possibly damaging	Het
Pecam1	A	G	11: 106,699,784 (GRCm38)	S55P	probably damaging	Het
Plin3	A	T	17: 56,284,192 (GRCm38)	V196E	possibly damaging	Het
Plxdc1	A	T	11: 97,956,490 (GRCm38)	L119Q	possibly damaging	Het
Pnliprp1	A	T	19: 58,738,249 (GRCm38)	N346I	probably damaging	Het
Ppp1r27	A	T	11: 120,551,030 (GRCm38)	Y8*	probably null	Het
Prg3	A	T	2: 84,989,402 (GRCm38)	D80V	probably damaging	Het
Prmt5	T	C	14: 54,507,890 (GRCm38)	N607D	possibly damaging	Het
Ptprs	A	G	17: 56,423,538 (GRCm38)	F1144L	probably benign	Het
Rai14	C	T	15: 10,593,103 (GRCm38)	G152R	probably damaging	Het
Rap1gds1	T	A	3: 138,956,215 (GRCm38)	R427*	probably null	Het
Recql5	A	G	11: 115,928,422 (GRCm38)	V106A	probably benign	Het
Resp18	T	C	1: 75,273,971 (GRCm38)	T155A	probably benign	Het
Rfx6	A	G	10: 51,681,818 (GRCm38)	D129G	probably benign	Het
Rsf1	T	A	7: 97,661,167 (GRCm38)	I368K		Het
Sema6a	C	G	18: 47,291,164 (GRCm38)	V226L	probably damaging	Het
Sf1	A	G	19: 6,372,204 (GRCm38)	E220G	probably damaging	Het
Sidt1	T	A	16: 44,259,485 (GRCm38)	Y602F	probably damaging	Het
Slc17a8	A	G	10: 89,592,146 (GRCm38)	I273T	probably benign	Het
Slc41a1	A	T	1: 131,839,151 (GRCm38)	I136F	probably damaging	Het
Snrpb	T	C	2: 130,177,019 (GRCm38)	I51V	probably benign	Het
Sprr2f	T	A	3: 92,365,947 (GRCm38)	C18S	unknown	Het
Stab1	T	C	14: 31,154,665 (GRCm38)	N864S	probably benign	Het
Svil	C	A	18: 5,095,188 (GRCm38)	T1457K	probably benign	Het
Syt1	A	T	10: 108,504,401 (GRCm38)	I352N	probably damaging	Het
Tas2r119	A	G	15: 32,178,133 (GRCm38)	K282E	probably damaging	Het
Timeless	T	C	10: 128,244,669 (GRCm38)	F473S	probably damaging	Het
Tmc3	A	G	7: 83,598,273 (GRCm38)	D192G	probably damaging	Het
Trmt1l	T	A	1: 151,440,840 (GRCm38)	I184N	possibly damaging	Het
Ttll6	G	A	11: 96,134,875 (GRCm38)	V61M	probably damaging	Het
Ttn	C	T	2: 76,802,411 (GRCm38)	E14100K	probably damaging	Het
Txndc2	T	A	17: 65,638,625 (GRCm38)	I186F	possibly damaging	Het
Ubr1	A	T	2: 120,873,191 (GRCm38)	S1553T	possibly damaging	Het
Vmn1r208	T	C	13: 22,772,535 (GRCm38)	N264S	probably benign	Het
Vmn1r87	T	A	7: 13,131,686 (GRCm38)	M225L	probably benign	Het
Vmn2r101	T	A	17: 19,611,637 (GRCm38)	C632S	possibly damaging	Het
Zfp474	T	C	18: 52,639,189 (GRCm38)	S305P	probably benign	Het
Zfp59	A	G	7: 27,853,438 (GRCm38)	N105S	probably benign	Het
Zfp804b	T	A	5: 6,772,301 (GRCm38)	Y254F	possibly damaging	Het

Other mutations in Birc6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00402:Birc6	APN	17	74,573,563 (GRCm38)	splice site	probably benign
IGL00542:Birc6	APN	17	74,623,771 (GRCm38)	splice site	probably null
IGL00659:Birc6	APN	17	74,660,653 (GRCm38)	missense	probably damaging	1.00
IGL00710:Birc6	APN	17	74,609,089 (GRCm38)	missense	probably benign	0.37
