Incidental Mutation 'R7073:Arap3'
| ID |
549071 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arap3
|
| Ensembl Gene |
ENSMUSG00000024451 |
| Gene Name |
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 |
| Synonyms |
Centd3, E030006K04Rik, DRAG1 |
| MMRRC Submission |
045169-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.814)
|
| Stock # |
R7073 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
18 |
| Chromosomal Location |
38105681-38132022 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 38107495 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Stop codon
at position 1341
(K1341*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000035662
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000042944]
[ENSMUST00000043437]
[ENSMUST00000163131]
[ENSMUST00000164222]
[ENSMUST00000166148]
|
| AlphaFold |
Q8R5G7 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000042944
AA Change: K1341*
|
| SMART Domains |
Protein: ENSMUSP00000035662
Gene: ENSMUSG00000024451
AA Change: K1341*
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
1 |
68 |
1.5e-7 |
SMART |
|
low complexity region
|
81 |
98 |
N/A |
INTRINSIC |
|
low complexity region
|
134 |
142 |
N/A |
INTRINSIC |
|
PH
|
283 |
376 |
3.4e-16 |
SMART |
|
PH
|
390 |
480 |
1.61e-8 |
SMART |
|
ArfGap
|
484 |
606 |
1.44e-25 |
SMART |
|
low complexity region
|
642 |
661 |
N/A |
INTRINSIC |
|
PH
|
671 |
785 |
2.86e1 |
SMART |
|
PH
|
795 |
901 |
6.87e-3 |
SMART |
|
RhoGAP
|
913 |
1089 |
2.11e-47 |
SMART |
|
Pfam:RA
|
1113 |
1206 |
6.2e-16 |
PFAM |
|
PH
|
1220 |
1323 |
3.46e-8 |
SMART |
|
low complexity region
|
1388 |
1407 |
N/A |
INTRINSIC |
|
low complexity region
|
1457 |
1469 |
N/A |
INTRINSIC |
|
low complexity region
|
1475 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1494 |
1529 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000043437
|
| SMART Domains |
Protein: ENSMUSP00000047878
Gene: ENSMUSG00000038524
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:FCH
|
21 |
100 |
1.6e-19 |
PFAM |
|
coiled coil region
|
188 |
209 |
N/A |
INTRINSIC |
|
low complexity region
|
346 |
357 |
N/A |
INTRINSIC |
|
SH3
|
469 |
526 |
1.34e-8 |
SMART |
|
SH3
|
547 |
606 |
1.94e-14 |
SMART |
|
low complexity region
|
622 |
634 |
N/A |
INTRINSIC |
|
low complexity region
|
657 |
686 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163131
|
| SMART Domains |
Protein: ENSMUSP00000133058
Gene: ENSMUSG00000038524
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:FCH
|
12 |
107 |
1.6e-18 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164222
|
| SMART Domains |
Protein: ENSMUSP00000128481
Gene: ENSMUSG00000038524
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:FCH
|
12 |
56 |
2.5e-11 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000166148
|
| SMART Domains |
Protein: ENSMUSP00000129825
Gene: ENSMUSG00000038524
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:FCH
|
12 |
93 |
1.6e-17 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
PHENOTYPE: Mice homozygous for a knock-out allele die around E11 exhibiting pallor, embryonic growth arrest, yolk sac and placental abnormalities, and an endothelial cell-autonomous defect in sprouting angiogenesis. Knock-in mice homozygous for a point mutation display similar angiogenesis defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(5) : Targeted(5)
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrv1 |
