Incidental Mutation 'R1299:Zfp882'
| ID |
158249 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp882
|
| Ensembl Gene |
ENSMUSG00000089857 |
| Gene Name |
zinc finger protein 882 |
| Synonyms |
ENSMUSG00000052439 |
| MMRRC Submission |
039365-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.167)
|
| Stock # |
R1299 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
72662452-72670198 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 72667317 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 88
(E88G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000119978
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000110002]
[ENSMUST00000125802]
[ENSMUST00000126607]
[ENSMUST00000131544]
|
| AlphaFold |
E9Q4R4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000110002
AA Change: E48G
PolyPhen 2
Score 0.606 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000105629
Gene: ENSMUSG00000089857
AA Change: E48G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
61 |
8.58e-14 |
SMART |
|
ZnF_C2H2
|
84 |
106 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
168 |
190 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
196 |
218 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
224 |
246 |
6.31e1 |
SMART |
|
ZnF_C2H2
|
251 |
273 |
1.16e-1 |
SMART |
|
ZnF_C2H2
|
279 |
301 |
1.25e-1 |
SMART |
|
ZnF_C2H2
|
307 |
329 |
5.42e-2 |
SMART |
|
ZnF_C2H2
|
335 |
357 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
363 |
385 |
7.26e-3 |
SMART |
|
ZnF_C2H2
|
391 |
413 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
419 |
441 |
3.29e1 |
SMART |
|
ZnF_C2H2
|
447 |
469 |
2.67e-1 |
SMART |
|
ZnF_C2H2
|
475 |
497 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
503 |
525 |
4.11e-2 |
SMART |
|
ZnF_C2H2
|
531 |
553 |
4.87e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000118290
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000125802
AA Change: E56G
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000121316
Gene: ENSMUSG00000089857
AA Change: E56G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
12 |
69 |
8.58e-14 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000126607
AA Change: E88G
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000119978
Gene: ENSMUSG00000089857
AA Change: E88G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
44 |
101 |
8.58e-14 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000131544
|
| SMART Domains |
Protein: ENSMUSP00000120213
Gene: ENSMUSG00000066880
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
56 |
1.08e-10 |
SMART |
|
ZnF_C2H2
|
167 |
189 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
195 |
217 |
8.34e-3 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000170898
|
| Meta Mutation Damage Score |
0.1718 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.3%
|
| Validation Efficiency |
100% (38/38) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
T |
C |
11: 9,244,821 (GRCm39) |
L2228P |
possibly damaging |
Het |
| Acnat1 |
T |
A |
4: 49,450,925 (GRCm39) |
E62V |
possibly damaging |
Het |
| Adam7 |
A |
G |
14: 68,763,748 (GRCm39) |
|
probably benign |
Het |
| Ate1 |
A |
T |
7: 130,106,485 (GRCm39) |
V292D |
probably damaging |
Het |
| Cbx8 |
T |
C |
11: 118,931,676 (GRCm39) |
M1V |
probably null |
Het |
| Cdc73 |
T |
C |
1: 143,575,019 (GRCm39) |
D58G |
probably benign |
Het |
| Cgnl1 |
G |
A |
9: 71,628,994 (GRCm39) |
|
probably benign |
Het |
| Col27a1 |
G |
A |
4: 63,183,868 (GRCm39) |
|
probably benign |
Het |
| Fam133b |
T |
C |
5: 3,604,626 (GRCm39) |
|
probably benign |
Het |
| Fndc3a |
A |
G |
14: 72,803,638 (GRCm39) |
|
probably benign |
Het |
| Golga3 |
G |
A |
5: 110,352,709 (GRCm39) |
A867T |
probably benign |
Het |
| Gpr142 |
A |
T |
11: 114,695,185 (GRCm39) |
Y50F |
probably benign |
Het |
| Gramd1c |
A |
G |
