Mutagenetix > Incidental Mutation

Incidental Mutation 'R7253:Ptprq'

564093

Institutional Source

Beutler Lab

Gene Symbol

Ptprq

Ensembl Gene

ENSMUSG00000035916

Gene Name

protein tyrosine phosphatase receptor type Q

Synonyms

MMRRC Submission

045314-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.236) question?

Stock #

R7253 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

107352910-107555912 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 107444134 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Leucine at position 1490 (Q1490L)

Ref Sequence

ENSEMBL: ENSMUSP00000058572 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050702]

AlphaFold

P0C5E4

Predicted Effect

probably benign
Transcript: ENSMUST00000050702
AA Change: Q1490L

PolyPhen 2 Score 0.296 (Sensitivity: 0.91; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000058572
Gene: ENSMUSG00000035916
AA Change: Q1490L

Domain	Start	End	E-Value	Type
FN3	57	141	3.17e-13	SMART
FN3	156	294	1.55e-7	SMART
FN3	307	384	4.45e-8	SMART
FN3	398	555	1.17e-7	SMART
FN3	569	648	7.06e-11	SMART
FN3	666	743	7.68e-12	SMART
FN3	760	839	1.88e-6	SMART
FN3	855	932	1.33e-6	SMART
FN3	949	1037	2.31e-6	SMART
FN3	1054	1135	1.24e-6	SMART
FN3	1151	1229	2.39e-8	SMART
FN3	1244	1325	6.29e-8	SMART
FN3	1341	1416	2.87e-11	SMART
FN3	1431	1524	2.82e-10	SMART
FN3	1540	1622	6.35e-4	SMART
FN3	1642	1732	7.93e-5	SMART
transmembrane domain	1907	1929	N/A	INTRINSIC
PTPc	2003	2262	1.14e-130	SMART

