Incidental Mutation 'R4176:Ankrd10'
ID 319512
Institutional Source Beutler Lab
Gene Symbol Ankrd10
Ensembl Gene ENSMUSG00000031508
Gene Name ankyrin repeat domain 10
Synonyms 4833425P12Rik
MMRRC Submission 041014-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # R4176 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 11661583-11685757 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 11662644 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 363 (I363T)
Ref Sequence ENSEMBL: ENSMUSP00000033905 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033905] [ENSMUST00000169782] [ENSMUST00000210530] [ENSMUST00000211174]
AlphaFold Q99LW0
Predicted Effect probably benign
Transcript: ENSMUST00000033905
AA Change: I363T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000033905
Gene: ENSMUSG00000031508
AA Change: I363T

DomainStartEndE-ValueType
Blast:ANK 20 49 2e-10 BLAST
ANK 56 85 2.66e-5 SMART
ANK 90 119 6.46e-4 SMART
ANK 123 152 1.03e-2 SMART
Blast:ANK 156 185 6e-6 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000169782
SMART Domains Protein: ENSMUSP00000131657
Gene: ENSMUSG00000031508

DomainStartEndE-ValueType
Blast:ANK 20 49 1e-10 BLAST
ANK 56 85 2.66e-5 SMART
ANK 90 119 6.46e-4 SMART
ANK 123 152 1.03e-2 SMART
Blast:ANK 156 185 4e-6 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000210530
Predicted Effect probably benign
Transcript: ENSMUST00000211174
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211445
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211690
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 96.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 T C 6: 128,522,000 (GRCm39) E1274G possibly damaging Het
Abi3bp A G 16: 56,472,563 (GRCm39) E424G probably damaging Het
Ankrd12 A T 17: 66,334,361 (GRCm39) N204K probably damaging Het
Brca2 C A 5: 150,463,098 (GRCm39) S954* probably null Het
Col11a1 A C 3: 114,001,872 (GRCm39) D432A possibly damaging Het
Dagla G T 19: 10,240,461 (GRCm39) D256E probably damaging Het
Dsg2 T A 18: 20,713,720 (GRCm39) F230L probably benign Het
Elp5 T C 11: 69,861,388 (GRCm39) Q197R probably null Het
Emilin2 A T 17: 71,581,258 (GRCm39) D489E probably benign Het
Entrep3 T C 3: 89,091,754 (GRCm39) V87A probably damaging Het
Ermp1 A G 19: 29,623,365 (GRCm39) probably null Het
Fam149a A G 8: 45,794,321 (GRCm39) Y614H probably benign Het
Fnbp1 T C 2: 30,926,131 (GRCm39) probably null Het
Gabrb3 T C 7: 57,241,061 (GRCm39) F13S probably benign Het
Hydin G A 8: 111,320,452 (GRCm39) A4499T probably benign Het
Islr2 A T 9: 58,107,183 (GRCm39) C26S probably damaging Het
Jup T A 11: 100,263,287 (GRCm39) D696V probably benign Het
Kcnq5 A C 1: 21,605,392 (GRCm39) V171G probably damaging Het
Kntc1 T G 5: 123,914,680 (GRCm39) S667A possibly damaging Het
Loxhd1 A G 18: 77,418,755 (GRCm39) T293A possibly damaging Het
Lrp1b C A 2: 41,298,405 (GRCm39) C138F probably damaging Het
Lrrc37 T A 11: 103,427,426 (GRCm39) H1388L unknown Het
Mctp2 A G 7: 71,909,085 (GRCm39) I76T probably benign Het
Or2z8 A G 8: 72,812,028 (GRCm39) Y168C probably damaging Het
Or5k16 T C 16: 58,736,947 (GRCm39) D19G probably benign Het
Pbx1 A G 1: 168,018,841 (GRCm39) probably null Het
Pelp1 A T 11: 70,287,693 (GRCm39) W410R probably damaging Het
Phaf1 T C 8: 105,967,763 (GRCm39) L218P probably benign Het
Pkd1 T C 17: 24,806,971 (GRCm39) L3482P probably benign Het
Plekhn1 C T 4: 156,306,258 (GRCm39) G604E probably benign Het
Ptpn22 A G 3: 103,793,561 (GRCm39) T571A probably benign Het
Qrsl1 A T 10: 43,760,828 (GRCm39) S252T probably damaging Het
Rab3gap2 T A 1: 184,978,863 (GRCm39) M280K probably damaging Het
Serpinh1 T C 7: 98,996,206 (GRCm39) M293V probably benign Het
Six4 G A 12: 73,155,605 (GRCm39) T454I probably damaging Het
Slc26a8 T A 17: 28,866,973 (GRCm39) E585D probably benign Het
Slc34a2 T G 5: 53,224,910 (GRCm39) C350W probably damaging Het
Slit2 T A 5: 48,394,586 (GRCm39) probably null Het
Trip11 G A 12: 101,861,957 (GRCm39) Q203* probably null Het
Trpm7 T C 2: 126,671,083 (GRCm39) K633R possibly damaging Het
Usp38 A C 8: 81,719,928 (GRCm39) S434A probably benign Het
Zbtb16 A G 9: 48,571,101 (GRCm39) F555S probably damaging Het
Zfp141 A T 7: 42,125,705 (GRCm39) S256T probably benign Het
Other mutations in Ankrd10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01480:Ankrd10 APN 8 11,685,592 (GRCm39) missense probably benign
IGL03029:Ankrd10 APN 8 11,669,304 (GRCm39) splice site probably null
R0098:Ankrd10 UTSW 8 11,662,560 (GRCm39) missense probably benign 0.01
R0393:Ankrd10 UTSW 8 11,685,482 (GRCm39) missense possibly damaging 0.58
R2870:Ankrd10 UTSW 8 11,665,682 (GRCm39) missense probably damaging 0.98
R2870:Ankrd10 UTSW 8 11,665,682 (GRCm39) missense probably damaging 0.98
R5985:Ankrd10 UTSW 8 11,669,077 (GRCm39) nonsense probably null
R6999:Ankrd10 UTSW 8 11,669,106 (GRCm39) missense probably damaging 1.00
R7108:Ankrd10 UTSW 8 11,662,624 (GRCm39) missense probably damaging 1.00
R7322:Ankrd10 UTSW 8 11,665,841 (GRCm39) missense probably damaging 0.97
R7522:Ankrd10 UTSW 8 11,682,910 (GRCm39) missense probably damaging 1.00
R7559:Ankrd10 UTSW 8 11,662,548 (GRCm39) missense probably damaging 0.97
R7629:Ankrd10 UTSW 8 11,665,769 (GRCm39) missense probably benign 0.13
R8263:Ankrd10 UTSW 8 11,665,707 (GRCm39) missense probably benign 0.22
R8493:Ankrd10 UTSW 8 11,678,518 (GRCm39) nonsense probably null
R8713:Ankrd10 UTSW 8 11,678,491 (GRCm39) missense probably damaging 1.00
R8897:Ankrd10 UTSW 8 11,665,788 (GRCm39) missense possibly damaging 0.61
Predicted Primers PCR Primer
(F):5'- GGAATCCAAGGACTCACTCTCTC -3'
(R):5'- GAGTCACCCGTGCTTAACAG -3'

Sequencing Primer
(F):5'- TCTCTCTCAGAAAGCCGAGG -3'
(R):5'- CCCGTGCTTAACAGGATCTAATGG -3'
Posted On 2015-06-10