Incidental Mutation 'R1965:Tasor'
ID 218310
Institutional Source Beutler Lab
Gene Symbol Tasor
Ensembl Gene ENSMUSG00000040651
Gene Name transcription activation suppressor
Synonyms D14Abb1e, Fam208a, 4933409E02Rik, MommeD6
MMRRC Submission 039978-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1965 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 27150791-27205512 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 27164511 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tryptophan at position 272 (C272W)
Ref Sequence ENSEMBL: ENSMUSP00000022450 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022450]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000022450
AA Change: C272W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000022450
Gene: ENSMUSG00000040651
AA Change: C272W

DomainStartEndE-ValueType
low complexity region 20 27 N/A INTRINSIC
low complexity region 42 61 N/A INTRINSIC
low complexity region 74 88 N/A INTRINSIC
Pfam:DUF3715 153 314 1.5e-55 PFAM
low complexity region 442 457 N/A INTRINSIC
low complexity region 1087 1102 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223970
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.6%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for ENU mutations are not viable past gastrulation. [provided by MGI curators]
Allele List at MGI

All alleles(26) : Gene trapped(26)

Other mutations in this stock
Total: 88 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aco1 T G 4: 40,175,730 (GRCm39) L157R probably damaging Het
Acot11 A T 4: 106,606,550 (GRCm39) L513Q probably damaging Het
Amd1 A G 10: 40,170,755 (GRCm39) I52T probably benign Het
Ap2b1 T C 11: 83,237,721 (GRCm39) I557T probably benign Het
Arel1 T A 12: 84,987,173 (GRCm39) probably null Het
Arg1 T A 10: 24,792,762 (GRCm39) probably null Het
Atf1 A T 15: 100,152,052 (GRCm39) M135L probably benign Het
Atf2 T C 2: 73,681,242 (GRCm39) E77G possibly damaging Het
Axin1 G T 17: 26,403,199 (GRCm39) A394S probably damaging Het
Axin1 A T 17: 26,409,202 (GRCm39) Q734L probably damaging Het
Brd8 G C 18: 34,735,819 (GRCm39) A886G probably damaging Het
Ccdc39 T C 3: 33,880,629 (GRCm39) K446R probably damaging Het
Celf3 T C 3: 94,392,634 (GRCm39) V35A probably damaging Het
Cfap299 T A 5: 98,494,093 (GRCm39) D32E probably damaging Het
Ckap2 T C 8: 22,665,803 (GRCm39) T415A possibly damaging Het
Crybg3 T C 16: 59,323,600 (GRCm39) Y1066C probably damaging Het
Csmd3 T C 15: 47,713,144 (GRCm39) H1506R probably benign Het
Dnah10 A G 5: 124,852,267 (GRCm39) D1808G probably damaging Het
Dsc3 C T 18: 20,113,729 (GRCm39) G398R probably damaging Het
Emc2 A G 15: 43,390,863 (GRCm39) Q293R probably damaging Het
Evc2 A G 5: 37,520,876 (GRCm39) N251D possibly damaging Het
Fam151a A T 4: 106,591,112 (GRCm39) probably benign Het
Fbxw16 T A 9: 109,270,289 (GRCm39) I151F probably damaging Het
Fmnl2 A G 2: 53,004,880 (GRCm39) D658G probably damaging Het
Fnip2 G A 3: 79,400,779 (GRCm39) T314I probably benign Het
Foxc2 T A 8: 121,843,413 (GRCm39) S20R probably damaging Het
Fpr-rs6 C T 17: 20,402,918 (GRCm39) G148R probably damaging Het
Fsip2 T C 2: 82,823,124 (GRCm39) S6286P possibly damaging Het
Fyb2 A T 4: 104,770,846 (GRCm39) I54F probably benign Het
Gbf1 T C 19: 46,260,003 (GRCm39) F999L probably damaging Het
Gldc G A 19: 30,114,513 (GRCm39) R466* probably null Het
