Incidental Mutation 'R9093:Vmn2r87'
| ID |
691159 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r87
|
| Ensembl Gene |
ENSMUSG00000091511 |
| Gene Name |
vomeronasal 2, receptor 87 |
| Synonyms |
EG625131 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
R9093 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
130307690-130333248 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 130308165 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 691
(T691I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129215
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164227]
|
| AlphaFold |
E9PZX4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164227
AA Change: T691I
PolyPhen 2
Score 0.080 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000129215
Gene: ENSMUSG00000091511
AA Change: T691I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
422 |
1.8e-27 |
PFAM |
|
Pfam:NCD3G
|
508 |
562 |
1.8e-19 |
PFAM |
|
Pfam:7tm_3
|
595 |
829 |
8.8e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.6%
|
| Validation Efficiency |
97% (76/78) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb11 |
A |
T |
2: 69,069,513 (GRCm39) |
V1294E |
probably damaging |
Het |
| Ada |
C |
T |
2: 163,577,308 (GRCm39) |
G60D |
probably benign |
Het |
| Aff3 |
G |
T |
1: 38,291,738 (GRCm39) |
R390S |
possibly damaging |
Het |
| Aldh3b3 |
T |
A |
19: 4,013,959 (GRCm39) |
N53K |
possibly damaging |
Het |
| Ankrd36 |
G |
A |
11: 5,589,132 (GRCm39) |
M410I |
probably benign |
Het |
| Ap2b1 |
T |
A |
11: 83,215,395 (GRCm39) |
I113N |
probably damaging |
Het |
| Art5 |
G |
T |
7: 101,747,396 (GRCm39) |
H128N |
probably benign |
Het |
| Calhm2 |
A |
C |
19: 47,121,599 (GRCm39) |
L190R |
probably benign |
Het |
| Catsperg1 |
G |
C |
7: 28,884,152 (GRCm39) |
T987R |
probably damaging |
Het |
| Cdh18 |
A |
T |
15: 23,474,064 (GRCm39) |
I645F |
probably damaging |
Het |
| Cenpe |
C |
T |
3: 134,945,641 (GRCm39) |
Q1052* |
probably null |
Het |
| Cfap221 |
G |
T |
1: 119,863,856 (GRCm39) |
Q563K |
probably damaging |
Het |
| Cfap54 |
T |
A |
10: 92,651,770 (GRCm39) |
E3093D |
probably benign |
Het |
| Chd4 |
A |
G |
6: 125,090,974 (GRCm39) |
M1186V |
probably benign |
Het |
| Chst15 |
A |
T |
7: 131,870,646 (GRCm39) |
|
probably null |
Het |
| Clca3a2 |
T |
C |
3: 144,781,481 (GRCm39) |
T688A |
probably benign |
Het |
| Cmtm1 |
TCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGG |
TCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGG |
8: 105,036,334 (GRCm39) |
|
probably null |
Het |
| Cul1 |
T |
A |
6: 47,495,173 (GRCm39) |
N518K |
probably damaging |
Het |
| E230025N22Rik |
G |
T |
18: 36,821,952 (GRCm39) |
L247I |
possibly damaging |
Het |
| Eno4 |
A |
T |
19: 58,941,600 (GRCm39) |
K174* |
probably null |
Het |
| Enpp3 |
G |
A |
10: 24,671,702 (GRCm39) |
P431S |
probably benign |
Het |
| Fbh1 |
T |
A |
2: 11,764,801 (GRCm39) |
Q444H |
probably damaging |
Het |
| Fbxo31 |
G |
A |
8: 122,281,136 (GRCm39) |
R337C |
probably damaging |
Het |
| Fbxw14 |
A |
G |
9: 109,105,250 (GRCm39) |
I305T |
probably benign |
Het |
| Fhip1b |
T |
A |
7: 105,034,599 (GRCm39) |
T408S |
probably damaging |
Het |
| Gas2 |
T |
A |
7: 51,602,969 (GRCm39) |
C216S |
probably damaging |
Het |
| Gjb3 |
GCCAGATGCGCCCA |
GCCAGATGCGCCCAGATGCGCCCA |
4: 127,220,458 (GRCm39) |
|
probably null |
Het |
| Glp2r |
T |
A |
11: 67,621,459 (GRCm39) |
R344* |
probably null |
Het |
| Gm17430 |
A |
G |
18: 9,726,640 (GRCm39) |
