Mutagenetix > Incidental Mutations

Incidental Mutation 'R7570:Nrxn1'

585768

Institutional Source

Beutler Lab

Gene Symbol

Nrxn1

Ensembl Gene

ENSMUSG00000024109

Gene Name

neurexin I

Synonyms

neurexin I beta, alpha-latrotoxin receptor (calcium-dependent), A230068P09Rik, neurexin I alpha, neurexin I alpha, neurexin I beta, 1700062G21Rik, 9330127H16Rik, neurexin I alpha, neurexin I beta

MMRRC Submission

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R7570 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

90033631-91093071 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 90162379 bp

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Alanine at position 1288 (E1288A)

Ref Sequence

ENSEMBL: ENSMUSP00000125407 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054059] [ENSMUST00000072671] [ENSMUST00000159778] [ENSMUST00000160800] [ENSMUST00000160844] [ENSMUST00000161402] [ENSMUST00000172466] [ENSMUST00000174331] [ENSMUST00000174337] [ENSMUST00000197104]

Predicted Effect

probably benign
Transcript: ENSMUST00000054059
AA Change: E1280A

PolyPhen 2 Score 0.255 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000057294
Gene: ENSMUSG00000024109
AA Change: E1280A

Domain	Start	End	E-Value	Type
low complexity region	9	23	N/A	INTRINSIC
LamG	50	192	2.29e-31	SMART
EGF	216	256	4.26e0	SMART
LamG	304	438	2.3e-36	SMART
LamG	492	644	2.74e-43	SMART
EGF	671	705	1.58e-3	SMART
LamG	730	869	7.27e-25	SMART
LamG	917	1053	8.46e-35	SMART
EGF	1078	1112	1.87e1	SMART
LamG	1140	1297	7.74e-20	SMART
low complexity region	1324	1355	N/A	INTRINSIC
low complexity region	1426	1441	N/A	INTRINSIC
4.1m	1444	1462	1.19e-6	SMART
low complexity region	1481	1493	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000072671
AA Change: E1280A

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000072458
Gene: ENSMUSG00000024109
AA Change: E1280A

Domain	Start	End	E-Value	Type
low complexity region	9	23	N/A	INTRINSIC
LamG	50	192	2.29e-31	SMART
EGF	216	256	4.26e0	SMART
LamG	304	438	2.3e-36	SMART
LamG	492	644	2.74e-43	SMART
EGF	671	705	1.58e-3	SMART
LamG	730	869	7.27e-25	SMART
LamG	917	1053	8.46e-35	SMART
EGF	1078	1112	1.87e1	SMART
LamG	1140	1297	7.74e-20	SMART
low complexity region	1324	1355	N/A	INTRINSIC
low complexity region	1423	1438	N/A	INTRINSIC
4.1m	1441	1459	1.19e-6	SMART
low complexity region	1478	1490	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000159778
AA Change: E219A

PolyPhen 2 Score 0.204 (Sensitivity: 0.92; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000125561
Gene: ENSMUSG00000024109
AA Change: E219A

Domain	Start	End	E-Value	Type
low complexity region	9	23	N/A	INTRINSIC
LamG	50	192	2.29e-31	SMART
EGF	216	256	4.26e0	SMART
LamG	284	418	2.3e-36	SMART
LamG	472	624	2.74e-43	SMART
EGF	651	685	1.58e-3	SMART
LamG	710	849	7.27e-25	SMART
LamG	897	1033	8.46e-35	SMART
EGF	1058	1092	1.87e1	SMART
LamG	1120	1277	7.74e-20	SMART
low complexity region	1304	1335	N/A	INTRINSIC
low complexity region	1403	1418	N/A	INTRINSIC
4.1m	1421	1439	1.19e-6	SMART
low complexity region	1458	1470	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000160800
AA Change: E1276A

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000124561
Gene: ENSMUSG00000024109
AA Change: E1276A

Domain	Start	End	E-Value	Type
low complexity region	9	23	N/A	INTRINSIC
LamG	50	192	2.29e-31	SMART
EGF	216	256	4.26e0	SMART
LamG	300	434	2.3e-36	SMART
LamG	488	640	2.74e-43	SMART
EGF	667	701	1.58e-3	SMART
LamG	726	865	7.27e-25	SMART
LamG	913	1049	8.46e-35	SMART
EGF	1074	1108	1.87e1	SMART
LamG	1136	1293	7.74e-20	SMART
low complexity region	1320	1351	N/A	INTRINSIC
low complexity region	1422	1437	N/A	INTRINSIC
4.1m	1440	1458	1.19e-6	SMART
low complexity region	1477	1489	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000160844
AA Change: E1288A

