Incidental Mutation 'R4342:Ntm'
ID 324179
Institutional Source Beutler Lab
Gene Symbol Ntm
Ensembl Gene ENSMUSG00000059974
Gene Name neurotrimin
Synonyms B230210G24Rik, Hnt, 6230410L23Rik
MMRRC Submission 041100-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.147) question?
Stock # R4342 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 28906046-29874437 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 29020727 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 164 (E164G)
Ref Sequence ENSEMBL: ENSMUSP00000074578 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075069] [ENSMUST00000115236] [ENSMUST00000115237]
AlphaFold Q99PJ0
Predicted Effect probably damaging
Transcript: ENSMUST00000075069
AA Change: E164G

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000074578
Gene: ENSMUSG00000059974
AA Change: E164G

DomainStartEndE-ValueType
IG 42 133 2.08e-10 SMART
IGc2 148 208 1.31e-16 SMART
IGc2 234 302 2.3e-12 SMART
low complexity region 332 342 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000115236
AA Change: E164G

PolyPhen 2 Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000110891
Gene: ENSMUSG00000059974
AA Change: E164G

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
IG 42 133 2.08e-10 SMART
IGc2 148 208 1.31e-16 SMART
IGc2 234 302 2.3e-12 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000115237
AA Change: E164G

PolyPhen 2 Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000110892
Gene: ENSMUSG00000059974
AA Change: E164G

