Incidental Mutation 'R0492:Lrp6'
| ID |
42550 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrp6
|
| Ensembl Gene |
ENSMUSG00000030201 |
| Gene Name |
low density lipoprotein receptor-related protein 6 |
| Synonyms |
ska, Cd, skax26, ska26 |
| MMRRC Submission |
038690-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.964)
|
| Stock # |
R0492 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
134423439-134543876 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 134457481 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 774
(D774E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000032322
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032322]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000032322
AA Change: D774E
PolyPhen 2
Score 0.581 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000032322
Gene: ENSMUSG00000030201
AA Change: D774E
| Domain | Start | End | E-Value | Type |
|---|
|
LY
|
43 |
85 |
1.55e-2 |
SMART |
|
LY
|
87 |
129 |
1.91e-11 |
SMART |
|
LY
|
130 |
173 |
5.19e-13 |
SMART |
|
LY
|
174 |
216 |
1.39e-13 |
SMART |
|
LY
|
217 |
258 |
2.87e-6 |
SMART |
|
EGF
|
285 |
324 |
2.16e-1 |
SMART |
|
low complexity region
|
330 |
341 |
N/A |
INTRINSIC |
|
LY
|
352 |
394 |
1.29e-8 |
SMART |
|
LY
|
395 |
437 |
5.73e-15 |
SMART |
|
LY
|
438 |
481 |
1.07e-14 |
SMART |
|
LY
|
482 |
524 |
3.07e-15 |
SMART |
|
LY
|
525 |
565 |
4.66e-6 |
SMART |
|
EGF
|
591 |
628 |
1.47e-3 |
SMART |
|
LY
|
654 |
696 |
2.06e-7 |
SMART |
|
LY
|
697 |
739 |
3.73e-14 |
SMART |
|
LY
|
740 |
783 |
3.37e-12 |
SMART |
|
LY
|
784 |
825 |
1.17e-6 |
SMART |
|
LY
|
827 |
865 |
1.91e-2 |
SMART |
|
EGF
|
892 |
930 |
7.35e-4 |
SMART |
|
LY
|
957 |
999 |
1.41e-5 |
SMART |
|
LY
|
1005 |
1048 |
5.32e-1 |
SMART |
|
LY
|
1049 |
1093 |
5e-6 |
SMART |
|
LY
|
1094 |
1136 |
4.25e-9 |
SMART |
|
LY
|
1137 |
1177 |
1.91e-2 |
SMART |
|
EGF
|
1206 |
1250 |
1.23e1 |
SMART |
|
LDLa
|
1248 |
1287 |
2.42e-12 |
SMART |
|
LDLa
|
1288 |
1324 |
4.37e-10 |
SMART |
|
LDLa
|
1325 |
1362 |
1.66e-10 |
SMART |
|
transmembrane domain
|
1371 |
1393 |
N/A |
INTRINSIC |
|
low complexity region
|
1429 |
1438 |
N/A |
INTRINSIC |
|
low complexity region
|
1444 |
1457 |
N/A |
INTRINSIC |
|
low complexity region
|
1508 |
1524 |
N/A |
INTRINSIC |
|
low complexity region
|
1566 |
1573 |
N/A |
INTRINSIC |
|
low complexity region
|
1596 |
1608 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0612 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.7%
- 20x: 93.7%
|
| Validation Efficiency |
99% (99/100) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
PHENOTYPE: Animals homozygous for this mutation exhibit partial embryonic lethality, growth retardation, crooked tail, abnormal vertebrae, small skull with occasional bent nose, absence of the third molars and small and/or unerupted lower incisors. Heterozygotes exhibit a crooked tail and abnormal vertebrae. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrb2 |
C |
G |
4: 129,901,624 (GRCm39) |
P416R |
probably damaging |
Het |
| Adgre1 |
A |
G |
17: 57,709,742 (GRCm39) |
D133G |
unknown |
Het |
| Alpl |
A |
C |
4: 137,476,887 (GRCm39) |
|
probably null |
Het |
| Ankrd65 |
T |
C |
4: 155,875,133 (GRCm39) |
|
probably benign |
