Incidental Mutation 'R4367:Fmo1'
ID 325784
Institutional Source Beutler Lab
Gene Symbol Fmo1
Ensembl Gene ENSMUSG00000040181
Gene Name flavin containing monooxygenase 1
Synonyms
MMRRC Submission 041673-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R4367 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 162657130-162694179 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to C at 162661217 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 355 (Y355*)
Ref Sequence ENSEMBL: ENSMUSP00000037259 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046049] [ENSMUST00000131058] [ENSMUST00000134098] [ENSMUST00000193078]
AlphaFold P50285
Predicted Effect probably null
Transcript: ENSMUST00000046049
AA Change: Y355*
SMART Domains Protein: ENSMUSP00000037259
Gene: ENSMUSG00000040181
AA Change: Y355*

DomainStartEndE-ValueType
Pfam:FMO-like 2 532 1.5e-279 PFAM
Pfam:Pyr_redox_2 3 228 3.8e-13 PFAM
Pfam:NAD_binding_8 7 63 8e-7 PFAM
Pfam:K_oxygenase 73 226 3.4e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000131058
SMART Domains Protein: ENSMUSP00000118534
Gene: ENSMUSG00000040181

DomainStartEndE-ValueType
Pfam:FMO-like 2 209 9.3e-122 PFAM
Pfam:Pyr_redox_2 4 208 8.2e-9 PFAM
Pfam:Pyr_redox_3 6 209 7.5e-16 PFAM
Pfam:NAD_binding_8 7 65 5.2e-8 PFAM
Pfam:K_oxygenase 72 209 1.4e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000134098
SMART Domains Protein: ENSMUSP00000117398
Gene: ENSMUSG00000040181

DomainStartEndE-ValueType
Pfam:FMO-like 2 303 1.4e-168 PFAM
Pfam:Pyr_redox_2 4 280 8e-9 PFAM
Pfam:Pyr_redox_3 6 220 5.5e-16 PFAM
Pfam:NAD_binding_8 7 65 9.5e-8 PFAM
Pfam:K_oxygenase 72 224 2.1e-10 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136120
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143902
Predicted Effect probably benign
Transcript: ENSMUST00000193078
SMART Domains Protein: ENSMUSP00000141210
Gene: ENSMUSG00000040181