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.4%

Validation Efficiency

99% (74/75)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This locus encodes a member of the type III receptor-like protein-tyrosine phosphatase family. The encoded protein catalyzes the dephosphorylation of phosphotyrosine and phosphatidylinositol and plays roles in cellular proliferation and differentiation. Mutations at this locus have been linked to autosomal recessive deafness. [provided by RefSeq, Mar 2014]
PHENOTYPE: Homozygotes for targeted mutations show absence of shaft connectors from vestibular hair bundles, postnatal degeneration in cochlear hair-bundle structure, reduced transducer currents but otherwise normal adaptation properties, a progressive loss of basal-coil cochlear hair cells, and deafness. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 76 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700009N14Rik	A	G	4: 39,451,391 (GRCm39)	H199R	not run	Het
Ak9	A	G	10: 41,308,480 (GRCm39)	N1804S	unknown	Het
Akr1c21	C	A	13: 4,627,139 (GRCm39)	T147N	probably damaging	Het
Aldh1a2	A	G	9: 71,123,216 (GRCm39)	T30A	probably benign	Het
Alox15	T	C	11: 70,236,724 (GRCm39)	D447G	probably damaging	Het
Amigo2	T	C	15: 97,142,956 (GRCm39)	I489V	probably benign	Het
Ano9	A	T	7: 140,687,350 (GRCm39)	Y322N	probably damaging	Het
Arhgap40	G	T	2: 158,389,576 (GRCm39)	W583L	probably benign	Het
Atxn2	A	G	5: 121,916,084 (GRCm39)	E430G	probably damaging	Het
Brip1	T	C	11: 86,034,104 (GRCm39)	Y539C	possibly damaging	Het
C87436	T	A	6: 86,442,790 (GRCm39)	L454Q	probably damaging	Het
Casp4	T	G	9: 5,324,868 (GRCm39)	Y227D	probably benign	Het
Ccn6	T	G	10: 39,031,031 (GRCm39)	N164T	probably benign	Het
Chd4	T	A	6: 125,083,555 (GRCm39)		probably null	Het
Chrna10	A	G	7: 101,761,293 (GRCm39)	C433R	probably benign	Het
Cntln	A	T	4: 85,036,710 (GRCm39)	N214I	probably damaging	Het
Colec12	G	A	18: 9,848,922 (GRCm39)	V367I	probably damaging	Het
Cyp46a1	T	C	12: 108,318,255 (GRCm39)	I222T	probably benign	Het
Dagla	A	T	19: 10,239,945 (GRCm39)		probably null	Het
Dcaf7	C	A	11: 105,938,669 (GRCm39)		probably null	Het
Dclk2	C	T	3: 86,700,566 (GRCm39)	R638H	probably damaging	Het
E2f7	A	G	10: 110,602,164 (GRCm39)		probably null	Het
Fam184a	G	T	10: 53,574,901 (GRCm39)	T236K	probably benign	Het
Glyctk	T	C	9: 106,032,661 (GRCm39)	T451A	probably damaging	Het
Hectd4	A	G	5: 121,452,944 (GRCm39)	K484E	possibly damaging	Het
Hspbap1	G	T	16: 35,637,600 (GRCm39)	C243F	unknown	Het
Hspg2	A	C	4: 137,247,257 (GRCm39)	N1160T	probably benign	Het
Ighv5-8	C	T	12: 113,618,728 (GRCm39)	L48F	probably benign	Het
Jazf1	C	A	6: 52,754,637 (GRCm39)	E146D	probably benign	Het
Katnb1	C	T	8: 95,822,125 (GRCm39)	Q284*	probably null	Het
Kctd18	G	T	1: 58,001,115 (GRCm39)	Y213*	probably null	Het