T |
G |
13: 81,709,593 (GRCm39) |
E1133D |
probably damaging |
Het |
| Ankrd13b |
A |
T |
11: 77,363,335 (GRCm39) |
D505E |
probably benign |
Het |
| Ano1 |
C |
T |
7: 144,192,289 (GRCm39) |
E361K |
probably damaging |
Het |
| Arhgef17 |
A |
C |
7: 100,579,198 (GRCm39) |
Y583* |
probably null |
Het |
| Ash1l |
G |
A |
3: 88,892,647 (GRCm39) |
E1509K |
probably damaging |
Het |
| B430305J03Rik |
T |
G |
3: 61,271,681 (GRCm39) |
R21S |
unknown |
Het |
| Bbof1 |
A |
G |
12: 84,473,609 (GRCm39) |
E313G |
probably damaging |
Het |
| Catsperb |
C |
T |
12: 101,475,497 (GRCm39) |
T347I |
probably benign |
Het |
| Ccdc24 |
G |
T |
4: 117,729,201 (GRCm39) |
A92D |
probably damaging |
Het |
| Ccdc63 |
T |
C |
5: 122,249,073 (GRCm39) |
T419A |
probably benign |
Het |
| Ccdc7a |
C |
T |
8: 129,618,866 (GRCm39) |
V893I |
possibly damaging |
Het |
| Ccdc88b |
G |
T |
19: 6,831,330 (GRCm39) |
D537E |
probably benign |
Het |
| Cd276 |
T |
C |
9: 58,444,615 (GRCm39) |
S119G |
probably damaging |
Het |
| Cdkn3 |
T |
C |
14: 47,004,647 (GRCm39) |
Y70H |
possibly damaging |
Het |
| Cdo1 |
G |
A |
18: 46,861,266 (GRCm39) |
|
probably benign |
Het |
| Cdr2 |
A |
T |
7: 120,581,247 (GRCm39) |
F10Y |
probably damaging |
Het |
| Cep290 |
A |
T |
10: 100,374,865 (GRCm39) |
K1370N |
possibly damaging |
Het |
| Crb1 |
T |
A |
1: 139,176,049 (GRCm39) |
I645F |
probably damaging |
Het |
| Cul7 |
T |
C |
17: 46,969,657 (GRCm39) |
W975R |
probably damaging |
Het |
| Ddx39b |
A |
C |
17: 35,471,826 (GRCm39) |
E324A |
probably benign |
Het |
| Diaph1 |
T |
G |
18: 38,022,867 (GRCm39) |
|
probably null |
Het |
| Dnah2 |
G |
A |
11: 69,321,318 (GRCm39) |
R3917* |
probably null |
Het |
| Dnph1 |
T |
A |
17: 46,807,815 (GRCm39) |
L27Q |
probably damaging |
Het |
| Duox2 |
A |
G |
2: 122,119,788 (GRCm39) |
F880S |
probably damaging |
Het |
| Ell2 |
C |
A |
13: 75,910,006 (GRCm39) |
L119M |
probably damaging |
Het |
| Enpep |
A |
T |
3: 129,106,319 (GRCm39) |
Y302* |
probably null |
Het |
| Ergic2 |
G |
T |
6: 148,096,707 (GRCm39) |
H186Q |
probably damaging |
Het |
| Fam83b |
T |
C |
9: 76,453,031 (GRCm39) |
D12G |
probably benign |
Het |
| Fbxw16 |
A |
T |
9: 109,270,123 (GRCm39) |
V206D |
probably damaging |
Het |
| Fhod1 |
A |
T |
8: 106,063,771 (GRCm39) |
V278D |
unknown |
Het |
| Gba2 |
G |
C |
4: 43,573,753 (GRCm39) |
Q180E |
probably damaging |
Het |
| Grhl3 |
G |
A |
4: 135,300,723 (GRCm39) |
L5F |
probably benign |
Het |
| H2-T15 |
A |
T |
17: 36,369,235 (GRCm39) |
C7S |
unknown |
Het |
| Ifit1bl1 |
C |
T |
19: 34,576,667 (GRCm39) |
|
probably null |
Het |
| Ift57 |
A |
G |
16: 49,584,230 (GRCm39) |
T413A |
probably benign |
Het |
| Itga2 |
A |
G |
13: 114,996,149 (GRCm39) |
F714S |
probably damaging |
Het |
| Jmy |
A |
G |
13: 93,577,841 (GRCm39) |
S776P |
probably benign |
Het |
| Kbtbd8 |
G |
A |
6: 95,098,814 (GRCm39) |
A108T |
probably damaging |
Het |
| Kpna6 |
G |
A |
4: 129,548,139 (GRCm39) |
A230V |
probably damaging |
Het |
| Lrfn1 |
C |
T |
7: 28,159,397 (GRCm39) |
L439F |
possibly damaging |
Het |
| Lrrc1 |
T |
A |
9: 77,375,847 (GRCm39) |
I147F |
probably benign |
Het |
| Lrrc7 |
C |
T |
3: 157,832,884 (GRCm39) |
G1425R |
probably damaging |
Het |
| Madd |
T |
A |
2: 90,992,854 (GRCm39) |
I1022F |
probably damaging |
Het |
| Map2k2 |
A |
T |
10: 80,942,017 (GRCm39) |
T13S |
probably benign |
Het |
| Mdc1 |
G |
A |
17: 36,164,960 (GRCm39) |
