Mutagenetix > Incidental Mutations

Incidental Mutation 'R0366:Olfr167'

36439

Institutional Source

Beutler Lab

Gene Symbol

Olfr167

Ensembl Gene

ENSMUSG00000045341

Gene Name

olfactory receptor 167

Synonyms

MOR272-1, GA_x54KRFPKG5P-15963726-15962788

MMRRC Submission

038572-MU

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.335) question?

Stock #

R0366 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

19509558-19522266 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 19514848 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 263 (S263P)

Ref Sequence

ENSEMBL: ENSMUSP00000150102 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054606] [ENSMUST00000214315]

AlphaFold

Q8VGJ5

Predicted Effect

probably benign
Transcript: ENSMUST00000054606
AA Change: S263P

PolyPhen 2 Score 0.126 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000055344
Gene: ENSMUSG00000045341
AA Change: S263P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	30	306	4.8e-46	PFAM
Pfam:7TM_GPCR_Srsx	33	295	1.2e-6	PFAM
Pfam:7tm_1	40	289	1.8e-26	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214315
AA Change: S263P

PolyPhen 2 Score 0.126 (Sensitivity: 0.93; Specificity: 0.86)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000217566

Meta Mutation Damage Score

0.4011

Coding Region Coverage

1x: 99.2%
3x: 98.3%
10x: 96.1%
20x: 91.9%

Validation Efficiency

99% (68/69)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 67 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc10	G	T	17: 46,324,798	S93*	probably null	Het
Ackr2	T	C	9: 121,909,360	L267P	probably damaging	Het
Adgre4	T	A	17: 55,792,001	L169*	probably null	Het
AI481877	A	C	4: 59,099,410	M94R	probably benign	Het
Ankrd12	T	A	17: 65,984,506	S1311C	possibly damaging	Het
Arid2	T	A	15: 96,361,720		probably benign	Het
Atp9b	A	T	18: 80,762,102	V747E	probably damaging	Het
Best1	T	C	19: 9,992,053		probably null	Het
Brwd1	C	A	16: 96,037,964	E836*	probably null	Het
Cachd1	A	G	4: 100,994,737	S1177G	possibly damaging	Het
Cacna1e	C	T	1: 154,416,138	E1766K	probably benign	Het
Cckar	A	G	5: 53,700,165	I301T	probably benign	Het
Cdc27	T	G	11: 104,505,648	T816P	probably damaging	Het
Cep162	T	G	9: 87,220,484	Q708H	probably damaging	Het
Cep250	C	A	2: 155,988,401	D1301E	probably benign	Het
D430041D05Rik	G	A	2: 104,255,340	H955Y	probably damaging	Het
Dcdc2a	T	A	13: 25,056,434	V55E	probably damaging	Het
Efcab12	A	G	6: 115,823,248		probably benign	Het
Ep400	A	G	5: 110,701,671	V1428A	unknown	Het
Erbb3	T	C	10: 128,572,570	E825G	possibly damaging	Het
Evl	A	T	12: 108,686,048		probably null	Het
Fuca2	G	A	10: 13,505,763	R140H	probably benign	Het
Gm4969	T	A	7: 19,107,039	I57F	probably damaging	Het
Gm5581	T	C	6: 131,166,447		noncoding transcript	Het
Gm7052	T	C	17: 22,040,517		probably benign	Het
Gpd1	T	G	15: 99,719,270	I119S	probably damaging	Het
Gzmc	A	T	14: 56,232,736	Y101*	probably null	Het
Hmcn2	G	T	2: 31,424,206	A3588S	possibly damaging	Het
Ikbkb	A	G	8: 22,695,260		probably benign	Het
Itgax	G	T	7: 128,149,089		probably benign	Het
Kif24	C	A	4: 41,428,717	S81I	possibly damaging	Het
Lct	G	A	1: 128,286,462	P1858S	probably benign	Het
Map2k1	C	A	9: 64,193,702		probably null	Het
Mdga1	A	G	17: 29,857,708	V30A	possibly damaging	Het
Mtcl1	G	A	17: 66,338,129	P1441L	probably damaging	Het
N4bp2	T	A	5: 65,806,396	F596Y	possibly damaging	Het
Notch4	A	T	17: 34,581,499		probably benign	Het
Olfr1061	A	G	2: 86,414,025	V9A	possibly damaging	Het
Olfr1259	A	C	2: 89,943,818	V99G	possibly damaging	Het
Olfr802	A	G	10: 129,681,971	M256T	possibly damaging	Het
Olfr907	T	A	9: 38,499,154	C162S	possibly damaging	Het
Pbld2	A	G	10: 63,053,957		probably benign	Het
Phip	T	C	9: 82,926,407	Y505C	probably damaging	Het
Plcb2	A	G	2: 118,724,447	F58L	probably benign	Het
Plcd1	T	A	9: 119,081,136	I72F	probably damaging	Het
Ppp5c	A	T	7: 17,022,583	Y63*	probably null	Het
Prdm4	T	C	10: 85,908,004	D129G	probably damaging	Het
Prkcq	C	A	2: 11,246,838		probably benign	Het
Rab5b	C	T	10: 128,682,903	R120Q	probably benign	Het
Rab7b	T	A	1: 131,698,504	V90D	probably damaging	Het
Ripk3	T	C	14: 55,786,835	T193A	probably damaging	Het
Rnf167	C	T	11: 70,649,317	R88*	probably null	Het
Robo1	A	G	16: 72,742,245	T59A	possibly damaging	Het
Scd2	G	A	19: 44,301,246	V227I	probably benign	Het
Scg3	T	A	9: 75,675,338		probably benign	Het
Sec31a	A	T	5: 100,382,766	L677H	probably damaging	Het
Sema6a	G	A	18: 47,290,045		probably null	Het
Setd7	T	C	3: 51,550,320	T29A	probably benign	Het
Slc4a5	A	G	6: 83,295,872	Y942C	probably benign	Het
Slit1	T	A	19: 41,611,031	Y1027F	probably damaging	Het
Sptan1	G	A	2: 29,992,752		probably null	Het
Tdrd12	T	C	7: 35,508,802	Q249R	probably benign	Het
Tmem171	T	A	13: 98,692,228	D138V	possibly damaging	Het
Ttll10	G	A	4: 156,035,155	R596W	probably damaging	Het
Usp53	G	T	3: 122,949,201	N695K	probably damaging	Het
Vmn2r25	A	T	6: 123,823,622	L587*	probably null	Het
Zglp1	C	T	9: 21,063,379	C171Y	probably benign	Het