IGL00806:Birc6	APN	17	74,611,529 (GRCm38)	missense	possibly damaging	0.85
IGL00848:Birc6	APN	17	74,696,393 (GRCm38)	nonsense	probably null
IGL01071:Birc6	APN	17	74,566,132 (GRCm38)	missense	possibly damaging	0.84
IGL01071:Birc6	APN	17	74,631,701 (GRCm38)	missense	probably damaging	1.00
IGL01121:Birc6	APN	17	74,631,038 (GRCm38)	missense	probably benign	0.08
IGL01132:Birc6	APN	17	74,603,060 (GRCm38)	missense	probably damaging	1.00
IGL01323:Birc6	APN	17	74,622,925 (GRCm38)	missense	probably damaging	1.00
IGL01444:Birc6	APN	17	74,631,687 (GRCm38)	missense	probably damaging	1.00
IGL01511:Birc6	APN	17	74,627,003 (GRCm38)	nonsense	probably null
IGL01576:Birc6	APN	17	74,677,370 (GRCm38)	missense	possibly damaging	0.80
IGL01578:Birc6	APN	17	74,648,197 (GRCm38)	missense	probably benign	0.08
IGL01649:Birc6	APN	17	74,604,546 (GRCm38)	missense	probably benign	0.03
IGL01657:Birc6	APN	17	74,660,611 (GRCm38)	missense	probably damaging	1.00
IGL01739:Birc6	APN	17	74,659,221 (GRCm38)	missense	probably benign
IGL01756:Birc6	APN	17	74,640,208 (GRCm38)	missense	probably benign	0.00
IGL01807:Birc6	APN	17	74,631,037 (GRCm38)	missense	probably benign
IGL01885:Birc6	APN	17	74,604,516 (GRCm38)	missense	possibly damaging	0.51
IGL01906:Birc6	APN	17	74,638,358 (GRCm38)	missense	probably damaging	1.00
IGL01915:Birc6	APN	17	74,631,720 (GRCm38)	missense	probably benign	0.34
IGL01998:Birc6	APN	17	74,579,885 (GRCm38)	missense	probably benign	0.06
IGL02084:Birc6	APN	17	74,608,282 (GRCm38)	missense	probably benign	0.45
IGL02086:Birc6	APN	17	74,639,827 (GRCm38)	missense	probably damaging	1.00
IGL02161:Birc6	APN	17	74,548,837 (GRCm38)	missense	probably damaging	0.99
IGL02195:Birc6	APN	17	74,697,381 (GRCm38)	splice site	probably benign
IGL02283:Birc6	APN	17	74,599,940 (GRCm38)	missense	probably benign
IGL02476:Birc6	APN	17	74,696,391 (GRCm38)	missense	possibly damaging	0.81
IGL02493:Birc6	APN	17	74,652,059 (GRCm38)	unclassified	probably benign
IGL02547:Birc6	APN	17	74,579,645 (GRCm38)	missense	probably benign	0.21
IGL02678:Birc6	APN	17	74,649,903 (GRCm38)	missense	probably damaging	1.00
IGL02713:Birc6	APN	17	74,579,324 (GRCm38)	missense	probably benign
IGL02851:Birc6	APN	17	74,609,189 (GRCm38)	missense	probably damaging	1.00
IGL02875:Birc6	APN	17	74,589,718 (GRCm38)	missense	probably damaging	1.00
IGL02985:Birc6	APN	17	74,640,190 (GRCm38)	missense	probably benign	0.00
IGL03004:Birc6	APN	17	74,612,185 (GRCm38)	missense	probably benign	0.10
IGL03053:Birc6	APN	17	74,565,972 (GRCm38)	missense	probably damaging	1.00
IGL03085:Birc6	APN	17	74,596,950 (GRCm38)	missense	probably damaging	0.97
IGL03109:Birc6	APN	17	74,579,334 (GRCm38)	missense	possibly damaging	0.71
IGL03143:Birc6	APN	17	74,598,999 (GRCm38)	missense	possibly damaging	0.89
