Incidental Mutation 'R7483:Brwd1'
| ID |
579965 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Brwd1
|
| Ensembl Gene |
ENSMUSG00000022914 |
| Gene Name |
bromodomain and WD repeat domain containing 1 |
| Synonyms |
5330419I02Rik, Wdr9, G1-403-16, D530019K20Rik, repro5 |
| MMRRC Submission |
045557-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7483 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
16 |
| Chromosomal Location |
95793292-95883726 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 95857373 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Glycine
at position 396
(R396G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000023631
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023631]
[ENSMUST00000099502]
|
| AlphaFold |
Q921C3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000023631
AA Change: R396G
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000023631
Gene: ENSMUSG00000022914
AA Change: R396G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
|
WD40
|
175 |
214 |
1.3e-7 |
SMART |
|
WD40
|
217 |
256 |
2.26e-7 |
SMART |
|
WD40
|
259 |
302 |
1.83e-7 |
SMART |
|
WD40
|
311 |
352 |
3.82e1 |
SMART |
|
WD40
|
357 |
396 |
4.27e-8 |
SMART |
|
WD40
|
417 |
454 |
8.59e-1 |
SMART |
|
WD40
|
457 |
497 |
1.47e-6 |
SMART |
|
WD40
|
504 |
544 |
9.21e0 |
SMART |
|
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
|
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
|
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
|
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
|
low complexity region
|
1497 |
1513 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1558 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1574 |
1762 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
1764 |
1775 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1857 |
2050 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
2165 |
2174 |
N/A |
INTRINSIC |
|
low complexity region
|
2260 |
2270 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000099502
AA Change: R396G
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000097101
Gene: ENSMUSG00000022914
AA Change: R396G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
|
WD40
|
175 |
214 |
1.3e-7 |
SMART |
|
WD40
|
217 |
256 |
2.26e-7 |
SMART |
|
WD40
|
259 |
302 |
1.83e-7 |
SMART |
|
WD40
|
311 |
352 |
3.82e1 |
SMART |
|
WD40
|
357 |
396 |
4.27e-8 |
SMART |
|
WD40
|
417 |
454 |
8.59e-1 |
SMART |
|
WD40
|
457 |
497 |
1.47e-6 |
SMART |
|
WD40
|
504 |
544 |
9.21e0 |
SMART |
|
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
|
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
|
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
|
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
|
low complexity region
|
1497 |
1513 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1558 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1574 |
1762 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
1764 |
1775 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1857 |
2050 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
2165 |
2174 |
N/A |
INTRINSIC |
|
low complexity region
|
2260 |
2270 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]
PHENOTYPE: Homozygous males and females are infertile. Spermiogenesis is impaired; males have low epididymal sperm concentration with low motility and abnormal sperm head morphology. Female oocytes commonly contain vacuoles and have low developmental competence to 2-cell and blastocyst stages. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acad10 |
A |
T |
5: 121,794,075 (GRCm39) |
|
probably null |
Het |
| Ahnak |
T |
C |
19: 8,982,186 (GRCm39) |
S1157P |
probably damaging |
Het |
| Akap12 |
T |
G |
10: 4,303,967 (GRCm39) |
V364G |
probably benign |
Het |
| Ankrd17 |
A |
G |
5: 90,447,855 (GRCm39) |
S229P |
probably benign |
Het |