Klk1b26	T	C	7: 43,664,213 (GRCm39)	S23P	possibly damaging	Het
Krt88	T	C	15: 101,348,392 (GRCm39)	L26P	probably damaging	Het
Lrrc8b	G	A	5: 105,629,522 (GRCm39)	V623I	probably benign	Het
Map3k4	T	A	17: 12,490,955 (GRCm39)	M159L	probably benign	Het
Mast3	C	A	8: 71,242,326 (GRCm39)		probably null	Het
Mier1	G	A	4: 102,996,544 (GRCm39)		probably null	Het
Mrpl46	T	C	7: 78,431,207 (GRCm39)	D117G	probably damaging	Het
Ms4a6b	A	G	19: 11,497,760 (GRCm39)	S20G	probably benign	Het
Mup10	A	T	4: 60,538,077 (GRCm39)	M4K	unknown	Het
Nlrp5	C	T	7: 23,116,816 (GRCm39)	A180V	possibly damaging	Het
Nlrx1	T	A	9: 44,176,001 (GRCm39)		probably null	Het
Odad3	T	C	9: 21,913,767 (GRCm39)	T2A	probably damaging	Het
Or2a52	T	C	6: 43,144,744 (GRCm39)	F251L	probably damaging	Het
Or2t45	T	C	11: 58,669,822 (GRCm39)	Y290H	probably damaging	Het
Or4c103	T	C	2: 88,513,969 (GRCm39)	T36A	possibly damaging	Het
Or51aa2	C	T	7: 103,187,995 (GRCm39)	A149T	probably benign	Het
Or5af2	T	A	11: 58,708,366 (GRCm39)	C177*	probably null	Het
Or5ak22	A	G	2: 85,229,983 (GRCm39)	I298T	probably benign	Het
Otud1	C	A	2: 19,663,742 (GRCm39)	D290E	probably damaging	Het
Pank4	A	G	4: 155,055,377 (GRCm39)	N249S	probably benign	Het
Pccb	G	T	9: 100,913,966 (GRCm39)	S84R	probably benign	Het
Pemt	A	T	11: 59,862,081 (GRCm39)	H194Q	possibly damaging	Het
Phtf2	A	G	5: 20,970,856 (GRCm39)	I634T	possibly damaging	Het
Pias2	T	G	18: 77,207,811 (GRCm39)	I232R	probably damaging	Het
Plce1	A	G	19: 38,686,952 (GRCm39)	E620G	probably damaging	Het
Pramel17	A	T	4: 101,692,725 (GRCm39)	V425E	probably benign	Het
Ptpn13	G	A	5: 103,713,150 (GRCm39)	E1758K	possibly damaging	Het
Ptx3	G	T	3: 66,132,368 (GRCm39)	M296I	probably benign	Het
R3hdm2	C	T	10: 127,317,644 (GRCm39)	P464L	probably damaging	Het
Rapgef1	A	G	2: 29,589,733 (GRCm39)	E258G	possibly damaging	Het
Rgl2	T	C	17: 34,153,964 (GRCm39)	F457L	possibly damaging	Het
Rsf1	GGCGGCGGC	GGCGGCGGCCGCGGCGGC	7: 97,229,122 (GRCm39)		probably benign	Het
Senp8	T	C	9: 59,644,478 (GRCm39)	N226S	probably benign	Het
Six5	C	T	7: 18,828,901 (GRCm39)	R114C	probably damaging	Het
Slc10a1	T	C	12: 81,004,958 (GRCm39)	T195A	probably benign	Het
Slpi	G	T	2: 164,197,467 (GRCm39)	Q51K	probably benign	Het
Smarca4	T	C	9: 21,570,256 (GRCm39)	V753A	probably benign	Het
Tbc1d32	C	A	10: 56,074,537 (GRCm39)	M225I	probably benign	Het
Tent5a	C	A	9: 85,208,770 (GRCm39)	G18C	probably benign	Het
Tnfrsf21	G	A	17: 43,348,558 (GRCm39)	V57I	probably benign	Het
Trim44	G	T	2: 102,177,313 (GRCm39)	P336T	possibly damaging	Het
Txlnb	A	G	10: 17,703,633 (GRCm39)	I264V	probably damaging	Het
Xirp2	A	C	2: 67,343,826 (GRCm39)	E2022D	probably benign	Het
Zfp975	A	G	7: 42,311,036 (GRCm39)	*526R	probably null	Het
Zp1	A	G	19: 10,893,933 (GRCm39)	L424P	probably damaging	Het