IGL03180:Birc6	APN	17	74,659,231 (GRCm38)	missense	probably benign
IGL03221:Birc6	APN	17	74,627,007 (GRCm38)	missense	probably benign	0.00
IGL03230:Birc6	APN	17	74,611,070 (GRCm38)	missense	probably damaging	1.00
IGL03294:Birc6	APN	17	74,649,886 (GRCm38)	missense	probably benign	0.02
IGL03399:Birc6	APN	17	74,594,373 (GRCm38)	missense	probably benign	0.01
Badlands	UTSW	17	74,603,036 (GRCm38)	missense	probably damaging	1.00
Big_sky	UTSW	17	74,528,538 (GRCm38)	missense	probably null	0.33
bitterroot	UTSW	17	74,649,696 (GRCm38)	missense	probably damaging	1.00
Black_hills	UTSW	17	74,692,332 (GRCm38)	missense	probably damaging	1.00
bottomlands	UTSW	17	74,609,659 (GRCm38)	missense	probably damaging	1.00
Chai	UTSW	17	74,670,374 (GRCm38)	missense	probably damaging	1.00
Dakota	UTSW	17	74,625,104 (GRCm38)	critical splice acceptor site	probably null
Sempervirens	UTSW	17	74,642,504 (GRCm38)	missense	probably damaging	1.00
E0370:Birc6	UTSW	17	74,677,357 (GRCm38)	missense	probably damaging	1.00
G1citation:Birc6	UTSW	17	74,598,044 (GRCm38)	missense	probably damaging	1.00
G1citation:Birc6	UTSW	17	74,580,382 (GRCm38)	missense	possibly damaging	0.82
PIT4494001:Birc6	UTSW	17	74,626,980 (GRCm38)	missense	probably damaging	1.00
R0081:Birc6	UTSW	17	74,643,441 (GRCm38)	missense	probably benign	0.01
R0086:Birc6	UTSW	17	74,593,166 (GRCm38)	missense	possibly damaging	0.54
R0089:Birc6	UTSW	17	74,638,376 (GRCm38)	missense	possibly damaging	0.90
R0116:Birc6	UTSW	17	74,623,746 (GRCm38)	splice site	probably benign
R0129:Birc6	UTSW	17	74,528,760 (GRCm38)	missense	probably benign	0.05
R0196:Birc6	UTSW	17	74,580,287 (GRCm38)	missense	possibly damaging	0.57
R0201:Birc6	UTSW	17	74,609,327 (GRCm38)	missense	possibly damaging	0.92
R0207:Birc6	UTSW	17	74,662,832 (GRCm38)	splice site	probably benign
R0295:Birc6	UTSW	17	74,613,362 (GRCm38)	intron	probably benign
R0386:Birc6	UTSW	17	74,599,340 (GRCm38)	missense	probably damaging	0.99
R0423:Birc6	UTSW	17	74,696,297 (GRCm38)	missense	probably damaging	1.00
R0449:Birc6	UTSW	17	74,692,295 (GRCm38)	missense	probably damaging	1.00
R0453:Birc6	UTSW	17	74,649,754 (GRCm38)	missense	probably damaging	1.00
R0457:Birc6	UTSW	17	74,662,625 (GRCm38)	missense	probably damaging	1.00
R0457:Birc6	UTSW	17	74,652,028 (GRCm38)	missense	probably benign
R0564:Birc6	UTSW	17	74,625,243 (GRCm38)	splice site	probably benign
R0575:Birc6	UTSW	17	74,689,237 (GRCm38)	missense	probably damaging	1.00
R0582:Birc6	UTSW	17	74,643,337 (GRCm38)	missense	probably damaging	1.00
R0624:Birc6	UTSW	17	74,580,349 (GRCm38)	missense	probably benign	0.20
R0973:Birc6	UTSW	17	74,565,861 (GRCm38)	missense	probably damaging	0.99
R1061:Birc6	UTSW	17	74,689,312 (GRCm38)	missense	probably damaging	1.00
