Incidental Mutation 'R3757:Cdh24'
ID 271495
Institutional Source Beutler Lab
Gene Symbol Cdh24
Ensembl Gene ENSMUSG00000059674
Gene Name cadherin-like 24
Synonyms EY-cadherin, ENSMUSG00000022188, cadherin 14-like, 1700040A22Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.202) question?
Stock # R3757 (G1)
Quality Score 107
Status Validated
Chromosome 14
Chromosomal Location 54868688-54878821 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 54869637 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 760 (D760G)
Ref Sequence ENSEMBL: ENSMUSP00000066005 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067784] [ENSMUST00000097177] [ENSMUST00000227124]
AlphaFold Q6PFX6
Predicted Effect possibly damaging
Transcript: ENSMUST00000067784
AA Change: D760G

PolyPhen 2 Score 0.915 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000066005
Gene: ENSMUSG00000059674
AA Change: D760G

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
CA 67 148 7.85e-18 SMART
CA 172 257 3.23e-28 SMART
CA 281 369 4.24e-14 SMART
CA 396 477 1.48e-22 SMART
Blast:CA 500 581 3e-31 BLAST
transmembrane domain 602 624 N/A INTRINSIC
Pfam:Cadherin_C 627 775 2e-48 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000097177
SMART Domains Protein: ENSMUSP00000132140
Gene: ENSMUSG00000072423