Gm12695 T A 4: 96,651,082 (GRCm39) S124C probably benign Het
Gm4846 A T 1: 166,314,533 (GRCm39) I370N possibly damaging Het
Gsdmc3 T C 15: 63,730,296 (GRCm39) T423A probably damaging Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Jarid2 T A 13: 45,059,752 (GRCm39) N661K probably damaging Het
Kcnmb3 T C 3: 32,526,492 (GRCm39) Y233C probably damaging Het
Kidins220 A G 12: 25,044,905 (GRCm39) D191G probably damaging Het
Kmt2a A G 9: 44,732,757 (GRCm39) probably benign Het
Krt1 T C 15: 101,757,427 (GRCm39) D261G probably benign Het
Lrba A G 3: 86,513,175 (GRCm39) probably null Het
Myo1f C T 17: 33,817,146 (GRCm39) R730* probably null Het
Ncoa7 C A 10: 30,530,426 (GRCm39) E30* probably null Het
Neurod4 T A 10: 130,106,918 (GRCm39) K119* probably null Het
Npy5r T C 8: 67,133,929 (GRCm39) D288G probably benign Het
Nr3c2 A T 8: 77,636,092 (GRCm39) I398L probably damaging Het
Or10a5 T C 7: 106,635,565 (GRCm39) S68P probably damaging Het
Or12j4 C A 7: 140,046,574 (GRCm39) F153L probably benign Het
Or4b1 T C 2: 89,979,748 (GRCm39) S201G probably damaging Het
Or4k35 T C 2: 111,099,938 (GRCm39) Y258C probably damaging Het
Or51v8 A T 7: 103,320,103 (GRCm39) I45N probably damaging Het
Or5g25 T C 2: 85,478,090 (GRCm39) T192A possibly damaging Het
Or5w8 A G 2: 87,687,759 (GRCm39) K80R probably benign Het
Or9m1b A G 2: 87,836,648 (GRCm39) F149S probably damaging Het
P3r3urf G A 4: 116,031,376 (GRCm39) C82Y probably damaging Het
Pcf11 A T 7: 92,310,809 (GRCm39) M393K probably benign Het
Pck2 T C 14: 55,779,964 (GRCm39) V71A probably benign Het
Pdzd8 G T 19: 59,288,554 (GRCm39) L949I probably benign Het
Pdzrn4 G A 15: 92,644,190 (GRCm39) probably null Het
Phospho1 A G 11: 95,721,705 (GRCm39) N125S probably damaging Het
Pirb A T 7: 3,720,637 (GRCm39) L287Q probably benign Het
Ppid A T 3: 79,509,606 (GRCm39) K308* probably null Het
Ppp1r1b A G 11: 98,246,189 (GRCm39) E57G probably damaging Het
Prtg T G 9: 72,755,604 (GRCm39) S269A probably benign Het
Rbbp5 T A 1: 132,422,035 (GRCm39) S312T probably damaging Het
Rbm11 T A 16: 75,395,656 (GRCm39) probably null Het
Retreg1 A G 15: 25,970,250 (GRCm39) T139A probably damaging Het
Riok3 T A 18: 12,270,019 (GRCm39) H120Q probably damaging Het
Rln1 A T 19: 29,311,995 (GRCm39) M1K probably null Het
Rpp30 C T 19: 36,066,549 (GRCm39) S94L probably damaging Het
Sccpdh C T 1: 179,511,879 (GRCm39) P117L probably damaging Het
Serac1 T C 17: 6,099,274 (GRCm39) K506E possibly damaging Het
Serping1 G T 2: 84,596,072 (GRCm39) T454K probably damaging Het
Slc1a2 T A 2: 102,570,245 (GRCm39) N174K probably damaging Het
Slc2a2 A G 3: 28,773,634 (GRCm39) Q313R probably damaging Het
Slc46a2 T A 4: 59,914,249 (GRCm39) S225C probably damaging Het
Smarcc2 G A 10: 128,310,627 (GRCm39) E419K probably damaging Het
Stkld1 T A 2: 26,836,744 (GRCm39) probably null Het
Szt2 A G 4: 118,241,162 (GRCm39) M1704T probably benign Het
Tfcp2l1 C T 1: 118,580,653 (GRCm39) Q116* probably null Het
Timm44 A G 8: 4,310,603 (GRCm39) M383T possibly damaging Het
Tnpo2 G A 8: 85,771,946 (GRCm39) probably null Het
Tnrc6b A G 15: 80,764,640 (GRCm39) K714R probably damaging Het
Wdfy3 A G 5: 102,099,178 (GRCm39) L290P probably damaging Het
Wdr59 A G 8: 112,177,709 (GRCm39) F898L probably damaging Het
Zfp120 A T 2: 149,959,318 (GRCm39) C335S probably damaging Het
Zfp518a T C 19: 40,901,954 (GRCm39) S628P probably benign Het
