Incidental Mutation 'R4860:Mink1'
| ID |
380201 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mink1
|
| Ensembl Gene |
ENSMUSG00000020827 |
| Gene Name |
misshapen-like kinase 1 (zebrafish) |
| Synonyms |
Misshapen/NIKs-related kinase, Map4k6, Ysk2, MINK |
| MMRRC Submission |
042471-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4860 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
70453707-70505309 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 70502418 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 1043
(N1043S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000072091
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000014753]
[ENSMUST00000072237]
[ENSMUST00000072873]
[ENSMUST00000079244]
[ENSMUST00000102556]
[ENSMUST00000102558]
[ENSMUST00000102559]
[ENSMUST00000180052]
[ENSMUST00000135865]
[ENSMUST00000144960]
|
| AlphaFold |
Q9JM52 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000014753
|
| SMART Domains |
Protein: ENSMUSP00000014753
Gene: ENSMUSG00000014609
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:Neur_chan_LBD
|
24 |
240 |
2.9e-65 |
PFAM |
|
Pfam:Neur_chan_memb
|
247 |
475 |
6.5e-58 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000072237
AA Change: N1043S
PolyPhen 2
Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000072091
Gene: ENSMUSG00000020827
AA Change: N1043S
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.86e-91 |
SMART |
|
low complexity region
|
307 |
338 |
N/A |
INTRINSIC |
|
coiled coil region
|
351 |
496 |
N/A |
INTRINSIC |
|
low complexity region
|
557 |
569 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
646 |
659 |
N/A |
INTRINSIC |
|
low complexity region
|
719 |
738 |
N/A |
INTRINSIC |
|
low complexity region
|
837 |
874 |
N/A |
INTRINSIC |
|
CNH
|
1026 |
1324 |
1.58e-113 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000072873
AA Change: N1036S
PolyPhen 2
Score 0.266 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000072649
Gene: ENSMUSG00000020827
AA Change: N1036S
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.86e-91 |
SMART |
|
low complexity region
|
307 |
338 |
N/A |
INTRINSIC |
|
coiled coil region
|
351 |
496 |
N/A |
INTRINSIC |
|
low complexity region
|
557 |
569 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
646 |
659 |
N/A |
INTRINSIC |
|
low complexity region
|
719 |
738 |
N/A |
INTRINSIC |
|
low complexity region
|
829 |
853 |
N/A |
INTRINSIC |
|
CNH
|
1019 |
1317 |
1.58e-113 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000079244
AA Change: N1033S
PolyPhen 2
Score 0.266 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000078234
Gene: ENSMUSG00000020827
AA Change: N1033S
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.86e-91 |
SMART |
|
low complexity region
|
314 |
338 |
N/A |
INTRINSIC |
|
coiled coil region
|
348 |
493 |
N/A |
INTRINSIC |
|
low complexity region
|
554 |
566 |
N/A |
INTRINSIC |
|
low complexity region
|
617 |
630 |
N/A |
INTRINSIC |
|
low complexity region
|
643 |
656 |
N/A |
INTRINSIC |
|
low complexity region
|
716 |
735 |
N/A |
INTRINSIC |
|
low complexity region
|
826 |
850 |
N/A |
INTRINSIC |
|
CNH
|
1016 |
1314 |
1.58e-113 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000102556
|
| SMART Domains |
Protein: ENSMUSP00000099616
Gene: ENSMUSG00000014609
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:Neur_chan_LBD
|
24 |
240 |
5.4e-65 |
PFAM |
|
Pfam:Neur_chan_memb
|
247 |
474 |
2.9e-53 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000102558
AA Change: N999S
PolyPhen 2
Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000099618
