Mutagenetix > Incidental Mutations

Incidental Mutation 'R6601:Taar9'

525277

Institutional Source

Beutler Lab

Gene Symbol

Taar9

Ensembl Gene

ENSMUSG00000037424

Gene Name

trace amine-associated receptor 9

Synonyms

Tar3, Ta3, Trar3

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.098) question?

Stock #

R6601 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

24108488-24109534 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 24109047 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 163 (Y163C)

Ref Sequence

ENSEMBL: ENSMUSP00000043552 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041180]

Predicted Effect

probably damaging
Transcript: ENSMUST00000041180
AA Change: Y163C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000043552
Gene: ENSMUSG00000037424
AA Change: Y163C

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	43	326	7.3e-13	PFAM
Pfam:7tm_1	49	311	8.4e-61	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 97.7%
20x: 93.0%

Validation Efficiency

98% (41/42)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] TAAR9 is a member of a large family of rhodopsin G protein-coupled receptors (GPCRs, or GPRs). GPCRs contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Jul 2005]

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aox1	T	G	1: 58,063,506	L527R	probably damaging	Het
Ccdc172	T	A	19: 58,537,291	C194S	possibly damaging	Het
Ccnb1ip1	G	T	14: 50,793,664	T64K	possibly damaging	Het
Ces1b	T	C	8: 93,079,481	E44G	probably benign	Het
Coro2a	A	T	4: 46,543,421	Y317*	probably null	Het
Csnk1a1	T	C	18: 61,578,758	F281S	probably damaging	Het
Ddx28	A	T	8: 106,010,616		probably null	Het
Dtnbp1	A	G	13: 44,931,245		probably null	Het
Eif2s1	T	C	12: 78,883,352	I258T	possibly damaging	Het
Elp3	T	C	14: 65,547,039	*554W	probably null	Het
Golga1	T	C	2: 39,020,106	M610V	probably damaging	Het
Hc	T	A	2: 35,045,894	K156N	probably benign	Het
Hcls1	G	A	16: 36,962,386	G428D	probably benign	Het
Il16	T	C	7: 83,722,469	D43G	probably damaging	Het
Klhl3	C	A	13: 58,095,116	K91N	probably damaging	Het
L3mbtl1	C	T	2: 162,948,175		probably benign	Het
Lamc3	T	C	2: 31,920,532	F805L	possibly damaging	Het
Lipg	T	C	18: 74,948,204	M269V	probably benign	Het
Ly75	G	A	2: 60,318,376	T1203I	probably benign	Het
Mat1a	T	A	14: 41,105,604	V5E	probably benign	Het
Muc16	A	T	9: 18,637,570	L5809Q	probably benign	Het
Naip6	G	A	13: 100,283,758	R1335C	probably benign	Het
Ndufaf3	T	C	9: 108,566,217	H128R	probably benign	Het
Nphp4	A	T	4: 152,503,007		probably null	Het
Olfr52	T	A	2: 86,181,965	I49F	probably damaging	Het
Otop3	T	C	11: 115,339,847	V148A	probably damaging	Het
Ovgp1	T	C	3: 105,986,431		probably benign	Het
Pcsk5	T	G	19: 17,511,380	R1025S	probably benign	Het
Pkd1l2	T	C	8: 117,040,666	D1295G	probably benign	Het
Polr1d	T	A	5: 147,078,549	L14*	probably null	Het
Rab26	T	A	17: 24,529,621	K270*	probably null	Het
Rasgef1c	T	A	11: 49,971,419	N378K	probably damaging	Het
Rpl7a	T	C	2: 26,911,524	V76A	probably benign	Het
Samd9l	T	A	6: 3,377,229	I11F	possibly damaging	Het
Smarca2	C	A	19: 26,654,377	Q531K	probably benign	Het
Styxl1	C	G	5: 135,755,496	G211A	probably benign	Het
Tmem198	T	A	1: 75,480,373	F48I	possibly damaging	Het
Ttn	T	A	2: 76,764,729	N12032I	probably damaging	Het
Ubr7	T	A	12: 102,761,464	C82S	probably damaging	Het
Wwtr1	T	C	3: 57,575,738	E48G	possibly damaging	Het
Zfp108	T	C	7: 24,261,394	V470A	probably damaging	Het
Zfp612	C	A	8: 110,089,549	Q424K	possibly damaging	Het
Zscan4-ps1	T	C	7: 11,068,834	T13A	probably benign	Het

Other mutations in Taar9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00955:Taar9	APN	10	24109531	missense	probably benign
IGL02011:Taar9	APN	10	24108579	missense	possibly damaging	0.93
IGL02883:Taar9	APN	10	24109480	missense	probably benign	0.08
R1468:Taar9	UTSW	10	24109484	missense	possibly damaging	0.47
R1468:Taar9	UTSW	10	24109484	missense	possibly damaging	0.47
R1598:Taar9	UTSW	10	24109407	missense	possibly damaging	0.90
R2072:Taar9	UTSW	10	24108979	missense	probably damaging	1.00
R2471:Taar9	UTSW	10	24109391	missense	probably benign	0.00
R2519:Taar9	UTSW	10	24109254	missense	probably damaging	1.00
R4205:Taar9	UTSW	10	24108579	missense	possibly damaging	0.93
R4793:Taar9	UTSW	10	24109510	missense	probably benign
R4801:Taar9	UTSW	10	24108843	missense	probably damaging	0.97
R4802:Taar9	UTSW	10	24108843	missense	probably damaging	0.97
R5457:Taar9	UTSW	10	24109105	missense	probably damaging	0.98
R6450:Taar9	UTSW	10	24109240	missense	probably damaging	1.00
R6915:Taar9	UTSW	10	24109012	missense	possibly damaging	0.53
R7179:Taar9	UTSW	10	24108984	missense	probably damaging	1.00
R7480:Taar9	UTSW	10	24108945	missense	possibly damaging	0.61
R8200:Taar9	UTSW	10	24109419	missense	probably damaging	0.99
Z1088:Taar9	UTSW	10	24108965	missense	probably damaging	1.00
Z1177:Taar9	UTSW	10	24109141	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- TATAGCTCTCAGAGGAGGCCTG -3'
(R):5'- TCCACACGTGTTTCGACAC -3'

Sequencing Primer
(F):5'- TCAGAGGAGGCCTGAGCTTG -3'
(R):5'- ACGTGTTTCGACACCTCCTTCTG -3'

Posted On

2018-06-22