Het |
| Baalc |
A |
T |
15: 38,797,480 (GRCm39) |
|
probably benign |
Het |
| Bpifb5 |
A |
G |
2: 154,070,820 (GRCm39) |
T204A |
probably benign |
Het |
| Bud31 |
A |
G |
5: 145,083,265 (GRCm39) |
Y77C |
probably damaging |
Het |
| Calhm6 |
G |
A |
10: 34,003,647 (GRCm39) |
R87* |
probably null |
Het |
| Capsl |
A |
G |
15: 9,461,930 (GRCm39) |
|
probably benign |
Het |
| Ccna1 |
A |
G |
3: 54,956,004 (GRCm39) |
V116A |
probably damaging |
Het |
| Cdc42bpa |
C |
A |
1: 179,928,755 (GRCm39) |
H723N |
probably benign |
Het |
| Cfap161 |
T |
C |
7: 83,443,245 (GRCm39) |
I40V |
possibly damaging |
Het |
| CK137956 |
C |
T |
4: 127,845,093 (GRCm39) |
V217I |
probably benign |
Het |
| Cog5 |
A |
G |
12: 31,919,460 (GRCm39) |
T540A |
probably damaging |
Het |
| Cps1 |
T |
C |
1: 67,196,995 (GRCm39) |
W349R |
probably damaging |
Het |
| Crispld2 |
G |
T |
8: 120,752,806 (GRCm39) |
V285L |
probably benign |
Het |
| Crtc2 |
T |
A |
3: 90,170,804 (GRCm39) |
F626I |
probably damaging |
Het |
| Daam1 |
G |
A |
12: 71,991,154 (GRCm39) |
R256H |
unknown |
Het |
| Dhx38 |
G |
T |
8: 110,288,576 (GRCm39) |
|
probably benign |
Het |
| Dok4 |
G |
A |
8: 95,591,764 (GRCm39) |
A324V |
probably benign |
Het |
| Dscam |
T |
C |
16: 96,626,982 (GRCm39) |
|
probably null |
Het |
| Dusp16 |
A |
T |
6: 134,695,365 (GRCm39) |
S489T |
probably benign |
Het |
| Ecpas |
A |
G |
4: 58,864,418 (GRCm39) |
W288R |
probably damaging |
Het |
| Erbin |
A |
T |
13: 103,970,866 (GRCm39) |
Y917N |
probably damaging |
Het |
| F13b |
A |
T |
1: 139,450,297 (GRCm39) |
|
probably null |
Het |
| Fdx1 |
C |
A |
9: 51,874,725 (GRCm39) |
A15S |
probably benign |
Het |
| Ffar4 |
A |
T |
19: 38,085,630 (GRCm39) |
Q19L |
probably benign |
Het |
| Folh1 |
A |
C |
7: 86,395,400 (GRCm39) |
V344G |
probably damaging |
Het |
| Fscb |
T |
A |
12: 64,520,292 (GRCm39) |
E391D |
possibly damaging |
Het |
| Gigyf2 |
G |
A |
1: 87,368,568 (GRCm39) |
G1083R |
probably damaging |
Het |
| Gm14403 |
C |
A |
2: 177,200,359 (GRCm39) |
H102N |
probably benign |
Het |
| Gm4847 |
A |
G |
1: 166,457,961 (GRCm39) |
F464S |
probably damaging |
Het |
| Gpam |
A |
T |
19: 55,084,611 (GRCm39) |
M56K |
possibly damaging |
Het |
| Gpr165 |
T |
A |
X: 95,760,778 (GRCm39) |
F352I |
probably damaging |
Het |
| Grik2 |
T |
G |
10: 48,977,260 (GRCm39) |
I891L |
probably damaging |
Het |
| Gsr |
T |
C |
8: 34,171,603 (GRCm39) |
|
probably benign |
Het |
| Hhla1 |
A |
G |
15: 65,808,140 (GRCm39) |
F302L |
probably benign |
Het |
| Impg1 |
T |
C |
9: 80,252,590 (GRCm39) |
D453G |
possibly damaging |
Het |
| Inpp5d |
T |
A |
1: 87,625,872 (GRCm39) |
V495E |
possibly damaging |
Het |
| Iqca1l |
A |
T |
5: 24,759,626 (GRCm39) |
L48Q |
probably damaging |
Het |
| Iqce |
A |
T |
5: 140,660,990 (GRCm39) |
L450H |
probably damaging |
Het |
| Itfg2 |
A |
G |
6: 128,390,486 (GRCm39) |
|
probably null |
Het |
| Kif13a |
A |
G |
13: 46,966,218 (GRCm39) |
V400A |
possibly damaging |
Het |
| Kif7 |
T |
C |
7: 79,363,629 (GRCm39) |
Y93C |
probably damaging |
Het |
| Krt33a |
A |
G |
11: 99,906,909 (GRCm39) |
V22A |
probably benign |
Het |
| Lct |
T |
C |
1: 128,228,319 (GRCm39) |
D1058G |
probably damaging |
Het |
| Lrrc9 |
T |
A |