PolyPhen 2 Score 0.351 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000125407
Gene: ENSMUSG00000024109
AA Change: E1288A

Domain	Start	End	E-Value	Type
low complexity region	9	23	N/A	INTRINSIC
LamG	50	192	2.29e-31	SMART
EGF	216	256	4.26e0	SMART
LamG	304	446	1.24e-32	SMART
LamG	500	652	2.74e-43	SMART
EGF	679	713	1.58e-3	SMART
LamG	738	877	7.27e-25	SMART
LamG	925	1061	8.46e-35	SMART
EGF	1086	1120	1.87e1	SMART
LamG	1148	1305	7.74e-20	SMART
low complexity region	1332	1363	N/A	INTRINSIC
low complexity region	1434	1449	N/A	INTRINSIC
4.1m	1452	1470	1.19e-6	SMART
low complexity region	1489	1501	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000161402
AA Change: E1295A

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000124116
Gene: ENSMUSG00000024109
AA Change: E1295A

Domain	Start	End	E-Value	Type
low complexity region	9	23	N/A	INTRINSIC
LamG	50	192	2.29e-31	SMART
EGF	216	256	4.26e0	SMART
LamG	304	453	3.46e-31	SMART
LamG	507	659	2.74e-43	SMART
EGF	686	720	1.58e-3	SMART
LamG	745	884	7.27e-25	SMART
LamG	932	1068	8.46e-35	SMART
EGF	1093	1127	1.87e1	SMART
LamG	1155	1312	7.74e-20	SMART
low complexity region	1339	1370	N/A	INTRINSIC
low complexity region	1441	1456	N/A	INTRINSIC
4.1m	1459	1477	1.19e-6	SMART
low complexity region	1496	1508	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000172466
AA Change: E249A

PolyPhen 2 Score 0.300 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000134402
Gene: ENSMUSG00000024109
AA Change: E249A

Domain	Start	End	E-Value	Type
transmembrane domain	27	49	N/A	INTRINSIC
LamG	109	266	7.74e-20	SMART
low complexity region	293	324	N/A	INTRINSIC
low complexity region	395	410	N/A	INTRINSIC
4.1m	413	431	1.19e-6	SMART
low complexity region	450	462	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000174331
AA Change: E1258A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000133491
Gene: ENSMUSG00000024109
AA Change: E1258A

Domain	Start	End	E-Value	Type
signal peptide	1	30	N/A	INTRINSIC
LamG	50	192	2.29e-31	SMART
EGF	216	256	4.26e0	SMART
LamG	304	446	1.24e-32	SMART
LamG	500	652	2.74e-43	SMART
EGF	679	713	1.58e-3	SMART
LamG	738	877	7.27e-25	SMART
LamG	925	1061	8.46e-35	SMART
EGF	1086	1120	1.87e1	SMART
LamG	1148	1275	3.29e-23	SMART
low complexity region	1302	1333	N/A	INTRINSIC
low complexity region	1404	1419	N/A	INTRINSIC
4.1m	1422	1440	1.19e-6	SMART
low complexity region	1459	1471	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000174337
AA Change: E249A

PolyPhen 2 Score 0.204 (Sensitivity: 0.92; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000133724
Gene: ENSMUSG00000024109
AA Change: E249A

Domain	Start	End	E-Value	Type
transmembrane domain	27	49	N/A	INTRINSIC
LamG	109	236	3.29e-23	SMART
low complexity region	263	294	N/A	INTRINSIC
low complexity region	365	380	N/A	INTRINSIC
4.1m	383	401	1.19e-6	SMART
low complexity region	420	432	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000197104
AA Change: E52A

PolyPhen 2 Score 0.553 (Sensitivity: 0.88; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000142621
Gene: ENSMUSG00000024109
AA Change: E52A

Domain	Start	End	E-Value	Type
Pfam:Laminin_G_2	1	69	3.2e-12	PFAM
low complexity region	96	127	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.1%

