Incidental Mutation 'R9327:Vmn2r45'
| ID |
706570 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r45
|
| Ensembl Gene |
ENSMUSG00000090662 |
| Gene Name |
vomeronasal 2, receptor 45 |
| Synonyms |
|
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
R9327 (G1)
|
| Quality Score |
218.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
8474468-8491958 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 8474532 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 832
(Y832C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129466
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164845]
|
| AlphaFold |
L7N2B5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000164845
AA Change: Y832C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000129466
Gene: ENSMUSG00000090662
AA Change: Y832C
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
154 |
469 |
4.5e-26 |
PFAM |
|
Pfam:NCD3G
|
512 |
565 |
6.4e-21 |
PFAM |
|
Pfam:7tm_3
|
598 |
833 |
2.1e-54 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
100% (57/57) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 58 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A1cf |
T |
A |
19: 31,895,499 (GRCm39) |
M194K |
probably benign |
Het |
| Abcg1 |
T |
C |
17: 31,333,122 (GRCm39) |
S622P |
probably benign |
Het |
| Ahnak2 |
A |
T |
12: 112,748,446 (GRCm39) |
V467E |
|
Het |
| Amdhd2 |
T |
C |
17: 24,377,421 (GRCm39) |
E164G |
probably benign |
Het |
| Ank3 |
G |
A |
10: 69,812,086 (GRCm39) |
|
probably null |
Het |
| Bank1 |
A |
T |
3: 135,799,308 (GRCm39) |
N545K |
probably benign |
Het |
| C9orf72 |
A |
G |
4: 35,205,883 (GRCm39) |
I247T |
|
Het |
| Cep63 |
T |
C |
9: 102,467,723 (GRCm39) |
I548V |
probably benign |
Het |
| Col28a1 |
T |
C |
6: 8,175,653 (GRCm39) |
D65G |
unknown |
Het |
| Cspg4b |
C |
A |
13: 113,453,710 (GRCm39) |
Q58K |
|
Het |
| Cyp2c50 |
A |
G |
19: 40,079,010 (GRCm39) |
N118D |
probably benign |
Het |
| Dock10 |
C |
T |
1: 80,510,184 (GRCm39) |
C1549Y |
probably damaging |
Het |
| Epg5 |
A |
G |
18: 77,991,435 (GRCm39) |
E44G |
probably benign |
Het |
| Ephb4 |
T |
C |
5: 137,361,529 (GRCm39) |
S520P |
probably damaging |
Het |
| Eppk1 |
T |
C |
15: 75,993,755 (GRCm39) |
E1042G |
probably benign |
Het |
| Fmod |
A |
T |
1: 133,968,589 (GRCm39) |
N210Y |
probably damaging |
Het |
| Fpr3 |
A |
G |
17: 18,191,713 (GRCm39) |
D328G |
probably damaging |
Het |
| Garem2 |
T |
G |
5: 30,321,989 (GRCm39) |
C783G |
probably benign |
Het |
| Gm10542 |
A |
G |
18: 44,337,689 (GRCm39) |
N56D |
probably damaging |
Het |
| Gm20939 |
T |
A |
17: 95,184,424 (GRCm39) |
N357K |
probably benign |
Het |
| Hr |
A |
G |
14: 70,805,228 (GRCm39) |
H990R |
possibly damaging |
Het |
| Il21r |
A |
G |
7: 125,226,163 (GRCm39) |
N53S |
unknown |
Het |
| Insrr |
C |
T |
3: 87,721,604 (GRCm39) |
T1170I |
probably damaging |
Het |
| Itga11 |
A |
G |
9: 62,638,034 (GRCm39) |
M103V |
probably damaging |
Het |
| Izumo3 |
G |
T |
4: 92,035,050 (GRCm39) |
Q56K |
probably damaging |
Het |
| Kcnh8 |
T |
C |
17: 53,146,084 (GRCm39) |
V324A |
probably damaging |
Het |
| Kcnj2 |
T |
A |
11: 110,963,719 (GRCm39) |
N370K |
probably benign |
Het |
| Klf16 |
G |
T |
10: 80,412,688 (GRCm39) |
S116* |
probably null |
Het |
| Mettl16 |
T |
C |
11: 74,696,089 (GRCm39) |
V310A |
probably benign |
Het |
| Misp3 |
G |
T |
8: 84,737,080 (GRCm39) |
Q105K |
unknown |
Het |
| Mmrn2 |
G |
A |
14: 34,097,473 (GRCm39) |
|
probably benign |
Het |
| Mtcl1 |
A |
G |
17: 66,645,130 (GRCm39) |
L1888P |
probably damaging |
Het |
| Muc5ac |
A |
C |
7: 141,365,429 (GRCm39) |
T1984P |
possibly damaging |
Het |
| Myo16 |
G |
T |
8: 10,489,705 (GRCm39) |
|
probably null |
Het |
| Nckipsd |
T |
C |
9: 108,691,699 (GRCm39) |
I466T |
possibly damaging |
Het |
| Nos1 |
G |
C |
5: 118,017,402 (GRCm39) |
R255P |
probably benign |
Het |