| Apof |
A |
T |
10: 128,104,636 (GRCm39) |
Y5F |
probably benign |
Het |
| Arhgap24 |
T |
A |
5: 102,989,174 (GRCm39) |
M94K |
probably benign |
Het |
| Ash2l |
G |
T |
8: 26,312,798 (GRCm39) |
D479E |
probably damaging |
Het |
| Atp8a2 |
A |
T |
14: 60,245,824 (GRCm39) |
C623S |
probably benign |
Het |
| Bmper |
T |
A |
9: 23,395,238 (GRCm39) |
N656K |
probably benign |
Het |
| Braf |
T |
C |
6: 39,604,772 (GRCm39) |
I619V |
possibly damaging |
Het |
| Car7 |
A |
T |
8: 105,276,216 (GRCm39) |
T234S |
probably benign |
Het |
| Catsper4 |
A |
T |
4: 133,945,552 (GRCm39) |
V169E |
probably damaging |
Het |
| Cemip |
T |
G |
7: 83,647,784 (GRCm39) |
I99L |
probably damaging |
Het |
| Chrna7 |
C |
A |
7: 62,754,738 (GRCm39) |
V290L |
probably damaging |
Het |
| Clip1 |
A |
T |
5: 123,755,447 (GRCm39) |
D944E |
probably benign |
Het |
| Cplane2 |
A |
G |
4: 140,947,153 (GRCm39) |
D178G |
probably damaging |
Het |
| Cyp2c68 |
T |
C |
19: 39,677,581 (GRCm39) |
T470A |
probably benign |
Het |
| Dmbx1 |
G |
T |
4: 115,780,908 (GRCm39) |
A31D |
probably damaging |
Het |
| Dnah7b |
T |
C |
1: 46,214,579 (GRCm39) |
F1115L |
probably damaging |
Het |
| Dock10 |
T |
C |
1: 80,493,283 (GRCm39) |
I1897V |
probably benign |
Het |
| Efcab3 |
A |
G |
11: 105,000,112 (GRCm39) |
I234V |
probably benign |
Het |
| Eid2b |
T |
G |
7: 27,977,243 (GRCm39) |
L13R |
probably damaging |
Het |
| Enam |
A |
G |
5: 88,649,679 (GRCm39) |
Y396C |
probably damaging |
Het |
| Fam161a |
A |
T |
11: 22,971,006 (GRCm39) |
T395S |
probably damaging |
Het |
| Fat1 |
A |
G |
8: 45,476,197 (GRCm39) |
R1748G |
probably benign |
Het |
| Fdxacb1 |
C |
A |
9: 50,681,451 (GRCm39) |
T124K |
possibly damaging |
Het |
| Fer1l6 |
A |
T |
15: 58,513,794 (GRCm39) |
D1563V |
possibly damaging |
Het |
| Gm20834 |
T |
C |
Y: 10,323,226 (GRCm39) |
H70R |
probably damaging |
Het |
| Gucy2d |
T |
A |
7: 98,098,964 (GRCm39) |
M261K |
probably damaging |
Het |
| Hcar2 |
T |
A |
5: 124,002,861 (GRCm39) |
Q214L |
probably benign |
Het |
| Hdac11 |
C |
T |
6: 91,136,214 (GRCm39) |
H75Y |
probably damaging |
Het |
| Hoxa2 |
C |
A |
6: 52,141,279 (GRCm39) |
A116S |
probably benign |
Het |
| Ints2 |
A |
G |
11: 86,106,444 (GRCm39) |
C989R |
probably damaging |
Het |
| Jpt1 |
T |
C |
11: 115,393,950 (GRCm39) |
E36G |
probably damaging |
Het |
| Kdm5d |
G |
A |
Y: 914,044 (GRCm39) |
R327Q |
possibly damaging |
Het |
| Klhl1 |
T |
C |
14: 96,584,304 (GRCm39) |
M309V |
probably benign |
Het |
| Larp4 |
A |
G |
15: 99,889,659 (GRCm39) |
K193E |
probably benign |
Het |
| Lmo3 |
C |
T |
6: 138,393,500 (GRCm39) |
C40Y |
probably damaging |
Het |
| Mcm4 |
A |
G |
16: 15,448,306 (GRCm39) |
V417A |
probably benign |
Het |
| Med8 |
A |
G |
4: 118,268,176 (GRCm39) |
E34G |
probably damaging |
Het |
| Mex3b |
G |
T |
7: 82,517,114 (GRCm39) |
A86S |
possibly damaging |
Het |
| Muc6 |
T |
C |
7: 141,224,245 (GRCm39) |
T1646A |
unknown |
Het |
| Myo15b |
A |
T |
11: 115,749,570 (GRCm39) |
E113D |
|
Het |
| Myo7a |
T |
A |
7: 97,712,881 (GRCm39) |
H1698L |
probably benign |
Het |
| Myocos |
T |
A |
1: 162,484,678 (GRCm39) |
M44L |
unknown |
Het |
| Nalcn |
A |
G |
14: 123,551,499 (GRCm39) |
V1036A |
probably damaging |
Het |
| Nfrkb |
C |
T |
9: 31,325,328 (GRCm39) |
Q924* |
probably null |
Het |
| Nol6 |
A |
G |
4: 41,117,424 (GRCm39) |
L923P |
possibly damaging |
Het |
| Nrxn3 |
T |
C |
12: 89,477,232 (GRCm39) |
Y472H |
probably damaging |
Het |
| Nudcd1 |
A |
G |
15: 44,269,253 (GRCm39) |
Y136H |
possibly damaging |
Het |
| Obox2 |
T |
C |
7: 15,131,241 (GRCm39) |
C116R |
probably damaging |
Het |
| Onecut3 |
A |
T |
10: 80,331,310 (GRCm39) |
S157C |
unknown |
Het |
| Or10ak11 |
A |
G |
4: 118,687,517 (GRCm39) |
V39A |
probably damaging |
Het |
| Or11g27 |
T |
A |
14: 50,771,472 (GRCm39) |
V201D |
probably benign |
Het |
| Or2d2b |
T |
A |
7: 106,705,982 (GRCm39) |
