Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02544:Naa16'

297750

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Naa16

Ensembl Gene

ENSMUSG00000022020

Gene Name

N(alpha)-acetyltransferase 16, NatA auxiliary subunit

Synonyms

Narg1l, 1300019C06Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

IGL02544

Quality Score

Status

Chromosome

Chromosomal Location

79325269-79390778 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 79335820 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 837 (F837L)

Ref Sequence

ENSEMBL: ENSMUSP00000022597 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022597]

AlphaFold

Q9DBB4

Predicted Effect

probably damaging
Transcript: ENSMUST00000022597
AA Change: F837L

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000022597
Gene: ENSMUSG00000022020
AA Change: F837L

Domain	Start	End	E-Value	Type
TPR	46	79	2.99e1	SMART
TPR	80	113	2.98e-3	SMART
Blast:TPR	224	257	1e-10	BLAST
TPR	374	407	9.96e0	SMART
TPR	408	441	7.47e0	SMART
low complexity region	616	633	N/A	INTRINSIC
Blast:TPR	672	705	3e-12	BLAST
low complexity region	830	841	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000171928

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000227775

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931428F04Rik	C	T	8: 105,283,460	V286M	probably benign	Het
Aasdh	A	C	5: 76,902,114	S12A	probably benign	Het
Abcb5	A	T	12: 118,906,268		probably benign	Het
Acap3	G	A	4: 155,892,410	E6K	possibly damaging	Het
Ano3	A	T	2: 110,658,249	I946K	possibly damaging	Het
Arid1a	A	G	4: 133,681,748	V1816A	unknown	Het
Cacna1c	C	T	6: 118,751,479	G335R	probably damaging	Het
Ccnh	C	A	13: 85,202,341	Y118*	probably null	Het
Cep76	C	T	18: 67,634,950		probably benign	Het
Cyp2c65	T	C	19: 39,090,638	V387A	probably damaging	Het
Dapk1	T	G	13: 60,751,217	S834A	probably benign	Het
Ddx39	T	C	8: 83,722,773	S367P	probably benign	Het
Dicer1	A	G	12: 104,714,832	I474T	probably damaging	Het
Dnah10	G	A	5: 124,799,005	R2579H	probably benign	Het
Dnajc16	T	C	4: 141,764,647	N622D	probably damaging	Het
Eif3c	G	T	7: 126,547,612	S799*	probably null	Het
Fbxo9	A	G	9: 78,087,259	Y259H	probably damaging	Het
Fpr-rs4	A	T	17: 18,022,211	H160L	probably benign	Het
Galc	A	T	12: 98,231,442	V336D	probably benign	Het
Gm14548	T	A	7: 3,897,186	Y139F	probably damaging	Het
Mfrp	T	C	9: 44,102,794	L153P	probably damaging	Het
Mtx1	C	A	3: 89,210,396	W30L	probably damaging	Het
Mysm1	A	T	4: 94,952,306	D624E	probably damaging	Het
Olfr1118	C	T	2: 87,309,127	R113C	possibly damaging	Het
Olfr193	A	T	16: 59,110,144	H155Q	probably damaging	Het
Olfr346	A	G	2: 36,688,836	Y278C	probably damaging	Het
Olfr705	T	C	7: 106,714,535	I49V	probably benign	Het
Pde4d	G	T	13: 109,740,523	D137Y	probably damaging	Het
Pik3r1	G	T	13: 101,687,276	R534S	probably damaging	Het
Plekha5	A	C	6: 140,589,728	E239A	possibly damaging	Het
Psap	G	T	10: 60,300,626		probably benign	Het
Rap2b	T	C	3: 61,365,139	F28S	probably damaging	Het
Rfc5	A	T	5: 117,386,866		probably benign	Het
Ryr1	C	T	7: 29,115,599	D175N	probably benign	Het
Sbno1	T	G	5: 124,403,983	I370L	probably damaging	Het
Slc17a6	T	A	7: 51,666,155	C390*	probably null	Het
Srsf7	A	T	17: 80,204,191		probably benign	Het
Tbc1d10c	C	T	19: 4,187,960	D272N	probably benign	Het
Tll2	A	G	19: 41,135,965	F204L	probably damaging	Het
Tmc1	T	A	19: 20,906,963	T38S	probably benign	Het
Tmem184b	A	T	15: 79,365,807	I256K	probably damaging	Het
Tmem214	G	A	5: 30,872,746	A296T	probably benign	Het
Trip11	G	A	12: 101,893,521	R365W	probably damaging	Het
Ubr4	C	T	4: 139,415,118	P1339S	probably damaging	Het
Vmn2r83	T	A	10: 79,481,459		probably benign	Het

