Mutagenetix > Incidental Mutation

Incidental Mutation 'R0492:Cps1'

42506

Institutional Source

Beutler Lab

Gene Symbol

Cps1

Ensembl Gene

ENSMUSG00000025991

Gene Name

carbamoyl-phosphate synthetase 1

Synonyms

CPS, 4732433M03Rik, D1Ucla3, CPSase I

MMRRC Submission

038690-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R0492 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

67162185-67270418 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 67196995 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Arginine at position 349 (W349R)

Ref Sequence

ENSEMBL: ENSMUSP00000027144 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027144]

AlphaFold

Q8C196

Predicted Effect

probably damaging
Transcript: ENSMUST00000027144
AA Change: W349R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000027144
Gene: ENSMUSG00000025991
AA Change: W349R

Domain	Start	End	E-Value	Type
CPSase_sm_chain	44	184	2.5e-70	SMART
Pfam:GATase	221	397	1.5e-40	PFAM
low complexity region	426	436	N/A	INTRINSIC
Pfam:ATP-grasp_4	543	724	6.8e-12	PFAM
Pfam:CPSase_L_D2	546	750	1.7e-85	PFAM
Pfam:ATP-grasp	554	722	4.9e-8	PFAM
Pfam:Dala_Dala_lig_C	561	718	1.5e-7	PFAM
CPSase_L_D3	839	962	1.18e-57	SMART
Pfam:ATP-grasp_4	1085	1264	1e-19	PFAM
Pfam:CPSase_L_D2	1088	1291	7.4e-32	PFAM
Pfam:Dala_Dala_lig_C	1095	1279	1.6e-6	PFAM
Pfam:ATP-grasp	1096	1263	2.8e-12	PFAM
MGS	1373	1465	1.53e-15	SMART

Meta Mutation Damage Score

0.9519

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.7%
20x: 93.7%

Validation Efficiency

99% (99/100)

