Incidental Mutation 'R1897:Vmn2r87'
| ID |
212060 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r87
|
| Ensembl Gene |
ENSMUSG00000091511 |
| Gene Name |
vomeronasal 2, receptor 87 |
| Synonyms |
EG625131 |
| MMRRC Submission |
039917-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
R1897 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
130307690-130333248 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 130307829 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 803
(M803K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129215
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164227]
|
| AlphaFold |
E9PZX4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000164227
AA Change: M803K
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000129215
Gene: ENSMUSG00000091511
AA Change: M803K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
422 |
1.8e-27 |
PFAM |
|
Pfam:NCD3G
|
508 |
562 |
1.8e-19 |
PFAM |
|
Pfam:7tm_3
|
595 |
829 |
8.8e-55 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000218030
|
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.3%
- 20x: 92.8%
|
| Validation Efficiency |
99% (72/73) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acbd6 |
A |
G |
1: 155,434,564 (GRCm39) |
S61G |
probably damaging |
Het |
| Acot12 |
A |
G |
13: 91,932,516 (GRCm39) |
N504S |
probably benign |
Het |
| Adcy3 |
C |
T |
12: 4,223,450 (GRCm39) |
|
probably benign |
Het |
| Adcyap1r1 |
A |
T |
6: 55,456,179 (GRCm39) |
H168L |
probably damaging |
Het |
| Adgrd1 |
A |
G |
5: 129,206,065 (GRCm39) |
E213G |
probably benign |
Het |
| Aldh1l2 |
G |
T |
10: 83,338,389 (GRCm39) |
T510K |
probably damaging |
Het |
| Apol7e |
A |
T |
15: 77,602,094 (GRCm39) |
M231L |
probably benign |
Het |
| Asb1 |
C |
A |
1: 91,474,647 (GRCm39) |
|
probably null |
Het |
| Atf7ip2 |
C |
T |
16: 10,028,948 (GRCm39) |
P160L |
probably damaging |
Het |
| Atp8a1 |
A |
G |
5: 67,895,772 (GRCm39) |
L554P |
probably damaging |
Het |
| Ccdc18 |
A |
T |
5: 108,343,908 (GRCm39) |
M884L |
probably benign |
Het |
| Ccdc93 |
A |
G |
1: 121,418,941 (GRCm39) |
I499V |
probably benign |
Het |
| Ccl20 |
A |
G |
1: 83,095,616 (GRCm39) |
D60G |
probably damaging |
Het |
| Cdhr3 |
T |
C |
12: 33,095,192 (GRCm39) |
T626A |
possibly damaging |
Het |
| Cep250 |
A |
G |
2: 155,818,015 (GRCm39) |
E789G |
probably damaging |
Het |
| Cmpk2 |
T |
C |
12: 26,524,046 (GRCm39) |
L281P |
probably damaging |
Het |
| Col6a6 |
A |
T |
9: 105,662,943 (GRCm39) |
M198K |
possibly damaging |
Het |
| Crocc |
G |
A |
4: 140,746,047 (GRCm39) |
R1691C |
probably damaging |
Het |
| Csf1 |
C |
T |
3: 107,655,595 (GRCm39) |
V90M |
probably damaging |
Het |
| Cul2 |
T |
G |
18: 3,414,164 (GRCm39) |
M86R |
probably benign |
Het |
| Dbndd2 |
T |
C |
2: 164,330,584 (GRCm39) |
F79S |
probably damaging |
Het |
| Dkk1 |
G |
T |
19: 30,526,678 (GRCm39) |
N34K |
possibly damaging |
Het |
| Dnah6 |
T |
A |
6: 73,158,745 (GRCm39) |
L619F |
probably benign |
Het |
| Eif2b5 |
T |
C |
16: 20,325,787 (GRCm39) |
V588A |
probably damaging |
Het |
| Elf3 |
A |
T |
1: 135,184,875 (GRCm39) |
Y104N |
probably damaging |
Het |
| Fahd2a |
T |
C |
2: 127,278,530 (GRCm39) |
D272G |
probably damaging |
Het |
| Fbxw15 |
A |
T |
9: 109,387,271 (GRCm39) |
C188* |
probably null |
Het |
| Fbxw8 |
T |
C |
5: 118,266,941 (GRCm39) |
Y174C |
probably benign |
Het |
| Gnl1 |
C |
A |
17: 36,299,584 (GRCm39) |
P585Q |
possibly damaging |
Het |
| Greb1l |
T |
C |
18: 10,498,992 (GRCm39) |
S292P |
probably benign |
Het |
| Gsk3b |
G |
A |
16: 38,037,446 (GRCm39) |
|
probably null |
Het |
| Hcls1 |
C |
T |
16: 36,783,005 (GRCm39) |
P452L |
probably damaging |
Het |
| Hdlbp |
A |
T |
1: 93,350,007 (GRCm39) |
|
probably benign |
Het |
| Hecw1 |
A |
G |
13: 14,552,525 (GRCm39) |
S25P |
probably damaging |
Het |
| Hells |
T |
C |
19: 38,928,928 (GRCm39) |
V100A |
probably benign |
Het |
| Isl1 |
C |
T |
13: 116,439,866 (GRCm39) |
E161K |
probably benign |
Het |
| Klra9 |
G |
T |
6: 130,162,555 (GRCm39) |
N160K |
possibly damaging |
Het |
| Lama4 |
T |
C |
10: 38,936,182 (GRCm39) |
V619A |
probably damaging |
Het |
| Mpc1 |
G |
A |
17: 8,515,710 (GRCm39) |
R134Q |
possibly damaging |
Het |
| Myo5c |
A |
T |
9: 75,199,523 (GRCm39) |
N1377I |
probably benign |
Het |
| Myrf |
T |
C |
19: 10,195,596 (GRCm39) |
I607V |
probably benign |
Het |
| Or2g1 |
T |
G |
17: 38,107,075 (GRCm39) |