V1459I |
probably benign |
Het |
| Mdh1b |
G |
A |
1: 63,760,719 (GRCm39) |
T114M |
probably damaging |
Het |
| Mfsd2a |
T |
C |
4: 122,845,088 (GRCm39) |
I208V |
possibly damaging |
Het |
| Mmrn1 |
T |
A |
6: 60,965,411 (GRCm39) |
D1147E |
probably damaging |
Het |
| Nbeal2 |
T |
A |
9: 110,455,177 (GRCm39) |
I2574F |
probably damaging |
Het |
| Nr1d1 |
T |
G |
11: 98,662,892 (GRCm39) |
S34R |
probably damaging |
Het |
| Nr3c1 |
A |
T |
18: 39,619,449 (GRCm39) |
D279E |
probably benign |
Het |
| Nrde2 |
T |
C |
12: 100,098,747 (GRCm39) |
D640G |
probably benign |
Het |
| Odf4 |
A |
G |
11: 68,817,514 (GRCm39) |
L58P |
probably damaging |
Het |
| Or4k41 |
A |
T |
2: 111,279,631 (GRCm39) |
I49F |
probably benign |
Het |
| Or4p22 |
A |
T |
2: 88,317,651 (GRCm39) |
I192F |
probably benign |
Het |
| Otud6b |
A |
C |
4: 14,811,743 (GRCm39) |
M300R |
probably damaging |
Het |
| Pamr1 |
T |
A |
2: 102,471,280 (GRCm39) |
D534E |
probably benign |
Het |
| Pcdh7 |
T |
A |
5: 57,878,299 (GRCm39) |
V618E |
probably benign |
Het |
| Pcgf6 |
A |
C |
19: 47,031,226 (GRCm39) |
N266K |
possibly damaging |
Het |
| Plcz1 |
A |
T |
6: 139,968,849 (GRCm39) |
Y196* |
probably null |
Het |
| Plxna1 |
A |
T |
6: 89,334,311 (GRCm39) |
L106Q |
probably damaging |
Het |
| Qrich2 |
G |
A |
11: 116,337,701 (GRCm39) |
A184V |
probably damaging |
Het |
| Rimkla |
A |
G |
4: 119,325,275 (GRCm39) |
L378S |
probably benign |
Het |
| Rufy1 |
G |
T |
11: 50,295,290 (GRCm39) |
H472Q |
probably benign |
Het |
| Samd7 |
T |
A |
3: 30,810,631 (GRCm39) |
M216K |
probably benign |
Het |
| Samd9l |
A |
T |
6: 3,375,856 (GRCm39) |
Y468* |
probably null |
Het |
| Scn2a |
T |
G |
2: 65,558,787 (GRCm39) |
L1194R |
probably benign |
Het |
| Sgo2a |
T |
A |
1: 58,056,944 (GRCm39) |
S1043T |
possibly damaging |
Het |
| Slc6a17 |
G |
T |
3: 107,378,755 (GRCm39) |
H642Q |
probably benign |
Het |
| Smox |
C |
T |
2: 131,364,031 (GRCm39) |
A45V |
possibly damaging |
Het |
| St6galnac3 |
T |
A |
3: 153,117,274 (GRCm39) |
T150S |
possibly damaging |
Het |
| Strip2 |
T |
A |
6: 29,941,911 (GRCm39) |
I627N |
possibly damaging |
Het |
| Sv2c |
A |
T |
13: 96,224,758 (GRCm39) |
C184S |
probably damaging |
Het |
| Tm7sf2 |
A |
T |
19: 6,116,527 (GRCm39) |
|
probably null |
Het |
| Ttc28 |
T |
C |
5: 111,371,282 (GRCm39) |
I608T |
possibly damaging |
Het |
| Vmn1r183 |
T |
G |
7: 23,754,926 (GRCm39) |
L243R |
probably damaging |
Het |
| Vmn1r68 |
T |
C |
7: 10,261,778 (GRCm39) |
T107A |
probably benign |
Het |
| Vnn3 |
G |
A |
10: 23,740,311 (GRCm39) |
G205R |
probably damaging |
Het |
| Zfp516 |
T |
A |
18: 83,006,325 (GRCm39) |
|
probably null |
Het |
| Zpbp2 |
A |
G |
11: 98,443,335 (GRCm39) |
D56G |
probably damaging |
Het |
|
| Other mutations in Arap3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00515:Arap3
|
APN |
18 |
38,108,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01145:Arap3
|
APN |
18 |
38,122,232 (GRCm39) |
missense |
probably benign |
|
|
IGL01154:Arap3
|
APN |
18 |
38,129,787 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL01305:Arap3
|
APN |
18 |
38,124,380 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01542:Arap3
|
APN |
18 |
38,123,889 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01543:Arap3
|
APN |
18 |
38,123,889 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01544:Arap3
|
APN |
18 |
38,123,889 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01545:Arap3