Other mutations in Ptprq

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00340:Ptprq	APN	10	107,412,790 (GRCm39)	missense	probably damaging	0.98
IGL00537:Ptprq	APN	10	107,546,383 (GRCm39)	missense	probably benign	0.07
IGL00547:Ptprq	APN	10	107,554,402 (GRCm39)	missense	probably damaging	0.99
IGL00586:Ptprq	APN	10	107,443,983 (GRCm39)	splice site	probably benign
IGL00648:Ptprq	APN	10	107,482,577 (GRCm39)	missense	probably benign	0.10
IGL01123:Ptprq	APN	10	107,522,079 (GRCm39)	missense	probably damaging	0.96
IGL01343:Ptprq	APN	10	107,474,700 (GRCm39)	missense	probably damaging	0.96
IGL01348:Ptprq	APN	10	107,547,765 (GRCm39)	missense	probably damaging	1.00
IGL01433:Ptprq	APN	10	107,412,741 (GRCm39)	missense	probably damaging	0.99
IGL01510:Ptprq	APN	10	107,547,909 (GRCm39)	missense	probably damaging	1.00
IGL01535:Ptprq	APN	10	107,535,457 (GRCm39)	missense	probably benign
IGL01631:Ptprq	APN	10	107,479,399 (GRCm39)	missense	probably benign	0.00
IGL01633:Ptprq	APN	10	107,535,584 (GRCm39)	splice site	probably benign
IGL01702:Ptprq	APN	10	107,353,727 (GRCm39)	missense	probably benign	0.00
IGL01733:Ptprq	APN	10	107,498,460 (GRCm39)	missense	probably benign	0.10
IGL01806:Ptprq	APN	10	107,535,469 (GRCm39)	missense	probably damaging	1.00
IGL01832:Ptprq	APN	10	107,401,700 (GRCm39)	critical splice donor site	probably null
IGL01961:Ptprq	APN	10	107,479,515 (GRCm39)	missense	probably damaging	1.00
IGL02108:Ptprq	APN	10	107,482,478 (GRCm39)	missense	probably damaging	1.00
IGL02120:Ptprq	APN	10	107,503,333 (GRCm39)	missense	probably damaging	1.00
IGL02160:Ptprq	APN	10	107,489,426 (GRCm39)	missense	probably benign	0.00
IGL02178:Ptprq	APN	10	107,522,180 (GRCm39)	missense	probably benign	0.03
IGL02249:Ptprq	APN	10	107,418,220 (GRCm39)	missense	probably damaging	1.00
IGL02267:Ptprq	APN	10	107,482,419 (GRCm39)	missense	probably damaging	1.00
IGL02527:Ptprq	APN	10	107,522,424 (GRCm39)	missense	probably benign	0.04
IGL02529:Ptprq	APN	10	107,471,226 (GRCm39)	missense	probably benign	0.03
IGL02542:Ptprq	APN	10	107,498,416 (GRCm39)	missense	probably damaging	1.00
IGL02582:Ptprq	APN	10	107,479,860 (GRCm39)	missense	probably benign	0.00
IGL02708:Ptprq	APN	10	107,488,561 (GRCm39)	missense	probably damaging	1.00
IGL02894:Ptprq	APN	10	107,503,285 (GRCm39)	missense	probably benign
IGL02903:Ptprq	APN	10	107,502,447 (GRCm39)	missense	possibly damaging	0.51
IGL02951:Ptprq	APN	10	107,503,321 (GRCm39)	missense	probably benign	0.03
IGL02982:Ptprq	APN	10	107,422,545 (GRCm39)	missense	probably damaging	1.00
IGL03000:Ptprq	APN	10	107,378,518 (GRCm39)	missense	probably damaging	1.00
IGL03024:Ptprq	APN	10	107,521,427 (GRCm39)	missense	possibly damaging	0.69
IGL03240:Ptprq	APN	10	107,524,368 (GRCm39)	missense	probably benign
P0043:Ptprq	UTSW	10	107,416,086 (GRCm39)	missense	probably benign	0.03
PIT4812001:Ptprq	UTSW	10	107,502,428 (GRCm39)	missense	probably damaging	1.00
R0200:Ptprq	UTSW	10	107,521,018 (GRCm39)	missense	probably benign
R0268:Ptprq	UTSW	10	107,541,409 (GRCm39)	missense	probably benign
R0276:Ptprq	UTSW	10	107,378,596 (GRCm39)	critical splice acceptor site	probably null
R0279:Ptprq	UTSW	10	107,444,278 (GRCm39)	missense	probably damaging	0.96