DomainStartEndE-ValueType
Pfam:Proteasome 46 228 3.9e-41 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000227124
Meta Mutation Damage Score 0.1465 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.3%
Validation Efficiency 92% (35/38)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl3 T A 7: 81,986,415 (GRCm39) I9K probably benign Het
Arhgap31 T C 16: 38,457,362 (GRCm39) E82G probably damaging Het
Asap2 T A 12: 21,317,767 (GRCm39) S993T probably damaging Het
Bmpr1a A T 14: 34,156,624 (GRCm39) L134* probably null Het
Cacna1e A G 1: 154,509,442 (GRCm39) V271A probably damaging Het
Cacna2d4 A G 6: 119,218,124 (GRCm39) E153G probably damaging Het
Cage1 A C 13: 38,209,705 (GRCm39) F91V possibly damaging Het
Col9a1 T C 1: 24,271,312 (GRCm39) probably null Het
Cts6 A T 13: 61,349,972 (GRCm39) Y36* probably null Het
Dennd3 C G 15: 73,394,083 (GRCm39) A36G probably benign Het
Dmxl1 G A 18: 50,068,384 (GRCm39) G2719D probably damaging Het
Dnajc28 G A 16: 91,413,755 (GRCm39) T187M probably damaging Het
Ep300 T A 15: 81,532,790 (GRCm39) V1676E unknown Het
Ercc4 C T 16: 12,962,360 (GRCm39) T668M probably benign Het
G530012D18Rik CAGAGAGA CAGAGAGAGA 1: 85,504,945 (GRCm39) probably null Het
Gm10985 GCTCTCTCTCTCTCTCTCTCTCTCTCTCT GCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT 3: 53,752,645 (GRCm39) probably null Het
H1f4 T A 13: 23,806,240 (GRCm39) K81* probably null Het
Havcr1 G T 11: 46,643,407 (GRCm39) R109L probably damaging Het
Krtap4-9 A G 11: 99,676,444 (GRCm39) probably benign Het
Layn T C 9: 50,970,856 (GRCm39) E229G probably benign Het
Lpcat3 T A 6: 124,676,955 (GRCm39) probably null Het
Lrrn1 T A 6: 107,546,169 (GRCm39) F656I possibly damaging Het
Lypd1 A G 1: 125,838,121 (GRCm39) probably benign Het
Or4k41 T A 2: 111,279,602 (GRCm39) V39E possibly damaging Het
Or5v1b T A 17: 37,841,246 (GRCm39) I126N probably damaging Het
Or6c207 T C 10: 129,104,934 (GRCm39) D86G probably damaging Het
Ptprt A T 2: 161,653,950 (GRCm39) L560Q probably damaging Het
Rbm11 T C 16: 75,393,469 (GRCm39) V55A probably damaging Het
Scn11a C T 9: 119,632,569 (GRCm39) V434I probably benign Het
Serpinc1 A G 1: 160,829,935 (GRCm39) T434A probably benign Het
Setd2 T C 9: 110,402,753 (GRCm39) I1798T probably damaging Het
Sfswap A G 5: 129,590,298 (GRCm39) Y265C probably damaging Het
Slc9a8 C A 2: 167,266,050 (GRCm39) T9K probably benign Het
Synpo T C 18: 60,736,062 (GRCm39) D389G probably damaging Het
Vmn1r181 C T 7: 23,683,909 (GRCm39) L125F possibly damaging Het
Wdfy4 A C 14: 32,745,331 (GRCm39) H2296Q probably benign Het
Other mutations in Cdh24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01362:Cdh24 APN 14 54,875,889 (GRCm39) missense probably benign 0.01
IGL02597:Cdh24 APN 14 54,870,972 (GRCm39) missense possibly damaging 0.55
R0088:Cdh24 UTSW 14 54,871,171 (GRCm39) missense probably damaging 1.00
R0480:Cdh24 UTSW 14 54,870,054 (GRCm39) missense probably benign 0.38
R0890:Cdh24 UTSW 14 54,870,051 (GRCm39) missense probably benign 0.00
R1525:Cdh24 UTSW 14 54,876,046 (GRCm39) missense probably damaging 1.00
R1591:Cdh24 UTSW 14 54,873,799 (GRCm39) missense probably benign 0.19
R1727:Cdh24 UTSW 14 54,876,095 (GRCm39) nonsense probably null
R4786:Cdh24 UTSW 14 54,875,007 (GRCm39) missense possibly damaging 0.65
R4921:Cdh24 UTSW 14 54,870,672 (GRCm39) missense probably damaging 1.00
R4929:Cdh24 UTSW 14 54,870,973 (GRCm39) missense probably benign 0.00
R5116:Cdh24 UTSW 14 54,873,870 (GRCm39) missense probably benign 0.34
R5589:Cdh24 UTSW 14 54,874,832 (GRCm39) missense probably damaging 1.00
R5682:Cdh24 UTSW 14 54,874,805 (GRCm39) missense probably damaging 1.00
R5774:Cdh24 UTSW 14 54,876,514 (GRCm39) missense probably damaging 0.99
R6305:Cdh24 UTSW 14 54,869,813 (GRCm39) missense possibly damaging 0.62
R7090:Cdh24 UTSW 14 54,876,964 (GRCm39) missense probably damaging 1.00
R7186:Cdh24 UTSW 14 54,870,949 (GRCm39) missense probably benign 0.03
R7361:Cdh24 UTSW 14 54,876,378 (GRCm39) missense possibly damaging 0.74
R7488:Cdh24 UTSW 14 54,869,637 (GRCm39) missense possibly damaging 0.92
R7623:Cdh24 UTSW 14 54,875,547 (GRCm39) missense probably damaging 1.00
R7823:Cdh24 UTSW 14 54,874,875 (GRCm39) missense probably damaging 1.00
R7973:Cdh24 UTSW 14 54,876,477 (GRCm39) missense possibly damaging 0.87
R8017:Cdh24 UTSW 14 54,876,089 (GRCm39) missense probably damaging 1.00
R8019:Cdh24 UTSW 14 54,876,089 (GRCm39) missense probably damaging 1.00
R8029:Cdh24 UTSW 14 54,876,856 (GRCm39) missense probably damaging 1.00
R8070:Cdh24 UTSW 14 54,870,030 (GRCm39) missense probably benign
R8160:Cdh24 UTSW 14 54,875,946 (GRCm39) missense probably damaging 0.99
R8692:Cdh24 UTSW 14 54,875,793 (GRCm39) missense probably benign 0.29
R8862:Cdh24 UTSW 14 54,869,874 (GRCm39) missense probably damaging 1.00
R8915:Cdh24 UTSW 14 54,876,612 (GRCm39) missense probably damaging 1.00
R9161:Cdh24 UTSW 14 54,876,097 (GRCm39) missense probably damaging 1.00
R9212:Cdh24 UTSW 14 54,878,679 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- AAGGAGGGTCATATTGGGCC -3'
(R):5'- CCTTCGACATCACAGCCTTG -3'

Sequencing Primer
(F):5'- TCATATTGGGCCCCTGGG -3'
(R):5'- CTTGCAGAACCCGGATGGAG -3'
Posted On 2015-03-18