16: 43,803,865 (GRCm39) |
|
probably benign |
Het |
| Gypa |
G |
A |
8: 81,223,382 (GRCm39) |
V53I |
unknown |
Het |
| H2-DMb2 |
T |
C |
17: 34,369,561 (GRCm39) |
V235A |
probably benign |
Het |
| Igkv10-94 |
T |
C |
6: 68,681,482 (GRCm39) |
|
probably benign |
Het |
| Katnip |
A |
C |
7: 125,451,195 (GRCm39) |
M1109L |
probably benign |
Het |
| Klhl17 |
T |
C |
4: 156,315,419 (GRCm39) |
Y484C |
probably damaging |
Het |
| Ltbp3 |
T |
C |
19: 5,795,456 (GRCm39) |
|
probably benign |
Het |
| Mapkbp1 |
G |
A |
2: 119,845,885 (GRCm39) |
C412Y |
probably damaging |
Het |
| Mblac2 |
C |
A |
13: 81,859,845 (GRCm39) |
C65* |
probably null |
Het |
| Or5b104 |
T |
A |
19: 13,072,494 (GRCm39) |
N173Y |
possibly damaging |
Het |
| Or6c217 |
A |
G |
10: 129,737,946 (GRCm39) |
I211T |
probably benign |
Het |
| Parn |
G |
A |
16: 13,482,593 (GRCm39) |
T85M |
probably benign |
Het |
| Pcdhb22 |
T |
C |
18: 37,653,643 (GRCm39) |
S704P |
probably damaging |
Het |
| Prex1 |
A |
G |
2: 166,427,827 (GRCm39) |
F942L |
possibly damaging |
Het |
| Prox1 |
G |
T |
1: 189,879,140 (GRCm39) |
|
probably benign |
Het |
| Prss55 |
A |
T |
14: 64,319,147 (GRCm39) |
I70N |
probably damaging |
Het |
| Slc25a13 |
C |
T |
6: 6,113,937 (GRCm39) |
|
probably null |
Het |
| Smarca2 |
T |
C |
19: 26,749,011 (GRCm39) |
|
probably null |
Het |
| Smarcc2 |
C |
A |
10: 128,297,247 (GRCm39) |
N46K |
probably damaging |
Het |
| Tdpoz4 |
A |
T |
3: 93,703,769 (GRCm39) |
Y22F |
probably benign |
Het |
| Tgfbr1 |
T |
A |
4: 47,396,587 (GRCm39) |
|
probably null |
Het |
| Xpr1 |
A |
C |
1: 155,292,949 (GRCm39) |
I11S |
probably damaging |
Het |
| Zfp354b |
A |
C |
11: 50,814,297 (GRCm39) |
S209R |
probably benign |
Het |
|
| Other mutations in Zfp882 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00676:Zfp882
|
APN |
8 |
72,667,671 (GRCm39) |
missense |
probably benign |
|
|
R0244:Zfp882
|
UTSW |
8 |
72,667,367 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0270:Zfp882
|
UTSW |
8 |
72,668,459 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0636:Zfp882
|
UTSW |
8 |
72,668,181 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0840:Zfp882
|
UTSW |
8 |
72,668,530 (GRCm39) |
nonsense |
probably null |
|
|
R4439:Zfp882
|
UTSW |
8 |
72,667,453 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4829:Zfp882
|
UTSW |
8 |
72,668,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5028:Zfp882
|
UTSW |
8 |
72,668,498 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R5296:Zfp882
|
UTSW |
8 |
72,668,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5882:Zfp882
|
UTSW |
8 |
72,667,303 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5974:Zfp882
|
UTSW |
8 |
72,666,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6052:Zfp882
|
UTSW |
8 |
72,668,349 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6383:Zfp882
|
UTSW |
8 |
72,668,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6888:Zfp882
|
UTSW |
8 |
72,668,130 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6987:Zfp882
|
UTSW |
8 |
72,668,517 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7045:Zfp882
|
UTSW |
8 |
72,667,093 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7780:Zfp882
|
UTSW |
8 |
72,668,073 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7793:Zfp882
|
UTSW |
8 |
72,666,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8386:Zfp882
|
UTSW |
8 |
72,667,962 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9452:Zfp882
|
UTSW |
8 |
72,668,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9694:Zfp882
|
UTSW |
8 |
72,667,915 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGATGACCCAACAGCATTACAGGC -3'
(R):5'- TGGGGAGAACTAAAGAATTTCCCGC -3'
Sequencing Primer
(F):5'- tcacccttcctcctgaaaatac -3'
(R):5'- AAAGAATTTCCCGCACTTCTTAC -3'
|
| Posted On |
2014-02-18 |
Incidental Mutation