Zfp879 A T 11: 50,724,355 (GRCm39) C234S probably damaging Het
Other mutations in Tasor
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00093:Tasor APN 14 27,170,163 (GRCm39) missense probably damaging 1.00
IGL00467:Tasor APN 14 27,170,121 (GRCm39) missense probably benign 0.02
IGL01071:Tasor APN 14 27,164,579 (GRCm39) critical splice donor site probably null
IGL01351:Tasor APN 14 27,186,258 (GRCm39) missense probably benign 0.02
IGL01375:Tasor APN 14 27,162,120 (GRCm39) missense probably damaging 1.00
IGL01509:Tasor APN 14 27,181,731 (GRCm39) splice site probably benign
IGL02342:Tasor APN 14 27,198,624 (GRCm39) missense possibly damaging 0.83
IGL03105:Tasor APN 14 27,164,509 (GRCm39) missense probably damaging 0.98
IGL03131:Tasor APN 14 27,183,136 (GRCm39) nonsense probably null
IGL03248:Tasor APN 14 27,198,649 (GRCm39) missense probably damaging 1.00
IGL03383:Tasor APN 14 27,163,918 (GRCm39) missense possibly damaging 0.93
balsam UTSW 14 27,183,107 (GRCm39) missense probably benign 0.01
santa_rosa UTSW 14 27,198,658 (GRCm39) splice site probably null
D4043:Tasor UTSW 14 27,193,949 (GRCm39) missense probably benign 0.07
R0147:Tasor UTSW 14 27,193,725 (GRCm39) missense probably benign 0.23
R0512:Tasor UTSW 14 27,168,363 (GRCm39) missense probably damaging 1.00
R0589:Tasor UTSW 14 27,183,107 (GRCm39) missense probably benign 0.01
R0609:Tasor UTSW 14 27,183,707 (GRCm39) missense probably benign 0.09
R0798:Tasor UTSW 14 27,198,593 (GRCm39) missense probably damaging 1.00
R1107:Tasor UTSW 14 27,201,680 (GRCm39) nonsense probably null
R1205:Tasor UTSW 14 27,183,275 (GRCm39) missense probably damaging 1.00
R1376:Tasor UTSW 14 27,151,338 (GRCm39) missense probably benign 0.00
R1376:Tasor UTSW 14 27,151,338 (GRCm39) missense probably benign 0.00
R1441:Tasor UTSW 14 27,186,217 (GRCm39) nonsense probably null
R1493:Tasor UTSW 14 27,171,926 (GRCm39) missense probably damaging 1.00
R1527:Tasor UTSW 14 27,202,050 (GRCm39) critical splice donor site probably null
R1729:Tasor UTSW 14 27,201,590 (GRCm39) missense probably damaging 1.00
R1752:Tasor UTSW 14 27,193,885 (GRCm39) nonsense probably null
R1960:Tasor UTSW 14 27,201,746 (GRCm39) missense possibly damaging 0.95
R1960:Tasor UTSW 14 27,160,621 (GRCm39) missense probably damaging 1.00
R2074:Tasor UTSW 14 27,183,170 (GRCm39) missense probably benign 0.03
R2107:Tasor UTSW 14 27,183,744 (GRCm39) critical splice donor site probably null
R2130:Tasor UTSW 14 27,198,571 (GRCm39) missense possibly damaging 0.74
R2130:Tasor UTSW 14 27,168,345 (GRCm39) missense probably damaging 1.00
R2131:Tasor UTSW 14 27,198,571 (GRCm39) missense possibly damaging 0.74
R2133:Tasor UTSW 14 27,198,571 (GRCm39) missense possibly damaging 0.74
R2140:Tasor UTSW 14 27,201,992 (GRCm39) missense probably damaging 1.00
R2184:Tasor UTSW 14 27,188,141 (GRCm39) missense possibly damaging 0.83
R2279:Tasor UTSW 14 27,164,452 (GRCm39) missense probably damaging 1.00
R3979:Tasor UTSW 14 27,199,087 (GRCm39) missense possibly damaging 0.95
R4113:Tasor UTSW 14 27,181,918 (GRCm39) nonsense probably null
R4434:Tasor UTSW 14 27,171,818 (GRCm39) critical splice donor site probably null
R4562:Tasor UTSW 14 27,188,265 (GRCm39) missense possibly damaging 0.67
R4568:Tasor UTSW 14 27,198,658 (GRCm39) splice site probably null