I29F |
probably benign |
Het |
| Or4f15 |
T |
C |
2: 111,814,124 (GRCm39) |
I98M |
probably damaging |
Het |
| Oscp1 |
C |
T |
4: 125,967,726 (GRCm39) |
R91* |
probably null |
Het |
| Pclo |
A |
T |
5: 14,762,606 (GRCm39) |
D408V |
|
Het |
| Pde8a |
T |
C |
7: 80,932,581 (GRCm39) |
V81A |
probably benign |
Het |
| Pde8b |
T |
A |
13: 95,164,251 (GRCm39) |
D653V |
probably damaging |
Het |
| Peg10 |
T |
TCCG |
6: 4,756,451 (GRCm39) |
|
probably benign |
Het |
| Pik3cg |
T |
C |
12: 32,245,647 (GRCm39) |
Y867C |
probably damaging |
Het |
| Pkd1l3 |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
8: 110,350,827 (GRCm39) |
|
probably benign |
Het |
| Psd4 |
A |
T |
2: 24,294,768 (GRCm39) |
D776V |
possibly damaging |
Het |
| Ptprb |
A |
G |
10: 116,119,334 (GRCm39) |
E156G |
probably benign |
Het |
| Rad54b |
A |
G |
4: 11,610,372 (GRCm39) |
Y663C |
probably damaging |
Het |
| Ranbp3l |
T |
A |
15: 9,030,955 (GRCm39) |
V78D |
possibly damaging |
Het |
| Rbm12 |
T |
C |
2: 155,940,138 (GRCm39) |
I45V |
unknown |
Het |
| Scn9a |
A |
G |
2: 66,363,692 (GRCm39) |
V862A |
probably damaging |
Het |
| Sdcbp |
T |
C |
4: 6,393,089 (GRCm39) |
I242T |
possibly damaging |
Het |
| Slc25a24 |
A |
G |
3: 109,066,751 (GRCm39) |
T302A |
probably damaging |
Het |
| Slc45a3 |
G |
T |
1: 131,904,549 (GRCm39) |
|
probably benign |
Het |
| Srpk1 |
T |
C |
17: 28,813,192 (GRCm39) |
I517M |
probably benign |
Het |
| Tmx4 |
A |
G |
2: 134,481,581 (GRCm39) |
M114T |
probably benign |
Het |
| Trhr |
T |
A |
15: 44,092,627 (GRCm39) |
V288D |
probably damaging |
Het |
| Tspoap1 |
A |
T |
11: 87,652,351 (GRCm39) |
I42F |
probably benign |
Het |
| Ttn |
A |
T |
2: 76,781,856 (GRCm39) |
D1063E |
unknown |
Het |
| Tusc3 |
A |
G |
8: 39,538,635 (GRCm39) |
I225V |
probably benign |
Het |
| Ugt2b38 |
A |
G |
5: 87,571,973 (GRCm39) |
S20P |
probably damaging |
Het |
| Upf2 |
A |
G |
2: 6,032,219 (GRCm39) |
T922A |
unknown |
Het |
| Usp38 |
C |
T |
8: 81,741,190 (GRCm39) |
|
probably benign |
Het |
| Vmn1r216 |
A |
G |
13: 23,283,738 (GRCm39) |
I140M |
probably damaging |
Het |
| Vmn2r115 |
T |
A |
17: 23,565,371 (GRCm39) |
N419K |
possibly damaging |
Het |
| Vmn2r55 |
C |
T |
7: 12,404,755 (GRCm39) |
G216D |
probably benign |
Het |
| Vwa8 |
A |
C |
14: 79,219,674 (GRCm39) |
|
probably null |
Het |
| Wnt7b |
C |
A |
15: 85,421,615 (GRCm39) |
R349L |
possibly damaging |
Het |
| Xbp1 |
T |
C |
11: 5,471,098 (GRCm39) |
V35A |
probably benign |
Het |
| Zan |
A |
T |
5: 137,445,057 (GRCm39) |
M1734K |
unknown |
Het |
| Zfhx4 |
A |
G |
3: 5,477,237 (GRCm39) |
E3284G |
probably damaging |
Het |
| Zfp458 |
A |
G |
13: 67,404,978 (GRCm39) |
L487S |
possibly damaging |
Het |
| Zfp687 |
C |
T |
3: 94,914,841 (GRCm39) |
R1220H |
probably damaging |
Het |
| Zp1 |
A |
G |
19: 10,895,280 (GRCm39) |
L324P |
possibly damaging |
Het |
|
| Other mutations in Brwd1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00690:Brwd1
|
APN |
16 |
95,818,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00974:Brwd1
|
APN |
16 |
95,844,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01014:Brwd1
|
APN |
16 |
95,817,373 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01447:Brwd1
|
APN |
16 |
95,848,579 (GRCm39) |
nonsense |
probably null |
|
|
IGL01459:Brwd1
|
APN |
16 |
95,848,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01631:Brwd1
|
APN |
16 |
95,847,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02184:Brwd1
|
APN |
16 |
95,815,029 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02264:Brwd1
|
APN |
16 |
95,820,656 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02679:Brwd1
|
APN |
16 |
95,804,023 (GRCm39) |
missense |
probably benign |
|
|
IGL02833:Brwd1
|
APN |
16 |
95,853,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02960:Brwd1
|
APN |
16 |
95,858,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03053:Brwd1