R1378:Birc6	UTSW	17	74,660,455 (GRCm38)	missense	probably damaging	1.00
R1402:Birc6	UTSW	17	74,697,533 (GRCm38)	splice site	probably benign
R1436:Birc6	UTSW	17	74,652,705 (GRCm38)	missense	probably damaging	1.00
R1456:Birc6	UTSW	17	74,609,290 (GRCm38)	missense	probably benign	0.35
R1465:Birc6	UTSW	17	74,623,858 (GRCm38)	missense	probably benign	0.03
R1465:Birc6	UTSW	17	74,623,858 (GRCm38)	missense	probably benign	0.03
R1474:Birc6	UTSW	17	74,579,678 (GRCm38)	missense	probably damaging	0.98
R1479:Birc6	UTSW	17	74,634,853 (GRCm38)	missense	probably damaging	1.00
R1486:Birc6	UTSW	17	74,639,820 (GRCm38)	missense	probably damaging	1.00
R1499:Birc6	UTSW	17	74,612,319 (GRCm38)	missense	probably damaging	1.00
R1515:Birc6	UTSW	17	74,528,636 (GRCm38)	nonsense	probably null
R1549:Birc6	UTSW	17	74,662,742 (GRCm38)	missense	probably damaging	1.00
R1559:Birc6	UTSW	17	74,692,237 (GRCm38)	missense	probably damaging	1.00
R1573:Birc6	UTSW	17	74,660,690 (GRCm38)	splice site	probably benign
R1615:Birc6	UTSW	17	74,609,409 (GRCm38)	splice site	probably null
R1621:Birc6	UTSW	17	74,670,250 (GRCm38)	missense	probably benign
R1680:Birc6	UTSW	17	74,548,746 (GRCm38)	missense	probably benign	0.01
R1743:Birc6	UTSW	17	74,579,756 (GRCm38)	missense	possibly damaging	0.95
R1774:Birc6	UTSW	17	74,640,013 (GRCm38)	missense	probably damaging	1.00
R1775:Birc6	UTSW	17	74,612,286 (GRCm38)	missense	probably damaging	1.00
R1818:Birc6	UTSW	17	74,649,849 (GRCm38)	missense	probably damaging	1.00
R1836:Birc6	UTSW	17	74,614,390 (GRCm38)	missense	probably benign	0.41
R1931:Birc6	UTSW	17	74,565,982 (GRCm38)	missense	probably damaging	0.99
R1939:Birc6	UTSW	17	74,670,337 (GRCm38)	missense	probably damaging	1.00
R1964:Birc6	UTSW	17	74,634,885 (GRCm38)	missense	possibly damaging	0.94
R1994:Birc6	UTSW	17	74,598,062 (GRCm38)	missense	probably benign	0.01
R2000:Birc6	UTSW	17	74,604,619 (GRCm38)	missense	possibly damaging	0.46
R2042:Birc6	UTSW	17	74,609,659 (GRCm38)	missense	probably damaging	1.00
R2090:Birc6	UTSW	17	74,662,796 (GRCm38)	missense	probably benign
R2130:Birc6	UTSW	17	74,659,154 (GRCm38)	splice site	probably benign
R2144:Birc6	UTSW	17	74,660,413 (GRCm38)	missense	possibly damaging	0.71
R2145:Birc6	UTSW	17	74,660,413 (GRCm38)	missense	possibly damaging	0.71
R2166:Birc6	UTSW	17	74,635,795 (GRCm38)	missense	probably benign	0.02
R2180:Birc6	UTSW	17	74,612,151 (GRCm38)	missense	probably benign	0.03
R2271:Birc6	UTSW	17	74,602,971 (GRCm38)	missense	probably benign	0.06
R2272:Birc6	UTSW	17	74,602,971 (GRCm38)	missense	probably benign	0.06
R2416:Birc6	UTSW	17	74,608,219 (GRCm38)	missense	possibly damaging	0.83
R2420:Birc6	UTSW	17	74,660,614 (GRCm38)	missense	probably damaging	1.00