Validation Efficiency

98% (104/106)

MGI Phenotype

FUNCTION: This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. Mouse knockouts display decreased spontaneous and evoked vesicle release resulting in impaired synaptic transmission. In addition, knockout mice show altered social approach, reduced social investigation, reduced locomotor activity, and in males, increased aggression. Alternative splicing and promoter usage result in multiple transcript variants. [provided by RefSeq, Nov 2016]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced Ca(2+)-dependent binding of alpha-latrotoxin to brain membranes. Isolated synaptosomes display only a small reduction in alpha-latrotoxin -triggered glutamate release in the absence of Ca(2+) but show a major decrease in the presence of Ca(2+). [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 106 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930590J08Rik	C	T	6: 91,934,610	T613I	probably benign	Het
9130019O22Rik	T	A	7: 127,385,283	S216C	probably benign	Het
Ajuba	T	C	14: 54,576,402	E288G	probably damaging	Het
Ankrd12	C	T	17: 65,985,360	R1026K	probably benign	Het
Apol7b	T	C	15: 77,423,474	T274A	probably benign	Het
Arid4a	A	T	12: 71,063,142	R86*	probably null	Het
Asnsd1	C	T	1: 53,348,258	G70D	probably damaging	Het
Atg4c	T	A	4: 99,228,560	V313D	possibly damaging	Het
Atp13a5	A	C	16: 29,266,963	C885G	probably damaging	Het
Bpifb9a	A	T	2: 154,262,263	I209F	possibly damaging	Het
Bsn	T	C	9: 108,113,543	D1670G	probably damaging	Het
Cct8	T	A	16: 87,491,322	I121F	probably benign	Het
Cd209a	T	G	8: 3,744,151	D217A	probably damaging	Het
Cdk19	C	T	10: 40,477,958	S456L	possibly damaging	Het
Chd9	C	T	8: 90,994,580	H999Y	unknown	Het
Col5a1	G	A	2: 27,951,383	V339M	unknown	Het
Cr2	G	A	1: 195,169,340	R115*	probably null	Het
Cyb561	A	T	11: 105,937,644	F62I	probably damaging	Het
Cyp2c38	A	T	19: 39,404,743	N293K	possibly damaging	Het
Cyp2c69	A	T	19: 39,859,898	D293E	probably damaging	Het
Dcbld2	T	A	16: 58,424,569	C69S	possibly damaging	Het
Dcdc2a	T	C	13: 25,119,373	S296P	probably benign	Het
Dmxl1	T	A	18: 49,893,957	I2044K	possibly damaging	Het
Dnah5	A	G	15: 28,346,952	D2527G	probably damaging	Het
Dnah6	T	C	6: 73,149,430	T1305A	probably benign	Het
Dnajc9	A	G	14: 20,388,644	V47A	probably benign	Het
Dnmt3b	A	G	2: 153,676,699	Y594C	probably damaging	Het
Dph7	A	G	2: 24,965,630	D147G	probably damaging	Het
Drap1	T	C	19: 5,423,352	H164R	possibly damaging	Het
Dsg3	T	A	18: 20,527,780	V392E	possibly damaging	Het
Dxo	A	G	17: 34,837,640	D81G	probably benign	Het
E230025N22Rik	G	T	18: 36,695,592	T11K	probably benign	Het
Esyt1	A	G	10: 128,518,932	V533A	possibly damaging	Het
Etv3	T	A	3: 87,536,031	C307*	probably null	Het
Fam114a1	T	A	5: 65,030,059		probably null	Het
Fam208b	A	G	13: 3,573,621	Y2110H	probably damaging	Het
Fam3c	T	A	6: 22,326,405		probably benign	Het
Fbn1	G	T	2: 125,397,852	T305K	probably benign	Het
Ggt1	A	T	10: 75,585,594	I484F	probably damaging	Het
Gm10639	A	T	9: 78,304,469	D171V	possibly damaging	Het
Gpatch1	T	C	7: 35,293,812	D536G	probably damaging	Het
Gpx4	T	C	10: 80,055,041	I189T	probably damaging	Het
Gsr	T	A	8: 33,669,165	C85S	probably damaging	Het
Havcr1	T	A	11: 46,770,542		probably null	Het