Other mutations in Naa16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00551:Naa16	APN	14	79355729	missense	probably damaging	1.00
IGL01025:Naa16	APN	14	79384756	missense	probably damaging	1.00
IGL01155:Naa16	APN	14	79384715	missense	probably damaging	0.98
IGL01335:Naa16	APN	14	79345116	splice site	probably benign
IGL01981:Naa16	APN	14	79381516	missense	probably benign	0.05
IGL02230:Naa16	APN	14	79377361	splice site	probably benign
IGL02313:Naa16	APN	14	79384668	missense	probably damaging	1.00
IGL02418:Naa16	APN	14	79383366	missense	probably damaging	1.00
IGL03051:Naa16	APN	14	79369082	missense	probably benign	0.01
IGL03064:Naa16	APN	14	79339628	missense	probably damaging	0.98
IGL03205:Naa16	APN	14	79356512	missense	possibly damaging	0.89
PIT4508001:Naa16	UTSW	14	79369087	missense	probably benign	0.15
R0651:Naa16	UTSW	14	79351392	missense	probably damaging	1.00
R1429:Naa16	UTSW	14	79359527	missense	probably benign	0.01
R1674:Naa16	UTSW	14	79387057	start codon destroyed	probably null	0.65
R1693:Naa16	UTSW	14	79351456	missense	probably damaging	1.00
R1874:Naa16	UTSW	14	79355743	missense	possibly damaging	0.62
R1992:Naa16	UTSW	14	79356491	missense	probably damaging	1.00
R2015:Naa16	UTSW	14	79345059	missense	probably damaging	1.00
R2391:Naa16	UTSW	14	79370049	missense	probably benign	0.16
R2847:Naa16	UTSW	14	79335883	missense	probably damaging	1.00
R2848:Naa16	UTSW	14	79335883	missense	probably damaging	1.00
R2877:Naa16	UTSW	14	79343298	missense	probably benign	0.00
R3884:Naa16	UTSW	14	79343262	missense	probably damaging	0.98
R4001:Naa16	UTSW	14	79343121	splice site	probably null
R4199:Naa16	UTSW	14	79355871	missense	probably damaging	1.00
R4638:Naa16	UTSW	14	79340033	splice site	probably null
R4676:Naa16	UTSW	14	79336348	unclassified	probably benign
R4690:Naa16	UTSW	14	79345057	missense	probably damaging	1.00
R4952:Naa16	UTSW	14	79345085	missense	probably damaging	1.00
R5087:Naa16	UTSW	14	79377415	missense	possibly damaging	0.68
R5104:Naa16	UTSW	14	79384700	nonsense	probably null
R5729:Naa16	UTSW	14	79355780	missense	probably damaging	1.00
R6178:Naa16	UTSW	14	79383340	missense	possibly damaging	0.93
R6960:Naa16	UTSW	14	79359471	missense	possibly damaging	0.65
R7794:Naa16	UTSW	14	79377494	missense	probably damaging	1.00
R7936:Naa16	UTSW	14	79341046	missense	possibly damaging	0.47
R8356:Naa16	UTSW	14	79359475	missense	probably benign	0.00
R8456:Naa16	UTSW	14	79359475	missense	probably benign	0.00
R8892:Naa16	UTSW	14	79390576	missense	probably benign	0.32
R8931:Naa16	UTSW	14	79344955	missense	probably damaging	1.00
R9010:Naa16	UTSW	14	79370042	missense	probably benign	0.01
R9068:Naa16	UTSW	14	79374849	missense	probably benign	0.18
R9360:Naa16	UTSW	14	79356503	missense	probably benign	0.05
R9688:Naa16	UTSW	14	79335869	nonsense	probably null
X0064:Naa16	UTSW	14	79351389	missense	probably damaging	1.00
Z1177:Naa16	UTSW	14	79344979	missense	probably damaging	1.00

Posted On

2015-04-16