Mutagenetix > Incidental Mutation

Incidental Mutation 'R4994:Birc6'

446628

Institutional Source

Beutler Lab

Gene Symbol

Birc6

Ensembl Gene

ENSMUSG00000024073

Gene Name

baculoviral IAP repeat-containing 6

Synonyms

D630005A10Rik, apollon, Bruce, A430032G04Rik, A430040A19Rik

MMRRC Submission

042588-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R4994 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

74528295-74703356 bp(+) (GRCm38)

Type of Mutation

intron

DNA Base Change (assembly)

A to G at 74594324 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000138732 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000180037] [ENSMUST00000182133] [ENSMUST00000182597] [ENSMUST00000182944] [ENSMUST00000183224]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000177957

Predicted Effect

probably benign
Transcript: ENSMUST00000180037

SMART Domains

Protein: ENSMUSP00000136329
Gene: ENSMUSG00000024073

Domain	Start	End	E-Value	Type
low complexity region	24	54	N/A	INTRINSIC
BIR	287	363	2.87e-24	SMART
low complexity region	472	493	N/A	INTRINSIC
low complexity region	624	635	N/A	INTRINSIC
low complexity region	674	685	N/A	INTRINSIC
low complexity region	769	781	N/A	INTRINSIC
low complexity region	1054	1071	N/A	INTRINSIC
low complexity region	1369	1380	N/A	INTRINSIC
coiled coil region	1620	1675	N/A	INTRINSIC
low complexity region	1709	1726	N/A	INTRINSIC
low complexity region	1993	1998	N/A	INTRINSIC
low complexity region	2044	2059	N/A	INTRINSIC
low complexity region	2142	2163	N/A	INTRINSIC
low complexity region	2253	2266	N/A	INTRINSIC
low complexity region	2491	2505	N/A	INTRINSIC
low complexity region	2671	2688	N/A	INTRINSIC
low complexity region	2893	2905	N/A	INTRINSIC
low complexity region	2958	2970	N/A	INTRINSIC
Pfam:DUF3643	3477	3632	1e-69	PFAM
low complexity region	3747	3772	N/A	INTRINSIC
low complexity region	3900	3919	N/A	INTRINSIC
low complexity region	3940	3958	N/A	INTRINSIC
low complexity region	3963	3972	N/A	INTRINSIC
low complexity region	4146	4157	N/A	INTRINSIC
low complexity region	4307	4318	N/A	INTRINSIC
low complexity region	4433	4444	N/A	INTRINSIC
UBCc	4592	4756	1.04e-25	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000181387

Predicted Effect

probably benign
Transcript: ENSMUST00000182133

SMART Domains

Protein: ENSMUSP00000138693
Gene: ENSMUSG00000024073

Domain	Start	End	E-Value	Type
low complexity region	24	54	N/A	INTRINSIC
BIR	287	363	2.87e-24	SMART
low complexity region	472	493	N/A	INTRINSIC
low complexity region	624	635	N/A	INTRINSIC
low complexity region	674	685	N/A	INTRINSIC
low complexity region	769	781	N/A	INTRINSIC
low complexity region	1054	1071	N/A	INTRINSIC
low complexity region	1369	1380	N/A	INTRINSIC
coiled coil region	1620	1675	N/A	INTRINSIC
low complexity region	1709	1726	N/A	INTRINSIC
low complexity region	1993	1998	N/A	INTRINSIC
low complexity region	2044	2055	N/A	INTRINSIC
low complexity region	2136	2157	N/A	INTRINSIC
low complexity region	2247	2260	N/A	INTRINSIC
low complexity region	2485	2499	N/A	INTRINSIC
low complexity region	2665	2682	N/A	INTRINSIC
low complexity region	2887	2899	N/A	INTRINSIC
low complexity region	2952	2964	N/A	INTRINSIC
Pfam:DUF3643	3470	3626	2.1e-71	PFAM
low complexity region	3741	3766	N/A	INTRINSIC
low complexity region	3894	3913	N/A	INTRINSIC
low complexity region	3934	3952	N/A	INTRINSIC
low complexity region	3957	3966	N/A	INTRINSIC
low complexity region	4140	4151	N/A	INTRINSIC
low complexity region	4301	4312	N/A	INTRINSIC
low complexity region	4427	4438	N/A	INTRINSIC
UBCc	4586	4750	1.04e-25	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000182597

SMART Domains

Protein: ENSMUSP00000138333
Gene: ENSMUSG00000024073

Domain	Start	End	E-Value	Type
low complexity region	24	54	N/A	INTRINSIC
BIR	287	363	2.87e-24	SMART
low complexity region	472	493	N/A	INTRINSIC
low complexity region	624	635	N/A	INTRINSIC
low complexity region	674	685	N/A	INTRINSIC
low complexity region	769	781	N/A	INTRINSIC
low complexity region	1054	1071	N/A	INTRINSIC
low complexity region	1369	1380	N/A	INTRINSIC
coiled coil region	1620	1675	N/A	INTRINSIC
low complexity region	1709	1726	N/A	INTRINSIC
low complexity region	1993	1998	N/A	INTRINSIC
low complexity region	2044	2059	N/A	INTRINSIC
low complexity region	2142	2163	N/A	INTRINSIC
low complexity region	2262	2275	N/A	INTRINSIC
low complexity region	2500	2514	N/A	INTRINSIC
low complexity region	2680	2697	N/A	INTRINSIC
low complexity region	2902	2914	N/A	INTRINSIC
low complexity region	2967	2979	N/A	INTRINSIC
Pfam:DUF3643	3485	3641	2.2e-71	PFAM
low complexity region	3756	3781	N/A	INTRINSIC
low complexity region	3909	3928	N/A	INTRINSIC
low complexity region	3949	3967	N/A	INTRINSIC
low complexity region	3972	3981	N/A	INTRINSIC
low complexity region	4155	4166	N/A	INTRINSIC
low complexity region	4316	4327	N/A	INTRINSIC
low complexity region	4442	4453	N/A	INTRINSIC
UBCc	4601	4765	1.04e-25	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000182944