Heatr4	T	C	12: 83,979,644	T280A	probably benign	Het
Hmcn2	A	T	2: 31,423,911	E3532D	probably benign	Het
Hnrnpc	T	C	14: 52,075,099	N308S	possibly damaging	Het
Ighv8-9	A	G	12: 115,468,738	V13A	probably benign	Het
Itgb2l	A	T	16: 96,426,239	F535I	probably benign	Het
Kdm5a	T	G	6: 120,427,842	D1348E	probably damaging	Het
Kndc1	CT	C	7: 139,923,775		probably null	Het
Ky	A	G	9: 102,542,329	I512V	probably benign	Het
Lamc1	A	T	1: 153,243,275	F866Y	possibly damaging	Het
Lbx1	C	A	19: 45,235,248		probably benign	Het
Magel2	A	G	7: 62,378,910	T521A	possibly damaging	Het
Mgam	A	T	6: 40,746,433	I491L	probably benign	Het
Mitd1	T	C	1: 37,890,192	E40G	probably damaging	Het
Mpzl3	A	G	9: 45,070,687	T218A	probably benign	Het
Mrpl42	A	G	10: 95,480,965	S77P	probably benign	Het
Mup5	C	T	4: 61,834,674	W37*	probably null	Het
Myh14	T	C	7: 44,632,426	I803V	probably benign	Het
Ncor2	T	A	5: 125,030,089	T744S		Het
Ndufv3	A	G	17: 31,527,622	D162G	probably damaging	Het
Nostrin	A	G	2: 69,175,806	E278G	probably damaging	Het
Olfr1205	A	G	2: 88,831,128	N4D	possibly damaging	Het
Olfr623	C	A	7: 103,660,881	R123L	probably damaging	Het
Olfr648	T	A	7: 104,179,748	Y220F	probably damaging	Het
Olfr972	A	T	9: 39,873,455	Y60F	possibly damaging	Het
Patj	T	A	4: 98,424,500		probably null	Het
Pcm1	T	G	8: 41,267,344	I314R	possibly damaging	Het
Pcsk6	A	G	7: 66,033,898	T754A	probably benign	Het
Pde2a	A	T	7: 101,502,834	N326I	probably benign	Het
Plekhg4	T	C	8: 105,378,684	S594P	possibly damaging	Het
Plekhm3	T	C	1: 64,937,906	D135G	probably damaging	Het
Plin4	A	T	17: 56,106,776	M283K	probably benign	Het
Ppfia3	T	C	7: 45,340,748		probably null	Het
Prdm9	T	C	17: 15,555,652	N179S	probably benign	Het
Prrt3	T	C	6: 113,494,488	S908G	probably damaging	Het
Psg22	C	A	7: 18,722,735	S181Y	possibly damaging	Het
Rcor3	C	A	1: 192,137,876	G8V	probably damaging	Het
Rp1l1	T	A	14: 64,031,574	C1536*	probably null	Het
Rpp25l	T	C	4: 41,712,529	H82R	probably damaging	Het
Rps3a1	T	A	3: 86,139,089	M172L	probably benign	Het
Rtbdn	T	C	8: 84,952,927	L110P	probably damaging	Het
Ryr1	T	A	7: 29,078,585	Q2169L	probably damaging	Het
Scn4a	A	T	11: 106,320,473	C1573S	possibly damaging	Het
Sec16b	A	T	1: 157,531,395		probably null	Het
Serpina1a	A	T	12: 103,853,837	D383E	possibly damaging	Het
Sh3gl3	T	C	7: 82,285,077	M262T	probably benign	Het
Sos2	G	A	12: 69,590,880	T1052M	probably damaging	Het
Spag16	G	A	1: 69,996,841	V343I	probably benign	Het
Spocd1	T	G	4: 129,930,164	D251E		Het
Stc2	G	T	11: 31,367,798	N74K	probably damaging	Het
Thbs3	C	T	3: 89,219,052	Q227*	probably null	Het
Tmem92	A	C	11: 94,778,990	I105R	probably benign	Het
Tmod1	T	A	4: 46,083,632	N20K	probably benign	Het
Tns1	T	C	1: 73,953,479	D53G	probably damaging	Het
Tspan33	T	A	6: 29,717,338	L246Q	probably damaging	Het
Ttc16	A	G	2: 32,768,968	L392P	probably damaging	Het
Uggt1	T	A	1: 36,185,838	T572S	probably benign	Het
Usp17la	A	T	7: 104,860,397	T70S	probably damaging	Het
Usp31	C	T	7: 121,674,963	R370H	probably damaging	Het
Wdr83	C	T	8: 85,079,834	V112M	probably damaging	Het
Zbtb25	T	A	12: 76,369,592		probably benign	Het
Zfp110	T	A	7: 12,849,340	N638K	possibly damaging	Het
Zfp820	T	C	17: 21,819,013	T445A	probably benign	Het

