Incidental Mutation 'R0499:Zranb3'
ID46984
Institutional Source Beutler Lab
Gene Symbol Zranb3
Ensembl Gene ENSMUSG00000036086
Gene Namezinc finger, RAN-binding domain containing 3
Synonyms4933425L19Rik
MMRRC Submission 038695-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.190) question?
Stock #R0499 (G1)
Quality Score143
Status Validated
Chromosome1
Chromosomal Location127954184-128103047 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to C at 127955080 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000108157 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086614] [ENSMUST00000112538]
Predicted Effect probably null
Transcript: ENSMUST00000086614
SMART Domains Protein: ENSMUSP00000083806
Gene: ENSMUSG00000036086

DomainStartEndE-ValueType
DEXDc 33 214 3.37e-19 SMART
HELICc 352 435 3.79e-13 SMART
ZnF_RBZ 619 643 6.93e-5 SMART
HNHc 985 1036 5.64e-3 SMART
Predicted Effect probably null
Transcript: ENSMUST00000112538
SMART Domains Protein: ENSMUSP00000108157
Gene: ENSMUSG00000036086

DomainStartEndE-ValueType
Pfam:SNF2_N 40 98 6.6e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000186230
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.2%
Validation Efficiency 99% (97/98)
Allele List at MGI
Other mutations in this stock
Total: 94 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad9 T C 3: 36,085,415 V388A probably damaging Het
Acpp T C 9: 104,320,002 E146G probably damaging Het
Adap2 A T 11: 80,176,079 R276S probably damaging Het
Agbl3 A T 6: 34,839,335 M727L probably benign Het
Ahnak T A 19: 9,000,264 probably benign Het
Ankmy1 G T 1: 92,886,226 D410E probably damaging Het
Ankra2 T C 13: 98,266,454 S70P probably damaging Het
Aox4 T C 1: 58,263,397 probably null Het
Arl13b G A 16: 62,801,733 T399I probably benign Het
Atad2 A T 15: 58,103,240 D652E possibly damaging Het
Atad2 T G 15: 58,120,949 M328L probably benign Het
BC052040 C T 2: 115,642,691 R101W probably damaging Het
Ccnb1 T C 13: 100,780,134 probably null Het
Ccr2 G C 9: 124,105,939 K85N possibly damaging Het
Ccr2 A T 9: 124,106,126 T148S possibly damaging Het
Cdc20b T C 13: 113,055,950 V59A probably benign Het
Cdkl3 T C 11: 52,032,416 S507P possibly damaging Het
Celf6 C A 9: 59,602,878 T86K probably benign Het
Ces1g A G 8: 93,333,689 F101L probably benign Het
Cntnap3 C T 13: 64,858,678 D107N probably benign Het
Col15a1 A T 4: 47,262,950 D534V probably damaging Het
Col27a1 A G 4: 63,300,741 probably benign Het
Csmd3 T C 15: 47,847,131 T1687A probably benign Het
Cstf3 A G 2: 104,649,605 I272M possibly damaging Het
Cyp2d40 T C 15: 82,761,217 T150A probably benign Het
Dnah8 T A 17: 30,715,509 F1489L possibly damaging Het
Dopey2 A T 16: 93,770,437 T1251S probably benign Het
Dtx2 G A 5: 136,029,103 G421R probably damaging Het
Dusp27 C A 1: 166,099,101 V981L probably benign Het
Epb41l3 T A 17: 69,247,659 D251E probably benign Het
Erg A C 16: 95,360,983 Y305* probably null Het
Exosc4 G A 15: 76,329,566 A197T probably benign Het