|
APN |
16 |
95,818,877 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL03074:Brwd1
|
APN |
16 |
95,813,050 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03135:Brwd1
|
APN |
16 |
95,822,458 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03168:Brwd1
|
APN |
16 |
95,818,877 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL03214:Brwd1
|
APN |
16 |
95,839,100 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL03328:Brwd1
|
APN |
16 |
95,803,925 (GRCm39) |
missense |
probably damaging |
0.99 |
|
bromide
|
UTSW |
16 |
95,866,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Embers
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Glowing
|
UTSW |
16 |
95,837,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Soporific
|
UTSW |
16 |
95,835,043 (GRCm39) |
nonsense |
probably null |
|
|
G1citation:Brwd1
|
UTSW |
16 |
95,842,474 (GRCm39) |
missense |
probably benign |
0.42 |
|
PIT4243001:Brwd1
|
UTSW |
16 |
95,803,871 (GRCm39) |
nonsense |
probably null |
|
|
R0012:Brwd1
|
UTSW |
16 |
95,860,852 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0012:Brwd1
|
UTSW |
16 |
95,860,852 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0030:Brwd1
|
UTSW |
16 |
95,822,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0135:Brwd1
|
UTSW |
16 |
95,848,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0366:Brwd1
|
UTSW |
16 |
95,839,164 (GRCm39) |
nonsense |
probably null |
|
|
R0551:Brwd1
|
UTSW |
16 |
95,837,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0586:Brwd1
|
UTSW |
16 |
95,844,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0865:Brwd1
|
UTSW |
16 |
95,869,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1226:Brwd1
|
UTSW |
16 |
95,832,748 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1329:Brwd1
|
UTSW |
16 |
95,804,434 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1378:Brwd1
|
UTSW |
16 |
95,842,570 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1420:Brwd1
|
UTSW |
16 |
95,837,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1441:Brwd1
|
UTSW |
16 |
95,867,351 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1484:Brwd1
|
UTSW |
16 |
95,829,491 (GRCm39) |
splice site |
probably null |
|
|
R1624:Brwd1
|
UTSW |
16 |
95,809,344 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1636:Brwd1
|
UTSW |
16 |
95,860,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1988:Brwd1
|
UTSW |
16 |
95,822,437 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1998:Brwd1
|
UTSW |
16 |
95,822,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2066:Brwd1
|
UTSW |
16 |
95,847,665 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2898:Brwd1
|
UTSW |
16 |
95,867,300 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2983:Brwd1
|
UTSW |
16 |
95,867,774 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3966:Brwd1
|
UTSW |
16 |
95,845,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4086:Brwd1
|
UTSW |
16 |
95,847,572 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4257:Brwd1
|
UTSW |
16 |
95,824,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4290:Brwd1
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4292:Brwd1
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4293:Brwd1
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4614:Brwd1
|
UTSW |
16 |
95,848,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Brwd1
|
UTSW |
16 |
95,804,518 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5025:Brwd1
|
UTSW |
16 |
95,855,172 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5155:Brwd1
|
UTSW |
16 |
95,803,993 (GRCm39) |
nonsense |
probably null |
|
|
R5229:Brwd1
|
UTSW |
16 |
95,803,409 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5246:Brwd1
|
UTSW |
16 |
95,803,757 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5668:Brwd1
|
UTSW |
16 |