S247A |
probably benign |
Het |
| Or8g53 |
A |
T |
9: 39,683,361 (GRCm39) |
I245K |
probably damaging |
Het |
| Pik3c2b |
A |
G |
1: 132,994,654 (GRCm39) |
D206G |
possibly damaging |
Het |
| Pipox |
A |
G |
11: 77,773,568 (GRCm39) |
Y228H |
probably damaging |
Het |
| Pitrm1 |
T |
A |
13: 6,610,131 (GRCm39) |
V401D |
possibly damaging |
Het |
| Plod1 |
C |
T |
4: 148,010,657 (GRCm39) |
E265K |
probably damaging |
Het |
| Ptpn21 |
A |
T |
12: 98,646,664 (GRCm39) |
|
probably null |
Het |
| Qars1 |
C |
T |
9: 108,391,282 (GRCm39) |
Q7* |
probably null |
Het |
| Rpap2 |
T |
A |
5: 107,780,961 (GRCm39) |
V479E |
possibly damaging |
Het |
| Rsf1 |
G |
A |
7: 97,229,117 (GRCm39) |
|
probably benign |
Het |
| Rusc2 |
A |
G |
4: 43,421,749 (GRCm39) |
Y723C |
probably damaging |
Het |
| Ryr2 |
A |
T |
13: 11,765,818 (GRCm39) |
M1306K |
probably benign |
Het |
| Sesn3 |
A |
C |
9: 14,219,941 (GRCm39) |
Y110S |
probably damaging |
Het |
| Sgce |
C |
T |
6: 4,691,511 (GRCm39) |
V319I |
probably benign |
Het |
| Slc15a5 |
G |
T |
6: 138,056,762 (GRCm39) |
F51L |
possibly damaging |
Het |
| Slit2 |
T |
A |
5: 48,395,765 (GRCm39) |
C723S |
probably damaging |
Het |
| Sncaip |
A |
G |
18: 53,027,862 (GRCm39) |
|
probably null |
Het |
| Snx2 |
T |
A |
18: 53,330,950 (GRCm39) |
D138E |
probably damaging |
Het |
| Spef2 |
A |
T |
15: 9,729,740 (GRCm39) |
L126* |
probably null |
Het |
| Stam |
T |
C |
2: 14,133,837 (GRCm39) |
S195P |
probably damaging |
Het |
| Strn |
T |
C |
17: 78,990,271 (GRCm39) |
I82V |
probably benign |
Het |
| Synj2 |
T |
A |
17: 6,072,412 (GRCm39) |
C202* |
probably null |
Het |
| Tecpr2 |
A |
G |
12: 110,899,681 (GRCm39) |
D683G |
probably benign |
Het |
| Tfec |
A |
G |
6: 16,835,307 (GRCm39) |
V157A |
probably damaging |
Het |
| Tff1 |
T |
G |
17: 31,383,912 (GRCm39) |
Q28P |
probably benign |
Het |
| Vmn2r86 |
A |
G |
10: 130,288,314 (GRCm39) |
Y396H |
probably damaging |
Het |
| Vmn2r90 |
A |
G |
17: 17,953,566 (GRCm39) |
K577E |
probably damaging |
Het |
| Vrk1 |
T |
C |
12: 106,002,799 (GRCm39) |
|
probably benign |
Het |
| Wdr20 |
A |
G |
12: 110,760,157 (GRCm39) |
T348A |
probably benign |
Het |
|
| Other mutations in Vmn2r87 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01090:Vmn2r87
|
APN |
10 |
130,333,247 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
IGL01295:Vmn2r87
|
APN |
10 |
130,307,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01411:Vmn2r87
|
APN |
10 |
130,308,429 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01680:Vmn2r87
|
APN |
10 |
130,315,586 (GRCm39) |
nonsense |
probably null |
|
|
IGL01822:Vmn2r87
|
APN |
10 |
130,307,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01835:Vmn2r87
|
APN |
10 |
130,314,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01965:Vmn2r87
|
APN |
10 |
130,314,924 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02562:Vmn2r87
|
APN |
10 |
130,314,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02665:Vmn2r87
|
APN |
10 |
130,333,049 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03202:Vmn2r87
|
APN |
10 |
130,333,091 (GRCm39) |
missense |
probably benign |
|
|
FR4304:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4340:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4342:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4589:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
LCD18:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0344:Vmn2r87
|
UTSW |
10 |
130,315,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0374:Vmn2r87
|
UTSW |
10 |
130,307,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0384:Vmn2r87
|
UTSW |
10 |
130,307,712 (GRCm39) |
missense |
probably benign |
|
|
R1144:Vmn2r87
|
UTSW |
10 |
130,312,098 (GRCm39) |
splice site |
probably benign |
|
|
R1172:Vmn2r87
|
UTSW |
10 |
130,313,453 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1860:Vmn2r87
|
UTSW |
10 |
130,315,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1866:Vmn2r87
|
UTSW |
10 |
130,308,441 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2360:Vmn2r87
|
UTSW |
10 |
130,315,631 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2909:Vmn2r87
|
UTSW |
10 |
130,314,865 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3874:Vmn2r87
|
UTSW |
10 |
130,315,856 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R4113:Vmn2r87
|
UTSW |
10 |
130,315,691 (GRCm39) |
missense |
probably benign |
