Incidental Mutation 'R9673:Brwd1'
| ID |
728192 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Brwd1
|
| Ensembl Gene |
ENSMUSG00000022914 |
| Gene Name |
bromodomain and WD repeat domain containing 1 |
| Synonyms |
5330419I02Rik, Wdr9, G1-403-16, D530019K20Rik, repro5 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9673 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
16 |
| Chromosomal Location |
95793292-95883726 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 95813096 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Leucine
at position 1471
(I1471L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000023631
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023631]
[ENSMUST00000099502]
|
| AlphaFold |
Q921C3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000023631
AA Change: I1471L
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000023631
Gene: ENSMUSG00000022914
AA Change: I1471L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
|
WD40
|
175 |
214 |
1.3e-7 |
SMART |
|
WD40
|
217 |
256 |
2.26e-7 |
SMART |
|
WD40
|
259 |
302 |
1.83e-7 |
SMART |
|
WD40
|
311 |
352 |
3.82e1 |
SMART |
|
WD40
|
357 |
396 |
4.27e-8 |
SMART |
|
WD40
|
417 |
454 |
8.59e-1 |
SMART |
|
WD40
|
457 |
497 |
1.47e-6 |
SMART |
|
WD40
|
504 |
544 |
9.21e0 |
SMART |
|
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
|
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
|
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
|
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
|
low complexity region
|
1497 |
1513 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1558 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1574 |
1762 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
1764 |
1775 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1857 |
2050 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
2165 |
2174 |
N/A |
INTRINSIC |
|
low complexity region
|
2260 |
2270 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099502
AA Change: I1471L
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000097101
Gene: ENSMUSG00000022914
AA Change: I1471L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
|
WD40
|
175 |
214 |
1.3e-7 |
SMART |
|
WD40
|
217 |
256 |
2.26e-7 |
SMART |
|
WD40
|
259 |
302 |
1.83e-7 |
SMART |
|
WD40
|
311 |
352 |
3.82e1 |
SMART |
|
WD40
|
357 |
396 |
4.27e-8 |
SMART |
|
WD40
|
417 |
454 |
8.59e-1 |
SMART |
|
WD40
|
457 |
497 |
1.47e-6 |
SMART |
|
WD40
|
504 |
544 |
9.21e0 |
SMART |
|
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
|
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
|
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
|
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
|
low complexity region
|
1497 |
1513 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1558 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1574 |
1762 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
1764 |
1775 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1857 |
2050 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
2165 |
2174 |
N/A |
INTRINSIC |
|
low complexity region
|
2260 |
2270 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]
PHENOTYPE: Homozygous males and females are infertile. Spermiogenesis is impaired; males have low epididymal sperm concentration with low motility and abnormal sperm head morphology. Female oocytes commonly contain vacuoles and have low developmental competence to 2-cell and blastocyst stages. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930568D16Rik |