DomainStartEndE-ValueType
Pfam:FMO-like 2 230 9.4e-132 PFAM
Pfam:Pyr_redox_2 4 223 4.9e-7 PFAM
Pfam:Pyr_redox_3 6 220 3.1e-14 PFAM
Pfam:NAD_binding_8 7 65 6.9e-6 PFAM
Pfam:K_oxygenase 72 222 3.8e-8 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193766
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.4%
Validation Efficiency 98% (54/55)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adrb2 T C 18: 62,312,127 (GRCm39) I233V probably damaging Het
Alox5 T A 6: 116,437,924 (GRCm39) Y21F possibly damaging Het
Ank2 T C 3: 126,739,798 (GRCm39) T1942A probably benign Het
Aoc1l1 T C 6: 48,953,064 (GRCm39) S330P probably damaging Het
B4galt3 C A 1: 171,101,613 (GRCm39) H196N probably damaging Het
Bckdk C T 7: 127,505,591 (GRCm39) A238V probably benign Het
Casp1 A G 9: 5,299,333 (GRCm39) T21A probably benign Het
Ccdc39 T C 3: 33,880,671 (GRCm39) H432R probably benign Het
Cttnbp2 A C 6: 18,405,248 (GRCm39) C574G probably damaging Het
Cyp1a1 T C 9: 57,607,432 (GRCm39) V20A probably benign Het
Dhx38 C T 8: 110,279,763 (GRCm39) V976I probably damaging Het
Dnah6 A G 6: 73,126,467 (GRCm39) S1287P possibly damaging Het
Dnttip2 T C 3: 122,070,146 (GRCm39) S454P probably damaging Het
Drp2 A T X: 133,335,884 (GRCm39) probably benign Het
Flcn C T 11: 59,694,610 (GRCm39) V121I possibly damaging Het
Git2 T A 5: 114,902,727 (GRCm39) H138L probably damaging Het
Gpr162 G A 6: 124,838,658 (GRCm39) probably benign Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Kcnt1 T C 2: 25,797,638 (GRCm39) I881T probably damaging Het
Lama3 T A 18: 12,646,747 (GRCm39) C1754S probably damaging Het
Mpp3 A T 11: 101,914,246 (GRCm39) D116E probably benign Het
Myh11 T C 16: 14,036,747 (GRCm39) D985G probably damaging Het
Necap1 T C 6: 122,864,337 (GRCm39) V273A probably damaging Het
Nlrc5 T C 8: 95,203,192 (GRCm39) S431P probably damaging Het
Nutm2 A T 13: 50,623,920 (GRCm39) T206S probably benign Het
Or2d3 GAACAACAACAA GAACAACAA 7: 106,490,567 (GRCm39) probably benign Het
Or5p79 C T 7: 108,221,096 (GRCm39) L26F probably benign Het
Or8g19 G A 9: 39,055,725 (GRCm39) A110T probably damaging Het
Phactr2 A G 10: 13,129,564 (GRCm39) S235P probably damaging Het
Podnl1 G A 8: 84,853,897 (GRCm39) R89H probably benign Het
Prpf38b T C 3: 108,818,487 (GRCm39) Y91C probably damaging Het
Radil C T 5: 142,480,560 (GRCm39) A632T probably benign Het
Rpap2 G A 5: 107,749,661 (GRCm39) V62I possibly damaging Het
Sdf2 C T 11: 78,141,863 (GRCm39) T66I probably damaging Het
Specc1 T C 11: 62,009,356 (GRCm39) S371P probably damaging Het
Suco T C 1: 161,674,799 (GRCm39) E416G probably damaging Het
Sys1 T C 2: 164,303,315 (GRCm39) W10R probably damaging Het
Tars3 C T 7: 65,332,567 (GRCm39) T556M probably damaging Het
Tcirg1 C T 19: 3,949,069 (GRCm39) D407N probably damaging Het
Tefm G T 11: 80,031,156 (GRCm39) L27I probably benign Het
Tenm2 A G 11: 35,918,225 (GRCm39) I1845T probably benign Het
Tfam A T 10: 71,069,233 (GRCm39) I119N probably damaging Het
Tle1 ACAGGTTTCTTCAGGTTTCTT ACAGGTTTCTT 4: 72,036,400 (GRCm39) probably benign Het
Trpm6 T C 19: 18,804,889 (GRCm39) I947T probably damaging Het
Ubqlnl C T 7: 103,798,925 (GRCm39) V191M probably benign Het
Usp54 T C 14: 20,611,202 (GRCm39) T1205A probably benign Het
Vmn2r25 T C 6: 123,805,496 (GRCm39) R454G probably damaging Het
Xylb T C 9: 119,217,781 (GRCm39) V477A probably benign Het
Other mutations in Fmo1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00418:Fmo1 APN 1 162,663,815 (GRCm39) missense probably damaging 1.00