R4754:Tasor UTSW 14 27,183,052 (GRCm39) missense probably benign
R4980:Tasor UTSW 14 27,183,382 (GRCm39) missense probably benign 0.39
R4993:Tasor UTSW 14 27,151,071 (GRCm39) missense possibly damaging 0.88
R5200:Tasor UTSW 14 27,151,183 (GRCm39) missense probably benign 0.41
R5316:Tasor UTSW 14 27,193,992 (GRCm39) missense possibly damaging 0.52
R5599:Tasor UTSW 14 27,201,886 (GRCm39) missense probably benign 0.01
R5678:Tasor UTSW 14 27,151,080 (GRCm39) small insertion probably benign
R5680:Tasor UTSW 14 27,151,080 (GRCm39) small insertion probably benign
R5887:Tasor UTSW 14 27,188,254 (GRCm39) nonsense probably null
R6181:Tasor UTSW 14 27,194,235 (GRCm39) missense probably benign 0.01
R6556:Tasor UTSW 14 27,151,215 (GRCm39) missense probably benign
R6603:Tasor UTSW 14 27,168,343 (GRCm39) missense probably damaging 1.00
R6829:Tasor UTSW 14 27,164,438 (GRCm39) missense possibly damaging 0.90
R6864:Tasor UTSW 14 27,183,115 (GRCm39) missense probably damaging 0.96
R6919:Tasor UTSW 14 27,171,758 (GRCm39) nonsense probably null
R7046:Tasor UTSW 14 27,194,392 (GRCm39) missense probably damaging 1.00
R7057:Tasor UTSW 14 27,183,608 (GRCm39) missense probably damaging 0.97
R7064:Tasor UTSW 14 27,194,288 (GRCm39) missense probably benign 0.09
R7290:Tasor UTSW 14 27,160,610 (GRCm39) missense probably damaging 1.00
R7303:Tasor UTSW 14 27,193,809 (GRCm39) missense probably damaging 1.00
R7439:Tasor UTSW 14 27,193,602 (GRCm39) missense probably damaging 1.00
R7524:Tasor UTSW 14 27,188,160 (GRCm39) missense probably damaging 0.99
R7580:Tasor UTSW 14 27,188,243 (GRCm39) missense probably benign 0.29
R7726:Tasor UTSW 14 27,169,454 (GRCm39) missense probably damaging 0.99
R7771:Tasor UTSW 14 27,189,516 (GRCm39) missense probably damaging 1.00
R7782:Tasor UTSW 14 27,193,901 (GRCm39) missense probably benign 0.07
R7795:Tasor UTSW 14 27,203,340 (GRCm39) missense
R7835:Tasor UTSW 14 27,198,600 (GRCm39) missense probably damaging 1.00
R7954:Tasor UTSW 14 27,169,481 (GRCm39) critical splice donor site probably null
R7981:Tasor UTSW 14 27,168,373 (GRCm39) missense possibly damaging 0.49
R8101:Tasor UTSW 14 27,164,438 (GRCm39) missense possibly damaging 0.90
R8160:Tasor UTSW 14 27,171,913 (GRCm39) missense probably damaging 1.00
R8307:Tasor UTSW 14 27,193,622 (GRCm39) missense probably damaging 1.00
R8913:Tasor UTSW 14 27,188,145 (GRCm39) missense probably damaging 1.00
R9070:Tasor UTSW 14 27,194,484 (GRCm39) missense probably benign 0.14
R9219:Tasor UTSW 14 27,186,344 (GRCm39) missense possibly damaging 0.50
R9420:Tasor UTSW 14 27,163,927 (GRCm39) missense probably damaging 0.99
R9513:Tasor UTSW 14 27,186,271 (GRCm39) nonsense probably null
R9562:Tasor UTSW 14 27,201,766 (GRCm39) critical splice donor site probably null
R9565:Tasor UTSW 14 27,201,766 (GRCm39) critical splice donor site probably null
R9627:Tasor UTSW 14 27,194,123 (GRCm39) missense probably benign
X0002:Tasor UTSW 14 27,194,063 (GRCm39) missense possibly damaging 0.90
Z1176:Tasor UTSW 14 27,199,105 (GRCm39) missense probably damaging 1.00
Z1176:Tasor UTSW 14 27,151,165 (GRCm39) missense probably damaging 0.97
Z1177:Tasor UTSW 14 27,170,207 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACATGTTGGTGATGTAAGTAGGTTAAC -3'
(R):5'- CAGGCATTCCAAGAGGTGC -3'

Sequencing Primer
(F):5'- ATCATGTTAAGTGGACACtt -3'
(R):5'- CTTAACAAGCCAGGTGAGTATCCTG -3'
Posted On 2014-08-01