Fam227b T A 2: 126,100,909 I323L probably benign Het
Far1 G T 7: 113,554,296 probably benign Het
Fmod A G 1: 134,041,196 I325V possibly damaging Het
Fshr C G 17: 89,009,285 S169T probably benign Het
Gm17359 T A 3: 79,405,786 W56R probably damaging Het
Gm17660 C A 5: 104,074,881 G24* probably null Het
Gm4076 G T 13: 85,127,226 noncoding transcript Het
Gm5134 A T 10: 75,992,525 Y313F probably benign Het
H2-Q6 T A 17: 35,425,203 F54I probably damaging Het
Hcrtr2 C A 9: 76,254,672 L145F probably damaging Het
Hepacam2 A G 6: 3,476,121 L268P probably damaging Het
Herc2 C A 7: 56,184,369 C3107* probably null Het
Herc4 T C 10: 63,264,032 V78A probably damaging Het
Hyal5 T C 6: 24,877,921 W339R probably damaging Het
Igfbp6 T A 15: 102,147,984 probably null Het
Il18rap A T 1: 40,525,058 H112L probably benign Het
Il1r2 T A 1: 40,123,149 Y317* probably null Het
Ints8 C A 4: 11,246,097 V190L probably benign Het
Ipo11 T C 13: 106,925,087 T22A probably benign Het
Itgb4 C A 11: 115,979,695 R117S probably benign Het
Lcorl C G 5: 45,734,369 G214A probably benign Het
Lgals3bp T A 11: 118,398,193 probably null Het
Lyst T A 13: 13,616,713 L54I probably damaging Het
Mcm9 T C 10: 53,538,154 T1015A probably benign Het
Mef2d T A 3: 88,156,518 I84N probably damaging Het
Mmrn2 A G 14: 34,397,956 N261S probably damaging Het
Mpdz T C 4: 81,292,531 T1693A probably benign Het
Mss51 T A 14: 20,484,688 Q338L possibly damaging Het
Mstn T A 1: 53,063,984 Y160N probably damaging Het
Muc6 T C 7: 141,640,468 T1431A probably benign Het
Nek9 A T 12: 85,301,883 M959K probably benign Het
Odf3l2 T C 10: 79,640,265 D155G probably damaging Het
Olfr1311 A T 2: 112,021,432 C141S probably damaging Het
Olfr319 G A 11: 58,702,243 V181I probably benign Het
Olfr911-ps1 A T 9: 38,524,505 M258L probably benign Het
Otog G T 7: 46,273,832 G1044W probably damaging Het
Pcdh9 G A 14: 93,886,235 T833M probably damaging Het
Pdcd10 T C 3: 75,527,651 K111R probably damaging Het
Pde5a A G 3: 122,748,458 N199S probably damaging Het
Plekhg1 T C 10: 3,937,971 V355A probably damaging Het
Podn G T 4: 108,021,594 L359I probably damaging Het
Psd T C 19: 46,322,161 E483G probably damaging Het
Ptch2 T A 4: 117,111,143 L905* probably null Het
Rxfp2 T A 5: 150,066,415 N420K probably damaging Het
Sde2 T A 1: 180,862,427 D237E probably benign Het
Serpina1d A T 12: 103,765,757 L281Q probably damaging Het
Serpina9 T C 12: 104,001,470 N222S probably benign Het
Sh3bgrl2 A G 9: 83,577,559 K57E probably damaging Het
Shc3 C T 13: 51,480,228 probably benign Het
Sik3 T C 9: 46,208,740 M659T possibly damaging Het
Slc23a2 A G 2: 132,072,017 L280P probably damaging Het
Smchd1 G T 17: 71,387,088 Q1221K probably benign Het
Spocd1 A G 4: 129,955,470 N694S possibly damaging Het
Tecta T C 9: 42,352,063 D1409G probably damaging Het
Tmem131 A T 1: 36,841,673 V172D probably damaging Het
Trpm3 T C 19: 22,986,873 M1244T possibly damaging Het
Ugcg G C 4: 59,217,036 V187L possibly damaging Het
Usp17le T C 7: 104,768,501 N478S probably benign Het