R0335:Ptprq	UTSW	10	107,544,589 (GRCm39)	missense	probably benign
R0344:Ptprq	UTSW	10	107,541,443 (GRCm39)	missense	probably benign
R0357:Ptprq	UTSW	10	107,522,060 (GRCm39)	splice site	probably benign
R0454:Ptprq	UTSW	10	107,418,391 (GRCm39)	nonsense	probably null
R0479:Ptprq	UTSW	10	107,479,855 (GRCm39)	nonsense	probably null
R0491:Ptprq	UTSW	10	107,444,036 (GRCm39)	missense	probably damaging	0.98
R0519:Ptprq	UTSW	10	107,374,781 (GRCm39)	splice site	probably benign
R0523:Ptprq	UTSW	10	107,416,081 (GRCm39)	missense	possibly damaging	0.54
R0553:Ptprq	UTSW	10	107,546,488 (GRCm39)	missense	probably benign	0.33
R0746:Ptprq	UTSW	10	107,353,692 (GRCm39)	missense	probably damaging	1.00
R0755:Ptprq	UTSW	10	107,418,400 (GRCm39)	missense	probably benign	0.09
R1434:Ptprq	UTSW	10	107,422,575 (GRCm39)	missense	probably damaging	1.00
R1445:Ptprq	UTSW	10	107,498,423 (GRCm39)	missense	probably damaging	1.00
R1470:Ptprq	UTSW	10	107,554,435 (GRCm39)	missense	probably damaging	0.97
R1470:Ptprq	UTSW	10	107,554,435 (GRCm39)	missense	probably damaging	0.97
R1558:Ptprq	UTSW	10	107,479,904 (GRCm39)	missense	probably damaging	1.00
R1567:Ptprq	UTSW	10	107,401,748 (GRCm39)	missense	probably benign	0.13
R1711:Ptprq	UTSW	10	107,370,560 (GRCm39)	nonsense	probably null
R1720:Ptprq	UTSW	10	107,522,155 (GRCm39)	missense	probably damaging	1.00
R1746:Ptprq	UTSW	10	107,474,691 (GRCm39)	missense	probably damaging	1.00
R1776:Ptprq	UTSW	10	107,520,950 (GRCm39)	missense	probably damaging	1.00
R1822:Ptprq	UTSW	10	107,554,339 (GRCm39)	missense	probably damaging	1.00
R1872:Ptprq	UTSW	10	107,479,860 (GRCm39)	missense	probably benign	0.19
R1944:Ptprq	UTSW	10	107,418,249 (GRCm39)	missense	probably benign	0.23
R1945:Ptprq	UTSW	10	107,418,249 (GRCm39)	missense	probably benign	0.23
R2006:Ptprq	UTSW	10	107,502,407 (GRCm39)	missense	probably damaging	1.00
R2014:Ptprq	UTSW	10	107,503,283 (GRCm39)	missense	probably damaging	0.96
R2015:Ptprq	UTSW	10	107,503,283 (GRCm39)	missense	probably damaging	0.96
R2097:Ptprq	UTSW	10	107,489,354 (GRCm39)	missense	probably benign	0.05
R2172:Ptprq	UTSW	10	107,426,855 (GRCm39)	nonsense	probably null
R2174:Ptprq	UTSW	10	107,541,414 (GRCm39)	missense	probably damaging	1.00
R2248:Ptprq	UTSW	10	107,478,931 (GRCm39)	splice site	probably null
R2404:Ptprq	UTSW	10	107,522,460 (GRCm39)	missense	probably damaging	1.00
R3423:Ptprq	UTSW	10	107,418,337 (GRCm39)	missense	probably damaging	0.99
R3683:Ptprq	UTSW	10	107,544,489 (GRCm39)	missense	probably benign	0.01
R3875:Ptprq	UTSW	10	107,520,965 (GRCm39)	missense	possibly damaging	0.88
R3945:Ptprq	UTSW	10	107,522,253 (GRCm39)	splice site	probably benign
R3946:Ptprq	UTSW	10	107,522,253 (GRCm39)	splice site	probably benign
R3974:Ptprq	UTSW	10	107,547,923 (GRCm39)	missense	possibly damaging	0.88
R3982:Ptprq	UTSW	10	107,379,257 (GRCm39)	missense	probably damaging	0.99
R4105:Ptprq	UTSW	10	107,408,828 (GRCm39)	missense	probably damaging	1.00
R4118:Ptprq	UTSW	10	107,547,781 (GRCm39)	missense	probably benign	0.37
R4175:Ptprq	UTSW	10	107,547,778 (GRCm39)	missense	probably benign
R4231:Ptprq	UTSW	10	107,522,144 (GRCm39)	nonsense	probably null
R4356:Ptprq	UTSW	10	107,444,225 (GRCm39)	missense	probably damaging	0.99
R4435:Ptprq	UTSW	10	107,520,916 (GRCm39)	missense	possibly damaging	0.89