T |
C |
2: 35,244,399 (GRCm39) |
K318E |
probably benign |
Het |
| Ap5z1 |
T |
C |
5: 142,463,113 (GRCm39) |
F766L |
probably benign |
Het |
| Atrnl1 |
A |
G |
19: 57,599,786 (GRCm39) |
M1V |
probably null |
Het |
| Atxn1 |
T |
C |
13: 45,710,622 (GRCm39) |
E770G |
probably benign |
Het |
| Bud23 |
T |
C |
5: 135,082,571 (GRCm39) |
E66G |
probably benign |
Het |
| Cdh8 |
T |
A |
8: 99,757,367 (GRCm39) |
I744L |
possibly damaging |
Het |
| Celsr1 |
G |
T |
15: 85,917,286 (GRCm39) |
S229* |
probably null |
Het |
| Cep95 |
C |
A |
11: 106,703,322 (GRCm39) |
H467Q |
probably benign |
Het |
| Chd1 |
A |
G |
17: 15,989,023 (GRCm39) |
Y1592C |
probably benign |
Het |
| Chkb |
C |
G |
15: 89,313,628 (GRCm39) |
G59A |
probably damaging |
Het |
| Copa |
A |
G |
1: 171,945,648 (GRCm39) |
S915G |
probably benign |
Het |
| Creb3 |
G |
T |
4: 43,563,191 (GRCm39) |
V97F |
probably damaging |
Het |
| Csmd2 |
T |
A |
4: 128,308,062 (GRCm39) |
H1273Q |
|
Het |
| Cxcr1 |
T |
C |
1: 74,231,074 (GRCm39) |
N316S |
probably benign |
Het |
| Cyct |
A |
T |
2: 76,184,523 (GRCm39) |
I76N |
probably damaging |
Het |
| Dmxl2 |
G |
T |
9: 54,294,840 (GRCm39) |
R2412S |
probably damaging |
Het |
| Dnah11 |
A |
G |
12: 117,982,513 (GRCm39) |
M2552T |
possibly damaging |
Het |
| Dnph1 |
G |
A |
17: 46,809,901 (GRCm39) |
E148K |
possibly damaging |
Het |
| Ecpas |
T |
C |
4: 58,822,060 (GRCm39) |
N1169S |
probably benign |
Het |
| Esp16 |
T |
A |
17: 39,848,731 (GRCm39) |
Y8* |
probably null |
Het |
| Fam186a |
T |
C |
15: 99,841,024 (GRCm39) |
D1740G |
possibly damaging |
Het |
| Fam76a |
C |
A |
4: 132,628,557 (GRCm39) |
K300N |
probably damaging |
Het |
| Fcgbpl1 |
A |
G |
7: 27,856,044 (GRCm39) |
T1944A |
probably benign |
Het |
| Frrs1l |
A |
C |
4: 56,990,191 (GRCm39) |
D27E |
|
Het |
| G6pc1 |
T |
C |
11: 101,267,380 (GRCm39) |
S277P |
probably damaging |
Het |
| Gabrg3 |
T |
A |
7: 56,973,422 (GRCm39) |
I82F |
probably damaging |
Het |
| Gm3604 |
G |
T |
13: 62,517,969 (GRCm39) |
Q130K |
probably benign |
Het |
| Hhip |
T |
A |
8: 80,719,108 (GRCm39) |
D473V |
probably damaging |
Het |
| Ifi209 |
T |
C |
1: 173,470,332 (GRCm39) |
S307P |
probably damaging |
Het |
| Ino80c |
C |
T |
18: 24,254,856 (GRCm39) |
M1I |
probably null |
Het |
| Jag2 |
G |
T |
12: 112,875,416 (GRCm39) |
C872* |
probably null |
Het |
| Kcnma1 |
A |
C |
14: 23,558,123 (GRCm39) |
H474Q |
probably benign |
Het |
| Krr1 |
G |
A |
10: 111,818,963 (GRCm39) |
|
probably null |
Het |
| Lats1 |
T |
G |
10: 7,588,387 (GRCm39) |
D1001E |
probably benign |
Het |
| Lilrb4b |
T |
C |
10: 51,357,753 (GRCm39) |
L149P |
probably benign |
Het |
| Lrrk2 |
T |
A |
15: 91,649,884 (GRCm39) |
S1674T |
probably damaging |
Het |
| Magi2 |
A |
G |
5: 20,670,582 (GRCm39) |
I309V |
possibly damaging |
Het |
| Mtmr4 |
A |
G |
11: 87,503,138 (GRCm39) |
D1064G |
probably damaging |
Het |
| Mtmr4 |
T |
C |
11: 87,504,916 (GRCm39) |
V1137A |
probably damaging |
Het |
| Neb |
C |
T |
2: 52,133,853 (GRCm39) |
|
probably null |
Het |
| Nhsl1 |
T |
A |
10: 18,402,665 (GRCm39) |
V1297E |
possibly damaging |
Het |
| Nlrp3 |
T |
A |
11: 59,440,148 (GRCm39) |
V575D |
probably damaging |
Het |
| Nptx2 |
T |
C |
5: 144,492,159 (GRCm39) |
I312T |
possibly damaging |
