Mutagenetix > Incidental Mutations

Incidental Mutation 'R6738:Olfr961'

530310

Institutional Source

Beutler Lab

Gene Symbol

Olfr961

Ensembl Gene

ENSMUSG00000059106

Gene Name

olfactory receptor 961

Synonyms

MOR224-5, GA_x6K02T2PVTD-33343617-33344561

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.165) question?

Stock #

R6738 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

39645085-39649556 bp(+) (GRCm38)

Type of Mutation

start gained

DNA Base Change (assembly)

A to G at 39646661 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000151840 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076548] [ENSMUST00000219295]

Predicted Effect

probably benign
Transcript: ENSMUST00000076548

SMART Domains

Protein: ENSMUSP00000075863
Gene: ENSMUSG00000059106

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	304	1.1e-50	PFAM
Pfam:7tm_1	39	286	4.5e-20	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000219295

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.3%
20x: 95.2%

Validation Efficiency

100% (55/55)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310007B03Rik	G	A	1: 93,159,985	L49F	probably benign	Het
Abat	C	T	16: 8,602,436		probably benign	Het
Abl1	T	C	2: 31,794,574	Y454H	probably damaging	Het
Ambp	A	T	4: 63,149,474	D166E	probably benign	Het
Amigo2	A	G	15: 97,245,464	V359A	possibly damaging	Het
Ankrd11	A	T	8: 122,891,921	S1710T	probably damaging	Het
Ankrd31	T	C	13: 96,904,127	S1713P	possibly damaging	Het
Arhgap45	A	T	10: 80,027,597	K758M	probably damaging	Het
Bclaf1	T	C	10: 20,323,769	I304T	possibly damaging	Het
C1ra	A	G	6: 124,517,759	Y327C	probably damaging	Het
Ccdc73	C	T	2: 104,992,088	S794L	probably benign	Het
Cd24a	A	G	10: 43,582,676	N48D	possibly damaging	Het
Col11a1	A	G	3: 114,112,467		probably benign	Het
Cyp11b2	G	A	15: 74,853,514	T252I	possibly damaging	Het
Dlx2	A	G	2: 71,546,062	Y111H	probably benign	Het
Dsp	T	C	13: 38,192,210	S1324P	possibly damaging	Het
Esyt3	A	T	9: 99,320,293	F522I	probably damaging	Het
Fam193b	C	T	13: 55,550,361	A45T	probably benign	Het
Flnb	A	G	14: 7,904,536	T980A	probably benign	Het
Gabrb2	G	T	11: 42,593,931	A272S	possibly damaging	Het
H2al2a	G	T	2: 17,996,618	Q86K	possibly damaging	Het
Ikbkb	T	G	8: 22,675,036	I243L	probably damaging	Het
Il18r1	A	G	1: 40,498,656	E527G	probably benign	Het
Krt35	A	T	11: 100,093,709	V320D	probably damaging	Het
Krt76	C	T	15: 101,887,478	R419H	probably benign	Het
Lrp2	T	A	2: 69,458,488	Y3678F	probably damaging	Het
Mnat1	T	G	12: 73,272,472	S290A	probably benign	Het
Mptx2	T	C	1: 173,274,855	E89G	probably benign	Het
Myom1	T	A	17: 71,100,398		probably null	Het
Naaladl2	A	G	3: 24,171,642	V541A	probably benign	Het
Nbeal2	T	C	9: 110,636,905	T851A	possibly damaging	Het
Ncoa4	A	G	14: 32,170,793	Y11C	probably benign	Het
Ntn5	T	A	7: 45,694,356		probably null	Het
Olfr347	C	T	2: 36,734,432	T37I	probably benign	Het
Otop2	A	G	11: 115,329,492	Y386C	probably damaging	Het
Ppp2r1a	T	A	17: 20,954,717		probably null	Het
Prkd2	C	A	7: 16,865,905	N764K	possibly damaging	Het
Ralgapa1	A	G	12: 55,762,727	L421S	probably damaging	Het
Ric3	G	A	7: 109,048,062	R184*	probably null	Het
Sfswap	A	G	5: 129,541,441	K480E	probably damaging	Het
Siah2	A	G	3: 58,691,553	V88A	probably benign	Het
Slc22a16	T	C	10: 40,585,302	F367L	probably damaging	Het
Slc23a2	T	C	2: 132,078,436	D183G	probably benign	Het
Svep1	T	C	4: 58,123,180	N712S	possibly damaging	Het
Tex21	A	G	12: 76,239,509	V72A	probably benign	Het
Tfap4	A	G	16: 4,549,447	Y184H	probably damaging	Het
Timeless	T	C	10: 128,240,635	Y138H	probably damaging	Het
Tln2	A	T	9: 67,386,664	N227K	possibly damaging	Het
Trip10	C	T	17: 57,256,899	P342S	probably benign	Het
Ttc6	A	T	12: 57,688,640	E1156V	probably damaging	Het
Ttn	T	C	2: 76,898,128		probably benign	Het
Vmn2r109	G	A	17: 20,554,523	S190L	possibly damaging	Het
Wdr54	A	G	6: 83,155,127	S99P	probably damaging	Het
Ythdf2	A	C	4: 132,204,961	I296R	probably benign	Het
Zfp445	A	G	9: 122,862,058	V24A	probably damaging	Het

Other mutations in Olfr961

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00309:Olfr961	APN	9	39647340	missense	probably benign	0.19
IGL01792:Olfr961	APN	9	39647659	missense	probably benign	0.07
R0344:Olfr961	UTSW	9	39647350	missense	probably damaging	1.00
R0503:Olfr961	UTSW	9	39647476	missense	probably damaging	1.00
R0525:Olfr961	UTSW	9	39647471	missense	probably damaging	1.00
R0531:Olfr961	UTSW	9	39646872	missense	probably benign
R1188:Olfr961	UTSW	9	39647476	missense	probably damaging	1.00
R1453:Olfr961	UTSW	9	39647163	missense	probably benign	0.01
R2970:Olfr961	UTSW	9	39646899	missense	probably damaging	1.00
R3883:Olfr961	UTSW	9	39647124	missense	probably benign	0.07
R4423:Olfr961	UTSW	9	39647116	missense	probably damaging	1.00
R5129:Olfr961	UTSW	9	39647494	missense	probably benign	0.03
R6148:Olfr961	UTSW	9	39647259	missense	probably damaging	1.00
R6778:Olfr961	UTSW	9	39646747	missense	probably damaging	1.00
R7194:Olfr961	UTSW	9	39647091	missense	probably benign	0.15
R7545:Olfr961	UTSW	9	39647107	missense	probably damaging	0.97
R8547:Olfr961	UTSW	9	39647502	nonsense	probably null
RF008:Olfr961	UTSW	9	39647263	missense	probably benign	0.09

Predicted Primers

PCR Primer
(F):5'- AGAACCTCAATGGAGCATCTGG -3'
(R):5'- CAGGGCACAGGCATACATTG -3'

Sequencing Primer
(F):5'- GAAACCATCTGCAATTGGCTTGG -3'
(R):5'- GCACAGGCATACATTGTTGAAAAC -3'

Posted On

2018-08-01