|
APN |
18 |
38,123,889 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01677:Arap3
|
APN |
18 |
38,129,700 (GRCm39) |
missense |
probably benign |
|
|
IGL01925:Arap3
|
APN |
18 |
38,117,299 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL01933:Arap3
|
APN |
18 |
38,111,506 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02048:Arap3
|
APN |
18 |
38,130,032 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL02064:Arap3
|
APN |
18 |
38,124,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02207:Arap3
|
APN |
18 |
38,120,906 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02376:Arap3
|
APN |
18 |
38,111,506 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02531:Arap3
|
APN |
18 |
38,122,804 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02568:Arap3
|
APN |
18 |
38,129,711 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL02640:Arap3
|
APN |
18 |
38,120,855 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02658:Arap3
|
APN |
18 |
38,124,047 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03090:Arap3
|
APN |
18 |
38,122,165 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03352:Arap3
|
APN |
18 |
38,114,355 (GRCm39) |
splice site |
probably benign |
|
|
ANU22:Arap3
|
UTSW |
18 |
38,124,380 (GRCm39) |
critical splice donor site |
probably null |
|
|
P0016:Arap3
|
UTSW |
18 |
38,117,401 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4260001:Arap3
|
UTSW |
18 |
38,129,948 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0066:Arap3
|
UTSW |
18 |
38,129,760 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0324:Arap3
|
UTSW |
18 |
38,106,278 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0562:Arap3
|
UTSW |
18 |
38,108,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1289:Arap3
|
UTSW |
18 |
38,115,026 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1346:Arap3
|
UTSW |
18 |
38,108,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1419:Arap3
|
UTSW |
18 |
38,111,485 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R1470:Arap3
|
UTSW |
18 |
38,122,249 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1470:Arap3
|
UTSW |
18 |
38,122,249 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1537:Arap3
|
UTSW |
18 |
38,122,737 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1644:Arap3
|
UTSW |
18 |
38,117,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1731:Arap3
|
UTSW |
18 |
38,122,965 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1758:Arap3
|
UTSW |
18 |
38,122,965 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1843:Arap3
|
UTSW |
18 |
38,108,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1907:Arap3
|
UTSW |
18 |
38,129,724 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1954:Arap3
|
UTSW |
18 |
38,115,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2124:Arap3
|
UTSW |
18 |
38,106,403 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2135:Arap3
|
UTSW |
18 |
38,107,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2172:Arap3
|
UTSW |
18 |
38,123,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2418:Arap3
|
UTSW |
18 |
38,122,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2419:Arap3
|
UTSW |
18 |
38,122,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2907:Arap3
|
UTSW |
18 |
38,123,580 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4425:Arap3
|
UTSW |
18 |