R2421:Birc6	UTSW	17	74,660,614 (GRCm38)	missense	probably damaging	1.00
R2422:Birc6	UTSW	17	74,660,614 (GRCm38)	missense	probably damaging	1.00
R2513:Birc6	UTSW	17	74,647,729 (GRCm38)	missense	probably damaging	0.97
R2912:Birc6	UTSW	17	74,692,206 (GRCm38)	missense	probably damaging	1.00
R3024:Birc6	UTSW	17	74,608,219 (GRCm38)	missense	possibly damaging	0.83
R3771:Birc6	UTSW	17	74,618,429 (GRCm38)	splice site	probably benign
R3772:Birc6	UTSW	17	74,618,429 (GRCm38)	splice site	probably benign
R3829:Birc6	UTSW	17	74,655,178 (GRCm38)	missense	probably damaging	1.00
R3913:Birc6	UTSW	17	74,573,613 (GRCm38)	nonsense	probably null
R3915:Birc6	UTSW	17	74,579,608 (GRCm38)	missense	probably benign	0.12
R3921:Birc6	UTSW	17	74,627,019 (GRCm38)	missense	probably damaging	0.98
R3928:Birc6	UTSW	17	74,638,409 (GRCm38)	missense	probably damaging	1.00
R3928:Birc6	UTSW	17	74,611,175 (GRCm38)	missense	possibly damaging	0.91
R4111:Birc6	UTSW	17	74,566,015 (GRCm38)	missense	probably damaging	1.00
R4155:Birc6	UTSW	17	74,596,939 (GRCm38)	missense	probably benign	0.00
R4163:Birc6	UTSW	17	74,626,980 (GRCm38)	missense	probably damaging	1.00
R4226:Birc6	UTSW	17	74,619,840 (GRCm38)	critical splice donor site	probably null
R4227:Birc6	UTSW	17	74,619,840 (GRCm38)	critical splice donor site	probably null
R4358:Birc6	UTSW	17	74,619,668 (GRCm38)	splice site	probably null
R4524:Birc6	UTSW	17	74,641,777 (GRCm38)	missense	probably damaging	1.00
R4605:Birc6	UTSW	17	74,639,934 (GRCm38)	missense	probably damaging	1.00
R4619:Birc6	UTSW	17	74,640,150 (GRCm38)	missense	probably benign	0.18
R4620:Birc6	UTSW	17	74,640,150 (GRCm38)	missense	probably benign	0.18
R4762:Birc6	UTSW	17	74,629,489 (GRCm38)	missense	probably damaging	1.00
R4814:Birc6	UTSW	17	74,649,672 (GRCm38)	missense	probably damaging	1.00
R4849:Birc6	UTSW	17	74,647,388 (GRCm38)	missense	probably damaging	0.99
R4869:Birc6	UTSW	17	74,586,012 (GRCm38)	missense	probably benign	0.05
R4912:Birc6	UTSW	17	74,565,905 (GRCm38)	missense	probably damaging	1.00
R4921:Birc6	UTSW	17	74,650,099 (GRCm38)	missense	probably damaging	1.00
R4942:Birc6	UTSW	17	74,623,050 (GRCm38)	missense	probably damaging	1.00
R4954:Birc6	UTSW	17	74,612,031 (GRCm38)	missense	probably damaging	1.00
R4992:Birc6	UTSW	17	74,689,256 (GRCm38)	missense	probably benign	0.44
R4994:Birc6	UTSW	17	74,594,324 (GRCm38)	intron	probably benign
R5018:Birc6	UTSW	17	74,640,059 (GRCm38)	missense	probably damaging	1.00
R5022:Birc6	UTSW	17	74,692,332 (GRCm38)	missense	probably damaging	1.00
R5054:Birc6	UTSW	17	74,655,325 (GRCm38)	missense	probably damaging	1.00
R5068:Birc6	UTSW	17	74,565,972 (GRCm38)	missense	probably damaging	1.00
R5069:Birc6	UTSW	17	74,565,972 (GRCm38)	missense	probably damaging	1.00