SMART Domains

Protein: ENSMUSP00000138732
Gene: ENSMUSG00000024073

Domain	Start	End	E-Value	Type
low complexity region	24	54	N/A	INTRINSIC
BIR	287	363	2.87e-24	SMART
low complexity region	472	493	N/A	INTRINSIC
low complexity region	624	635	N/A	INTRINSIC
low complexity region	674	685	N/A	INTRINSIC
low complexity region	769	781	N/A	INTRINSIC
low complexity region	1054	1071	N/A	INTRINSIC
low complexity region	1369	1380	N/A	INTRINSIC
coiled coil region	1616	1671	N/A	INTRINSIC
low complexity region	1705	1722	N/A	INTRINSIC
low complexity region	1989	1994	N/A	INTRINSIC
low complexity region	2040	2055	N/A	INTRINSIC
low complexity region	2138	2159	N/A	INTRINSIC
low complexity region	2249	2262	N/A	INTRINSIC
low complexity region	2487	2501	N/A	INTRINSIC
low complexity region	2667	2684	N/A	INTRINSIC
low complexity region	2889	2901	N/A	INTRINSIC
low complexity region	2954	2966	N/A	INTRINSIC
Pfam:DUF3643	3472	3628	3.2e-71	PFAM
low complexity region	3743	3768	N/A	INTRINSIC
low complexity region	3896	3915	N/A	INTRINSIC
low complexity region	3936	3954	N/A	INTRINSIC
low complexity region	3959	3968	N/A	INTRINSIC
low complexity region	4142	4153	N/A	INTRINSIC
low complexity region	4303	4314	N/A	INTRINSIC
low complexity region	4429	4440	N/A	INTRINSIC
UBCc	4588	4752	1.04e-25	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000183224
AA Change: T1114A

SMART Domains

Protein: ENSMUSP00000138270
Gene: ENSMUSG00000024073
AA Change: T1114A

Domain	Start	End	E-Value	Type
low complexity region	2	26	N/A	INTRINSIC
BIR	259	335	2.87e-24	SMART
low complexity region	444	465	N/A	INTRINSIC
low complexity region	596	607	N/A	INTRINSIC
low complexity region	646	657	N/A	INTRINSIC
low complexity region	741	753	N/A	INTRINSIC
low complexity region	1026	1043	N/A	INTRINSIC
low complexity region	1355	1366	N/A	INTRINSIC
coiled coil region	1606	1661	N/A	INTRINSIC
low complexity region	1695	1712	N/A	INTRINSIC
low complexity region	1979	1984	N/A	INTRINSIC
low complexity region	2030	2041	N/A	INTRINSIC
low complexity region	2122	2143	N/A	INTRINSIC
low complexity region	2233	2246	N/A	INTRINSIC
low complexity region	2471	2485	N/A	INTRINSIC
low complexity region	2651	2668	N/A	INTRINSIC
low complexity region	2873	2885	N/A	INTRINSIC
low complexity region	2938	2950	N/A	INTRINSIC
Pfam:DUF3643	3456	3612	3.2e-71	PFAM
low complexity region	3727	3752	N/A	INTRINSIC
low complexity region	3880	3899	N/A	INTRINSIC
low complexity region	3920	3938	N/A	INTRINSIC
low complexity region	3943	3952	N/A	INTRINSIC
low complexity region	4126	4137	N/A	INTRINSIC
low complexity region	4287	4298	N/A	INTRINSIC
low complexity region	4413	4424	N/A	INTRINSIC
UBCc	4572	4736	1.04e-25	SMART

