Mutagenetix > Incidental Mutation

Incidental Mutation 'R4397:Gvin-ps3'

325540

Institutional Source

Beutler Lab

Gene Symbol

Gvin-ps3

Ensembl Gene

ENSMUSG00000095649

Gene Name

GTPase, very large interferon inducible, pseudogene 3

Synonyms

Gm8979, Gm21884

MMRRC Submission

041685-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.133) question?

Stock #

R4397 (G1)

Quality Score

170

Status

Validated

Chromosome

Chromosomal Location

105674938-105678355 bp(-) (GRCm39)

Type of Mutation

exon

DNA Base Change (assembly)

A to G at 105682130 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176647

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000183386

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 95.1%

Validation Efficiency

96% (55/57)

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrg4	T	G	X: 55,977,703 (GRCm39)	L2193V	probably damaging	Het
Agap2	G	A	10: 126,926,352 (GRCm39)	A866T	unknown	Het
Aig1	A	C	10: 13,528,726 (GRCm39)	S237A	probably benign	Het
Baz1b	C	T	5: 135,273,300 (GRCm39)	R1475W	probably damaging	Het
Bmp1	C	T	14: 70,727,982 (GRCm39)		probably null	Het
Crybg3	A	G	16: 59,380,458 (GRCm39)		probably benign	Het
Dnajc15	T	C	14: 78,112,234 (GRCm39)		probably null	Het
Fam135b	T	A	15: 71,320,525 (GRCm39)	H1334L	probably benign	Het
Fancg	A	T	4: 43,008,897 (GRCm39)	H113Q	probably benign	Het
Gfap	G	A	11: 102,787,810 (GRCm39)	A45V	probably benign	Het
Gjd3	A	T	11: 98,873,247 (GRCm39)	L199Q	probably damaging	Het
H13	A	G	2: 152,519,472 (GRCm39)	D65G	probably damaging	Het
Hcls1	T	C	16: 36,757,662 (GRCm39)	V5A	possibly damaging	Het
Hjurp	GT	GTT	1: 88,194,246 (GRCm39)		probably null	Het
Homer3	G	A	8: 70,742,793 (GRCm39)		probably null	Het
Iqgap3	T	C	3: 88,011,665 (GRCm39)	Y817H	probably damaging	Het
Iqsec2	C	T	X: 150,992,049 (GRCm39)	T562I	probably damaging	Het
Klb	A	G	5: 65,537,382 (GRCm39)	Y904C	probably damaging	Het
Kremen1	A	T	11: 5,149,610 (GRCm39)	S354T	probably benign	Het
Lamc3	A	G	2: 31,821,964 (GRCm39)	E1304G	probably benign	Het
Lrp4	T	C	2: 91,342,015 (GRCm39)	V1876A	probably benign	Het
Magi3	T	C	3: 104,127,030 (GRCm39)	T85A	probably damaging	Het
Map3k12	C	T	15: 102,409,694 (GRCm39)	A694T	probably benign	Het
Mex3b	T	C	7: 82,519,031 (GRCm39)	S449P	possibly damaging	Het
Naip6	C	T	13: 100,437,108 (GRCm39)	A472T	probably benign	Het
Nars2	T	C	7: 96,622,771 (GRCm39)		probably null	Het
Nlrp1a	T	G	11: 70,988,030 (GRCm39)	M1046L	probably benign	Het
Nphs1	T	G	7: 30,181,390 (GRCm39)		probably null	Het
Nup133	G	A	8: 124,671,040 (GRCm39)	T119M	probably benign	Het
Or6c201	G	T	10: 128,969,450 (GRCm39)	N62K	possibly damaging	Het
Pcdhga9	A	T	18: 37,871,694 (GRCm39)	I508F	probably damaging	Het
Phactr3	A	G	2: 177,817,199 (GRCm39)		probably benign	Het
Plcb3	T	C	19: 6,943,193 (GRCm39)	K155E	probably damaging	Het
Plxna2	C	T	1: 194,431,625 (GRCm39)	S538F	probably damaging	Het
Prss38	T	C	11: 59,263,854 (GRCm39)	Y286C	probably damaging	Het
Psg16	T	C	7: 16,824,623 (GRCm39)	S45P	possibly damaging	Het
Ptpn21	G	T	12: 98,654,507 (GRCm39)	P820Q	probably damaging	Het
Ptpn21	A	G	12: 98,681,319 (GRCm39)	V105A	probably damaging	Het
Rnf7	A	G	9: 96,360,463 (GRCm39)	M58T	probably benign	Het
Slc25a11	G	A	11: 70,535,677 (GRCm39)	A287V	probably benign	Het
Slit2	G	T	5: 48,377,423 (GRCm39)		probably null	Het
Suco	A	G	1: 161,672,421 (GRCm39)	Y460H	probably damaging	Het
Tnxb	C	T	17: 34,897,636 (GRCm39)	Q804*	probably null	Het
Trpv6	A	G	6: 41,602,172 (GRCm39)	I379T	possibly damaging	Het
Ugt1a1	CAGAGAGAGAGAGA	CAGAGAGAGAGA	1: 88,139,706 (GRCm39)		probably benign	Het
Virma	A	G	4: 11,513,901 (GRCm39)	E585G	possibly damaging	Het
Vmn2r79	A	G	7: 86,651,099 (GRCm39)	H166R	possibly damaging	Het
Vmn2r88	A	T	14: 51,655,435 (GRCm39)	D549V	probably damaging	Het

Other mutations in Gvin-ps3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00971:Gvin-ps3	APN	7	105,681,008 (GRCm39)	exon	noncoding transcript
IGL01125:Gvin-ps3	APN	7	105,682,021 (GRCm39)	missense	unknown	0.00
IGL01392:Gvin-ps3	APN	7	105,682,962 (GRCm39)	missense	probably benign	0.01
R1184:Gvin-ps3	UTSW	7	105,683,159 (GRCm39)	missense	probably benign	0.03
R1411:Gvin-ps3	UTSW	7	105,682,686 (GRCm39)	missense	probably benign	0.39
R2198:Gvin-ps3	UTSW	7	105,682,758 (GRCm39)	missense	probably benign	0.00
R2311:Gvin-ps3	UTSW	7	105,682,797 (GRCm39)	missense	probably damaging	0.99
R2380:Gvin-ps3	UTSW	7	105,681,374 (GRCm39)	missense	possibly damaging	0.86
R3825:Gvin-ps3	UTSW	7	105,682,780 (GRCm39)	missense	possibly damaging	0.92
R4693:Gvin-ps3	UTSW	7	105,681,585 (GRCm39)	exon	noncoding transcript
R4787:Gvin-ps3	UTSW	7	105,681,041 (GRCm39)	exon	noncoding transcript
R4840:Gvin-ps3	UTSW	7	105,680,627 (GRCm39)	exon	noncoding transcript
R4972:Gvin-ps3	UTSW	7	105,682,521 (GRCm39)	exon	noncoding transcript
R5221:Gvin-ps3	UTSW	7	105,683,181 (GRCm39)	exon	noncoding transcript
R5296:Gvin-ps3	UTSW	7	105,681,055 (GRCm39)	exon	noncoding transcript

Predicted Primers

PCR Primer
(F):5'- GGCAATTCCATCTGCTTCTG -3'
(R):5'- CTTCAACTCTCCAAGGCTGC -3'

Sequencing Primer
(F):5'- TGCTGGTCCACCTATCTGGG -3'
(R):5'- AAGGCTGCTCTCCAGGAAC -3'

Posted On

2015-07-06