Other mutations in Olfr167

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01535:Olfr167	APN	16	19515478	missense	probably benign	0.01
IGL02115:Olfr167	APN	16	19515103	missense	probably damaging	1.00
IGL02562:Olfr167	APN	16	19514964	missense	possibly damaging	0.74
BB008:Olfr167	UTSW	16	19515508	missense	possibly damaging	0.94
BB018:Olfr167	UTSW	16	19515508	missense	possibly damaging	0.94
R0673:Olfr167	UTSW	16	19515396	missense	probably damaging	1.00
R1187:Olfr167	UTSW	16	19515046	missense	probably benign	0.01
R1237:Olfr167	UTSW	16	19515625	missense	probably benign	0.01
R1975:Olfr167	UTSW	16	19514836	missense	probably damaging	0.99
R1977:Olfr167	UTSW	16	19514836	missense	probably damaging	0.99
R1997:Olfr167	UTSW	16	19515042	missense	probably damaging	1.00
R2225:Olfr167	UTSW	16	19515246	missense	probably benign	0.05
R2226:Olfr167	UTSW	16	19515246	missense	probably benign	0.05
R4078:Olfr167	UTSW	16	19515232	missense	possibly damaging	0.76
R5019:Olfr167	UTSW	16	19515535	missense	probably damaging	0.99
R5071:Olfr167	UTSW	16	19515027	missense	probably benign	0.00
R5278:Olfr167	UTSW	16	19515378	nonsense	probably null
R5415:Olfr167	UTSW	16	19515246	missense	possibly damaging	0.94
R5744:Olfr167	UTSW	16	19515336	missense	probably benign	0.00
R5991:Olfr167	UTSW	16	19514757	missense	probably damaging	0.99
R6151:Olfr167	UTSW	16	19515531	missense	probably damaging	1.00
R6540:Olfr167	UTSW	16	19514821	missense	probably benign
R7014:Olfr167	UTSW	16	19515456	missense	probably benign	0.20
R7145:Olfr167	UTSW	16	19514899	missense	probably damaging	0.99
R7535:Olfr167	UTSW	16	19514794	missense	probably damaging	1.00
R7677:Olfr167	UTSW	16	19514928	missense	probably benign	0.42
R7715:Olfr167	UTSW	16	19514730	missense	probably benign	0.00
R7931:Olfr167	UTSW	16	19515508	missense	possibly damaging	0.94
R8137:Olfr167	UTSW	16	19515096	missense	possibly damaging	0.89
R8671:Olfr167	UTSW	16	19515054	missense	possibly damaging	0.63

Predicted Primers

Posted On

2013-05-09