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.8%
20x: 94.0%

Validation Efficiency

100% (79/79)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mice exhibit perinatal lethality and exhibit placental defects. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 76 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1190002N15Rik	C	A	9: 94,537,433	R148L	probably benign	Het
1700030K09Rik	A	G	8: 72,455,118	E364G	probably benign	Het
4930505A04Rik	C	T	11: 30,426,349	V173M	probably damaging	Het
Abcb4	A	G	5: 8,928,524	T557A	probably damaging	Het
Acadm	C	T	3: 153,929,584	E298K	probably damaging	Het
Adrb3	T	C	8: 27,227,827		probably null	Het
Aldh1b1	A	G	4: 45,803,128	Y222C	possibly damaging	Het
Ankrd6	A	G	4: 32,860,387	Y19H	probably damaging	Het
Arhgap21	T	A	2: 20,849,890	T1554S	probably benign	Het
BC043934	T	C	9: 96,437,120		noncoding transcript	Het
Blm	A	C	7: 80,458,825	F1357C	probably benign	Het
Cd209a	T	C	8: 3,747,713		probably null	Het
Cdk7	G	A	13: 100,717,595	H129Y	probably damaging	Het
Clec14a	G	T	12: 58,268,284	P184Q	probably damaging	Het
Cma1	T	A	14: 55,941,671	I243F	probably damaging	Het
Cntnap3	G	T	13: 64,761,984	T769K	possibly damaging	Het
Col5a1	A	C	2: 28,032,739	K273T	possibly damaging	Het
Csnk1e	A	G	15: 79,424,929	Y266H	probably damaging	Het
Cyb5d1	A	G	11: 69,393,771	L185S	probably damaging	Het
Dennd5b	T	C	6: 149,041,500		probably null	Het
Drp2	G	A	X: 134,441,316	R567H	probably damaging	Homo
Dzank1	T	G	2: 144,522,566	D37A	probably damaging	Het
Echdc2	A	G	4: 108,165,628	I34V	probably benign	Het
Esm1	A	T	13: 113,213,431	R128S	probably benign	Het
Fbrsl1	A	G	5: 110,447,951	S73P	probably damaging	Het
Fbxo18	T	A	2: 11,764,230	I251F	probably damaging	Het
Fbxo6	A	T	4: 148,149,491	S49R	probably damaging	Het
Gm13089	T	A	4: 143,698,369	Q168L	possibly damaging	Het
Gm17093	A	T	14: 44,519,322	Q82L	probably damaging	Het
Hmcn2	T	C	2: 31,458,055		probably null	Het
Hspa4l	C	A	3: 40,745,649		probably benign	Het
Il3ra	G	A	14: 14,351,080	A201T	probably benign	Het
Irx5	T	A	8: 92,360,781	V447E	probably damaging	Het
Kif14	G	T	1: 136,482,959	L668F	probably damaging	Het
Lag3	T	A	6: 124,904,453	R519W	unknown	Het
Lgr4	A	G	2: 110,011,938	N756S	probably damaging	Het
Lingo4	T	A	3: 94,403,001	H415Q	probably benign	Het
Lingo4	A	G	3: 94,402,541	H262R	probably benign	Het
Lkaaear1	C	A	2: 181,697,583	G25*	probably null	Het
Marf1	T	C	16: 14,114,231	K1641E	probably benign	Het
Mtfmt	T	C	9: 65,443,851		probably benign	Het
Mtif3	G	A	5: 146,956,788	T203M	probably benign	Het
Mycbp2	A	G	14: 103,169,994	I2740T	probably benign	Het
Nrd1	A	G	4: 109,046,612	T720A	probably benign	Het
Olfr715	T	C	7: 107,129,064	T110A	probably benign	Het
Peak1	T	A	9: 56,241,276	D32V	possibly damaging	Het
Pigr	G	A	1: 130,841,817	D122N	probably benign	Het
Plekhg3	A	G	12: 76,565,537	R391G	possibly damaging	Het
Ppfia3	T	C	7: 45,341,118	D919G	probably damaging	Het
Rnase2b	T	A	14: 51,162,751	D96E	possibly damaging	Het
Rsf1	G	GACGGCGGCT	7: 97,579,909		probably benign	Het
Rsf1	CGGCGGC	CGGCGGCCGCGGCGGC	7: 97,579,923		probably benign	Het
Serpina3f	A	G	12: 104,220,356	T394A	probably benign	Het
Six3	A	G	17: 85,621,292	N18S	possibly damaging	Het
Slc12a5	T	A	2: 164,983,365		probably null	Het
Slc35f6	A	G	5: 30,648,083	N21S	probably damaging	Het
Slc39a6	A	T	18: 24,596,294	I454N	probably damaging	Het
Slc40a1	T	A	1: 45,909,664	E485D	probably damaging	Het
Sort1	G	A	3: 108,328,069	C255Y	probably damaging	Het
Stab2	T	A	10: 86,949,907	T624S	probably benign	Het
Stk33	T	A	7: 109,340,398	I99L	probably benign	Het
Taf4b	T	A	18: 14,898,043	I828N	probably damaging	Het
Terf2	T	C	8: 107,076,478		probably benign	Het
Timd4	C	T	11: 46,815,517	R49C	probably damaging	Het
Tmem57	A	G	4: 134,828,299	Y288H	probably damaging	Het
Tpte	T	C	8: 22,318,346	S166P	probably benign	Het
Trabd2b	T	C	4: 114,406,855	L13P	probably benign	Het
Trappc11	A	T	8: 47,522,441	Y247*	probably null	Het
Trnt1	C	T	6: 106,778,892	Q303*	probably null	Het
Tspyl5	T	A	15: 33,687,055	Q248L	possibly damaging	Het
Ubxn7	A	T	16: 32,381,504	K337N	probably damaging	Het
Unc13a	T	A	8: 71,643,172	I1234F	probably benign	Het
Vmn1r127	A	T	7: 21,319,018	F282I	probably damaging	Het
Wdhd1	A	T	14: 47,268,654		probably null	Het
Zfp605	A	G	5: 110,127,486	K157E	probably damaging	Het
Zhx2	T	A	15: 57,821,359	D41E	probably benign	Het