95,817,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5763:Brwd1
|
UTSW |
16 |
95,835,043 (GRCm39) |
nonsense |
probably null |
|
|
R5782:Brwd1
|
UTSW |
16 |
95,844,243 (GRCm39) |
nonsense |
probably null |
|
|
R5831:Brwd1
|
UTSW |
16 |
95,820,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5836:Brwd1
|
UTSW |
16 |
95,865,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5906:Brwd1
|
UTSW |
16 |
95,859,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5995:Brwd1
|
UTSW |
16 |
95,865,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6143:Brwd1
|
UTSW |
16 |
95,804,156 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6241:Brwd1
|
UTSW |
16 |
95,815,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6313:Brwd1
|
UTSW |
16 |
95,809,141 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6362:Brwd1
|
UTSW |
16 |
95,803,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6551:Brwd1
|
UTSW |
16 |
95,795,162 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6736:Brwd1
|
UTSW |
16 |
95,869,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6822:Brwd1
|
UTSW |
16 |
95,842,474 (GRCm39) |
missense |
probably benign |
0.42 |
|
R7080:Brwd1
|
UTSW |
16 |
95,810,730 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7131:Brwd1
|
UTSW |
16 |
95,867,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7208:Brwd1
|
UTSW |
16 |
95,837,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7322:Brwd1
|
UTSW |
16 |
95,867,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7615:Brwd1
|
UTSW |
16 |
95,835,039 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7621:Brwd1
|
UTSW |
16 |
95,866,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7665:Brwd1
|
UTSW |
16 |
95,842,543 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7697:Brwd1
|
UTSW |
16 |
95,847,601 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7740:Brwd1
|
UTSW |
16 |
95,828,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8120:Brwd1
|
UTSW |
16 |
95,820,649 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8187:Brwd1
|
UTSW |
16 |
95,803,934 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8359:Brwd1
|
UTSW |
16 |
95,817,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8480:Brwd1
|
UTSW |
16 |
95,848,630 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8511:Brwd1
|
UTSW |
16 |
95,859,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9046:Brwd1
|
UTSW |
16 |
95,829,402 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9074:Brwd1
|
UTSW |
16 |
95,824,610 (GRCm39) |
missense |
|
|
|
R9102:Brwd1
|
UTSW |
16 |
95,869,725 (GRCm39) |
missense |
probably benign |
0.43 |
|
R9115:Brwd1
|
UTSW |
16 |
95,848,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9130:Brwd1
|
UTSW |
16 |
95,866,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9200:Brwd1
|
UTSW |
16 |
95,839,154 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9246:Brwd1
|
UTSW |
16 |
95,804,016 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9407:Brwd1
|
UTSW |
16 |
95,803,693 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R9444:Brwd1
|
UTSW |
16 |
95,855,180 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9451:Brwd1
|
UTSW |
16 |
95,845,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9673:Brwd1
|
UTSW |
16 |
95,813,096 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9751:Brwd1
|
UTSW |
16 |
95,795,015 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9753:Brwd1
|
UTSW |
16 |
95,825,028 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0017:Brwd1
|
UTSW |
16 |
95,845,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0028:Brwd1
|
UTSW |
16 |
95,813,123 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGTGCACTTTCCTTCATTAATTCAG -3'
(R):5'- AGCCTTGTCCTGAATAATCTGAC -3'
Sequencing Primer
(F):5'- CCAACAACTCACCTATGTG -3'
(R):5'- CCTTGAATAACATCTGTAGATCAGG -3'
|
| Posted On |
2019-10-07 |
Incidental Mutation