Y11H |
probably damaging |
Het |
| Gyg1 |
T |
A |
3: 20,176,901 (GRCm39) |
D363V |
probably damaging |
Het |
| H2bc18 |
G |
A |
3: 96,177,290 (GRCm39) |
A75T |
probably benign |
Het |
| Hectd4 |
A |
G |
5: 121,411,677 (GRCm39) |
N451S |
probably benign |
Het |
| Hif1a |
T |
C |
12: 73,979,111 (GRCm39) |
Y212H |
probably benign |
Het |
| Hoxd11 |
A |
T |
2: 74,514,482 (GRCm39) |
*337C |
probably null |
Het |
| Kif24 |
A |
G |
4: 41,428,691 (GRCm39) |
F90L |
probably benign |
Het |
| Klhl20 |
A |
T |
1: 160,923,231 (GRCm39) |
C497* |
probably null |
Het |
| Loxl1 |
C |
A |
9: 58,219,224 (GRCm39) |
A316S |
probably benign |
Het |
| Lrig3 |
C |
T |
10: 125,845,950 (GRCm39) |
P793L |
possibly damaging |
Het |
| Macc1 |
A |
G |
12: 119,410,561 (GRCm39) |
D443G |
probably benign |
Het |
| Maip1 |
A |
T |
1: 57,446,311 (GRCm39) |
Y127F |
possibly damaging |
Het |
| Mrm2 |
A |
T |
5: 140,314,427 (GRCm39) |
F136Y |
probably benign |
Het |
| Nasp |
G |
T |
4: 116,468,017 (GRCm39) |
L323I |
probably benign |
Het |
| Ndufb8 |
A |
T |
19: 44,538,823 (GRCm39) |
L166Q |
probably damaging |
Het |
| Nid2 |
C |
T |
14: 19,858,009 (GRCm39) |
T1274I |
|
Het |
| Nup210 |
T |
A |
6: 91,066,872 (GRCm39) |
T160S |
probably benign |
Het |
| Nutm2 |
A |
G |
13: 50,628,964 (GRCm39) |
K676R |
probably damaging |
Het |
| Odad1 |
G |
A |
7: 45,596,965 (GRCm39) |
V431I |
possibly damaging |
Het |
| Or10a3n |
T |
C |
7: 108,493,609 (GRCm39) |
R7G |
probably benign |
Het |
| Or2a20 |
A |
G |
6: 43,194,500 (GRCm39) |
T218A |
probably benign |
Het |
| Or56b1b |
A |
T |
7: 108,164,454 (GRCm39) |
C183S |
probably damaging |
Het |
| Or5ak20 |
T |
A |
2: 85,183,852 (GRCm39) |
R139S |
probably benign |
Het |
| Or7g33 |
A |
G |
9: 19,448,914 (GRCm39) |
V104A |
probably benign |
Het |
| Or8b9 |
A |
T |
9: 37,766,294 (GRCm39) |
Y60F |
probably damaging |
Het |
| Or9m1 |
A |
T |
2: 87,733,480 (GRCm39) |
I180N |
probably benign |
Het |
| Pcdhga12 |
C |
A |
18: 37,899,931 (GRCm39) |
N254K |
possibly damaging |
Het |
| Pm20d1 |
G |
T |
1: 131,743,753 (GRCm39) |
V473F |
probably benign |
Het |
| Pou2af2 |
G |
A |
9: 51,201,516 (GRCm39) |
P180L |
possibly damaging |
Het |
| Rab11fip1 |
A |
G |
8: 27,633,355 (GRCm39) |
V596A |
probably damaging |
Het |
| Rapgef6 |
C |
T |
11: 54,487,912 (GRCm39) |
Q13* |
probably null |
Het |
| Rasef |
T |
C |
4: 73,698,583 (GRCm39) |
D26G |
probably benign |
Het |
| Rbfox2 |
A |
T |
15: 77,190,658 (GRCm39) |
V29E |
probably benign |
Het |
| Recql4 |
G |
A |
15: 76,589,685 (GRCm39) |
P787S |
unknown |
Het |
| Rnf19a |
A |
C |
15: 36,253,450 (GRCm39) |
|
probably benign |
Het |
| Rnf214 |
A |
G |
9: 45,811,054 (GRCm39) |
I203T |
probably damaging |
Het |
| Rnmt |
A |
C |
18: 68,451,146 (GRCm39) |
E396D |
probably benign |
Het |
| Scn4a |
G |
A |
11: 106,210,638 (GRCm39) |
S1793L |
probably benign |
Het |
| Sdcbp |
G |
T |
4: 6,386,709 (GRCm39) |
|
probably null |
Het |
| Slfn3 |
A |
G |
11: 83,103,948 (GRCm39) |
N273S |
probably damaging |
Het |
| Slk |
A |
G |
19: 47,603,883 (GRCm39) |
D209G |
|
Het |
| Tent5b |
A |
G |
4: 133,214,352 (GRCm39) |
T408A |
probably damaging |
Het |
| Tmem135 |
T |
A |
7: 88,797,204 (GRCm39) |
M351L |
probably benign |
Het |
| Tmem64 |
A |
G |
4: 15,266,391 (GRCm39) |
H147R |
probably benign |
Het |
| Tnfsf4 |
T |
C |
1: 161,244,629 (GRCm39) |
L106P |
probably damaging |
Het |
| Tonsl |
A |
T |
15: 76,515,270 (GRCm39) |
C1039S |
probably damaging |
Het |
| Ube4a |
A |
T |