Other mutations in Birc6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00402:Birc6	APN	17	74,573,563 (GRCm38)	splice site	probably benign
IGL00542:Birc6	APN	17	74,623,771 (GRCm38)	splice site	probably null
IGL00659:Birc6	APN	17	74,660,653 (GRCm38)	missense	probably damaging	1.00
IGL00710:Birc6	APN	17	74,609,089 (GRCm38)	missense	probably benign	0.37
IGL00806:Birc6	APN	17	74,611,529 (GRCm38)	missense	possibly damaging	0.85
IGL00848:Birc6	APN	17	74,696,393 (GRCm38)	nonsense	probably null
IGL01071:Birc6	APN	17	74,566,132 (GRCm38)	missense	possibly damaging	0.84
IGL01071:Birc6	APN	17	74,631,701 (GRCm38)	missense	probably damaging	1.00
IGL01121:Birc6	APN	17	74,631,038 (GRCm38)	missense	probably benign	0.08
IGL01132:Birc6	APN	17	74,603,060 (GRCm38)	missense	probably damaging	1.00
IGL01323:Birc6	APN	17	74,622,925 (GRCm38)	missense	probably damaging	1.00
IGL01444:Birc6	APN	17	74,631,687 (GRCm38)	missense	probably damaging	1.00
IGL01511:Birc6	APN	17	74,627,003 (GRCm38)	nonsense	probably null
IGL01576:Birc6	APN	17	74,677,370 (GRCm38)	missense	possibly damaging	0.80
IGL01578:Birc6	APN	17	74,648,197 (GRCm38)	missense	probably benign	0.08
IGL01649:Birc6	APN	17	74,604,546 (GRCm38)	missense	probably benign	0.03
IGL01657:Birc6	APN	17	74,660,611 (GRCm38)	missense	probably damaging	1.00
IGL01739:Birc6	APN	17	74,659,221 (GRCm38)	missense	probably benign
IGL01756:Birc6	APN	17	74,640,208 (GRCm38)	missense	probably benign	0.00
IGL01807:Birc6	APN	17	74,631,037 (GRCm38)	missense	probably benign
IGL01885:Birc6	APN	17	74,604,516 (GRCm38)	missense	possibly damaging	0.51
IGL01906:Birc6	APN	17	74,638,358 (GRCm38)	missense	probably damaging	1.00
IGL01915:Birc6	APN	17	74,631,720 (GRCm38)	missense	probably benign	0.34
IGL01998:Birc6	APN	17	74,579,885 (GRCm38)	missense	probably benign	0.06
IGL02084:Birc6	APN	17	74,608,282 (GRCm38)	missense	probably benign	0.45
IGL02086:Birc6	APN	17	74,639,827 (GRCm38)	missense	probably damaging	1.00
IGL02161:Birc6	APN	17	74,548,837 (GRCm38)	missense	probably damaging	0.99
IGL02195:Birc6	APN	17	74,697,381 (GRCm38)	splice site	probably benign
IGL02283:Birc6	APN	17	74,599,940 (GRCm38)	missense	probably benign
IGL02476:Birc6	APN	17	74,696,391 (GRCm38)	missense	possibly damaging	0.81
IGL02493:Birc6	APN	17	74,652,059 (GRCm38)	unclassified	probably benign
IGL02547:Birc6	APN	17	74,579,645 (GRCm38)	missense	probably benign	0.21
IGL02678:Birc6	APN	17	74,649,903 (GRCm38)	missense	probably damaging	1.00
IGL02713:Birc6	APN	17	74,579,324 (GRCm38)	missense	probably benign
IGL02851:Birc6	APN	17	74,609,189 (GRCm38)	missense	probably damaging	1.00
IGL02875:Birc6	APN	17	74,589,718 (GRCm38)	missense	probably damaging	1.00
IGL02985:Birc6	APN	17	74,640,190 (GRCm38)	missense	probably benign	0.00
IGL03004:Birc6	APN	17	74,612,185 (GRCm38)	missense	probably benign	0.10
IGL03053:Birc6	APN	17	74,565,972 (GRCm38)	missense	probably damaging	1.00
IGL03085:Birc6	APN	17	74,596,950 (GRCm38)	missense	probably damaging	0.97
IGL03109:Birc6	APN	17	74,579,334 (GRCm38)	missense	possibly damaging	0.71
IGL03143:Birc6	APN	17	74,598,999 (GRCm38)	missense	possibly damaging	0.89
IGL03180:Birc6	APN	17	74,659,231 (GRCm38)	missense	probably benign
IGL03221:Birc6	APN	17	74,627,007 (GRCm38)	missense	probably benign	0.00
IGL03230:Birc6	APN	17	74,611,070 (GRCm38)	missense	probably damaging	1.00
IGL03294:Birc6	APN	17	74,649,886 (GRCm38)	missense	probably benign	0.02
IGL03399:Birc6	APN	17	74,594,373 (GRCm38)	missense	probably benign	0.01
Badlands	UTSW	17	74,603,036 (GRCm38)	missense	probably damaging	1.00
Big_sky	UTSW	17	74,528,538 (GRCm38)	missense	probably null	0.33
bitterroot	UTSW	17	74,649,696 (GRCm38)	missense	probably damaging	1.00
Black_hills	UTSW	17	74,692,332 (GRCm38)	missense	probably damaging	1.00
bottomlands	UTSW	17	74,609,659 (GRCm38)	missense	probably damaging	1.00
Chai	UTSW	17	74,670,374 (GRCm38)	missense	probably damaging	1.00