MGI Phenotype

FUNCTION: This gene encodes a protein localized to the inner mitochondrial matrix. The encoded protein plays a role in the detoxification of ammonia by catalyzing the first step in the urea cycle in which carbomyl-phosphate is synthesized from ammonia and bicarbonate. Carbamoyl-phosphate is subsequently converted to urea that is excreted by the kidneys. Deficiency of the encoded enzyme leads to an accumulation of ammonia in the blood. High levels of ammonia are toxic to the central nervous system and result in neurological disorders. [provided by RefSeq, Oct 2013]
PHENOTYPE: Homozygous mutation of this gene results in death by 36 hours after birth and hyperammonemia. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 98 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrb2	C	G	4: 129,901,624 (GRCm39)	P416R	probably damaging	Het
Adgre1	A	G	17: 57,709,742 (GRCm39)	D133G	unknown	Het
Alpl	A	C	4: 137,476,887 (GRCm39)		probably null	Het
Ankrd65	T	C	4: 155,875,133 (GRCm39)		probably benign	Het
Baalc	A	T	15: 38,797,480 (GRCm39)		probably benign	Het
Bpifb5	A	G	2: 154,070,820 (GRCm39)	T204A	probably benign	Het
Bud31	A	G	5: 145,083,265 (GRCm39)	Y77C	probably damaging	Het
Calhm6	G	A	10: 34,003,647 (GRCm39)	R87*	probably null	Het
Capsl	A	G	15: 9,461,930 (GRCm39)		probably benign	Het
Ccna1	A	G	3: 54,956,004 (GRCm39)	V116A	probably damaging	Het
Cdc42bpa	C	A	1: 179,928,755 (GRCm39)	H723N	probably benign	Het
Cfap161	T	C	7: 83,443,245 (GRCm39)	I40V	possibly damaging	Het
CK137956	C	T	4: 127,845,093 (GRCm39)	V217I	probably benign	Het
Cog5	A	G	12: 31,919,460 (GRCm39)	T540A	probably damaging	Het
Crispld2	G	T	8: 120,752,806 (GRCm39)	V285L	probably benign	Het
Crtc2	T	A	3: 90,170,804 (GRCm39)	F626I	probably damaging	Het
Daam1	G	A	12: 71,991,154 (GRCm39)	R256H	unknown	Het
Dhx38	G	T	8: 110,288,576 (GRCm39)		probably benign	Het
Dok4	G	A	8: 95,591,764 (GRCm39)	A324V	probably benign	Het
Dscam	T	C	16: 96,626,982 (GRCm39)		probably null	Het
Dusp16	A	T	6: 134,695,365 (GRCm39)	S489T	probably benign	Het
Ecpas	A	G	4: 58,864,418 (GRCm39)	W288R	probably damaging	Het
Erbin	A	T	13: 103,970,866 (GRCm39)	Y917N	probably damaging	Het
F13b	A	T	1: 139,450,297 (GRCm39)		probably null	Het
Fdx1	C	A	9: 51,874,725 (GRCm39)	A15S	probably benign	Het
Ffar4	A	T	19: 38,085,630 (GRCm39)	Q19L	probably benign	Het
Folh1	A	C	7: 86,395,400 (GRCm39)	V344G	probably damaging	Het
Fscb	T	A	12: 64,520,292 (GRCm39)	E391D	possibly damaging	Het
Gigyf2	G	A	1: 87,368,568 (GRCm39)	G1083R	probably damaging	Het
Gm14403	C	A	2: 177,200,359 (GRCm39)	H102N	probably benign	Het
Gm4847	A	G	1: 166,457,961 (GRCm39)	F464S	probably damaging	Het
Gpam	A	T	19: 55,084,611 (GRCm39)	M56K	possibly damaging	Het
Gpr165	T	A	X: 95,760,778 (GRCm39)	F352I	probably damaging	Het
Grik2	T	G	10: 48,977,260 (GRCm39)	I891L	probably damaging	Het
Gsr	T	C	8: 34,171,603 (GRCm39)		probably benign	Het
Hhla1	A	G	15: 65,808,140 (GRCm39)	F302L	probably benign	Het
Impg1	T	C	9: 80,252,590 (GRCm39)	D453G	possibly damaging	Het
Inpp5d	T	A	1: 87,625,872 (GRCm39)	V495E	possibly damaging	Het
Iqca1l	A	T	5: 24,759,626 (GRCm39)	L48Q	probably damaging	Het
Iqce	A	T	5: 140,660,990 (GRCm39)	L450H	probably damaging	Het
Itfg2	A	G	6: 128,390,486 (GRCm39)		probably null	Het
Kif13a	A	G	13: 46,966,218 (GRCm39)	V400A	possibly damaging	Het
Kif7	T	C	7: 79,363,629 (GRCm39)	Y93C	probably damaging	Het