| Npffr2 |
A |
G |
5: 89,730,661 (GRCm39) |
H197R |
probably benign |
Het |
| Nrap |
T |
A |
19: 56,340,100 (GRCm39) |
M842L |
probably benign |
Het |
| Nxpe4 |
G |
A |
9: 48,309,984 (GRCm39) |
A416T |
probably benign |
Het |
| Nxt2 |
C |
T |
X: 141,020,747 (GRCm39) |
A118V |
possibly damaging |
Het |
| Or51t4 |
T |
C |
7: 102,597,687 (GRCm39) |
V5A |
probably benign |
Het |
| Or52n20 |
A |
G |
7: 104,320,742 (GRCm39) |
I278V |
probably damaging |
Het |
| Or5p53 |
T |
A |
7: 107,533,019 (GRCm39) |
C97* |
probably null |
Het |
| Ppp1r15a |
C |
T |
7: 45,174,035 (GRCm39) |
A258T |
possibly damaging |
Het |
| Prss36 |
A |
T |
7: 127,532,570 (GRCm39) |
Y760* |
probably null |
Het |
| Psg26 |
T |
A |
7: 18,216,480 (GRCm39) |
T120S |
probably damaging |
Het |
| Ptk7 |
A |
T |
17: 46,878,977 (GRCm39) |
L908Q |
probably benign |
Het |
| S100a13 |
G |
T |
3: 90,423,170 (GRCm39) |
D54Y |
unknown |
Het |
| Slc25a44 |
A |
T |
3: 88,328,025 (GRCm39) |
H155Q |
probably benign |
Het |
| Smarcc2 |
A |
G |
10: 128,321,486 (GRCm39) |
T894A |
probably damaging |
Het |
| Tle4 |
A |
G |
19: 14,574,149 (GRCm39) |
F39L |
probably damaging |
Het |
| Tmem181a |
G |
A |
17: 6,346,048 (GRCm39) |
V181M |
possibly damaging |
Het |
| Tmt1b |
A |
G |
10: 128,794,607 (GRCm39) |
M239T |
probably benign |
Het |
| Trpm3 |
T |
C |
19: 22,896,004 (GRCm39) |
V947A |
possibly damaging |
Het |
| Txndc16 |
G |
A |
14: 45,379,448 (GRCm39) |
T663I |
probably benign |
Het |
| Vmn2r9 |
T |
C |
5: 108,996,841 (GRCm39) |
T143A |
probably damaging |
Het |
| Vps26b |
T |
C |
9: 26,930,750 (GRCm39) |
N82D |
probably benign |
Het |
| Zfp318 |
T |
G |
17: 46,721,892 (GRCm39) |
F1298L |
probably damaging |
Het |
|
| Other mutations in Vmn2r45 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01287:Vmn2r45
|
APN |
7 |
8,488,622 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01322:Vmn2r45
|
APN |
7 |
8,484,332 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL01402:Vmn2r45
|
APN |
7 |
8,484,467 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01404:Vmn2r45
|
APN |
7 |
8,484,467 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01529:Vmn2r45
|
APN |
7 |
8,486,493 (GRCm39) |
missense |
probably benign |
|
|
IGL01596:Vmn2r45
|
APN |
7 |
8,486,272 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01646:Vmn2r45
|
APN |
7 |
8,486,337 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01819:Vmn2r45
|
APN |
7 |
8,488,556 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02096:Vmn2r45
|
APN |
7 |
8,484,443 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02130:Vmn2r45
|
APN |
7 |
8,486,556 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL02409:Vmn2r45
|
APN |
7 |
8,488,727 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02517:Vmn2r45
|
APN |
7 |
8,486,185 (GRCm39) |
nonsense |
probably null |
|
|
IGL02633:Vmn2r45
|
APN |
7 |
8,488,728 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02940:Vmn2r45
|
APN |
7 |
8,475,369 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03281:Vmn2r45
|
APN |
7 |
8,486,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03358:Vmn2r45
|
APN |
7 |
8,474,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB004:Vmn2r45
|
UTSW |
7 |
8,486,513 (GRCm39) |
missense |
probably benign |
|
|
BB014:Vmn2r45
|
UTSW |
7 |
8,486,513 (GRCm39) |
missense |
probably benign |
|
|
R0382:Vmn2r45
|
UTSW |
7 |
8,486,098 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0532:Vmn2r45
|
UTSW |
7 |
8,474,820 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0932:Vmn2r45
|
UTSW |
7 |
8,478,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1125:Vmn2r45
|
UTSW |
7 |
8,488,542 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1580:Vmn2r45
|
UTSW |
7 |
8,474,746 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1817:Vmn2r45
|
UTSW |
7 |