R4678:Ptprq	UTSW	10	107,521,043 (GRCm39)	missense	probably benign	0.19
R4679:Ptprq	UTSW	10	107,521,043 (GRCm39)	missense	probably benign	0.19
R4745:Ptprq	UTSW	10	107,360,114 (GRCm39)	missense	probably damaging	1.00
R4771:Ptprq	UTSW	10	107,524,288 (GRCm39)	missense	probably benign
R4778:Ptprq	UTSW	10	107,426,883 (GRCm39)	missense	probably benign	0.15
R4808:Ptprq	UTSW	10	107,554,368 (GRCm39)	missense	probably damaging	1.00
R4809:Ptprq	UTSW	10	107,399,036 (GRCm39)	missense	probably damaging	1.00
R4818:Ptprq	UTSW	10	107,546,442 (GRCm39)	missense	possibly damaging	0.86
R4845:Ptprq	UTSW	10	107,489,393 (GRCm39)	missense	probably benign	0.00
R4901:Ptprq	UTSW	10	107,524,275 (GRCm39)	missense	probably benign	0.01
R4942:Ptprq	UTSW	10	107,524,290 (GRCm39)	missense	probably benign	0.01
R4946:Ptprq	UTSW	10	107,361,595 (GRCm39)	missense	probably benign
R4959:Ptprq	UTSW	10	107,522,416 (GRCm39)	missense	probably damaging	1.00
R4973:Ptprq	UTSW	10	107,522,416 (GRCm39)	missense	probably damaging	1.00
R5007:Ptprq	UTSW	10	107,444,137 (GRCm39)	missense	probably benign	0.00
R5053:Ptprq	UTSW	10	107,399,063 (GRCm39)	missense	probably damaging	1.00
R5055:Ptprq	UTSW	10	107,370,540 (GRCm39)	missense	probably benign	0.37
R5090:Ptprq	UTSW	10	107,361,950 (GRCm39)	missense	probably damaging	1.00
R5158:Ptprq	UTSW	10	107,370,565 (GRCm39)	missense	probably damaging	1.00
R5163:Ptprq	UTSW	10	107,360,192 (GRCm39)	missense	probably damaging	1.00
R5222:Ptprq	UTSW	10	107,498,425 (GRCm39)	missense	probably damaging	0.96
R5244:Ptprq	UTSW	10	107,422,556 (GRCm39)	missense	possibly damaging	0.62
R5249:Ptprq	UTSW	10	107,535,496 (GRCm39)	missense	probably damaging	0.99
R5503:Ptprq	UTSW	10	107,524,189 (GRCm39)	splice site	probably null
R5508:Ptprq	UTSW	10	107,522,092 (GRCm39)	missense	probably benign	0.00
R5601:Ptprq	UTSW	10	107,444,291 (GRCm39)	missense	probably benign
R5722:Ptprq	UTSW	10	107,522,226 (GRCm39)	missense	possibly damaging	0.72
R5819:Ptprq	UTSW	10	107,555,744 (GRCm39)	start gained	probably benign
R5862:Ptprq	UTSW	10	107,401,739 (GRCm39)	missense	probably benign	0.02
R5891:Ptprq	UTSW	10	107,412,756 (GRCm39)	missense	possibly damaging	0.94
R5916:Ptprq	UTSW	10	107,359,374 (GRCm39)	missense	probably damaging	1.00
R6054:Ptprq	UTSW	10	107,418,219 (GRCm39)	missense	probably damaging	1.00
R6058:Ptprq	UTSW	10	107,471,135 (GRCm39)	missense	probably benign	0.00
R6075:Ptprq	UTSW	10	107,361,621 (GRCm39)	missense	probably damaging	1.00
R6101:Ptprq	UTSW	10	107,416,127 (GRCm39)	missense	possibly damaging	0.93
R6189:Ptprq	UTSW	10	107,353,748 (GRCm39)	missense	probably damaging	1.00
R6235:Ptprq	UTSW	10	107,471,199 (GRCm39)	missense	possibly damaging	0.61
R6351:Ptprq	UTSW	10	107,544,529 (GRCm39)	missense	probably damaging	0.99
R6394:Ptprq	UTSW	10	107,478,804 (GRCm39)	nonsense	probably null
R6449:Ptprq	UTSW	10	107,541,444 (GRCm39)	missense	probably benign	0.00
R6526:Ptprq	UTSW	10	107,378,514 (GRCm39)	nonsense	probably null
R6544:Ptprq	UTSW	10	107,444,102 (GRCm39)	missense	probably damaging	1.00
R6609:Ptprq	UTSW	10	107,408,829 (GRCm39)	missense	probably damaging	0.99
R6862:Ptprq	UTSW	10	107,522,086 (GRCm39)	missense	probably damaging	0.96
