Mutagenetix > Incidental Mutation

Incidental Mutation 'R3921:Vmn2r9'

315733

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r9

Ensembl Gene

ENSMUSG00000091624

Gene Name

vomeronasal 2, receptor 9

Synonyms

EG435864

MMRRC Submission

040818-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.113) question?

Stock #

R3921 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

108990813-109000376 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 108996921 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Serine at position 116 (Y116S)

Ref Sequence

ENSEMBL: ENSMUSP00000129520 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170419]

AlphaFold

K7N6Z8

Predicted Effect

probably benign
Transcript: ENSMUST00000170419
AA Change: Y116S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000129520
Gene: ENSMUSG00000091624
AA Change: Y116S

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Pfam:ANF_receptor	77	412	8.1e-29	PFAM
Pfam:NCD3G	507	561	2.3e-16	PFAM
Pfam:7tm_3	592	829	3.4e-54	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176157

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.6%
20x: 96.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl2fm2	T	A	3: 59,659,498 (GRCm39)	L317Q	probably damaging	Het
Aebp2	C	T	6: 140,579,461 (GRCm39)	R11C	probably damaging	Het
Anxa8	T	C	14: 33,816,403 (GRCm39)	F201L	probably damaging	Het
Armh4	A	G	14: 50,011,659 (GRCm39)	F16S	probably benign	Het
Bcl7a	A	G	5: 123,509,136 (GRCm39)	N206S	probably benign	Het
Birc6	A	G	17: 74,934,014 (GRCm39)	N2542D	probably damaging	Het
Cubn	A	G	2: 13,331,488 (GRCm39)	Y2562H	probably damaging	Het
Dnah12	C	G	14: 26,493,008 (GRCm39)	D1256E	probably damaging	Het
Dnajb14	A	T	3: 137,610,613 (GRCm39)	R280S	probably damaging	Het
Dop1a	A	T	9: 86,402,324 (GRCm39)	I1173F	probably benign	Het
Fam228a	T	C	12: 4,781,506 (GRCm39)	T118A	probably benign	Het
Gata2	TGCCATGGGCTAGGCAAGCC	TGCC	6: 88,182,464 (GRCm39)		probably null	Het
Hif3a	T	C	7: 16,771,097 (GRCm39)	D618G	possibly damaging	Het
Ighv1-43	C	A	12: 114,909,772 (GRCm39)	G50V	probably benign	Het
Lrrc37a	G	T	11: 103,392,296 (GRCm39)	T1043N	probably benign	Het
Masp2	T	A	4: 148,690,188 (GRCm39)	D232E	possibly damaging	Het
Ms4a4a	A	C	19: 11,356,172 (GRCm39)	Q19P	probably benign	Het
Nckipsd	A	G	9: 108,691,275 (GRCm39)	E399G	possibly damaging	Het
Nnt	T	A	13: 119,503,030 (GRCm39)	T572S	probably damaging	Het
Olig3	A	G	10: 19,232,423 (GRCm39)	D16G	probably damaging	Het
Or4a74	C	T	2: 89,439,853 (GRCm39)	V198I	probably benign	Het
Or5p57	T	A	7: 107,665,108 (GRCm39)	D299V	possibly damaging	Het
Polr2b	T	C	5: 77,474,500 (GRCm39)	Y446H	probably damaging	Het
Prtg	T	C	9: 72,755,629 (GRCm39)	V277A	probably damaging	Het
Rnf31	T	C	14: 55,838,599 (GRCm39)	Y857H	probably damaging	Het
Serac1	T	C	17: 6,117,067 (GRCm39)	D163G	probably damaging	Het
Slc22a22	C	A	15: 57,119,940 (GRCm39)	V197F	probably benign	Het
Slc2a10	C	T	2: 165,357,521 (GRCm39)	P394S	probably benign	Het
Spg7	G	C	8: 123,814,112 (GRCm39)	R457P	probably damaging	Het
St7	A	G	6: 17,846,244 (GRCm39)	N120D	probably benign	Het
Sult2a6	C	T	7: 13,988,668 (GRCm39)	V31M	possibly damaging	Het
Taf3	T	C	2: 10,053,109 (GRCm39)	T35A	probably benign	Het
Tmem131l	A	G	3: 83,847,908 (GRCm39)	I319T	possibly damaging	Het
Ttc23l	G	A	15: 10,537,652 (GRCm39)	S206L	probably benign	Het
Ttc23l	T	TTGGATG	15: 10,537,649 (GRCm39)		probably benign	Het
Ttc23l	CT	CTTGGATT	15: 10,537,648 (GRCm39)		probably benign	Het
Vstm2l	A	G	2: 157,777,283 (GRCm39)	T54A	probably benign	Het
Xrn1	T	A	9: 95,851,337 (GRCm39)	M153K	probably benign	Het
Zfp106	G	A	2: 120,364,097 (GRCm39)	P770L	probably damaging	Het

Other mutations in Vmn2r9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00920:Vmn2r9	APN	5	108,995,890 (GRCm39)	missense	possibly damaging	0.79
IGL00972:Vmn2r9	APN	5	108,996,903 (GRCm39)	missense	probably benign	0.02
IGL01102:Vmn2r9	APN	5	108,990,811 (GRCm39)	splice site	probably null
IGL01892:Vmn2r9	APN	5	108,995,700 (GRCm39)	missense	probably damaging	1.00
IGL02086:Vmn2r9	APN	5	108,995,433 (GRCm39)	missense	probably damaging	1.00
IGL02118:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02119:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02120:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02121:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02123:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02131:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02132:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02171:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02185:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02186:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02346:Vmn2r9	APN	5	108,990,850 (GRCm39)	missense	probably benign	0.07
IGL02508:Vmn2r9	APN	5	108,996,067 (GRCm39)	missense	possibly damaging	0.70
IGL02815:Vmn2r9	APN	5	108,990,856 (GRCm39)	missense	possibly damaging	0.69
IGL03077:Vmn2r9	APN	5	108,996,173 (GRCm39)	splice site	probably benign
IGL03269:Vmn2r9	APN	5	108,995,820 (GRCm39)	missense	probably damaging	1.00
IGL03293:Vmn2r9	APN	5	108,995,997 (GRCm39)	missense	probably damaging	1.00
R0112:Vmn2r9	UTSW	5	108,990,991 (GRCm39)	missense	probably damaging	1.00
R0328:Vmn2r9	UTSW	5	108,995,405 (GRCm39)	missense	probably benign	0.11
R0382:Vmn2r9	UTSW	5	108,995,463 (GRCm39)	missense	probably damaging	1.00
R0521:Vmn2r9	UTSW	5	108,996,154 (GRCm39)	nonsense	probably null
R0975:Vmn2r9	UTSW	5	108,991,169 (GRCm39)	missense	probably damaging	1.00
R1216:Vmn2r9	UTSW	5	108,995,440 (GRCm39)	missense	probably damaging	1.00
R1458:Vmn2r9	UTSW	5	108,996,850 (GRCm39)	missense	probably benign	0.44
R1469:Vmn2r9	UTSW	5	108,991,694 (GRCm39)	missense	probably benign
R1469:Vmn2r9	UTSW	5	108,991,694 (GRCm39)	missense	probably benign
R1704:Vmn2r9	UTSW	5	108,994,266 (GRCm39)	missense	probably damaging	1.00
R1967:Vmn2r9	UTSW	5	108,995,388 (GRCm39)	missense	probably benign	0.03
R1991:Vmn2r9	UTSW	5	108,994,305 (GRCm39)	missense	probably damaging	0.99
R2410:Vmn2r9	UTSW	5	108,996,123 (GRCm39)	missense	probably damaging	1.00
R3419:Vmn2r9	UTSW	5	108,994,299 (GRCm39)	missense	probably damaging	0.96
R3852:Vmn2r9	UTSW	5	108,995,997 (GRCm39)	missense	probably damaging	1.00
R3873:Vmn2r9	UTSW	5	108,995,701 (GRCm39)	missense	probably benign	0.14
R3905:Vmn2r9	UTSW	5	108,995,785 (GRCm39)	missense	probably benign	0.37
R3908:Vmn2r9	UTSW	5	108,995,785 (GRCm39)	missense	probably benign	0.37
R4156:Vmn2r9	UTSW	5	108,995,743 (GRCm39)	missense	possibly damaging	0.64
R4477:Vmn2r9	UTSW	5	108,994,143 (GRCm39)	missense	probably benign
R4478:Vmn2r9	UTSW	5	108,994,143 (GRCm39)	missense	probably benign
R4544:Vmn2r9	UTSW	5	108,995,551 (GRCm39)	missense	probably benign	0.00
R4546:Vmn2r9	UTSW	5	108,995,551 (GRCm39)	missense	probably benign	0.00
R4627:Vmn2r9	UTSW	5	108,995,463 (GRCm39)	missense	probably damaging	1.00
R5215:Vmn2r9	UTSW	5	108,994,351 (GRCm39)	missense	probably benign	0.03
R5361:Vmn2r9	UTSW	5	108,995,929 (GRCm39)	missense	probably damaging	1.00
R5587:Vmn2r9	UTSW	5	108,995,427 (GRCm39)	missense	probably damaging	1.00
R6054:Vmn2r9	UTSW	5	108,996,126 (GRCm39)	missense	probably damaging	0.99
R6106:Vmn2r9	UTSW	5	108,992,902 (GRCm39)	missense	probably benign
R6125:Vmn2r9	UTSW	5	108,990,836 (GRCm39)	missense	probably benign	0.01
R6137:Vmn2r9	UTSW	5	108,996,882 (GRCm39)	missense	probably benign	0.00
R6920:Vmn2r9	UTSW	5	108,996,912 (GRCm39)	missense	possibly damaging	0.72
R7579:Vmn2r9	UTSW	5	108,992,948 (GRCm39)	missense	probably damaging	1.00
R8683:Vmn2r9	UTSW	5	108,996,873 (GRCm39)	missense	probably benign
R8964:Vmn2r9	UTSW	5	108,996,031 (GRCm39)	missense	probably benign	0.05
R9022:Vmn2r9	UTSW	5	108,992,923 (GRCm39)	missense	possibly damaging	0.90
R9118:Vmn2r9	UTSW	5	108,990,937 (GRCm39)	missense	probably damaging	0.99
R9125:Vmn2r9	UTSW	5	108,996,047 (GRCm39)	missense
R9240:Vmn2r9	UTSW	5	108,996,099 (GRCm39)	missense	possibly damaging	0.78
R9327:Vmn2r9	UTSW	5	108,996,841 (GRCm39)	missense	probably damaging	0.96
R9412:Vmn2r9	UTSW	5	108,991,484 (GRCm39)	missense	probably damaging	1.00
R9499:Vmn2r9	UTSW	5	108,995,584 (GRCm39)	missense	probably damaging	1.00
R9757:Vmn2r9	UTSW	5	108,995,908 (GRCm39)	missense	possibly damaging	0.87
R9790:Vmn2r9	UTSW	5	108,995,409 (GRCm39)	missense	probably damaging	0.99
R9791:Vmn2r9	UTSW	5	108,995,409 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- CTTGCAGGCACATGTAAATGG -3'
(R):5'- GAGGCTTATTCCAATACAGTTAGAC -3'

Sequencing Primer
(F):5'- GAGGTCCTAAGTTCAATTCCCAGG -3'
(R):5'- TACCTGCAAGAAGATATGAG -3'

Posted On

2015-05-15