9: 44,864,462 (GRCm39) |
F44I |
possibly damaging |
Het |
| Vmn2r40 |
A |
G |
7: 8,911,172 (GRCm39) |
L707P |
|
Het |
| Wbp11 |
A |
T |
6: 136,803,044 (GRCm39) |
S7T |
possibly damaging |
Het |
| Zfp386 |
C |
A |
12: 116,023,878 (GRCm39) |
S532* |
probably null |
Het |
|
| Other mutations in Vmn2r87 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01090:Vmn2r87
|
APN |
10 |
130,333,247 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
IGL01295:Vmn2r87
|
APN |
10 |
130,307,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01411:Vmn2r87
|
APN |
10 |
130,308,429 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01680:Vmn2r87
|
APN |
10 |
130,315,586 (GRCm39) |
nonsense |
probably null |
|
|
IGL01822:Vmn2r87
|
APN |
10 |
130,307,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01835:Vmn2r87
|
APN |
10 |
130,314,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01965:Vmn2r87
|
APN |
10 |
130,314,924 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02562:Vmn2r87
|
APN |
10 |
130,314,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02665:Vmn2r87
|
APN |
10 |
130,333,049 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03202:Vmn2r87
|
APN |
10 |
130,333,091 (GRCm39) |
missense |
probably benign |
|
|
FR4304:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4340:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4342:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4589:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
LCD18:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0344:Vmn2r87
|
UTSW |
10 |
130,315,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0374:Vmn2r87
|
UTSW |
10 |
130,307,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0384:Vmn2r87
|
UTSW |
10 |
130,307,712 (GRCm39) |
missense |
probably benign |
|
|
R1144:Vmn2r87
|
UTSW |
10 |
130,312,098 (GRCm39) |
splice site |
probably benign |
|
|
R1172:Vmn2r87
|
UTSW |
10 |
130,313,453 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1860:Vmn2r87
|
UTSW |
10 |
130,315,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1866:Vmn2r87
|
UTSW |
10 |
130,308,441 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1897:Vmn2r87
|
UTSW |
10 |
130,307,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2360:Vmn2r87
|
UTSW |
10 |
130,315,631 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2909:Vmn2r87
|
UTSW |
10 |
130,314,865 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3874:Vmn2r87
|
UTSW |
10 |
130,315,856 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R4113:Vmn2r87
|
UTSW |
10 |
130,315,691 (GRCm39) |
missense |
probably benign |
|
|
R4190:Vmn2r87
|
UTSW |
10 |
130,308,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4197:Vmn2r87
|
UTSW |
10 |
130,315,779 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4201:Vmn2r87
|
UTSW |
10 |
130,308,448 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4202:Vmn2r87
|
UTSW |
10 |
130,308,448 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4368:Vmn2r87
|
UTSW |
10 |
130,315,676 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4485:Vmn2r87
|
UTSW |
10 |
130,315,678 (GRCm39) |
nonsense |
probably null |
|
|
R4537:Vmn2r87
|
UTSW |
10 |
130,308,054 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4590:Vmn2r87
|
UTSW |
10 |
130,315,014 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4752:Vmn2r87
|
UTSW |
10 |
130,314,336 (GRCm39) |
nonsense |
probably null |
|
|
R4873:Vmn2r87
|
UTSW |
10 |