Gene: ENSMUSG00000020827
AA Change: N999S
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.86e-91 |
SMART |
|
low complexity region
|
307 |
338 |
N/A |
INTRINSIC |
|
coiled coil region
|
351 |
496 |
N/A |
INTRINSIC |
|
low complexity region
|
557 |
569 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
646 |
659 |
N/A |
INTRINSIC |
|
low complexity region
|
792 |
816 |
N/A |
INTRINSIC |
|
CNH
|
982 |
1280 |
1.58e-113 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000102559
AA Change: N1007S
PolyPhen 2
Score 0.707 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000099619
Gene: ENSMUSG00000020827
AA Change: N1007S
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.86e-91 |
SMART |
|
low complexity region
|
307 |
338 |
N/A |
INTRINSIC |
|
coiled coil region
|
351 |
496 |
N/A |
INTRINSIC |
|
low complexity region
|
557 |
569 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
646 |
659 |
N/A |
INTRINSIC |
|
low complexity region
|
800 |
824 |
N/A |
INTRINSIC |
|
CNH
|
990 |
1288 |
1.58e-113 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000136663
AA Change: N896S
|
| SMART Domains |
Protein: ENSMUSP00000117959
Gene: ENSMUSG00000020827
AA Change: N896S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase_Tyr
|
1 |
140 |
2.3e-22 |
PFAM |
|
Pfam:Pkinase
|
1 |
143 |
1.6e-30 |
PFAM |
|
low complexity region
|
161 |
192 |
N/A |
INTRINSIC |
|
coiled coil region
|
204 |
349 |
N/A |
INTRINSIC |
|
low complexity region
|
411 |
423 |
N/A |
INTRINSIC |
|
low complexity region
|
474 |
487 |
N/A |
INTRINSIC |
|
low complexity region
|
500 |
513 |
N/A |
INTRINSIC |
|
low complexity region
|
573 |
592 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
728 |
N/A |
INTRINSIC |
|
CNH
|
880 |
1178 |
1.58e-113 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000125853
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134836
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000132208
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142650
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000125387
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000135920
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000152857
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000153503
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000149845
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000180052
|
| SMART Domains |
Protein: ENSMUSP00000137259
Gene: ENSMUSG00000087279
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
29 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
130 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000135865
|
| SMART Domains |
Protein: ENSMUSP00000135933
Gene: ENSMUSG00000087279
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
29 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
101 |
107 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000178764
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144960
|
| SMART Domains |
Protein: ENSMUSP00000136077
Gene: ENSMUSG00000087279
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
29 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
130 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.7686 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.2%
- 10x: 96.0%
- 20x: 91.6%
|
| Validation Efficiency |
94% (98/104) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 99 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700030K09Rik |
T |
C |
8: 73,209,267 (GRCm39) |
S466P |
possibly damaging |
Het |
| Ablim1 |
T |
C |
19: 57,068,298 (GRCm39) |
T267A |
probably damaging |