Dakota	UTSW	17	74,625,104 (GRCm38)	critical splice acceptor site	probably null
Sempervirens	UTSW	17	74,642,504 (GRCm38)	missense	probably damaging	1.00
E0370:Birc6	UTSW	17	74,677,357 (GRCm38)	missense	probably damaging	1.00
G1citation:Birc6	UTSW	17	74,598,044 (GRCm38)	missense	probably damaging	1.00
G1citation:Birc6	UTSW	17	74,580,382 (GRCm38)	missense	possibly damaging	0.82
PIT4494001:Birc6	UTSW	17	74,626,980 (GRCm38)	missense	probably damaging	1.00
R0081:Birc6	UTSW	17	74,643,441 (GRCm38)	missense	probably benign	0.01
R0086:Birc6	UTSW	17	74,593,166 (GRCm38)	missense	possibly damaging	0.54
R0089:Birc6	UTSW	17	74,638,376 (GRCm38)	missense	possibly damaging	0.90
R0116:Birc6	UTSW	17	74,623,746 (GRCm38)	splice site	probably benign
R0129:Birc6	UTSW	17	74,528,760 (GRCm38)	missense	probably benign	0.05
R0196:Birc6	UTSW	17	74,580,287 (GRCm38)	missense	possibly damaging	0.57
R0201:Birc6	UTSW	17	74,609,327 (GRCm38)	missense	possibly damaging	0.92
R0207:Birc6	UTSW	17	74,662,832 (GRCm38)	splice site	probably benign
R0295:Birc6	UTSW	17	74,613,362 (GRCm38)	intron	probably benign
R0386:Birc6	UTSW	17	74,599,340 (GRCm38)	missense	probably damaging	0.99
R0423:Birc6	UTSW	17	74,696,297 (GRCm38)	missense	probably damaging	1.00
R0449:Birc6	UTSW	17	74,692,295 (GRCm38)	missense	probably damaging	1.00
R0453:Birc6	UTSW	17	74,649,754 (GRCm38)	missense	probably damaging	1.00
R0457:Birc6	UTSW	17	74,662,625 (GRCm38)	missense	probably damaging	1.00
R0457:Birc6	UTSW	17	74,652,028 (GRCm38)	missense	probably benign
R0564:Birc6	UTSW	17	74,625,243 (GRCm38)	splice site	probably benign
R0575:Birc6	UTSW	17	74,689,237 (GRCm38)	missense	probably damaging	1.00
R0582:Birc6	UTSW	17	74,643,337 (GRCm38)	missense	probably damaging	1.00
R0624:Birc6	UTSW	17	74,580,349 (GRCm38)	missense	probably benign	0.20
R0973:Birc6	UTSW	17	74,565,861 (GRCm38)	missense	probably damaging	0.99
R1061:Birc6	UTSW	17	74,689,312 (GRCm38)	missense	probably damaging	1.00
R1378:Birc6	UTSW	17	74,660,455 (GRCm38)	missense	probably damaging	1.00
R1402:Birc6	UTSW	17	74,697,533 (GRCm38)	splice site	probably benign
R1436:Birc6	UTSW	17	74,652,705 (GRCm38)	missense	probably damaging	1.00
R1456:Birc6	UTSW	17	74,609,290 (GRCm38)	missense	probably benign	0.35
R1465:Birc6	UTSW	17	74,623,858 (GRCm38)	missense	probably benign	0.03
R1465:Birc6	UTSW	17	74,623,858 (GRCm38)	missense	probably benign	0.03
R1474:Birc6	UTSW	17	74,579,678 (GRCm38)	missense	probably damaging	0.98
R1479:Birc6	UTSW	17	74,634,853 (GRCm38)	missense	probably damaging	1.00
R1486:Birc6	UTSW	17	74,639,820 (GRCm38)	missense	probably damaging	1.00
R1499:Birc6	UTSW	17	74,612,319 (GRCm38)	missense	probably damaging	1.00
R1515:Birc6	UTSW	17	74,528,636 (GRCm38)	nonsense	probably null
R1549:Birc6	UTSW	17	74,662,742 (GRCm38)	missense	probably damaging	1.00
R1559:Birc6	UTSW	17	74,692,237 (GRCm38)	missense	probably damaging	1.00
R1573:Birc6	UTSW	17	74,660,690 (GRCm38)	splice site	probably benign
R1615:Birc6	UTSW	17	74,609,409 (GRCm38)	splice site	probably null
R1621:Birc6	UTSW	17	74,670,250 (GRCm38)	missense	probably benign
R1680:Birc6	UTSW	17	74,548,746 (GRCm38)	missense	probably benign	0.01
R1743:Birc6	UTSW	17	74,579,756 (GRCm38)	missense	possibly damaging	0.95
R1774:Birc6	UTSW	17	74,640,013 (GRCm38)	missense	probably damaging	1.00
R1775:Birc6	UTSW	17	74,612,286 (GRCm38)	missense	probably damaging	1.00
R1818:Birc6	UTSW	17	74,649,849 (GRCm38)	missense	probably damaging	1.00
R1836:Birc6	UTSW	17	74,614,390 (GRCm38)	missense	probably benign	0.41
R1931:Birc6	UTSW	17	74,565,982 (GRCm38)	missense	probably damaging	0.99
R1939:Birc6	UTSW	17	74,670,337 (GRCm38)	missense	probably damaging	1.00
R1964:Birc6	UTSW	17	74,634,885 (GRCm38)	missense	possibly damaging	0.94
R1994:Birc6	UTSW	17	74,598,062 (GRCm38)	missense	probably benign	0.01
R2000:Birc6	UTSW	17	74,604,619 (GRCm38)	missense	possibly damaging	0.46