Krt33a	A	G	11: 99,906,909 (GRCm39)	V22A	probably benign	Het
Lct	T	C	1: 128,228,319 (GRCm39)	D1058G	probably damaging	Het
Lrp6	G	T	6: 134,457,481 (GRCm39)	D774E	possibly damaging	Het
Lrrc9	T	A	12: 72,525,537 (GRCm39)	S828R	possibly damaging	Het
Ly75	A	G	2: 60,138,620 (GRCm39)	W1416R	probably damaging	Het
Mdh2	T	C	5: 135,819,004 (GRCm39)	I320T	possibly damaging	Het
Med13l	T	A	5: 118,876,560 (GRCm39)	V912E	probably damaging	Het
Mgarp	T	C	3: 51,296,456 (GRCm39)	D182G	possibly damaging	Het
Mllt10	T	C	2: 18,151,698 (GRCm39)		probably benign	Het
Mmp28	G	A	11: 83,334,629 (GRCm39)	A375V	probably damaging	Het
Mrps23	T	A	11: 88,101,511 (GRCm39)	H133Q	probably benign	Het
Msh6	T	C	17: 88,282,679 (GRCm39)	S35P	probably benign	Het
Myo3a	A	G	2: 22,328,447 (GRCm39)	D347G	possibly damaging	Het
Npc1l1	T	C	11: 6,173,040 (GRCm39)	K800E	possibly damaging	Het
Or2ag13	A	T	7: 106,473,084 (GRCm39)	Y123N	probably damaging	Het
Or51ai2	T	C	7: 103,586,971 (GRCm39)	I128T	probably benign	Het
Or5i1	T	G	2: 87,613,166 (GRCm39)	I94S	probably damaging	Het
Or5m9	T	C	2: 85,876,931 (GRCm39)	V35A	probably benign	Het
Or5m9	T	C	2: 85,877,278 (GRCm39)	F151L	possibly damaging	Het
Or5t7	G	A	2: 86,506,834 (GRCm39)	P281L	probably damaging	Het
Or6p1	T	A	1: 174,258,129 (GRCm39)	I45N	possibly damaging	Het
Osmr	A	C	15: 6,853,999 (GRCm39)	W570G	probably damaging	Het
Otol1	A	T	3: 69,935,117 (GRCm39)	I370F	probably damaging	Het
Pank2	A	G	2: 131,122,180 (GRCm39)	Y235C	probably damaging	Het
Pias2	T	C	18: 77,193,581 (GRCm39)	S187P	probably damaging	Het
Pkhd1l1	A	G	15: 44,383,086 (GRCm39)	N1115S	probably benign	Het
Pld1	G	T	3: 28,163,966 (GRCm39)	A800S	probably damaging	Het
Prex2	T	C	1: 11,256,857 (GRCm39)		probably benign	Het
Ptpn3	T	C	4: 57,194,304 (GRCm39)	Q908R	probably benign	Het
Rab3gap2	T	A	1: 184,984,589 (GRCm39)		probably benign	Het
Rbm24	A	T	13: 46,573,826 (GRCm39)	N82Y	probably damaging	Het
Rpl27	T	C	11: 101,336,081 (GRCm39)	V47A	possibly damaging	Het
Serpina1f	A	G	12: 103,659,826 (GRCm39)	V152A	possibly damaging	Het
Serpina5	A	G	12: 104,068,392 (GRCm39)	Y151C	probably damaging	Het
Serpinb7	A	G	1: 107,379,737 (GRCm39)	*381W	probably null	Het
Sh2b2	A	G	5: 136,261,117 (GRCm39)	F33S	probably damaging	Het
Slc22a2	A	C	17: 12,834,159 (GRCm39)	I476L	probably benign	Het
Slc6a12	A	T	6: 121,332,331 (GRCm39)	I222F	probably benign	Het
Smim26	G	A	2: 144,437,033 (GRCm39)	D61N	probably damaging	Het
Soat1	A	T	1: 156,268,924 (GRCm39)	Y209N	probably benign	Het
Sorl1	T	C	9: 41,902,667 (GRCm39)	H1630R	probably null	Het
Sptlc2	A	T	12: 87,393,580 (GRCm39)		probably null	Het
Strn3	G	A	12: 51,657,187 (GRCm39)	T642I	probably damaging	Het
Syce1l	T	A	8: 114,380,700 (GRCm39)	D137E	possibly damaging	Het
Syne2	T	C	12: 76,028,837 (GRCm39)		probably null	Het
Tcf25	C	A	8: 124,108,203 (GRCm39)	P86Q	probably benign	Het
Tmem19	A	T	10: 115,197,715 (GRCm39)	Y43*	probably null	Het
Tmem30b	T	C	12: 73,592,942 (GRCm39)	N58D	probably benign	Het
Tnn	A	C	1: 159,948,327 (GRCm39)	I795M	probably damaging	Het
Tnpo1	A	G	13: 98,991,954 (GRCm39)	Y641H	probably damaging	Het
Tra2a	A	T	6: 49,227,889 (GRCm39)		probably benign	Het
Trappc8	A	T	18: 20,999,243 (GRCm39)	F295I	probably benign	Het
Vmn2r101	T	A	17: 19,809,245 (GRCm39)	W125R	probably damaging	Het
Vps8	C	A	16: 21,261,107 (GRCm39)	F82L	probably damaging	Het
Ythdf2	A	T	4: 131,931,779 (GRCm39)	S460R	probably damaging	Het