12: 72,525,537 (GRCm39) |
S828R |
possibly damaging |
Het |
| Ly75 |
A |
G |
2: 60,138,620 (GRCm39) |
W1416R |
probably damaging |
Het |
| Mdh2 |
T |
C |
5: 135,819,004 (GRCm39) |
I320T |
possibly damaging |
Het |
| Med13l |
T |
A |
5: 118,876,560 (GRCm39) |
V912E |
probably damaging |
Het |
| Mgarp |
T |
C |
3: 51,296,456 (GRCm39) |
D182G |
possibly damaging |
Het |
| Mllt10 |
T |
C |
2: 18,151,698 (GRCm39) |
|
probably benign |
Het |
| Mmp28 |
G |
A |
11: 83,334,629 (GRCm39) |
A375V |
probably damaging |
Het |
| Mrps23 |
T |
A |
11: 88,101,511 (GRCm39) |
H133Q |
probably benign |
Het |
| Msh6 |
T |
C |
17: 88,282,679 (GRCm39) |
S35P |
probably benign |
Het |
| Myo3a |
A |
G |
2: 22,328,447 (GRCm39) |
D347G |
possibly damaging |
Het |
| Npc1l1 |
T |
C |
11: 6,173,040 (GRCm39) |
K800E |
possibly damaging |
Het |
| Or2ag13 |
A |
T |
7: 106,473,084 (GRCm39) |
Y123N |
probably damaging |
Het |
| Or51ai2 |
T |
C |
7: 103,586,971 (GRCm39) |
I128T |
probably benign |
Het |
| Or5i1 |
T |
G |
2: 87,613,166 (GRCm39) |
I94S |
probably damaging |
Het |
| Or5m9 |
T |
C |
2: 85,876,931 (GRCm39) |
V35A |
probably benign |
Het |
| Or5m9 |
T |
C |
2: 85,877,278 (GRCm39) |
F151L |
possibly damaging |
Het |
| Or5t7 |
G |
A |
2: 86,506,834 (GRCm39) |
P281L |
probably damaging |
Het |
| Or6p1 |
T |
A |
1: 174,258,129 (GRCm39) |
I45N |
possibly damaging |
Het |
| Osmr |
A |
C |
15: 6,853,999 (GRCm39) |
W570G |
probably damaging |
Het |
| Otol1 |
A |
T |
3: 69,935,117 (GRCm39) |
I370F |
probably damaging |
Het |
| Pank2 |
A |
G |
2: 131,122,180 (GRCm39) |
Y235C |
probably damaging |
Het |
| Pias2 |
T |
C |
18: 77,193,581 (GRCm39) |
S187P |
probably damaging |
Het |
| Pkhd1l1 |
A |
G |
15: 44,383,086 (GRCm39) |
N1115S |
probably benign |
Het |
| Pld1 |
G |
T |
3: 28,163,966 (GRCm39) |
A800S |
probably damaging |
Het |
| Prex2 |
T |
C |
1: 11,256,857 (GRCm39) |
|
probably benign |
Het |
| Ptpn3 |
T |
C |
4: 57,194,304 (GRCm39) |
Q908R |
probably benign |
Het |
| Rab3gap2 |
T |
A |
1: 184,984,589 (GRCm39) |
|
probably benign |
Het |
| Rbm24 |
A |
T |
13: 46,573,826 (GRCm39) |
N82Y |
probably damaging |
Het |
| Rpl27 |
T |
C |
11: 101,336,081 (GRCm39) |
V47A |
possibly damaging |
Het |
| Serpina1f |
A |
G |
12: 103,659,826 (GRCm39) |
V152A |
possibly damaging |
Het |
| Serpina5 |
A |
G |
12: 104,068,392 (GRCm39) |
Y151C |
probably damaging |
Het |
| Serpinb7 |
A |
G |
1: 107,379,737 (GRCm39) |
*381W |
probably null |
Het |
| Sh2b2 |
A |
G |
5: 136,261,117 (GRCm39) |
F33S |
probably damaging |
Het |
| Slc22a2 |
A |
C |
17: 12,834,159 (GRCm39) |
I476L |
probably benign |
Het |
| Slc6a12 |
A |
T |
6: 121,332,331 (GRCm39) |
I222F |
probably benign |
Het |
| Smim26 |
G |
A |
2: 144,437,033 (GRCm39) |
D61N |
probably damaging |
Het |
| Soat1 |
A |
T |
1: 156,268,924 (GRCm39) |
Y209N |
probably benign |
Het |
| Sorl1 |
T |
C |
9: 41,902,667 (GRCm39) |
H1630R |
probably null |
Het |
| Sptlc2 |
A |
T |
12: 87,393,580 (GRCm39) |
|
probably null |
Het |
| Strn3 |
G |
A |
12: 51,657,187 (GRCm39) |
T642I |
probably damaging |
Het |
| Syce1l |
T |
A |
8: 114,380,700 (GRCm39) |
D137E |
possibly damaging |
Het |
| Syne2 |
T |
C |
12: 76,028,837 (GRCm39) |
|
probably null |
Het |
| Tcf25 |
C |
A |