R2042:Birc6	UTSW	17	74,609,659 (GRCm38)	missense	probably damaging	1.00
R2090:Birc6	UTSW	17	74,662,796 (GRCm38)	missense	probably benign
R2130:Birc6	UTSW	17	74,659,154 (GRCm38)	splice site	probably benign
R2144:Birc6	UTSW	17	74,660,413 (GRCm38)	missense	possibly damaging	0.71
R2145:Birc6	UTSW	17	74,660,413 (GRCm38)	missense	possibly damaging	0.71
R2166:Birc6	UTSW	17	74,635,795 (GRCm38)	missense	probably benign	0.02
R2180:Birc6	UTSW	17	74,612,151 (GRCm38)	missense	probably benign	0.03
R2271:Birc6	UTSW	17	74,602,971 (GRCm38)	missense	probably benign	0.06
R2272:Birc6	UTSW	17	74,602,971 (GRCm38)	missense	probably benign	0.06
R2416:Birc6	UTSW	17	74,608,219 (GRCm38)	missense	possibly damaging	0.83
R2420:Birc6	UTSW	17	74,660,614 (GRCm38)	missense	probably damaging	1.00
R2421:Birc6	UTSW	17	74,660,614 (GRCm38)	missense	probably damaging	1.00
R2422:Birc6	UTSW	17	74,660,614 (GRCm38)	missense	probably damaging	1.00
R2513:Birc6	UTSW	17	74,647,729 (GRCm38)	missense	probably damaging	0.97
R2912:Birc6	UTSW	17	74,692,206 (GRCm38)	missense	probably damaging	1.00
R3024:Birc6	UTSW	17	74,608,219 (GRCm38)	missense	possibly damaging	0.83
R3771:Birc6	UTSW	17	74,618,429 (GRCm38)	splice site	probably benign
R3772:Birc6	UTSW	17	74,618,429 (GRCm38)	splice site	probably benign
R3829:Birc6	UTSW	17	74,655,178 (GRCm38)	missense	probably damaging	1.00
R3913:Birc6	UTSW	17	74,573,613 (GRCm38)	nonsense	probably null
R3915:Birc6	UTSW	17	74,579,608 (GRCm38)	missense	probably benign	0.12
R3921:Birc6	UTSW	17	74,627,019 (GRCm38)	missense	probably damaging	0.98
R3928:Birc6	UTSW	17	74,638,409 (GRCm38)	missense	probably damaging	1.00
R3928:Birc6	UTSW	17	74,611,175 (GRCm38)	missense	possibly damaging	0.91
R4111:Birc6	UTSW	17	74,566,015 (GRCm38)	missense	probably damaging	1.00
R4155:Birc6	UTSW	17	74,596,939 (GRCm38)	missense	probably benign	0.00
R4163:Birc6	UTSW	17	74,626,980 (GRCm38)	missense	probably damaging	1.00
R4226:Birc6	UTSW	17	74,619,840 (GRCm38)	critical splice donor site	probably null
R4227:Birc6	UTSW	17	74,619,840 (GRCm38)	critical splice donor site	probably null
R4358:Birc6	UTSW	17	74,619,668 (GRCm38)	splice site	probably null
R4524:Birc6	UTSW	17	74,641,777 (GRCm38)	missense	probably damaging	1.00
R4605:Birc6	UTSW	17	74,639,934 (GRCm38)	missense	probably damaging	1.00
R4619:Birc6	UTSW	17	74,640,150 (GRCm38)	missense	probably benign	0.18
R4620:Birc6	UTSW	17	74,640,150 (GRCm38)	missense	probably benign	0.18
R4762:Birc6	UTSW	17	74,629,489 (GRCm38)	missense	probably damaging	1.00
R4814:Birc6	UTSW	17	74,649,672 (GRCm38)	missense	probably damaging	1.00
R4849:Birc6	UTSW	17	74,647,388 (GRCm38)	missense	probably damaging	0.99
R4869:Birc6	UTSW	17	74,586,012 (GRCm38)	missense	probably benign	0.05
R4912:Birc6	UTSW	17	74,565,905 (GRCm38)	missense	probably damaging	1.00
R4921:Birc6	UTSW	17	74,650,099 (GRCm38)	missense	probably damaging	1.00
R4942:Birc6	UTSW	17	74,623,050 (GRCm38)	missense	probably damaging	1.00
R4954:Birc6	UTSW	17	74,612,031 (GRCm38)	missense	probably damaging	1.00
R4992:Birc6	UTSW	17	74,689,256 (GRCm38)	missense	probably benign	0.44
R5018:Birc6	UTSW	17	74,640,059 (GRCm38)	missense	probably damaging	1.00
R5022:Birc6	UTSW	17	74,692,332 (GRCm38)	missense	probably damaging	1.00
R5054:Birc6	UTSW	17	74,655,325 (GRCm38)	missense	probably damaging	1.00
R5068:Birc6	UTSW	17	74,565,972 (GRCm38)	missense	probably damaging	1.00
R5069:Birc6	UTSW	17	74,565,972 (GRCm38)	missense	probably damaging	1.00
R5070:Birc6	UTSW	17	74,565,972 (GRCm38)	missense	probably damaging	1.00
R5196:Birc6	UTSW	17	74,606,141 (GRCm38)	splice site	probably benign
R5209:Birc6	UTSW	17	74,670,374 (GRCm38)	missense	probably damaging	1.00
R5212:Birc6	UTSW	17	74,670,374 (GRCm38)	missense	probably damaging	1.00
R5216:Birc6	UTSW	17	74,613,470 (GRCm38)	missense	probably damaging	1.00
R5279:Birc6	UTSW	17	74,650,047 (GRCm38)	missense	probably damaging	0.98