R5070:Birc6	UTSW	17	74,565,972 (GRCm38)	missense	probably damaging	1.00
R5196:Birc6	UTSW	17	74,606,141 (GRCm38)	splice site	probably benign
R5209:Birc6	UTSW	17	74,670,374 (GRCm38)	missense	probably damaging	1.00
R5212:Birc6	UTSW	17	74,670,374 (GRCm38)	missense	probably damaging	1.00
R5216:Birc6	UTSW	17	74,613,470 (GRCm38)	missense	probably damaging	1.00
R5279:Birc6	UTSW	17	74,650,047 (GRCm38)	missense	probably damaging	0.98
R5286:Birc6	UTSW	17	74,670,247 (GRCm38)	missense	probably damaging	1.00
R5399:Birc6	UTSW	17	74,604,578 (GRCm38)	missense	possibly damaging	0.75
R5482:Birc6	UTSW	17	74,662,690 (GRCm38)	missense	probably damaging	1.00
R5482:Birc6	UTSW	17	74,641,782 (GRCm38)	missense	possibly damaging	0.86
R5492:Birc6	UTSW	17	74,670,374 (GRCm38)	missense	probably damaging	1.00
R5504:Birc6	UTSW	17	74,655,213 (GRCm38)	missense	probably damaging	1.00
R5519:Birc6	UTSW	17	74,580,178 (GRCm38)	missense	probably benign
R5544:Birc6	UTSW	17	74,670,374 (GRCm38)	missense	probably damaging	1.00
R5608:Birc6	UTSW	17	74,613,544 (GRCm38)	missense	probably damaging	0.99
R5623:Birc6	UTSW	17	74,528,656 (GRCm38)	missense	probably damaging	0.99
R5701:Birc6	UTSW	17	74,697,425 (GRCm38)	missense	possibly damaging	0.59
R5707:Birc6	UTSW	17	74,696,404 (GRCm38)	missense	probably damaging	1.00
R5715:Birc6	UTSW	17	74,631,620 (GRCm38)	missense	probably damaging	1.00
R5734:Birc6	UTSW	17	74,618,424 (GRCm38)	splice site	probably benign
R5792:Birc6	UTSW	17	74,631,053 (GRCm38)	missense	probably benign	0.05
R5809:Birc6	UTSW	17	74,670,374 (GRCm38)	missense	probably damaging	1.00
R5810:Birc6	UTSW	17	74,670,374 (GRCm38)	missense	probably damaging	1.00
R5813:Birc6	UTSW	17	74,646,502 (GRCm38)	missense	probably damaging	1.00
R5933:Birc6	UTSW	17	74,599,237 (GRCm38)	missense	probably damaging	1.00
R5933:Birc6	UTSW	17	74,599,238 (GRCm38)	missense	probably damaging	0.98
R5960:Birc6	UTSW	17	74,528,765 (GRCm38)	missense	probably damaging	0.97
R5961:Birc6	UTSW	17	74,646,601 (GRCm38)	missense	probably damaging	1.00
R5967:Birc6	UTSW	17	74,660,439 (GRCm38)	missense	probably damaging	0.99
R5970:Birc6	UTSW	17	74,618,502 (GRCm38)	missense	possibly damaging	0.95
R5977:Birc6	UTSW	17	74,603,036 (GRCm38)	missense	probably damaging	1.00
R5982:Birc6	UTSW	17	74,648,158 (GRCm38)	missense	probably benign
R6023:Birc6	UTSW	17	74,654,377 (GRCm38)	missense	probably benign	0.24
R6034:Birc6	UTSW	17	74,615,283 (GRCm38)	missense	probably damaging	1.00
R6034:Birc6	UTSW	17	74,615,283 (GRCm38)	missense	probably damaging	1.00
R6243:Birc6	UTSW	17	74,609,387 (GRCm38)	missense	probably damaging	0.96
R6294:Birc6	UTSW	17	74,689,257 (GRCm38)	missense	probably benign	0.00
R6327:Birc6	UTSW	17	74,662,779 (GRCm38)	missense	probably damaging	1.00