|
|
R4190:Vmn2r87
|
UTSW |
10 |
130,308,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4197:Vmn2r87
|
UTSW |
10 |
130,315,779 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4201:Vmn2r87
|
UTSW |
10 |
130,308,448 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4202:Vmn2r87
|
UTSW |
10 |
130,308,448 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4368:Vmn2r87
|
UTSW |
10 |
130,315,676 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4485:Vmn2r87
|
UTSW |
10 |
130,315,678 (GRCm39) |
nonsense |
probably null |
|
|
R4537:Vmn2r87
|
UTSW |
10 |
130,308,054 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4590:Vmn2r87
|
UTSW |
10 |
130,315,014 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4752:Vmn2r87
|
UTSW |
10 |
130,314,336 (GRCm39) |
nonsense |
probably null |
|
|
R4873:Vmn2r87
|
UTSW |
10 |
130,308,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4875:Vmn2r87
|
UTSW |
10 |
130,308,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4923:Vmn2r87
|
UTSW |
10 |
130,314,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4970:Vmn2r87
|
UTSW |
10 |
130,314,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5049:Vmn2r87
|
UTSW |
10 |
130,308,298 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5112:Vmn2r87
|
UTSW |
10 |
130,314,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5187:Vmn2r87
|
UTSW |
10 |
130,333,208 (GRCm39) |
missense |
probably null |
0.99 |
|
R5618:Vmn2r87
|
UTSW |
10 |
130,315,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6057:Vmn2r87
|
UTSW |
10 |
130,308,226 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6220:Vmn2r87
|
UTSW |
10 |
130,315,807 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6287:Vmn2r87
|
UTSW |
10 |
130,314,291 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6383:Vmn2r87
|
UTSW |
10 |
130,314,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6576:Vmn2r87
|
UTSW |
10 |
130,314,654 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6742:Vmn2r87
|
UTSW |
10 |
130,308,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7086:Vmn2r87
|
UTSW |
10 |
130,333,178 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7162:Vmn2r87
|
UTSW |
10 |
130,313,416 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7419:Vmn2r87
|
UTSW |
10 |
130,307,992 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7425:Vmn2r87
|
UTSW |
10 |
130,314,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7443:Vmn2r87
|
UTSW |
10 |
130,308,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7571:Vmn2r87
|
UTSW |
10 |
130,314,940 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7663:Vmn2r87
|
UTSW |
10 |
130,308,054 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7716:Vmn2r87
|
UTSW |
10 |
130,308,018 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7793:Vmn2r87
|
UTSW |
10 |
130,313,413 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7806:Vmn2r87
|
UTSW |
10 |
130,315,679 (GRCm39) |
missense |
probably benign |
|
|
R7841:Vmn2r87
|
UTSW |
10 |
130,333,095 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8326:Vmn2r87
|
UTSW |
10 |
130,308,180 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8411:Vmn2r87
|
UTSW |
10 |
130,308,126 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8445:Vmn2r87
|
UTSW |
10 |
130,313,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8540:Vmn2r87
|
UTSW |
10 |
130,314,762 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8892:Vmn2r87
|
UTSW |
10 |
130,308,105 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9093:Vmn2r87
|
UTSW |
10 |
130,308,165 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9623:Vmn2r87
|
UTSW |
10 |
130,315,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9667:Vmn2r87
|
UTSW |
10 |
130,314,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9797:Vmn2r87
|
UTSW |
10 |
130,312,064 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9797:Vmn2r87
|
UTSW |
10 |
130,308,138 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Vmn2r87
|
UTSW |
10 |
130,308,183 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Vmn2r87
|
UTSW |
10 |
130,307,713 (GRCm39) |
missense |
probably benign |
0.04 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTTCCACCAAGCTTTGATACTTAG -3'
(R):5'- TCCTGGGATACTTGGGTTCC -3'
Sequencing Primer
(F):5'- ACAGTGTTGTCCTGTTTGTAAGTTC -3'
(R):5'- ATACTTGGGTTCCTTGGCTC -3'
|
| Posted On |
2014-06-30 |
Incidental Mutation