8: 124,108,203 (GRCm39) |
P86Q |
probably benign |
Het |
| Tmem19 |
A |
T |
10: 115,197,715 (GRCm39) |
Y43* |
probably null |
Het |
| Tmem30b |
T |
C |
12: 73,592,942 (GRCm39) |
N58D |
probably benign |
Het |
| Tnn |
A |
C |
1: 159,948,327 (GRCm39) |
I795M |
probably damaging |
Het |
| Tnpo1 |
A |
G |
13: 98,991,954 (GRCm39) |
Y641H |
probably damaging |
Het |
| Tra2a |
A |
T |
6: 49,227,889 (GRCm39) |
|
probably benign |
Het |
| Trappc8 |
A |
T |
18: 20,999,243 (GRCm39) |
F295I |
probably benign |
Het |
| Vmn2r101 |
T |
A |
17: 19,809,245 (GRCm39) |
W125R |
probably damaging |
Het |
| Vps8 |
C |
A |
16: 21,261,107 (GRCm39) |
F82L |
probably damaging |
Het |
| Ythdf2 |
A |
T |
4: 131,931,779 (GRCm39) |
S460R |
probably damaging |
Het |
|
| Other mutations in Lrp6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00340:Lrp6
|
APN |
6 |
134,433,053 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL00765:Lrp6
|
APN |
6 |
134,518,817 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL00898:Lrp6
|
APN |
6 |
134,456,702 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00916:Lrp6
|
APN |
6 |
134,461,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00961:Lrp6
|
APN |
6 |
134,484,609 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01620:Lrp6
|
APN |
6 |
134,488,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01765:Lrp6
|
APN |
6 |
134,433,108 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02066:Lrp6
|
APN |
6 |
134,427,900 (GRCm39) |
nonsense |
probably null |
|
|
IGL02067:Lrp6
|
APN |
6 |
134,457,359 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02169:Lrp6
|
APN |
6 |
134,490,290 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02281:Lrp6
|
APN |
6 |
134,434,697 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL02484:Lrp6
|
APN |
6 |
134,518,886 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02724:Lrp6
|
APN |
6 |
134,461,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02876:Lrp6
|
APN |
6 |
134,433,077 (GRCm39) |
missense |
probably benign |
0.43 |
|
IGL03011:Lrp6
|
APN |
6 |
134,497,380 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL03352:Lrp6
|
APN |
6 |
134,456,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Aileron
|
UTSW |
6 |
134,439,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Cielo
|
UTSW |
6 |
134,484,624 (GRCm39) |
nonsense |
probably null |
|
|
Coiled
|
UTSW |
6 |
134,484,521 (GRCm39) |
nonsense |
probably null |
|
|
flap
|
UTSW |
6 |
134,463,549 (GRCm39) |
missense |
probably damaging |
0.99 |
|
soar
|
UTSW |
6 |
134,488,169 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Swoop
|
UTSW |
6 |
134,463,504 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Upswing
|
UTSW |
6 |
134,441,414 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Wingman
|
UTSW |
6 |
134,434,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB004:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB014:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4494001:Lrp6
|
UTSW |
6 |
134,456,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0008:Lrp6
|
UTSW |
6 |
134,462,716 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0008:Lrp6
|
UTSW |
6 |