R6874:Ptprq	UTSW	10	107,554,460 (GRCm39)	missense	possibly damaging	0.80
R6892:Ptprq	UTSW	10	107,411,865 (GRCm39)	missense	probably benign	0.00
R7082:Ptprq	UTSW	10	107,544,591 (GRCm39)	missense	probably benign	0.10
R7210:Ptprq	UTSW	10	107,521,032 (GRCm39)	missense	probably damaging	1.00
R7293:Ptprq	UTSW	10	107,471,367 (GRCm39)	nonsense	probably null
R7445:Ptprq	UTSW	10	107,426,820 (GRCm39)	missense	probably damaging	1.00
R7632:Ptprq	UTSW	10	107,547,783 (GRCm39)	missense	probably benign	0.32
R7685:Ptprq	UTSW	10	107,479,839 (GRCm39)	missense	probably damaging	1.00
R7703:Ptprq	UTSW	10	107,480,007 (GRCm39)	missense	probably benign	0.01
R7774:Ptprq	UTSW	10	107,479,530 (GRCm39)	missense	probably damaging	0.96
R7897:Ptprq	UTSW	10	107,546,484 (GRCm39)	missense	probably benign	0.21
R7936:Ptprq	UTSW	10	107,488,572 (GRCm39)	missense	probably damaging	1.00
R7983:Ptprq	UTSW	10	107,444,272 (GRCm39)	nonsense	probably null
R8023:Ptprq	UTSW	10	107,488,477 (GRCm39)	nonsense	probably null
R8071:Ptprq	UTSW	10	107,479,896 (GRCm39)	missense	possibly damaging	0.62
R8084:Ptprq	UTSW	10	107,444,294 (GRCm39)	missense	probably benign
R8086:Ptprq	UTSW	10	107,482,500 (GRCm39)	nonsense	probably null
R8169:Ptprq	UTSW	10	107,418,351 (GRCm39)	missense	probably damaging	1.00
R8223:Ptprq	UTSW	10	107,535,499 (GRCm39)	missense	probably benign	0.00
R8235:Ptprq	UTSW	10	107,541,351 (GRCm39)	missense	probably benign	0.32
R8235:Ptprq	UTSW	10	107,418,402 (GRCm39)	missense	probably damaging	1.00
R8278:Ptprq	UTSW	10	107,522,239 (GRCm39)	missense	possibly damaging	0.87
R8710:Ptprq	UTSW	10	107,411,919 (GRCm39)	missense	possibly damaging	0.67
R8828:Ptprq	UTSW	10	107,482,513 (GRCm39)	missense	probably benign
R8830:Ptprq	UTSW	10	107,422,556 (GRCm39)	missense	possibly damaging	0.62
R8869:Ptprq	UTSW	10	107,535,469 (GRCm39)	missense	probably damaging	1.00
R9012:Ptprq	UTSW	10	107,489,411 (GRCm39)	missense	probably benign	0.09
R9072:Ptprq	UTSW	10	107,401,736 (GRCm39)	missense
R9153:Ptprq	UTSW	10	107,416,126 (GRCm39)	missense	probably damaging	0.98
R9202:Ptprq	UTSW	10	107,522,416 (GRCm39)	missense	probably damaging	1.00
R9252:Ptprq	UTSW	10	107,522,247 (GRCm39)	missense	probably benign	0.12
R9306:Ptprq	UTSW	10	107,422,599 (GRCm39)	missense	probably benign	0.00
R9492:Ptprq	UTSW	10	107,478,813 (GRCm39)	missense	probably damaging	1.00
R9519:Ptprq	UTSW	10	107,520,961 (GRCm39)	missense	probably damaging	1.00
R9581:Ptprq	UTSW	10	107,547,771 (GRCm39)	missense	possibly damaging	0.53
R9593:Ptprq	UTSW	10	107,524,254 (GRCm39)	missense	possibly damaging	0.92
R9621:Ptprq	UTSW	10	107,378,523 (GRCm39)	missense	probably damaging	1.00
R9732:Ptprq	UTSW	10	107,412,767 (GRCm39)	missense	probably damaging	1.00
R9743:Ptprq	UTSW	10	107,520,982 (GRCm39)	missense	probably damaging	1.00
R9771:Ptprq	UTSW	10	107,521,085 (GRCm39)	missense	probably damaging	0.99
R9788:Ptprq	UTSW	10	107,401,751 (GRCm39)	missense	probably benign	0.24
Z1088:Ptprq	UTSW	10	107,535,533 (GRCm39)	missense	possibly damaging	0.56
Z1176:Ptprq	UTSW	10	107,361,931 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GCCTAACAGAAAGCAGTGTG -3'
(R):5'- TGAACGCCATAGCTTGCATTG -3'

Sequencing Primer
(F):5'- GTGAATAGATGTCAGGACAATACTC -3'
(R):5'- CGCCATAGCTTGCATTGTAATG -3'

Posted On

2019-06-26