Het |
| Acap2 |
A |
T |
16: 30,922,317 (GRCm39) |
L724Q |
possibly damaging |
Het |
| Acsbg3 |
A |
G |
17: 57,195,655 (GRCm39) |
N684S |
probably benign |
Het |
| Adcy4 |
T |
C |
14: 56,019,384 (GRCm39) |
T89A |
possibly damaging |
Het |
| Agrp |
T |
C |
8: 106,294,000 (GRCm39) |
E41G |
probably benign |
Het |
| Ajm1 |
T |
C |
2: 25,468,765 (GRCm39) |
Y382C |
probably damaging |
Het |
| Akap9 |
G |
A |
5: 4,084,916 (GRCm39) |
|
probably benign |
Het |
| Akr1d1 |
G |
A |
6: 37,541,426 (GRCm39) |
V308M |
probably damaging |
Het |
| Ap1m2 |
C |
T |
9: 21,220,970 (GRCm39) |
R54Q |
probably benign |
Het |
| Arhgap45 |
T |
A |
10: 79,862,900 (GRCm39) |
V692E |
probably damaging |
Het |
| Arid5b |
G |
T |
10: 68,078,925 (GRCm39) |
N137K |
probably damaging |
Het |
| Arsi |
G |
A |
18: 61,049,723 (GRCm39) |
G202E |
probably benign |
Het |
| BC048679 |
T |
C |
7: 81,145,468 (GRCm39) |
N27D |
probably benign |
Het |
| Ccdc78 |
A |
G |
17: 26,007,674 (GRCm39) |
N237S |
probably benign |
Het |
| Cd46 |
G |
A |
1: 194,744,704 (GRCm39) |
L345F |
possibly damaging |
Het |
| Cngb3 |
A |
T |
4: 19,425,569 (GRCm39) |
N459I |
possibly damaging |
Het |
| Ctnnd2 |
A |
G |
15: 30,881,313 (GRCm39) |
E731G |
probably damaging |
Het |
| Cul1 |
G |
T |
6: 47,494,080 (GRCm39) |
K464N |
probably benign |
Het |
| Cul1 |
T |
A |
6: 47,494,125 (GRCm39) |
S479R |
probably damaging |
Het |
| Dcaf5 |
A |
T |
12: 80,387,006 (GRCm39) |
D373E |
probably benign |
Het |
| Dhcr7 |
A |
G |
7: 143,394,237 (GRCm39) |
Q126R |
probably benign |
Het |
| Dnd1 |
C |
T |
18: 36,899,016 (GRCm39) |
|
probably benign |
Het |
| Dok2 |
T |
C |
14: 71,014,956 (GRCm39) |
F228L |
probably damaging |
Het |
| Dpep3 |
T |
G |
8: 106,702,821 (GRCm39) |
I314L |
probably benign |
Het |
| Eps8 |
A |
G |
6: 137,491,293 (GRCm39) |
F362L |
probably damaging |
Het |
| Espn |
G |
T |
4: 152,223,303 (GRCm39) |
R250S |
probably damaging |
Het |
| Faf1 |
A |
C |
4: 109,600,093 (GRCm39) |
N163H |
probably damaging |
Het |
| Fcho1 |
C |
T |
8: 72,163,125 (GRCm39) |
V635I |
probably benign |
Het |
| Garin5b |
C |
T |
7: 4,760,468 (GRCm39) |
|
probably null |
Het |
| Gask1b |
C |
A |
3: 79,843,981 (GRCm39) |
S36* |
probably null |
Het |
| Gm7579 |
G |
A |
7: 141,765,645 (GRCm39) |
C17Y |
unknown |
Het |
| Gpx8 |
G |
T |
13: 113,182,042 (GRCm39) |
Y130* |
probably null |
Het |
| Grm6 |
C |
T |
11: 50,755,439 (GRCm39) |
T857M |
probably benign |
Het |
| Gvin1 |
A |
T |
7: 105,762,643 (GRCm39) |
Y609N |
possibly damaging |
Het |
| Hectd4 |
T |
A |
5: 121,443,881 (GRCm39) |
M30K |
probably benign |
Het |
| Ilkap |
A |
G |
1: 91,315,105 (GRCm39) |
|
probably benign |
Het |
| Iqub |
T |
C |
6: 24,450,841 (GRCm39) |
D586G |
probably damaging |
Het |
| Klhl22 |
G |
A |
16: 17,594,880 (GRCm39) |
|
silent |
Het |
| Klhl25 |
T |
C |
7: 75,516,798 (GRCm39) |
I568T |
probably benign |
Het |
| Krr1 |
C |
T |
10: 111,821,596 (GRCm39) |
|
probably benign |
Het |
| Larp6 |
A |
G |
9: 60,645,093 (GRCm39) |
E411G |
probably damaging |
Het |
| Lepr |
A |
C |
4: 101,646,534 (GRCm39) |
I822L |
probably benign |
Het |
| Lrig3 |
C |
A |
10: 125,846,921 (GRCm39) |
D896E |
probably benign |
Het |
| Lrp1 |
C |
T |
10: 127,389,693 (GRCm39) |
G3114D |
probably damaging |
Het |
| Lyset |
A |
T |
12: 102,710,314 (GRCm39) |
|
probably benign |
Het |
| Macf1 |
A |
T |
4: 123,380,543 (GRCm39) |
Y1263N |
probably damaging |
Het |
| Mapk10 |
T |
C |
5: 103,138,485 (GRCm39) |
D180G |
probably damaging |
Het |
| Matr3 |
T |
A |
18: 35,714,693 (GRCm39) |
V113E |
probably damaging |
Het |
| Mbd4 |
A |
T |
6: 115,825,887 (GRCm39) |
F368Y |
possibly damaging |
Het |
| Mcpt8 |
G |
A |
14: 56,319,737 (GRCm39) |
R238W |
probably benign |
Het |
| Mcrip2 |
G |
T |
17: 26,083,621 (GRCm39) |
T86N |
possibly damaging |
Het |
| Nbeal2 |
G |
A |
9: 110,464,262 (GRCm39) |
T1128I |
probably benign |
Het |
| Nrg2 |
T |
A |
18: 36,329,600 (GRCm39) |
Y205F |
probably damaging |
Het |
| Nsmce4a |
A |
T |
7: 130,135,321 (GRCm39) |
|
probably benign |
Het |
| Nubp2 |
A |
G |
17: 25,103,430 (GRCm39) |
M149T |
probably benign |
Het |
| Or4d2b |
T |
A |
11: 87,780,051 (GRCm39) |
M224L |
probably damaging |
Het |
| Or8d6 |
G |
T |
9: 39,853,800 (GRCm39) |
M81I |
probably benign |
Het |
| Or8j3c |
T |
C |
2: 86,253,301 (GRCm39) |
T240A |
probably damaging |
Het |
| Pax3 |
A |
G |
1: 78,169,093 (GRCm39) |
I191T |
possibly damaging |
Het |
| Pdcd5 |
T |
C |
7: 35,343,135 (GRCm39) |
N137D |
possibly damaging |
Het |
| Pik3c2a |
G |
A |
7: 115,939,391 (GRCm39) |
A1649V |
probably damaging |
Het |
| Pik3r6 |
T |
A |
11: 68,434,879 (GRCm39) |
|
probably benign |
Het |
| Pkhd1l1 |
T |
C |
15: 44,400,774 (GRCm39) |
S2183P |
possibly damaging |
Het |
| Plekho1 |
T |
A |
3: 95,896,305 (GRCm39) |
Q388L |
possibly damaging |
Het |
| Ppfibp1 |
A |
G |
6: 146,892,012 (GRCm39) |
T91A |
probably benign |
Het |
| Ptger4 |
G |
T |
15: 5,272,087 (GRCm39) |
N177K |
probably benign |
Het |
| Reln |
A |
G |
5: 22,106,749 (GRCm39) |
F3207S |
probably benign |
Het |
| Rigi |
G |
T |
4: 40,210,000 (GRCm39) |
S644R |
probably damaging |
Het |
| Ripk4 |
C |
T |
16: 97,552,736 (GRCm39) |
R194H |
probably damaging |
Het |
| Rnf112 |
A |
T |
11: 61,343,570 (GRCm39) |
C112S |
possibly damaging |
Het |
| Rprd1b |
T |
G |
2: 157,916,855 (GRCm39) |
Y278* |
probably null |
Het |
| Sel1l |
A |
G |
12: 91,798,376 (GRCm39) |
L140P |
probably damaging |
Het |
| Shroom3 |
G |
T |
5: 93,090,945 (GRCm39) |
V1151F |
probably damaging |
Het |
| Slc38a3 |
A |
G |
9: 107,532,263 (GRCm39) |
V423A |
probably damaging |
Het |
| Slitrk6 |
T |
C |
14: 110,989,315 (GRCm39) |
T131A |
probably damaging |
Het |
| Slmap |
A |
T |
14: 26,181,364 (GRCm39) |
V323E |
probably benign |
Het |
| Smim6 |
T |
C |
11: 115,804,330 (GRCm39) |
V39A |
probably benign |
Het |
| Snapc3 |
C |
T |
4: 83,383,134 (GRCm39) |
|
probably benign |
Het |
| Sorbs1 |
T |
C |
19: 40,325,449 (GRCm39) |
T382A |
probably benign |
Het |
| Sparc |
G |
A |
11: 55,290,037 (GRCm39) |
T218I |
possibly damaging |
Het |
| Steap1 |
A |
T |
5: 5,786,589 (GRCm39) |
F283I |
probably damaging |
Het |
| Stil |
A |
G |
4: 114,895,671 (GRCm39) |
T586A |
probably benign |
Het |
| Tango2 |
A |
G |
16: 18,128,765 (GRCm39) |
|
silent |
Het |
| Tbce |
T |
A |
13: 14,194,380 (GRCm39) |
D93V |
probably damaging |
Het |
| Tcf12 |
C |
T |
9: 71,766,122 (GRCm39) |
G504S |
probably null |
Het |
| Tex55 |
A |
G |
16: 38,648,507 (GRCm39) |
S201P |
probably damaging |
Het |
| Tle4 |
A |
T |
19: 14,441,709 (GRCm39) |
I435K |
probably benign |
Het |
| Tmem245 |
A |
G |
4: 56,899,164 (GRCm39) |
F254S |
probably damaging |
Het |
| Tubgcp3 |
T |
C |
8: 12,699,722 (GRCm39) |
K377R |
probably benign |
Het |
| Ulk4 |
G |
A |
9: 121,079,968 (GRCm39) |
T497M |
possibly damaging |
Het |
| Ush2a |
A |
T |
1: 188,285,472 (GRCm39) |
T2003S |
probably benign |
Het |
| Usp53 |
A |
G |
3: 122,755,012 (GRCm39) |
S32P |
possibly damaging |
Het |
| Vmn1r78 |
T |
A |
7: 11,886,683 (GRCm39) |
L98Q |
probably damaging |
Het |
| Vmn2r84 |
T |
A |
10: 130,221,712 (GRCm39) |
D836V |
probably damaging |
Het |
| Vps13d |
A |
G |
4: 144,813,731 (GRCm39) |
F165L |
probably benign |
Het |
| Vstm4 |
A |
G |
14: 32,585,742 (GRCm39) |
E103G |
possibly damaging |
Het |
| Zfp384 |
G |
A |
6: 125,007,893 (GRCm39) |
|
silent |
Het |
| Zfp870 |
A |
T |
17: 33,102,314 (GRCm39) |
C339* |
probably null |
Het |
|
| Other mutations in Mink1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00501:Mink1
|
APN |
11 |
70,494,638 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00709:Mink1
|
APN |
11 |
70,503,845 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01064:Mink1
|
APN |
11 |
70,494,307 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02612:Mink1
|
APN |
11 |
70,488,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02797:Mink1
|
APN |
11 |
70,501,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03056:Mink1
|
APN |
11 |
70,503,409 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03066:Mink1
|
APN |
11 |
70,499,715 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03185:Mink1
|
APN |
11 |
70,494,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4498001:Mink1
|
UTSW |
11 |
70,489,714 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0025:Mink1
|
UTSW |
11 |
70,503,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0025:Mink1
|
UTSW |
11 |
70,503,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0488:Mink1
|
UTSW |
11 |
70,488,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0637:Mink1
|
UTSW |
11 |
70,492,502 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0828:Mink1
|
UTSW |
11 |
70,500,971 (GRCm39) |
nonsense |
probably null |
|
|
R1081:Mink1
|
UTSW |
11 |
70,497,861 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1175:Mink1
|
UTSW |
11 |
70,502,166 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1441:Mink1
|
UTSW |
11 |
70,497,940 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R1532:Mink1
|
UTSW |
11 |
70,492,833 (GRCm39) |
missense |
probably null |
1.00 |
|
R1545:Mink1
|
UTSW |
11 |
70,489,717 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R1634:Mink1
|
UTSW |
11 |
70,499,706 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1932:Mink1
|
UTSW |
11 |
70,499,254 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2033:Mink1
|
UTSW |
11 |
70,503,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2184:Mink1
|
UTSW |
11 |
70,494,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2267:Mink1
|
UTSW |
11 |
70,492,550 (GRCm39) |
splice site |
probably null |
|
|
R2268:Mink1
|
UTSW |
11 |
70,492,550 (GRCm39) |
splice site |
probably null |
|
|
R2859:Mink1
|
UTSW |
11 |
70,503,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3713:Mink1
|
UTSW |
11 |
70,499,776 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3714:Mink1
|
UTSW |
11 |
70,499,776 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3715:Mink1
|
UTSW |
11 |
70,499,776 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3716:Mink1
|
UTSW |
11 |
70,498,587 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3717:Mink1
|
UTSW |
11 |
70,498,587 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4607:Mink1
|
UTSW |
11 |
70,496,893 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R4735:Mink1
|
UTSW |
11 |
70,500,086 (GRCm39) |
splice site |
probably null |
|
|
R4790:Mink1
|
UTSW |
11 |
70,489,867 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4847:Mink1
|
UTSW |
11 |
70,492,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4860:Mink1
|
UTSW |
11 |
70,502,418 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5081:Mink1
|
UTSW |
11 |
70,495,970 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5310:Mink1
|
UTSW |
11 |
70,498,169 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5677:Mink1
|
UTSW |
11 |
70,495,991 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5767:Mink1
|
UTSW |
11 |
70,496,901 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5795:Mink1
|
UTSW |
11 |
70,498,616 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5888:Mink1
|
UTSW |
11 |
70,500,885 (GRCm39) |
unclassified |
probably benign |
|
|
R5950:Mink1
|
UTSW |
11 |
70,500,412 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6024:Mink1
|
UTSW |
11 |
70,489,915 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R6034:Mink1
|
UTSW |
11 |
70,497,866 (GRCm39) |
small deletion |
probably benign |
|
|
R6034:Mink1
|
UTSW |
11 |
70,497,866 (GRCm39) |
small deletion |
probably benign |
|
|
R6058:Mink1
|
UTSW |
11 |
70,502,546 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6144:Mink1
|
UTSW |
11 |
70,501,478 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6154:Mink1
|
UTSW |
11 |
70,500,927 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6218:Mink1
|
UTSW |
11 |
70,489,720 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6262:Mink1
|
UTSW |
11 |
70,494,151 (GRCm39) |
splice site |
probably null |
|
|
R6269:Mink1
|
UTSW |
11 |
70,489,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6273:Mink1
|
UTSW |
11 |
70,502,261 (GRCm39) |
nonsense |
probably null |
|
|
R6301:Mink1
|
UTSW |
11 |
70,503,120 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R6603:Mink1
|
UTSW |
11 |
70,500,419 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6876:Mink1
|
UTSW |
11 |
70,498,261 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7030:Mink1
|
UTSW |
11 |
70,498,601 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7050:Mink1
|
UTSW |
11 |
70,503,158 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7094:Mink1
|
UTSW |
11 |
70,500,901 (GRCm39) |
splice site |
probably null |
|
|
R7135:Mink1
|
UTSW |
11 |
70,494,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7238:Mink1
|
UTSW |
11 |
70,502,305 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7320:Mink1
|
UTSW |
11 |
70,489,899 (GRCm39) |
missense |
probably benign |
0.23 |
|
R7396:Mink1
|
UTSW |
11 |
70,495,994 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7446:Mink1
|
UTSW |
11 |
70,500,455 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7723:Mink1
|
UTSW |
11 |
70,503,736 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7896:Mink1
|
UTSW |
11 |
70,503,108 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8058:Mink1
|
UTSW |
11 |
70,494,594 (GRCm39) |
nonsense |
probably null |
|
|
R8082:Mink1
|
UTSW |
11 |
70,504,103 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8160:Mink1
|
UTSW |
11 |
70,496,907 (GRCm39) |
nonsense |
probably null |
|
|
R8335:Mink1
|
UTSW |
11 |
70,500,401 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8353:Mink1
|
UTSW |
11 |
70,501,154 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8453:Mink1
|
UTSW |
11 |
70,501,154 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8732:Mink1
|
UTSW |
11 |
70,500,902 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9072:Mink1
|
UTSW |
11 |
70,499,207 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9073:Mink1
|
UTSW |
11 |
70,499,207 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9324:Mink1
|
UTSW |
11 |
70,502,477 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9596:Mink1
|
UTSW |
11 |
70,497,915 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGTGGTCAACGTCAATCCC -3'
(R):5'- AGCAATTAAGCCCCTTGTCC -3'
Sequencing Primer
(F):5'- CGAGCTCATAGTGAAACTCCTG -3'
(R):5'- TTAAGCCCCTTGTCCCCAAAC -3'
|
| Posted On |
2016-04-15 |
Incidental Mutation