8,475,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1996:Vmn2r45
|
UTSW |
7 |
8,475,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2050:Vmn2r45
|
UTSW |
7 |
8,475,021 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2284:Vmn2r45
|
UTSW |
7 |
8,488,765 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4019:Vmn2r45
|
UTSW |
7 |
8,474,580 (GRCm39) |
nonsense |
probably null |
|
|
R4227:Vmn2r45
|
UTSW |
7 |
8,486,277 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4381:Vmn2r45
|
UTSW |
7 |
8,474,912 (GRCm39) |
nonsense |
probably null |
|
|
R4618:Vmn2r45
|
UTSW |
7 |
8,486,436 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4624:Vmn2r45
|
UTSW |
7 |
8,484,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4704:Vmn2r45
|
UTSW |
7 |
8,486,535 (GRCm39) |
nonsense |
probably null |
|
|
R4735:Vmn2r45
|
UTSW |
7 |
8,486,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4868:Vmn2r45
|
UTSW |
7 |
8,484,480 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4983:Vmn2r45
|
UTSW |
7 |
8,486,116 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5246:Vmn2r45
|
UTSW |
7 |
8,486,251 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5430:Vmn2r45
|
UTSW |
7 |
8,486,333 (GRCm39) |
nonsense |
probably null |
|
|
R5504:Vmn2r45
|
UTSW |
7 |
8,486,176 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5511:Vmn2r45
|
UTSW |
7 |
8,474,832 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5745:Vmn2r45
|
UTSW |
7 |
8,486,074 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5814:Vmn2r45
|
UTSW |
7 |
8,474,475 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6223:Vmn2r45
|
UTSW |
7 |
8,486,301 (GRCm39) |
missense |
probably benign |
|
|
R6267:Vmn2r45
|
UTSW |
7 |
8,475,207 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6623:Vmn2r45
|
UTSW |
7 |
8,474,500 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6999:Vmn2r45
|
UTSW |
7 |
8,486,219 (GRCm39) |
missense |
probably benign |
|
|
R7242:Vmn2r45
|
UTSW |
7 |
8,488,612 (GRCm39) |
nonsense |
probably null |
|
|
R7491:Vmn2r45
|
UTSW |
7 |
8,484,342 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7620:Vmn2r45
|
UTSW |
7 |
8,486,222 (GRCm39) |
nonsense |
probably null |
|
|
R7719:Vmn2r45
|
UTSW |
7 |
8,486,460 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7720:Vmn2r45
|
UTSW |
7 |
8,486,460 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7853:Vmn2r45
|
UTSW |
7 |
8,485,987 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7873:Vmn2r45
|
UTSW |
7 |
8,486,074 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7882:Vmn2r45
|
UTSW |
7 |
8,486,409 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7927:Vmn2r45
|
UTSW |
7 |
8,486,513 (GRCm39) |
missense |
probably benign |
|
|
R8684:Vmn2r45
|
UTSW |
7 |
8,486,511 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8780:Vmn2r45
|
UTSW |
7 |
8,484,371 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8811:Vmn2r45
|
UTSW |
7 |
8,474,881 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8893:Vmn2r45
|
UTSW |
7 |
8,488,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9043:Vmn2r45
|
UTSW |
7 |
8,474,904 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9208:Vmn2r45
|
UTSW |
7 |
8,486,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9586:Vmn2r45
|
UTSW |
7 |
8,486,050 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9599:Vmn2r45
|
UTSW |
7 |
8,478,457 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
U24488:Vmn2r45
|
UTSW |
7 |
8,475,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r45
|
UTSW |
7 |
8,474,484 (GRCm39) |
missense |
probably benign |
0.16 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGGACACTGTAGGGAAGTTC -3'
(R):5'- CCTGACGCATTCAATGAAGCC -3'
Sequencing Primer
(F):5'- TCATGATATCACTAGAGCAACCAGTG -3'
(R):5'- GAAGCCAAGTTCTTGACCTTCAG -3'
|
| Posted On |
2022-04-18 |
Incidental Mutation