R5286:Birc6	UTSW	17	74,670,247 (GRCm38)	missense	probably damaging	1.00
R5399:Birc6	UTSW	17	74,604,578 (GRCm38)	missense	possibly damaging	0.75
R5482:Birc6	UTSW	17	74,662,690 (GRCm38)	missense	probably damaging	1.00
R5482:Birc6	UTSW	17	74,641,782 (GRCm38)	missense	possibly damaging	0.86
R5492:Birc6	UTSW	17	74,670,374 (GRCm38)	missense	probably damaging	1.00
R5504:Birc6	UTSW	17	74,655,213 (GRCm38)	missense	probably damaging	1.00
R5519:Birc6	UTSW	17	74,580,178 (GRCm38)	missense	probably benign
R5544:Birc6	UTSW	17	74,670,374 (GRCm38)	missense	probably damaging	1.00
R5608:Birc6	UTSW	17	74,613,544 (GRCm38)	missense	probably damaging	0.99
R5623:Birc6	UTSW	17	74,528,656 (GRCm38)	missense	probably damaging	0.99
R5701:Birc6	UTSW	17	74,697,425 (GRCm38)	missense	possibly damaging	0.59
R5707:Birc6	UTSW	17	74,696,404 (GRCm38)	missense	probably damaging	1.00
R5715:Birc6	UTSW	17	74,631,620 (GRCm38)	missense	probably damaging	1.00
R5734:Birc6	UTSW	17	74,618,424 (GRCm38)	splice site	probably benign
R5792:Birc6	UTSW	17	74,631,053 (GRCm38)	missense	probably benign	0.05
R5809:Birc6	UTSW	17	74,670,374 (GRCm38)	missense	probably damaging	1.00
R5810:Birc6	UTSW	17	74,670,374 (GRCm38)	missense	probably damaging	1.00
R5813:Birc6	UTSW	17	74,646,502 (GRCm38)	missense	probably damaging	1.00
R5933:Birc6	UTSW	17	74,599,237 (GRCm38)	missense	probably damaging	1.00
R5933:Birc6	UTSW	17	74,599,238 (GRCm38)	missense	probably damaging	0.98
R5960:Birc6	UTSW	17	74,528,765 (GRCm38)	missense	probably damaging	0.97
R5961:Birc6	UTSW	17	74,646,601 (GRCm38)	missense	probably damaging	1.00
R5967:Birc6	UTSW	17	74,660,439 (GRCm38)	missense	probably damaging	0.99
R5970:Birc6	UTSW	17	74,618,502 (GRCm38)	missense	possibly damaging	0.95
R5977:Birc6	UTSW	17	74,603,036 (GRCm38)	missense	probably damaging	1.00
R5982:Birc6	UTSW	17	74,648,158 (GRCm38)	missense	probably benign
R6023:Birc6	UTSW	17	74,654,377 (GRCm38)	missense	probably benign	0.24
R6034:Birc6	UTSW	17	74,615,283 (GRCm38)	missense	probably damaging	1.00
R6034:Birc6	UTSW	17	74,615,283 (GRCm38)	missense	probably damaging	1.00
R6243:Birc6	UTSW	17	74,609,387 (GRCm38)	missense	probably damaging	0.96
R6294:Birc6	UTSW	17	74,689,257 (GRCm38)	missense	probably benign	0.00
R6327:Birc6	UTSW	17	74,662,779 (GRCm38)	missense	probably damaging	1.00
R6501:Birc6	UTSW	17	74,579,281 (GRCm38)	missense	probably damaging	1.00
R6810:Birc6	UTSW	17	74,612,220 (GRCm38)	missense	possibly damaging	0.63
R6822:Birc6	UTSW	17	74,598,044 (GRCm38)	missense	probably damaging	1.00
R6822:Birc6	UTSW	17	74,580,382 (GRCm38)	missense	possibly damaging	0.82
R6835:Birc6	UTSW	17	74,642,504 (GRCm38)	missense	probably damaging	1.00
R6945:Birc6	UTSW	17	74,579,531 (GRCm38)	missense	probably benign	0.04
R6957:Birc6	UTSW	17	74,579,491 (GRCm38)	missense	probably benign
R6989:Birc6	UTSW	17	74,630,989 (GRCm38)	missense	probably benign	0.18
R6991:Birc6	UTSW	17	74,562,095 (GRCm38)	missense	probably damaging	1.00
R7019:Birc6	UTSW	17	74,609,345 (GRCm38)	missense	probably benign	0.01
R7092:Birc6	UTSW	17	74,646,745 (GRCm38)	missense	probably damaging	1.00
R7158:Birc6	UTSW	17	74,594,376 (GRCm38)	missense	probably benign	0.25
R7204:Birc6	UTSW	17	74,640,108 (GRCm38)	missense	probably damaging	1.00
R7267:Birc6	UTSW	17	74,585,985 (GRCm38)	missense	probably benign	0.00
R7316:Birc6	UTSW	17	74,604,494 (GRCm38)	missense	probably damaging	0.99
R7341:Birc6	UTSW	17	74,612,074 (GRCm38)	missense	probably damaging	1.00
R7404:Birc6	UTSW	17	74,639,794 (GRCm38)	missense	possibly damaging	0.73
R7449:Birc6	UTSW	17	74,702,341 (GRCm38)	missense	probably benign
R7498:Birc6	UTSW	17	74,660,470 (GRCm38)	missense	probably damaging	1.00
R7539:Birc6	UTSW	17	74,649,696 (GRCm38)	missense	probably damaging	1.00
R7569:Birc6	UTSW	17	74,598,082 (GRCm38)	missense	possibly damaging	0.71
R7574:Birc6	UTSW	17	74,579,884 (GRCm38)	missense	probably benign
R7611:Birc6	UTSW	17	74,662,718 (GRCm38)	missense	probably damaging	0.98