IGL00479:Fmo1 APN 1 162,657,632 (GRCm39) missense probably benign 0.00
IGL01612:Fmo1 APN 1 162,661,168 (GRCm39) missense probably benign 0.42
IGL01650:Fmo1 APN 1 162,661,153 (GRCm39) missense probably benign 0.04
IGL02052:Fmo1 APN 1 162,677,629 (GRCm39) critical splice donor site probably null
IGL02340:Fmo1 APN 1 162,660,559 (GRCm39) missense probably benign 0.02
IGL03348:Fmo1 APN 1 162,677,720 (GRCm39) missense possibly damaging 0.76
IGL03388:Fmo1 APN 1 162,663,716 (GRCm39) missense probably benign 0.17
PIT1430001:Fmo1 UTSW 1 162,657,622 (GRCm39) missense probably benign 0.00
R0279:Fmo1 UTSW 1 162,657,841 (GRCm39) missense possibly damaging 0.92
R0314:Fmo1 UTSW 1 162,687,031 (GRCm39) missense probably damaging 1.00
R0348:Fmo1 UTSW 1 162,663,704 (GRCm39) missense probably benign 0.00
R0385:Fmo1 UTSW 1 162,663,773 (GRCm39) missense possibly damaging 0.94
R0699:Fmo1 UTSW 1 162,661,341 (GRCm39) missense probably benign 0.00
R1413:Fmo1 UTSW 1 162,661,431 (GRCm39) missense probably damaging 0.98
R1424:Fmo1 UTSW 1 162,657,635 (GRCm39) missense probably damaging 1.00
R1430:Fmo1 UTSW 1 162,667,293 (GRCm39) missense probably damaging 1.00
R1851:Fmo1 UTSW 1 162,657,554 (GRCm39) nonsense probably null
R1929:Fmo1 UTSW 1 162,661,424 (GRCm39) missense probably damaging 1.00
R1982:Fmo1 UTSW 1 162,667,325 (GRCm39) missense possibly damaging 0.83
R2272:Fmo1 UTSW 1 162,661,424 (GRCm39) missense probably damaging 1.00
R2568:Fmo1 UTSW 1 162,663,828 (GRCm39) missense probably benign 0.00
R3787:Fmo1 UTSW 1 162,657,583 (GRCm39) missense possibly damaging 0.54
R3825:Fmo1 UTSW 1 162,678,916 (GRCm39) splice site probably benign
R3904:Fmo1 UTSW 1 162,661,337 (GRCm39) missense possibly damaging 0.54
R4320:Fmo1 UTSW 1 162,661,200 (GRCm39) missense probably damaging 1.00
R4431:Fmo1 UTSW 1 162,661,281 (GRCm39) missense possibly damaging 0.76
R4473:Fmo1 UTSW 1 162,677,732 (GRCm39) missense possibly damaging 0.90
R5340:Fmo1 UTSW 1 162,657,551 (GRCm39) missense probably benign 0.39
R5354:Fmo1 UTSW 1 162,657,714 (GRCm39) missense probably benign 0.01
R5479:Fmo1 UTSW 1 162,677,793 (GRCm39) missense probably damaging 0.99
R5930:Fmo1 UTSW 1 162,667,185 (GRCm39) critical splice donor site probably null
R6148:Fmo1 UTSW 1 162,679,088 (GRCm39) missense probably damaging 0.99
R6160:Fmo1 UTSW 1 162,663,867 (GRCm39) missense probably benign 0.00
R6164:Fmo1 UTSW 1 162,678,979 (GRCm39) missense probably benign 0.24
R6263:Fmo1 UTSW 1 162,677,629 (GRCm39) critical splice donor site probably null
R7046:Fmo1 UTSW 1 162,667,263 (GRCm39) missense possibly damaging 0.92
R7590:Fmo1 UTSW 1 162,687,251 (GRCm39) intron probably benign
R7663:Fmo1 UTSW 1 162,663,866 (GRCm39) missense possibly damaging 0.74
R7692:Fmo1 UTSW 1 162,661,402 (GRCm39) missense probably benign 0.16
R7712:Fmo1 UTSW 1 162,663,704 (GRCm39) missense probably benign 0.00
R8207:Fmo1 UTSW 1 162,677,676 (GRCm39) missense probably benign 0.28
R8895:Fmo1 UTSW 1 162,657,827 (GRCm39) missense probably benign 0.01
R8917:Fmo1 UTSW 1 162,663,773 (GRCm39) missense probably benign 0.03
R9583:Fmo1 UTSW 1 162,686,996 (GRCm39) missense
R9620:Fmo1 UTSW 1 162,661,390 (GRCm39) missense probably benign
X0022:Fmo1 UTSW 1 162,657,569 (GRCm39) missense possibly damaging 0.57
X0066:Fmo1 UTSW 1 162,667,273 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TATGATTCACATGGCAAACAGC -3'
(R):5'- GCCTGTGCTAAATGATGAGC -3'

Sequencing Primer
(F):5'- AGCCACTTTATACATGTGCCCAG -3'
(R):5'- CTGTGCTAAATGATGAGCTCCCAG -3'
Posted On 2015-07-06