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
IG 42 133 2.08e-10 SMART
IGc2 148 208 1.31e-16 SMART
IGc2 234 302 2.3e-12 SMART
low complexity region 332 342 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124119
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126044
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148606
Meta Mutation Damage Score 0.2251 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 99% (68/69)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML), on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars2 T C 17: 45,827,421 (GRCm39) C488R probably benign Het
Adamts19 A T 18: 59,075,572 (GRCm39) H489L probably damaging Het
Ahnak T C 19: 8,989,447 (GRCm39) V3577A possibly damaging Het
Ajm1 A G 2: 25,469,120 (GRCm39) Y264H possibly damaging Het
Arhgap44 G A 11: 64,902,887 (GRCm39) R401* probably null Het
Cbx3-ps2 T C 13: 65,707,502 (GRCm39) noncoding transcript Het
Ccdc174 T A 6: 91,862,337 (GRCm39) L86* probably null Het
Cd38 A C 5: 44,026,431 (GRCm39) I72L probably benign Het
Cers4 T C 8: 4,571,223 (GRCm39) L264P probably damaging Het
Cldn23 A G 8: 36,292,652 (GRCm39) S279P probably benign Het
Cth T A 3: 157,630,613 (GRCm39) T19S probably damaging Het
Dnajc22 T A 15: 99,002,345 (GRCm39) L330* probably null Het
Epas1 G A 17: 87,131,228 (GRCm39) C336Y probably damaging Het
Evi5l A C 8: 4,233,492 (GRCm39) probably benign Het
Fbxl2 A T 9: 113,814,374 (GRCm39) H272Q probably benign Het
Fgd3 C T 13: 49,427,185 (GRCm39) probably null Het
Fhdc1 C A 3: 84,352,133 (GRCm39) V1031F probably benign Het
Fscn1 T C 5: 142,957,776 (GRCm39) Y308H probably damaging Het
Garin3 A G 11: 46,298,043 (GRCm39) D449G possibly damaging Het
Gm5878 G A 6: 85,102,633 (GRCm39) R31* probably null Het
Gpatch2l T C 12: 86,307,453 (GRCm39) V277A probably benign Het
Greb1l T A 18: 10,544,561 (GRCm39) M1385K probably benign Het
Grin2a A G 16: 9,471,453 (GRCm39) I605T possibly damaging Het
Hoxc11 C T 15: 102,863,106 (GRCm39) S49F probably damaging Het
Igf2r C T 17: 12,928,398 (GRCm39) E982K possibly damaging Het
Ighv10-3 A T 12: 114,487,124 (GRCm39) M99K possibly damaging Het
Itgb4 A T 11: 115,879,555 (GRCm39) T614S probably benign Het
Kcnv1 G A 15: 44,977,840 (GRCm39) T66M probably damaging Het
Mast4 A G 13: 102,910,756 (GRCm39) V461A probably damaging Het
Mcts2 G A 2: 152,529,584 (GRCm39) V132M probably damaging Het
Mical3 C A 6: 120,911,799 (GRCm39) E1083* probably null Het
Nbeal2 A G 9: 110,460,861 (GRCm39) probably benign Het
Nek4 T C 14: 30,675,863 (GRCm39) V66A probably damaging Het
Nfasc A G 1: 132,559,443 (GRCm39) F229S probably damaging Het
Nhsl1 T C 10: 18,402,437 (GRCm39) F1221S probably damaging Het
Nr1d1 T G 11: 98,662,640 (GRCm39) K118Q probably damaging Het
Ntaq1 T C 15: 58,016,110 (GRCm39) S120P probably benign Het
Or51a7 A G 7: 102,615,231 (GRCm39) N308S probably benign Het
Parp1 G T 1: 180,414,894 (GRCm39) A411S probably benign Het
Pds5b A G 5: 150,724,319 (GRCm39) T1301A probably benign Het
Pkhd1 A G 1: 20,128,841 (GRCm39) V3954A probably benign Het
Pkp4 A T 2: 59,180,952 (GRCm39) K739I probably damaging Het
Pla2g4e T C 2: 120,016,927 (GRCm39) probably benign Het
Plod3 G C 5: 137,017,000 (GRCm39) A50P probably benign Het
Ralgds T C 2: 28,442,107 (GRCm39) L96P probably damaging Het
Rbm6 A T 9: 107,724,446 (GRCm39) probably benign Het
Scp2d1 T C 2: 144,666,087 (GRCm39) L142P probably damaging Het
Setd5 AT ATT 6: 113,088,281 (GRCm39) probably benign Het
Sgf29 G A 7: 126,270,949 (GRCm39) C143Y probably damaging Het
Slc22a12 A G 19: 6,591,129 (GRCm39) I156T probably benign Het
Stambpl1 A G 19: 34,211,446 (GRCm39) Q169R probably benign Het
Tex2 T C 11: 106,457,832 (GRCm39) probably benign Het
Trip11 A T 12: 101,850,575 (GRCm39) I878N probably damaging Het
Ttf1 C T 2: 28,955,488 (GRCm39) S284L probably benign Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Ugt2b5 A T 5: 87,287,582 (GRCm39) V195E probably damaging Het
Vmn1r14 T A 6: 57,210,808 (GRCm39) Y85N probably benign Het
Zfp131 C T 13: 120,237,554 (GRCm39) R268H probably damaging Het
Other mutations in Ntm
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01315:Ntm APN 9 28,925,480 (GRCm39) missense probably damaging 1.00
IGL01790:Ntm APN 9 29,322,886 (GRCm39) missense probably benign 0.05
IGL03236:Ntm APN 9 29,020,802 (GRCm39) missense probably benign 0.04
Frowsy UTSW 9 28,923,516 (GRCm39) nonsense probably null
R0423:Ntm UTSW 9 29,090,395 (GRCm39) missense probably damaging 0.99
R1772:Ntm UTSW 9 29,090,396 (GRCm39) missense probably benign 0.02
R1905:Ntm UTSW 9 29,090,393 (GRCm39) missense probably damaging 1.00
R2295:Ntm UTSW 9 29,020,817 (GRCm39) missense possibly damaging 0.89
R4433:Ntm UTSW 9 28,923,516 (GRCm39) nonsense probably null
R4696:Ntm UTSW 9 29,090,501 (GRCm39) missense possibly damaging 0.46
R5572:Ntm UTSW 9 28,925,512 (GRCm39) missense probably damaging 1.00
R6031:Ntm UTSW 9 28,920,671 (GRCm39) missense probably damaging 1.00
R6031:Ntm UTSW 9 28,920,671 (GRCm39) missense probably damaging 1.00
R6431:Ntm UTSW 9 29,322,978 (GRCm39) missense probably damaging 1.00
R7250:Ntm UTSW 9 29,322,988 (GRCm39) missense probably benign 0.06
R8283:Ntm UTSW 9 28,923,508 (GRCm39) missense probably damaging 0.96
R9477:Ntm UTSW 9 29,322,922 (GRCm39) missense probably benign 0.03
R9713:Ntm UTSW 9 29,090,327 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- AGCTATGTCCACTGTGCATAG -3'
(R):5'- TAGTTCATACATGTCCATCTTTGGC -3'

Sequencing Primer
(F):5'- GCTATGTCCACTGTGCATAGAACAAC -3'
(R):5'- ATACATGTCCATCTTTGGCTATTCTG -3'
Posted On 2015-06-24