Other mutations in Cps1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00757:Cps1	APN	1	67,191,539 (GRCm39)	splice site	probably benign
IGL00897:Cps1	APN	1	67,254,723 (GRCm39)	missense	probably benign	0.08
IGL00928:Cps1	APN	1	67,162,393 (GRCm39)	missense	probably benign
IGL01063:Cps1	APN	1	67,234,325 (GRCm39)	missense	possibly damaging	0.91
IGL01081:Cps1	APN	1	67,245,983 (GRCm39)	missense	probably damaging	1.00
IGL01361:Cps1	APN	1	67,234,304 (GRCm39)	missense	probably benign	0.03
IGL01396:Cps1	APN	1	67,196,945 (GRCm39)	missense	probably damaging	1.00
IGL01516:Cps1	APN	1	67,269,443 (GRCm39)	missense	probably damaging	0.99
IGL01695:Cps1	APN	1	67,236,194 (GRCm39)	missense	probably benign
IGL02022:Cps1	APN	1	67,212,031 (GRCm39)	splice site	probably benign
IGL02032:Cps1	APN	1	67,269,474 (GRCm39)	missense	probably benign	0.03
IGL02049:Cps1	APN	1	67,183,113 (GRCm39)	missense	possibly damaging	0.68
IGL02197:Cps1	APN	1	67,196,923 (GRCm39)	missense	probably benign
IGL02217:Cps1	APN	1	67,213,541 (GRCm39)	missense	probably benign	0.06
IGL02555:Cps1	APN	1	67,253,180 (GRCm39)	missense	probably benign	0.06
IGL02570:Cps1	APN	1	67,187,862 (GRCm39)	splice site	probably benign
IGL02633:Cps1	APN	1	67,162,396 (GRCm39)	missense	probably benign
IGL02711:Cps1	APN	1	67,251,676 (GRCm39)	splice site	probably benign
IGL02737:Cps1	APN	1	67,187,933 (GRCm39)	missense	probably benign	0.35
IGL03030:Cps1	APN	1	67,182,080 (GRCm39)	missense	probably damaging	1.00
IGL03255:Cps1	APN	1	67,184,960 (GRCm39)	nonsense	probably null
Madman	UTSW	1	67,200,030 (GRCm39)	missense	probably damaging	0.96
maniac	UTSW	1	67,197,037 (GRCm39)	critical splice donor site	probably null
R0109:Cps1	UTSW	1	67,268,577 (GRCm39)	missense	possibly damaging	0.82
R0109:Cps1	UTSW	1	67,268,577 (GRCm39)	missense	possibly damaging	0.82
R0140:Cps1	UTSW	1	67,219,275 (GRCm39)	missense	probably benign
R0318:Cps1	UTSW	1	67,216,173 (GRCm39)	missense	probably damaging	0.99
R0486:Cps1	UTSW	1	67,204,551 (GRCm39)	missense	probably damaging	1.00
R0488:Cps1	UTSW	1	67,187,967 (GRCm39)	splice site	probably benign
R0521:Cps1	UTSW	1	67,254,723 (GRCm39)	missense	probably benign	0.02
R0534:Cps1	UTSW	1	67,183,059 (GRCm39)	missense	probably benign	0.06
R0565:Cps1	UTSW	1	67,205,608 (GRCm39)	missense	possibly damaging	0.57
R0609:Cps1	UTSW	1	67,211,961 (GRCm39)	missense	probably damaging	1.00
R0612:Cps1	UTSW	1	67,178,929 (GRCm39)	missense	probably benign	0.01
R1185:Cps1	UTSW	1	67,234,358 (GRCm39)	missense	probably benign	0.00
R1185:Cps1	UTSW	1	67,234,358 (GRCm39)	missense	probably benign	0.00
R1185:Cps1	UTSW	1	67,234,358 (GRCm39)	missense	probably benign	0.00
R1220:Cps1	UTSW	1	67,243,862 (GRCm39)	critical splice donor site	probably null
R1321:Cps1	UTSW	1	67,182,178 (GRCm39)	splice site	probably benign
R1343:Cps1	UTSW	1	67,248,768 (GRCm39)	missense	probably damaging	1.00
R1373:Cps1	UTSW	1	67,268,583 (GRCm39)	missense	possibly damaging	0.89
R1374:Cps1	UTSW	1	67,269,440 (GRCm39)	missense	probably damaging	0.97
R1481:Cps1	UTSW	1	67,183,041 (GRCm39)	missense	probably damaging	0.99
R1711:Cps1	UTSW	1	67,207,533 (GRCm39)	splice site	probably null