Usp36 A G 11: 118,273,571 V205A probably damaging Het
Vmn1r25 T A 6: 57,978,509 Q265L probably damaging Het
Vwf A T 6: 125,638,114 H1176L probably benign Het
Zfyve28 C T 5: 34,232,206 D217N possibly damaging Het
Other mutations in Zranb3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00565:Zranb3 APN 1 128016140 missense probably benign 0.01
IGL00818:Zranb3 APN 1 128032867 missense probably damaging 1.00
IGL01360:Zranb3 APN 1 127959885 nonsense probably null
IGL01704:Zranb3 APN 1 127967939 missense possibly damaging 0.93
IGL02131:Zranb3 APN 1 127992951 missense probably damaging 1.00
IGL02466:Zranb3 APN 1 128016092 missense probably benign 0.08
IGL02825:Zranb3 APN 1 127959752 missense probably benign 0.13
IGL02836:Zranb3 APN 1 127960825 missense probably benign 0.00
R0088:Zranb3 UTSW 1 127976462 missense probably benign
R0279:Zranb3 UTSW 1 127963773 missense probably benign 0.01
R0423:Zranb3 UTSW 1 128091870 missense probably damaging 1.00
R0562:Zranb3 UTSW 1 128036558 missense probably benign 0.04
R0972:Zranb3 UTSW 1 127956646 missense probably damaging 1.00
R1480:Zranb3 UTSW 1 128091862 missense probably damaging 1.00
R1552:Zranb3 UTSW 1 127960751 splice site probably benign
R1704:Zranb3 UTSW 1 128092003 start codon destroyed probably null 0.22
R1817:Zranb3 UTSW 1 128017556 critical splice donor site probably null
R1818:Zranb3 UTSW 1 128017556 critical splice donor site probably null
R1819:Zranb3 UTSW 1 128017556 critical splice donor site probably null
R1951:Zranb3 UTSW 1 127999399 missense probably damaging 1.00
R1953:Zranb3 UTSW 1 127999399 missense probably damaging 1.00
R1988:Zranb3 UTSW 1 127959743 missense probably benign
R2011:Zranb3 UTSW 1 128091901 missense probably benign 0.00
R3159:Zranb3 UTSW 1 127972949 missense probably benign
R4179:Zranb3 UTSW 1 127960864 missense possibly damaging 0.88
R4281:Zranb3 UTSW 1 127963877 missense possibly damaging 0.69
R4400:Zranb3 UTSW 1 127956655 missense possibly damaging 0.87
R5236:Zranb3 UTSW 1 128040989 missense probably damaging 1.00
R5330:Zranb3 UTSW 1 127959720 missense probably damaging 0.99
R5719:Zranb3 UTSW 1 127963876 missense probably benign 0.00
R6125:Zranb3 UTSW 1 127959745 missense probably benign
R6220:Zranb3 UTSW 1 127999404 missense probably benign 0.44
R6414:Zranb3 UTSW 1 128040957 missense probably benign 0.08
R6751:Zranb3 UTSW 1 127959819 missense probably benign
R7229:Zranb3 UTSW 1 128040893 missense probably benign 0.00
R7419:Zranb3 UTSW 1 127963851 missense possibly damaging 0.86
R7537:Zranb3 UTSW 1 128032847 critical splice donor site probably null
R7771:Zranb3 UTSW 1 128032868 missense probably damaging 1.00
Z1176:Zranb3 UTSW 1 127965148 missense possibly damaging 0.55
Z1176:Zranb3 UTSW 1 128036481 missense probably benign 0.25
Predicted Primers PCR Primer
(F):5'- TGTGACAACTGCTTCTGCCTGC -3'
(R):5'- CATGGCTTCTCCTAGTTCCCACATAGAT -3'

Sequencing Primer
(F):5'- TGCAGGCCATCTGCTTC -3'
(R):5'- gttagttcatactgttgttcctcc -3'
Posted On2013-06-12