130,308,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4875:Vmn2r87
|
UTSW |
10 |
130,308,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4923:Vmn2r87
|
UTSW |
10 |
130,314,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4970:Vmn2r87
|
UTSW |
10 |
130,314,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5049:Vmn2r87
|
UTSW |
10 |
130,308,298 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5112:Vmn2r87
|
UTSW |
10 |
130,314,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5187:Vmn2r87
|
UTSW |
10 |
130,333,208 (GRCm39) |
missense |
probably null |
0.99 |
|
R5618:Vmn2r87
|
UTSW |
10 |
130,315,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6057:Vmn2r87
|
UTSW |
10 |
130,308,226 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6220:Vmn2r87
|
UTSW |
10 |
130,315,807 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6287:Vmn2r87
|
UTSW |
10 |
130,314,291 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6383:Vmn2r87
|
UTSW |
10 |
130,314,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6576:Vmn2r87
|
UTSW |
10 |
130,314,654 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6742:Vmn2r87
|
UTSW |
10 |
130,308,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7086:Vmn2r87
|
UTSW |
10 |
130,333,178 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7162:Vmn2r87
|
UTSW |
10 |
130,313,416 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7419:Vmn2r87
|
UTSW |
10 |
130,307,992 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7425:Vmn2r87
|
UTSW |
10 |
130,314,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7443:Vmn2r87
|
UTSW |
10 |
130,308,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7571:Vmn2r87
|
UTSW |
10 |
130,314,940 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7663:Vmn2r87
|
UTSW |
10 |
130,308,054 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7716:Vmn2r87
|
UTSW |
10 |
130,308,018 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7793:Vmn2r87
|
UTSW |
10 |
130,313,413 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7806:Vmn2r87
|
UTSW |
10 |
130,315,679 (GRCm39) |
missense |
probably benign |
|
|
R7841:Vmn2r87
|
UTSW |
10 |
130,333,095 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8326:Vmn2r87
|
UTSW |
10 |
130,308,180 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8411:Vmn2r87
|
UTSW |
10 |
130,308,126 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8445:Vmn2r87
|
UTSW |
10 |
130,313,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8540:Vmn2r87
|
UTSW |
10 |
130,314,762 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8892:Vmn2r87
|
UTSW |
10 |
130,308,105 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9623:Vmn2r87
|
UTSW |
10 |
130,315,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9667:Vmn2r87
|
UTSW |
10 |
130,314,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9797:Vmn2r87
|
UTSW |
10 |
130,312,064 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9797:Vmn2r87
|
UTSW |
10 |
130,308,138 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Vmn2r87
|
UTSW |
10 |
130,308,183 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Vmn2r87
|
UTSW |
10 |
130,307,713 (GRCm39) |
missense |
probably benign |
0.04 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAAGTATCCCAGGACAACATGG -3'
(R):5'- GGCCAATAACTGCATTCTCAGC -3'
Sequencing Primer
(F):5'- CAGGACAACATGGAAGGCAATGAC -3'
(R):5'- ATAACTGCATTCTCAGCTACATCC -3'
|
| Posted On |
2021-12-30 |
Incidental Mutation