R6501:Birc6	UTSW	17	74,579,281 (GRCm38)	missense	probably damaging	1.00
R6810:Birc6	UTSW	17	74,612,220 (GRCm38)	missense	possibly damaging	0.63
R6822:Birc6	UTSW	17	74,598,044 (GRCm38)	missense	probably damaging	1.00
R6822:Birc6	UTSW	17	74,580,382 (GRCm38)	missense	possibly damaging	0.82
R6835:Birc6	UTSW	17	74,642,504 (GRCm38)	missense	probably damaging	1.00
R6945:Birc6	UTSW	17	74,579,531 (GRCm38)	missense	probably benign	0.04
R6957:Birc6	UTSW	17	74,579,491 (GRCm38)	missense	probably benign
R6989:Birc6	UTSW	17	74,630,989 (GRCm38)	missense	probably benign	0.18
R6991:Birc6	UTSW	17	74,562,095 (GRCm38)	missense	probably damaging	1.00
R7019:Birc6	UTSW	17	74,609,345 (GRCm38)	missense	probably benign	0.01
R7092:Birc6	UTSW	17	74,646,745 (GRCm38)	missense	probably damaging	1.00
R7158:Birc6	UTSW	17	74,594,376 (GRCm38)	missense	probably benign	0.25
R7204:Birc6	UTSW	17	74,640,108 (GRCm38)	missense	probably damaging	1.00
R7267:Birc6	UTSW	17	74,585,985 (GRCm38)	missense	probably benign	0.00
R7316:Birc6	UTSW	17	74,604,494 (GRCm38)	missense	probably damaging	0.99
R7341:Birc6	UTSW	17	74,612,074 (GRCm38)	missense	probably damaging	1.00
R7404:Birc6	UTSW	17	74,639,794 (GRCm38)	missense	possibly damaging	0.73
R7449:Birc6	UTSW	17	74,702,341 (GRCm38)	missense	probably benign
R7498:Birc6	UTSW	17	74,660,470 (GRCm38)	missense	probably damaging	1.00
R7539:Birc6	UTSW	17	74,649,696 (GRCm38)	missense	probably damaging	1.00
R7569:Birc6	UTSW	17	74,598,082 (GRCm38)	missense	possibly damaging	0.71
R7611:Birc6	UTSW	17	74,662,718 (GRCm38)	missense	probably damaging	0.98
R7653:Birc6	UTSW	17	74,647,734 (GRCm38)	missense	possibly damaging	0.91
R7716:Birc6	UTSW	17	74,562,061 (GRCm38)	missense	probably damaging	0.99
R7728:Birc6	UTSW	17	74,622,105 (GRCm38)	missense	probably benign	0.01
R7810:Birc6	UTSW	17	74,548,820 (GRCm38)	missense	probably damaging	0.98
R7828:Birc6	UTSW	17	74,579,506 (GRCm38)	missense	probably damaging	0.97
R7881:Birc6	UTSW	17	74,641,671 (GRCm38)	missense	probably damaging	0.99
R7896:Birc6	UTSW	17	74,622,082 (GRCm38)	missense	probably damaging	0.99
R7950:Birc6	UTSW	17	74,593,100 (GRCm38)	missense	probably damaging	1.00
R7988:Birc6	UTSW	17	74,599,373 (GRCm38)	splice site	probably null
R8073:Birc6	UTSW	17	74,603,085 (GRCm38)	missense	probably damaging	1.00
R8128:Birc6	UTSW	17	74,609,258 (GRCm38)	missense	probably damaging	1.00
R8167:Birc6	UTSW	17	74,643,394 (GRCm38)	missense	probably damaging	1.00
R8236:Birc6	UTSW	17	74,611,131 (GRCm38)	missense	probably damaging	1.00
R8237:Birc6	UTSW	17	74,611,131 (GRCm38)	missense	probably damaging	1.00
R8255:Birc6	UTSW	17	74,662,780 (GRCm38)	missense	probably damaging	0.99
R8259:Birc6	UTSW	17	74,598,078 (GRCm38)	missense	probably benign	0.01