R1712:Cps1	UTSW	1	67,269,440 (GRCm39)	missense	probably damaging	0.97
R1774:Cps1	UTSW	1	67,210,041 (GRCm39)	missense	possibly damaging	0.94
R1799:Cps1	UTSW	1	67,248,801 (GRCm39)	missense	probably damaging	1.00
R1954:Cps1	UTSW	1	67,234,355 (GRCm39)	missense	possibly damaging	0.71
R2074:Cps1	UTSW	1	67,243,797 (GRCm39)	missense	probably benign	0.21
R2078:Cps1	UTSW	1	67,234,424 (GRCm39)	missense	possibly damaging	0.74
R2078:Cps1	UTSW	1	67,196,965 (GRCm39)	missense	probably damaging	1.00
R2111:Cps1	UTSW	1	67,216,139 (GRCm39)	missense	probably benign	0.01
R2112:Cps1	UTSW	1	67,216,139 (GRCm39)	missense	probably benign	0.01
R2146:Cps1	UTSW	1	67,191,538 (GRCm39)	splice site	probably benign
R2355:Cps1	UTSW	1	67,195,383 (GRCm39)	missense	probably damaging	1.00
R2375:Cps1	UTSW	1	67,257,019 (GRCm39)	missense	probably benign	0.00
R2860:Cps1	UTSW	1	67,205,534 (GRCm39)	missense	probably benign	0.44
R2861:Cps1	UTSW	1	67,205,534 (GRCm39)	missense	probably benign	0.44
R2979:Cps1	UTSW	1	67,243,863 (GRCm39)	critical splice donor site	probably null
R3427:Cps1	UTSW	1	67,213,653 (GRCm39)	missense	probably damaging	1.00
R3833:Cps1	UTSW	1	67,178,946 (GRCm39)	missense	probably damaging	1.00
R3857:Cps1	UTSW	1	67,207,437 (GRCm39)	missense	probably damaging	1.00
R3858:Cps1	UTSW	1	67,207,437 (GRCm39)	missense	probably damaging	1.00
R3859:Cps1	UTSW	1	67,207,437 (GRCm39)	missense	probably damaging	1.00
R3886:Cps1	UTSW	1	67,204,659 (GRCm39)	missense	possibly damaging	0.83
R3887:Cps1	UTSW	1	67,204,659 (GRCm39)	missense	possibly damaging	0.83
R3888:Cps1	UTSW	1	67,204,659 (GRCm39)	missense	possibly damaging	0.83
R3889:Cps1	UTSW	1	67,204,659 (GRCm39)	missense	possibly damaging	0.83
R4386:Cps1	UTSW	1	67,210,154 (GRCm39)	critical splice donor site	probably null
R4497:Cps1	UTSW	1	67,244,358 (GRCm39)	missense	probably null	1.00
R4671:Cps1	UTSW	1	67,235,719 (GRCm39)	missense	probably damaging	1.00
R4774:Cps1	UTSW	1	67,259,671 (GRCm39)	missense	probably damaging	0.99
R4799:Cps1	UTSW	1	67,182,145 (GRCm39)	missense	probably damaging	0.96
R4853:Cps1	UTSW	1	67,195,361 (GRCm39)	missense	possibly damaging	0.51
R4884:Cps1	UTSW	1	67,216,183 (GRCm39)	missense	probably benign	0.11
R4900:Cps1	UTSW	1	67,200,063 (GRCm39)	missense	probably damaging	1.00
R4906:Cps1	UTSW	1	67,178,922 (GRCm39)	missense	probably benign	0.10
R5091:Cps1	UTSW	1	67,268,679 (GRCm39)	critical splice donor site	probably null
R5102:Cps1	UTSW	1	67,245,952 (GRCm39)	missense	probably benign	0.00
R5215:Cps1	UTSW	1	67,205,539 (GRCm39)	missense	possibly damaging	0.62
R5290:Cps1	UTSW	1	67,211,868 (GRCm39)	missense	probably benign	0.21
R5732:Cps1	UTSW	1	67,196,923 (GRCm39)	missense	probably benign	0.22
R5818:Cps1	UTSW	1	67,205,647 (GRCm39)	missense	possibly damaging	0.96
R5878:Cps1	UTSW	1	67,197,037 (GRCm39)	critical splice donor site	probably null
R6002:Cps1	UTSW	1	67,211,914 (GRCm39)	missense	possibly damaging	0.94
R6034:Cps1	UTSW	1	67,196,872 (GRCm39)	splice site	probably null
R6034:Cps1	UTSW	1	67,196,872 (GRCm39)	splice site	probably null
R6199:Cps1	UTSW	1	67,201,774 (GRCm39)	frame shift	probably null