Other mutations in Nrxn1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01310:Nrxn1	APN	17	90059474	critical splice donor site	probably null
IGL01644:Nrxn1	APN	17	90620873	missense	possibly damaging	0.94
IGL01820:Nrxn1	APN	17	90643103	missense	probably damaging	0.98
IGL01902:Nrxn1	APN	17	91088491	splice site	probably null
IGL02079:Nrxn1	APN	17	90643083	missense	probably damaging	0.99
IGL02089:Nrxn1	APN	17	91088401	missense	probably benign	0.01
IGL02133:Nrxn1	APN	17	90643243	missense	probably damaging	1.00
IGL02179:Nrxn1	APN	17	90630083	missense	probably damaging	0.99
IGL02199:Nrxn1	APN	17	90037258	missense	probably damaging	1.00
IGL02262:Nrxn1	APN	17	90704208	missense	probably damaging	1.00
IGL02941:Nrxn1	APN	17	90208383	missense	probably damaging	1.00
PIT4449001:Nrxn1	UTSW	17	90597579	missense	probably damaging	1.00
PIT4791001:Nrxn1	UTSW	17	90455503	intron	probably benign
R0123:Nrxn1	UTSW	17	90995487	splice site	probably null
R0212:Nrxn1	UTSW	17	90362758	unclassified	probably benign
R0277:Nrxn1	UTSW	17	90700742	critical splice donor site	probably null
R0323:Nrxn1	UTSW	17	90700742	critical splice donor site	probably null
R0384:Nrxn1	UTSW	17	90208347	missense	probably damaging	1.00
R0395:Nrxn1	UTSW	17	91088314	missense	possibly damaging	0.90
R0606:Nrxn1	UTSW	17	90565373	missense	probably damaging	1.00
R0616:Nrxn1	UTSW	17	90362857	missense	probably damaging	1.00
R0624:Nrxn1	UTSW	17	91088689	missense	unknown
R0633:Nrxn1	UTSW	17	90704181	missense	probably damaging	1.00
R0927:Nrxn1	UTSW	17	90037330	missense	probably damaging	1.00
R1035:Nrxn1	UTSW	17	90163874	missense	probably damaging	0.96
R1221:Nrxn1	UTSW	17	90643294	missense	probably damaging	0.97
R1403:Nrxn1	UTSW	17	90643053	missense	probably benign	0.11
R1403:Nrxn1	UTSW	17	90643053	missense	probably benign	0.11
R1691:Nrxn1	UTSW	17	90162289	missense	probably damaging	0.98
R1703:Nrxn1	UTSW	17	90208417	missense	probably damaging	1.00
R1709:Nrxn1	UTSW	17	90037187	missense	probably damaging	1.00
R1721:Nrxn1	UTSW	17	90162404	missense	probably damaging	1.00
R1792:Nrxn1	UTSW	17	90588824	missense	probably damaging	0.96
R1980:Nrxn1	UTSW	17	91088318	missense	probably benign	0.01
R2116:Nrxn1	UTSW	17	90704277	missense	probably damaging	1.00
R2117:Nrxn1	UTSW	17	90704277	missense	probably damaging	1.00
R2162:Nrxn1	UTSW	17	90162431	missense	probably damaging	1.00
R3119:Nrxn1	UTSW	17	90597519	nonsense	probably null
R3409:Nrxn1	UTSW	17	90208367	missense	probably damaging	1.00
R3683:Nrxn1	UTSW	17	90623452	missense	probably damaging	1.00
R3885:Nrxn1	UTSW	17	90623471	missense	probably damaging	1.00
R3939:Nrxn1	UTSW	17	90208421	missense	probably damaging	1.00
R4475:Nrxn1	UTSW	17	90701982	missense	probably damaging	0.98
R4640:Nrxn1	UTSW	17	90560768	missense	probably damaging	1.00
R4678:Nrxn1	UTSW	17	90623422	missense	probably damaging	1.00