R7653:Birc6	UTSW	17	74,647,734 (GRCm38)	missense	possibly damaging	0.91
R7716:Birc6	UTSW	17	74,562,061 (GRCm38)	missense	probably damaging	0.99
R7728:Birc6	UTSW	17	74,622,105 (GRCm38)	missense	probably benign	0.01
R7810:Birc6	UTSW	17	74,548,820 (GRCm38)	missense	probably damaging	0.98
R7828:Birc6	UTSW	17	74,579,506 (GRCm38)	missense	probably damaging	0.97
R7881:Birc6	UTSW	17	74,641,671 (GRCm38)	missense	probably damaging	0.99
R7896:Birc6	UTSW	17	74,622,082 (GRCm38)	missense	probably damaging	0.99
R7950:Birc6	UTSW	17	74,593,100 (GRCm38)	missense	probably damaging	1.00
R7988:Birc6	UTSW	17	74,599,373 (GRCm38)	splice site	probably null
R8073:Birc6	UTSW	17	74,603,085 (GRCm38)	missense	probably damaging	1.00
R8128:Birc6	UTSW	17	74,609,258 (GRCm38)	missense	probably damaging	1.00
R8167:Birc6	UTSW	17	74,643,394 (GRCm38)	missense	probably damaging	1.00
R8236:Birc6	UTSW	17	74,611,131 (GRCm38)	missense	probably damaging	1.00
R8237:Birc6	UTSW	17	74,611,131 (GRCm38)	missense	probably damaging	1.00
R8255:Birc6	UTSW	17	74,662,780 (GRCm38)	missense	probably damaging	0.99
R8259:Birc6	UTSW	17	74,598,078 (GRCm38)	missense	probably benign	0.01
R8297:Birc6	UTSW	17	74,625,104 (GRCm38)	critical splice acceptor site	probably null
R8376:Birc6	UTSW	17	74,589,640 (GRCm38)	missense	probably benign	0.18
R8413:Birc6	UTSW	17	74,546,393 (GRCm38)	missense	possibly damaging	0.54
R8503:Birc6	UTSW	17	74,692,244 (GRCm38)	missense	probably damaging	1.00
R8504:Birc6	UTSW	17	74,652,005 (GRCm38)	missense	probably damaging	0.98
R8543:Birc6	UTSW	17	74,565,865 (GRCm38)	missense	probably damaging	1.00
R8550:Birc6	UTSW	17	74,557,954 (GRCm38)	missense	probably benign	0.37
R8551:Birc6	UTSW	17	74,557,954 (GRCm38)	missense	probably benign	0.37
R8556:Birc6	UTSW	17	74,557,954 (GRCm38)	missense	probably benign	0.37
R8683:Birc6	UTSW	17	74,609,119 (GRCm38)	missense	possibly damaging	0.74
R8751:Birc6	UTSW	17	74,648,140 (GRCm38)	missense	probably damaging	0.98
R8803:Birc6	UTSW	17	74,652,038 (GRCm38)	missense	probably damaging	0.99
R8806:Birc6	UTSW	17	74,642,316 (GRCm38)	missense	probably damaging	1.00
R8825:Birc6	UTSW	17	74,613,505 (GRCm38)	missense	probably damaging	0.99
R8888:Birc6	UTSW	17	74,528,538 (GRCm38)	missense	probably null	0.33
R8972:Birc6	UTSW	17	74,702,318 (GRCm38)	missense	probably benign	0.05
R9069:Birc6	UTSW	17	74,561,265 (GRCm38)	splice site	probably benign
R9111:Birc6	UTSW	17	74,659,345 (GRCm38)	missense	probably damaging	0.99
R9130:Birc6	UTSW	17	74,612,151 (GRCm38)	missense
R9352:Birc6	UTSW	17	74,658,352 (GRCm38)	critical splice donor site	probably null
R9354:Birc6	UTSW	17	74,614,406 (GRCm38)	missense	probably benign
R9432:Birc6	UTSW	17	74,659,221 (GRCm38)	missense	probably benign
R9446:Birc6	UTSW	17	74,618,496 (GRCm38)	missense	probably damaging	1.00
R9485:Birc6	UTSW	17	74,638,403 (GRCm38)	missense	probably damaging	1.00
R9499:Birc6	UTSW	17	74,609,069 (GRCm38)	missense	probably benign	0.05
R9551:Birc6	UTSW	17	74,609,069 (GRCm38)	missense	probably benign	0.05
R9552:Birc6	UTSW	17	74,609,069 (GRCm38)	missense	probably benign	0.05
R9585:Birc6	UTSW	17	74,609,270 (GRCm38)	missense	probably damaging	1.00
R9647:Birc6	UTSW	17	74,692,310 (GRCm38)	missense	probably damaging	1.00
R9648:Birc6	UTSW	17	74,631,701 (GRCm38)	missense	probably damaging	1.00
R9667:Birc6	UTSW	17	74,697,425 (GRCm38)	missense	possibly damaging	0.59
R9696:Birc6	UTSW	17	74,640,297 (GRCm38)	missense	probably damaging	0.99
RF016:Birc6	UTSW	17	74,689,324 (GRCm38)	missense	probably damaging	1.00
Z1088:Birc6	UTSW	17	74,611,542 (GRCm38)	missense	probably damaging	0.99
Z1177:Birc6	UTSW	17	74,647,280 (GRCm38)	missense	probably benign	0.10

Predicted Primers

PCR Primer
(F):5'- TGTGCAGCTTAGGGAGGAAC -3'
(R):5'- CTTTACTGCCAGGGACAACAG -3'

Sequencing Primer
(F):5'- AGGGAGGAACTTTTAATTTAGTTGCC -3'
(R):5'- CAACAGCTCTGTGGTTGAAC -3'

Posted On

2016-11-30