134,462,716 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0201:Lrp6
|
UTSW |
6 |
134,427,860 (GRCm39) |
nonsense |
probably null |
|
|
R0295:Lrp6
|
UTSW |
6 |
134,434,656 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0370:Lrp6
|
UTSW |
6 |
134,456,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0382:Lrp6
|
UTSW |
6 |
134,444,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0413:Lrp6
|
UTSW |
6 |
134,484,587 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0468:Lrp6
|
UTSW |
6 |
134,462,624 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0584:Lrp6
|
UTSW |
6 |
134,433,039 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0631:Lrp6
|
UTSW |
6 |
134,456,738 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0738:Lrp6
|
UTSW |
6 |
134,519,008 (GRCm39) |
missense |
probably benign |
0.13 |
|
R0907:Lrp6
|
UTSW |
6 |
134,484,488 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1273:Lrp6
|
UTSW |
6 |
134,444,470 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1548:Lrp6
|
UTSW |
6 |
134,436,392 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1639:Lrp6
|
UTSW |
6 |
134,430,529 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1650:Lrp6
|
UTSW |
6 |
134,445,732 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1696:Lrp6
|
UTSW |
6 |
134,445,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1751:Lrp6
|
UTSW |
6 |
134,441,531 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1780:Lrp6
|
UTSW |
6 |
134,441,414 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2013:Lrp6
|
UTSW |
6 |
134,457,337 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2015:Lrp6
|
UTSW |
6 |
134,457,337 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2165:Lrp6
|
UTSW |
6 |
134,436,246 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2294:Lrp6
|
UTSW |
6 |
134,434,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2336:Lrp6
|
UTSW |
6 |
134,484,546 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2964:Lrp6
|
UTSW |
6 |
134,444,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3716:Lrp6
|
UTSW |
6 |
134,484,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4017:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4370:Lrp6
|
UTSW |
6 |
134,483,321 (GRCm39) |
nonsense |
probably null |
|
|
R4521:Lrp6
|
UTSW |
6 |
134,462,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4573:Lrp6
|
UTSW |
6 |
134,447,693 (GRCm39) |
nonsense |
probably null |
|
|
R4645:Lrp6
|
UTSW |
6 |
134,461,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4661:Lrp6
|
UTSW |
6 |
134,488,230 (GRCm39) |
missense |
probably benign |
|
|
R4688:Lrp6
|
UTSW |
6 |
134,456,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4784:Lrp6
|
UTSW |
6 |
134,456,502 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5236:Lrp6
|
UTSW |
6 |
134,488,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5506:Lrp6
|
UTSW |
6 |
134,436,259 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5508:Lrp6
|
UTSW |
6 |
134,441,479 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6001:Lrp6
|
UTSW |
6 |
134,441,481 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6319:Lrp6
|
UTSW |
6 |
134,518,798 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6537:Lrp6
|
UTSW |
6 |