38,111,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4669:Arap3
|
UTSW |
18 |
38,129,307 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4734:Arap3
|
UTSW |
18 |
38,129,328 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4815:Arap3
|
UTSW |
18 |
38,106,296 (GRCm39) |
missense |
probably benign |
|
|
R5328:Arap3
|
UTSW |
18 |
38,124,740 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5350:Arap3
|
UTSW |
18 |
38,115,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5466:Arap3
|
UTSW |
18 |
38,129,789 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5482:Arap3
|
UTSW |
18 |
38,107,727 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5572:Arap3
|
UTSW |
18 |
38,124,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5779:Arap3
|
UTSW |
18 |
38,117,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6053:Arap3
|
UTSW |
18 |
38,123,824 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6144:Arap3
|
UTSW |
18 |
38,118,486 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6166:Arap3
|
UTSW |
18 |
38,107,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6248:Arap3
|
UTSW |
18 |
38,124,407 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6266:Arap3
|
UTSW |
18 |
38,123,844 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6385:Arap3
|
UTSW |
18 |
38,130,084 (GRCm39) |
nonsense |
probably null |
|
|
R6694:Arap3
|
UTSW |
18 |
38,124,590 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6856:Arap3
|
UTSW |
18 |
38,112,916 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7297:Arap3
|
UTSW |
18 |
38,106,616 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7352:Arap3
|
UTSW |
18 |
38,106,331 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7652:Arap3
|
UTSW |
18 |
38,111,505 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7726:Arap3
|
UTSW |
18 |
38,122,520 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7747:Arap3
|
UTSW |
18 |
38,121,941 (GRCm39) |
splice site |
probably null |
|
|
R7944:Arap3
|
UTSW |
18 |
38,122,232 (GRCm39) |
missense |
probably benign |
|
|
R8152:Arap3
|
UTSW |
18 |
38,124,410 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R8338:Arap3
|
UTSW |
18 |
38,106,683 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8549:Arap3
|
UTSW |
18 |
38,106,365 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8793:Arap3
|
UTSW |
18 |
38,107,492 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8876:Arap3
|
UTSW |
18 |
38,130,077 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9142:Arap3
|
UTSW |
18 |
38,112,934 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9237:Arap3
|
UTSW |
18 |
38,112,934 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9583:Arap3
|
UTSW |
18 |
38,109,096 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9696:Arap3
|
UTSW |
18 |
38,112,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0011:Arap3
|
UTSW |
18 |
38,107,154 (GRCm39) |
critical splice donor site |
probably null |
|
|
X0026:Arap3
|
UTSW |
18 |
38,118,364 (GRCm39) |
critical splice donor site |
probably null |
|
|
X0027:Arap3
|
UTSW |
18 |
38,106,538 (GRCm39) |
splice site |
probably null |
|
|
X0066:Arap3
|
UTSW |
18 |
38,124,699 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACAAAGTGAGACCTGGCAAC -3'
(R):5'- TCCTTAAAGCCCAGGTGAGG -3'
Sequencing Primer
(F):5'- CTGTGGACAAGAGGATCGTG -3'
(R):5'- CCTTAAAGCCCAGGTGAGGAGAAG -3'
|
| Posted On |
2019-05-15 |
Incidental Mutation