R6310:Cps1	UTSW	1	67,182,140 (GRCm39)	missense	probably benign	0.00
R6554:Cps1	UTSW	1	67,213,628 (GRCm39)	nonsense	probably null
R6700:Cps1	UTSW	1	67,268,682 (GRCm39)	splice site	probably null
R6731:Cps1	UTSW	1	67,200,030 (GRCm39)	missense	probably damaging	0.96
R7052:Cps1	UTSW	1	67,237,569 (GRCm39)	missense	probably damaging	1.00
R7278:Cps1	UTSW	1	67,210,080 (GRCm39)	missense	probably damaging	1.00
R7313:Cps1	UTSW	1	67,237,517 (GRCm39)	missense	probably damaging	0.99
R7323:Cps1	UTSW	1	67,197,028 (GRCm39)	missense	probably benign	0.03
R7339:Cps1	UTSW	1	67,236,174 (GRCm39)	missense	possibly damaging	0.64
R7485:Cps1	UTSW	1	67,179,016 (GRCm39)	missense	probably damaging	1.00
R7505:Cps1	UTSW	1	67,219,240 (GRCm39)	missense	probably benign
R7748:Cps1	UTSW	1	67,178,965 (GRCm39)	missense	probably damaging	1.00
R7853:Cps1	UTSW	1	67,213,640 (GRCm39)	missense	possibly damaging	0.92
R8097:Cps1	UTSW	1	67,267,429 (GRCm39)	missense	probably benign	0.08
R8357:Cps1	UTSW	1	67,196,013 (GRCm39)	missense	probably damaging	1.00
R8435:Cps1	UTSW	1	67,251,589 (GRCm39)	missense	probably benign	0.07
R8457:Cps1	UTSW	1	67,196,013 (GRCm39)	missense	probably damaging	1.00
R8680:Cps1	UTSW	1	67,243,772 (GRCm39)	missense	probably damaging	1.00
R8805:Cps1	UTSW	1	67,216,110 (GRCm39)	missense	probably damaging	1.00
R8811:Cps1	UTSW	1	67,253,246 (GRCm39)	missense	probably benign	0.03
R8819:Cps1	UTSW	1	67,267,439 (GRCm39)	missense	possibly damaging	0.56
R8820:Cps1	UTSW	1	67,267,439 (GRCm39)	missense	possibly damaging	0.56
R8854:Cps1	UTSW	1	67,200,048 (GRCm39)	missense	probably damaging	1.00
R9138:Cps1	UTSW	1	67,254,569 (GRCm39)	missense	probably damaging	1.00
R9185:Cps1	UTSW	1	67,248,831 (GRCm39)	missense	probably benign	0.08
R9273:Cps1	UTSW	1	67,191,445 (GRCm39)	missense	possibly damaging	0.69
R9286:Cps1	UTSW	1	67,198,030 (GRCm39)	missense	probably damaging	0.99
R9308:Cps1	UTSW	1	67,200,118 (GRCm39)	critical splice donor site	probably null
R9326:Cps1	UTSW	1	67,248,795 (GRCm39)	missense	probably damaging	1.00
R9449:Cps1	UTSW	1	67,259,671 (GRCm39)	missense	probably damaging	0.99
R9454:Cps1	UTSW	1	67,219,311 (GRCm39)	missense	probably damaging	0.97
R9518:Cps1	UTSW	1	67,259,662 (GRCm39)	missense	probably damaging	1.00
R9564:Cps1	UTSW	1	67,198,048 (GRCm39)	missense	probably benign	0.26
R9585:Cps1	UTSW	1	67,195,341 (GRCm39)	missense	probably damaging	0.99
R9618:Cps1	UTSW	1	67,196,975 (GRCm39)	missense	possibly damaging	0.87
R9641:Cps1	UTSW	1	67,234,342 (GRCm39)	missense	probably benign	0.03
R9650:Cps1	UTSW	1	67,254,636 (GRCm39)	missense
R9668:Cps1	UTSW	1	67,213,649 (GRCm39)	missense	probably benign	0.24
R9726:Cps1	UTSW	1	67,195,395 (GRCm39)	missense	probably benign	0.39
X0024:Cps1	UTSW	1	67,162,406 (GRCm39)	missense	probably benign
Z1176:Cps1	UTSW	1	67,187,878 (GRCm39)	frame shift	probably null
Z1176:Cps1	UTSW	1	67,162,427 (GRCm39)	missense	possibly damaging	0.54

Predicted Primers

PCR Primer
(F):5'- CTTAAAGTGATTTCCGCGAACGCTG -3'
(R):5'- AGGGTGCAAGTGCTGACTCTTAAC -3'

Sequencing Primer
(F):5'- CGAACGCTGTTGAAAGTTCTG -3'
(R):5'- agacagtaatgtgaagaacaatcc -3'

Posted On

2013-05-23