134,457,458 (GRCm39) |
missense |
probably benign |
|
|
R6552:Lrp6
|
UTSW |
6 |
134,431,692 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6559:Lrp6
|
UTSW |
6 |
134,490,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6575:Lrp6
|
UTSW |
6 |
134,518,934 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6585:Lrp6
|
UTSW |
6 |
134,484,521 (GRCm39) |
nonsense |
probably null |
|
|
R6700:Lrp6
|
UTSW |
6 |
134,456,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6724:Lrp6
|
UTSW |
6 |
134,463,504 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7159:Lrp6
|
UTSW |
6 |
134,484,514 (GRCm39) |
missense |
probably benign |
|
|
R7266:Lrp6
|
UTSW |
6 |
134,484,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7339:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7341:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7342:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7348:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7359:Lrp6
|
UTSW |
6 |
134,427,923 (GRCm39) |
nonsense |
probably null |
|
|
R7366:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7368:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7501:Lrp6
|
UTSW |
6 |
134,463,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7548:Lrp6
|
UTSW |
6 |
134,484,471 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7652:Lrp6
|
UTSW |
6 |
134,488,208 (GRCm39) |
nonsense |
probably null |
|
|
R7771:Lrp6
|
UTSW |
6 |
134,439,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7927:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8717:Lrp6
|
UTSW |
6 |
134,434,711 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8726:Lrp6
|
UTSW |
6 |
134,484,624 (GRCm39) |
nonsense |
probably null |
|
|
R8792:Lrp6
|
UTSW |
6 |
134,463,549 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8812:Lrp6
|
UTSW |
6 |
134,433,141 (GRCm39) |
missense |
probably benign |
|
|
R8855:Lrp6
|
UTSW |
6 |
134,445,785 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8866:Lrp6
|
UTSW |
6 |
134,445,785 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8994:Lrp6
|
UTSW |
6 |
134,518,656 (GRCm39) |
missense |
probably benign |
|
|
R9021:Lrp6
|
UTSW |
6 |
134,518,930 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9089:Lrp6
|
UTSW |
6 |
134,488,169 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9154:Lrp6
|
UTSW |
6 |
134,518,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9263:Lrp6
|
UTSW |
6 |
134,457,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9287:Lrp6
|
UTSW |
6 |
134,483,259 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9545:Lrp6
|
UTSW |
6 |
134,483,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9574:Lrp6
|
UTSW |
6 |
134,447,662 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9640:Lrp6
|
UTSW |
6 |
134,441,414 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Lrp6
|
UTSW |
6 |
134,433,120 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
Z1177:Lrp6
|
UTSW |
6 |
134,439,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCGTAGTCTGACTCCTGCCTAAAAG -3'
(R):5'- TGGATTGGATGACTGAAGAGAGCCC -3'
Sequencing Primer
(F):5'- TCCTGTGCATGAGACTCAGAG -3'
(R):5'- TTTCCACTGTTTTGAATCCAGG -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation