Mutagenetix > Incidental Mutation

Incidental Mutation 'R9757:Vmn2r9'

732790

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r9

Ensembl Gene

ENSMUSG00000091624

Gene Name

vomeronasal 2, receptor 9

Synonyms

EG435864

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.113) question?

Stock #

R9757 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

108990813-109000376 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 108995908 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Asparagine at position 247 (Y247N)

Ref Sequence

ENSEMBL: ENSMUSP00000129520 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170419]

AlphaFold

K7N6Z8

Predicted Effect

possibly damaging
Transcript: ENSMUST00000170419
AA Change: Y247N

PolyPhen 2 Score 0.865 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000129520
Gene: ENSMUSG00000091624
AA Change: Y247N

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Pfam:ANF_receptor	77	412	8.1e-29	PFAM
Pfam:NCD3G	507	561	2.3e-16	PFAM
Pfam:7tm_3	592	829	3.4e-54	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 99.3%
20x: 98.6%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrl3	T	C	5: 81,613,086 (GRCm39)	V105A	probably benign	Het
Agrn	C	A	4: 156,261,235 (GRCm39)	V621L	probably benign	Het
Anapc1	A	G	2: 128,517,676 (GRCm39)	S323P	probably damaging	Het
Anxa6	T	A	11: 54,885,182 (GRCm39)	K456*	probably null	Het
C7	G	T	15: 5,075,134 (GRCm39)	T186K	probably damaging	Het
Cacna1b	T	C	2: 24,609,113 (GRCm39)	E396G	probably damaging	Het
Ccdc191	C	T	16: 43,762,170 (GRCm39)	T20I		Het
Ces1b	G	T	8: 93,806,501 (GRCm39)	P15Q	probably benign	Het
Dnah14	G	T	1: 181,513,349 (GRCm39)	A1901S	probably benign	Het
Dock3	T	C	9: 106,901,035 (GRCm39)	H310R	possibly damaging	Het
Eif2ak4	T	G	2: 118,269,398 (GRCm39)	S23R	probably benign	Het
Gli2	A	G	1: 118,773,652 (GRCm39)	C485R	probably damaging	Het
Gm17093	T	A	14: 44,758,990 (GRCm39)	W171R		Het
Ing2	G	A	8: 48,128,075 (GRCm39)		probably benign	Het
Itpkb	T	C	1: 180,160,372 (GRCm39)	I166T	probably benign	Het
Kcnj8	T	A	6: 142,515,805 (GRCm39)	I101F	probably benign	Het
Krtap6-2	C	T	16: 89,216,958 (GRCm39)	C3Y	unknown	Het
Lep	A	G	6: 29,069,083 (GRCm39)	I45V	probably benign	Het
Lrrk2	A	T	15: 91,695,229 (GRCm39)	I2355L	probably benign	Het
Mettl3	C	A	14: 52,537,361 (GRCm39)	A174S	probably benign	Het
Mmp23	T	C	4: 155,735,515 (GRCm39)	N317S	probably damaging	Het
Mybpc1	A	T	10: 88,372,257 (GRCm39)	V777E	probably damaging	Het
Nlrp9b	T	A	7: 19,782,617 (GRCm39)	C844S	probably damaging	Het
Obscn	T	C	11: 58,892,338 (GRCm39)	E6823G	probably benign	Het
Or6y1	A	T	1: 174,276,866 (GRCm39)	I226F	probably damaging	Het
Pcdhb1	A	T	18: 37,400,302 (GRCm39)	Q751L	probably benign	Het
Pdgfrl	T	A	8: 41,379,454 (GRCm39)	L16Q	possibly damaging	Het
Pdzph1	A	C	17: 59,281,898 (GRCm39)	L128*	probably null	Het
Pramel24	A	G	4: 143,454,992 (GRCm39)	D430G	probably benign	Het
Prr36	A	T	8: 4,260,998 (GRCm39)	S940T	probably damaging	Het
Rad54l2	A	T	9: 106,595,120 (GRCm39)	I279N	probably damaging	Het
Rasgrp3	A	T	17: 75,807,719 (GRCm39)	T259S	probably damaging	Het
Rrn3	T	A	16: 13,628,433 (GRCm39)	I538N	probably damaging	Het
Sdf2l1	A	T	16: 16,948,398 (GRCm39)	D213E	probably benign	Het
Sorcs3	T	C	19: 48,711,363 (GRCm39)	Y643H	probably damaging	Het
Sval2	G	T	6: 41,838,774 (GRCm39)	C4F	possibly damaging	Het
Taldo1	A	G	7: 140,980,263 (GRCm39)	E131G	probably benign	Het
Tas2r130	T	C	6: 131,607,296 (GRCm39)	I166M	probably benign	Het
Tmem178	A	G	17: 81,308,289 (GRCm39)	Y228C	probably damaging	Het
Ttn	A	T	2: 76,612,423 (GRCm39)	L17188*	probably null	Het
Unc45b	A	G	11: 82,810,558 (GRCm39)	K273E	probably damaging	Het
Usp32	A	C	11: 84,968,155 (GRCm39)	Y169*	probably null	Het
Zkscan2	A	T	7: 123,079,310 (GRCm39)	C882*	probably null	Het

Other mutations in Vmn2r9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00920:Vmn2r9	APN	5	108,995,890 (GRCm39)	missense	possibly damaging	0.79
IGL00972:Vmn2r9	APN	5	108,996,903 (GRCm39)	missense	probably benign	0.02
IGL01102:Vmn2r9	APN	5	108,990,811 (GRCm39)	splice site	probably null
IGL01892:Vmn2r9	APN	5	108,995,700 (GRCm39)	missense	probably damaging	1.00
IGL02086:Vmn2r9	APN	5	108,995,433 (GRCm39)	missense	probably damaging	1.00
IGL02118:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02119:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02120:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02121:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02123:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02131:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02132:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02171:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02185:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02186:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02346:Vmn2r9	APN	5	108,990,850 (GRCm39)	missense	probably benign	0.07
IGL02508:Vmn2r9	APN	5	108,996,067 (GRCm39)	missense	possibly damaging	0.70
IGL02815:Vmn2r9	APN	5	108,990,856 (GRCm39)	missense	possibly damaging	0.69
IGL03077:Vmn2r9	APN	5	108,996,173 (GRCm39)	splice site	probably benign
IGL03269:Vmn2r9	APN	5	108,995,820 (GRCm39)	missense	probably damaging	1.00
IGL03293:Vmn2r9	APN	5	108,995,997 (GRCm39)	missense	probably damaging	1.00
R0112:Vmn2r9	UTSW	5	108,990,991 (GRCm39)	missense	probably damaging	1.00
R0328:Vmn2r9	UTSW	5	108,995,405 (GRCm39)	missense	probably benign	0.11
R0382:Vmn2r9	UTSW	5	108,995,463 (GRCm39)	missense	probably damaging	1.00
R0521:Vmn2r9	UTSW	5	108,996,154 (GRCm39)	nonsense	probably null
R0975:Vmn2r9	UTSW	5	108,991,169 (GRCm39)	missense	probably damaging	1.00
R1216:Vmn2r9	UTSW	5	108,995,440 (GRCm39)	missense	probably damaging	1.00
R1458:Vmn2r9	UTSW	5	108,996,850 (GRCm39)	missense	probably benign	0.44
R1469:Vmn2r9	UTSW	5	108,991,694 (GRCm39)	missense	probably benign
R1469:Vmn2r9	UTSW	5	108,991,694 (GRCm39)	missense	probably benign
R1704:Vmn2r9	UTSW	5	108,994,266 (GRCm39)	missense	probably damaging	1.00
R1967:Vmn2r9	UTSW	5	108,995,388 (GRCm39)	missense	probably benign	0.03
R1991:Vmn2r9	UTSW	5	108,994,305 (GRCm39)	missense	probably damaging	0.99
R2410:Vmn2r9	UTSW	5	108,996,123 (GRCm39)	missense	probably damaging	1.00
R3419:Vmn2r9	UTSW	5	108,994,299 (GRCm39)	missense	probably damaging	0.96
R3852:Vmn2r9	UTSW	5	108,995,997 (GRCm39)	missense	probably damaging	1.00
R3873:Vmn2r9	UTSW	5	108,995,701 (GRCm39)	missense	probably benign	0.14
R3905:Vmn2r9	UTSW	5	108,995,785 (GRCm39)	missense	probably benign	0.37
R3908:Vmn2r9	UTSW	5	108,995,785 (GRCm39)	missense	probably benign	0.37
R3921:Vmn2r9	UTSW	5	108,996,921 (GRCm39)	missense	probably benign
R4156:Vmn2r9	UTSW	5	108,995,743 (GRCm39)	missense	possibly damaging	0.64
R4477:Vmn2r9	UTSW	5	108,994,143 (GRCm39)	missense	probably benign
R4478:Vmn2r9	UTSW	5	108,994,143 (GRCm39)	missense	probably benign
R4544:Vmn2r9	UTSW	5	108,995,551 (GRCm39)	missense	probably benign	0.00
R4546:Vmn2r9	UTSW	5	108,995,551 (GRCm39)	missense	probably benign	0.00
R4627:Vmn2r9	UTSW	5	108,995,463 (GRCm39)	missense	probably damaging	1.00
R5215:Vmn2r9	UTSW	5	108,994,351 (GRCm39)	missense	probably benign	0.03
R5361:Vmn2r9	UTSW	5	108,995,929 (GRCm39)	missense	probably damaging	1.00
R5587:Vmn2r9	UTSW	5	108,995,427 (GRCm39)	missense	probably damaging	1.00
R6054:Vmn2r9	UTSW	5	108,996,126 (GRCm39)	missense	probably damaging	0.99
R6106:Vmn2r9	UTSW	5	108,992,902 (GRCm39)	missense	probably benign
R6125:Vmn2r9	UTSW	5	108,990,836 (GRCm39)	missense	probably benign	0.01
R6137:Vmn2r9	UTSW	5	108,996,882 (GRCm39)	missense	probably benign	0.00
R6920:Vmn2r9	UTSW	5	108,996,912 (GRCm39)	missense	possibly damaging	0.72
R7579:Vmn2r9	UTSW	5	108,992,948 (GRCm39)	missense	probably damaging	1.00
R8683:Vmn2r9	UTSW	5	108,996,873 (GRCm39)	missense	probably benign
R8964:Vmn2r9	UTSW	5	108,996,031 (GRCm39)	missense	probably benign	0.05
R9022:Vmn2r9	UTSW	5	108,992,923 (GRCm39)	missense	possibly damaging	0.90
R9118:Vmn2r9	UTSW	5	108,990,937 (GRCm39)	missense	probably damaging	0.99
R9125:Vmn2r9	UTSW	5	108,996,047 (GRCm39)	missense
R9240:Vmn2r9	UTSW	5	108,996,099 (GRCm39)	missense	possibly damaging	0.78
R9327:Vmn2r9	UTSW	5	108,996,841 (GRCm39)	missense	probably damaging	0.96
R9412:Vmn2r9	UTSW	5	108,991,484 (GRCm39)	missense	probably damaging	1.00
R9499:Vmn2r9	UTSW	5	108,995,584 (GRCm39)	missense	probably damaging	1.00
R9790:Vmn2r9	UTSW	5	108,995,409 (GRCm39)	missense	probably damaging	0.99
R9791:Vmn2r9	UTSW	5	108,995,409 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- TTTGTGATAACGTCCCATTGTG -3'
(R):5'- ACCTGAGTGACCATGACCAG -3'

Sequencing Primer
(F):5'- ATAACGTCCCATTGTGAGGTTG -3'
(R):5'- GAGTGACCATGACCAGTTTCC -3'

Posted On

2022-11-14