R8297:Birc6	UTSW	17	74,625,104 (GRCm38)	critical splice acceptor site	probably null
R8376:Birc6	UTSW	17	74,589,640 (GRCm38)	missense	probably benign	0.18
R8413:Birc6	UTSW	17	74,546,393 (GRCm38)	missense	possibly damaging	0.54
R8503:Birc6	UTSW	17	74,692,244 (GRCm38)	missense	probably damaging	1.00
R8504:Birc6	UTSW	17	74,652,005 (GRCm38)	missense	probably damaging	0.98
R8543:Birc6	UTSW	17	74,565,865 (GRCm38)	missense	probably damaging	1.00
R8550:Birc6	UTSW	17	74,557,954 (GRCm38)	missense	probably benign	0.37
R8551:Birc6	UTSW	17	74,557,954 (GRCm38)	missense	probably benign	0.37
R8556:Birc6	UTSW	17	74,557,954 (GRCm38)	missense	probably benign	0.37
R8683:Birc6	UTSW	17	74,609,119 (GRCm38)	missense	possibly damaging	0.74
R8751:Birc6	UTSW	17	74,648,140 (GRCm38)	missense	probably damaging	0.98
R8803:Birc6	UTSW	17	74,652,038 (GRCm38)	missense	probably damaging	0.99
R8806:Birc6	UTSW	17	74,642,316 (GRCm38)	missense	probably damaging	1.00
R8825:Birc6	UTSW	17	74,613,505 (GRCm38)	missense	probably damaging	0.99
R8888:Birc6	UTSW	17	74,528,538 (GRCm38)	missense	probably null	0.33
R8972:Birc6	UTSW	17	74,702,318 (GRCm38)	missense	probably benign	0.05
R9069:Birc6	UTSW	17	74,561,265 (GRCm38)	splice site	probably benign
R9111:Birc6	UTSW	17	74,659,345 (GRCm38)	missense	probably damaging	0.99
R9130:Birc6	UTSW	17	74,612,151 (GRCm38)	missense
R9352:Birc6	UTSW	17	74,658,352 (GRCm38)	critical splice donor site	probably null
R9354:Birc6	UTSW	17	74,614,406 (GRCm38)	missense	probably benign
R9432:Birc6	UTSW	17	74,659,221 (GRCm38)	missense	probably benign
R9446:Birc6	UTSW	17	74,618,496 (GRCm38)	missense	probably damaging	1.00
R9485:Birc6	UTSW	17	74,638,403 (GRCm38)	missense	probably damaging	1.00
R9499:Birc6	UTSW	17	74,609,069 (GRCm38)	missense	probably benign	0.05
R9551:Birc6	UTSW	17	74,609,069 (GRCm38)	missense	probably benign	0.05
R9552:Birc6	UTSW	17	74,609,069 (GRCm38)	missense	probably benign	0.05
R9585:Birc6	UTSW	17	74,609,270 (GRCm38)	missense	probably damaging	1.00
R9647:Birc6	UTSW	17	74,692,310 (GRCm38)	missense	probably damaging	1.00
R9648:Birc6	UTSW	17	74,631,701 (GRCm38)	missense	probably damaging	1.00
R9667:Birc6	UTSW	17	74,697,425 (GRCm38)	missense	possibly damaging	0.59
R9696:Birc6	UTSW	17	74,640,297 (GRCm38)	missense	probably damaging	0.99
RF016:Birc6	UTSW	17	74,689,324 (GRCm38)	missense	probably damaging	1.00
Z1088:Birc6	UTSW	17	74,611,542 (GRCm38)	missense	probably damaging	0.99
Z1177:Birc6	UTSW	17	74,647,280 (GRCm38)	missense	probably benign	0.10

Predicted Primers

PCR Primer
(F):5'- CCAGGAGCAGCTGTTGTTAC -3'
(R):5'- CACATCTGCTGGTGACTCATG -3'

Sequencing Primer
(F):5'- TGTTGTTACAGGATCCGCC -3'
(R):5'- CTGGTGACTCATGTTGGATCACAC -3'

Posted On

2019-10-24