R4690:Nrxn1	UTSW	17	90037081	missense	probably damaging	1.00
R4790:Nrxn1	UTSW	17	90455049	missense	possibly damaging	0.86
R4877:Nrxn1	UTSW	17	91088177	missense	probably benign	0.33
R4989:Nrxn1	UTSW	17	90620846	intron	probably benign
R5204:Nrxn1	UTSW	17	90162364	missense	probably damaging	1.00
R5205:Nrxn1	UTSW	17	90163874	missense	probably damaging	0.96
R5239:Nrxn1	UTSW	17	90704109	missense	probably damaging	1.00
R5250:Nrxn1	UTSW	17	90535441	intron	probably benign
R5473:Nrxn1	UTSW	17	90590092	missense	probably damaging	1.00
R5629:Nrxn1	UTSW	17	90590032	missense	possibly damaging	0.75
R5743:Nrxn1	UTSW	17	90643224	missense	probably damaging	1.00
R5910:Nrxn1	UTSW	17	90704318	nonsense	probably null
R5961:Nrxn1	UTSW	17	90454943	missense	probably damaging	0.99
R5979:Nrxn1	UTSW	17	91088203	missense	possibly damaging	0.54
R5992:Nrxn1	UTSW	17	90623507	missense	probably benign	0.01
R6024:Nrxn1	UTSW	17	90590098	missense	possibly damaging	0.88
R6031:Nrxn1	UTSW	17	90588790	missense	probably damaging	1.00
R6031:Nrxn1	UTSW	17	90588790	missense	probably damaging	1.00
R6185:Nrxn1	UTSW	17	90037136	missense	probably damaging	1.00
R6220:Nrxn1	UTSW	17	91088476	missense	probably benign	0.14
R6306:Nrxn1	UTSW	17	90565446	missense	possibly damaging	0.55
R6621:Nrxn1	UTSW	17	90162182	missense	probably damaging	1.00
R6669:Nrxn1	UTSW	17	90059563	missense	probably damaging	0.98
R6770:Nrxn1	UTSW	17	90037179	missense	probably damaging	1.00
R6798:Nrxn1	UTSW	17	90629950	missense	probably damaging	1.00
R6923:Nrxn1	UTSW	17	91088233	missense	probably benign	0.06
R7140:Nrxn1	UTSW	17	91088764	start gained	probably benign
R7374:Nrxn1	UTSW	17	90588669	critical splice donor site	probably null
R7564:Nrxn1	UTSW	17	90362906	missense	possibly damaging	0.64
R7800:Nrxn1	UTSW	17	91089207	unclassified	probably benign
R7828:Nrxn1	UTSW	17	90059551	missense	probably damaging	0.99
R7974:Nrxn1	UTSW	17	90700779	missense	probably damaging	1.00
R8001:Nrxn1	UTSW	17	91088536	missense	possibly damaging	0.49
R8189:Nrxn1	UTSW	17	90704209	missense	probably damaging	0.96
R8258:Nrxn1	UTSW	17	90163821	missense	probably damaging	0.99
R8259:Nrxn1	UTSW	17	90163821	missense	probably damaging	0.99
R8298:Nrxn1	UTSW	17	90704169	missense	probably damaging	1.00
R8801:Nrxn1	UTSW	17	90701965	critical splice donor site	probably benign
R8814:Nrxn1	UTSW	17	90630101	missense	probably damaging	1.00
RF005:Nrxn1	UTSW	17	90362876	missense	probably damaging	1.00
RF024:Nrxn1	UTSW	17	90362876	missense	probably damaging	1.00
X0021:Nrxn1	UTSW	17	90590212	missense	probably damaging	1.00
X0063:Nrxn1	UTSW	17	90362831	missense	possibly damaging	0.54
Z1088:Nrxn1	UTSW	17	90059505	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGGACATCTCAGACTGCATG -3'
(R):5'- TTTCATGGACACCTCATTTCTAAGC -3'

Sequencing Primer
(F):5'- ATGGCAGTGGCTGTCGACTC -3'
(R):5'- TGAGCCAAATGCCTCTCTTATAG -3'

Posted On

2019-10-17