Het |
| Osm |
A |
G |
11: 4,189,926 (GRCm39) |
T237A |
probably benign |
Het |
| Pcdha12 |
T |
C |
18: 37,155,234 (GRCm39) |
V651A |
possibly damaging |
Het |
| Pclo |
A |
G |
5: 14,908,758 (GRCm39) |
|
probably null |
Het |
| Pdlim3 |
C |
T |
8: 46,368,195 (GRCm39) |
S183L |
possibly damaging |
Het |
| Peg10 |
GC |
GCTCC |
6: 4,756,452 (GRCm39) |
|
probably benign |
Het |
| Pgm2 |
T |
A |
5: 64,273,671 (GRCm39) |
M552K |
probably damaging |
Het |
| Pkhd1l1 |
T |
C |
15: 44,386,901 (GRCm39) |
L1258S |
probably benign |
Het |
| Proser3 |
T |
G |
7: 30,248,530 (GRCm39) |
T55P |
probably damaging |
Het |
| Ranbp2 |
C |
A |
10: 58,300,963 (GRCm39) |
P611Q |
probably damaging |
Het |
| Rangap1 |
T |
C |
15: 81,590,637 (GRCm39) |
D485G |
probably benign |
Het |
| Rp1 |
G |
A |
1: 4,337,792 (GRCm39) |
T421I |
unknown |
Het |
| Ryr3 |
G |
A |
2: 112,486,883 (GRCm39) |
L3862F |
possibly damaging |
Het |
| Sbf1 |
C |
T |
15: 89,179,675 (GRCm39) |
G1337R |
possibly damaging |
Het |
| Setd2 |
A |
G |
9: 110,378,138 (GRCm39) |
E651G |
probably damaging |
Het |
| Shmt1 |
A |
G |
11: 60,692,769 (GRCm39) |
W105R |
probably damaging |
Het |
| Skor2 |
C |
T |
18: 76,946,376 (GRCm39) |
H33Y |
unknown |
Het |
| Slc22a29 |
T |
C |
19: 8,140,104 (GRCm39) |
I434V |
probably benign |
Het |
| Sord |
C |
T |
2: 122,090,712 (GRCm39) |
T221I |
probably benign |
Het |
| Speer1g |
T |
A |
5: 11,178,990 (GRCm39) |
N55K |
probably benign |
Het |
| Tbcd |
T |
C |
11: 121,464,647 (GRCm39) |
Y561H |
probably damaging |
Het |
| Tcaf1 |
G |
A |
6: 42,663,808 (GRCm39) |
S24F |
probably benign |
Het |
| Tenm4 |
A |
T |
7: 96,517,196 (GRCm39) |
D1429V |
probably damaging |
Het |
| Tesk1 |
A |
G |
4: 43,444,574 (GRCm39) |
Y126C |
probably damaging |
Het |
| Tmem176a |
G |
A |
6: 48,820,952 (GRCm39) |
V141I |
probably benign |
Het |
| Tmem204 |
A |
T |
17: 25,299,243 (GRCm39) |
V92D |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,572,605 (GRCm39) |
D26096V |
probably damaging |
Het |
| Vmn1r70 |
T |
A |
7: 10,368,364 (GRCm39) |
L284Q |
probably damaging |
Het |
| Vmn2r77 |
T |
C |
7: 86,450,171 (GRCm39) |
V139A |
possibly damaging |
Het |
| Wdpcp |
A |
G |
11: 21,671,285 (GRCm39) |
R509G |
possibly damaging |
Het |
| Wee1 |
C |
T |
7: 109,725,210 (GRCm39) |
T284I |
probably damaging |
Het |
| Wfs1 |
A |
G |
5: 37,125,113 (GRCm39) |
S593P |
probably damaging |
Het |
| Zbtb11 |
A |
G |
16: 55,827,336 (GRCm39) |
H934R |
probably damaging |
Het |
| Zfp277 |
A |
T |
12: 40,370,611 (GRCm39) |
V446E |
probably benign |
Het |
| Zfp874a |
C |
A |
13: 67,591,156 (GRCm39) |
R176L |
probably benign |
Het |
| Znrf2 |
A |
T |
6: 54,840,978 (GRCm39) |
N184I |
probably damaging |
Het |
| Zp2 |
T |
A |
7: 119,733,238 (GRCm39) |
T568S |
probably damaging |
Het |
|
| Other mutations in Brwd1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00690:Brwd1
|
APN |
16 |
95,818,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00974:Brwd1
|
APN |
16 |
95,844,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01014:Brwd1
|
APN |
16 |
95,817,373 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01447:Brwd1
|
APN |
16 |
95,848,579 (GRCm39) |
nonsense |
probably null |
|
|
IGL01459:Brwd1
|
APN |
16 |
95,848,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01631:Brwd1
|
APN |
16 |
95,847,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02184:Brwd1
|
APN |
16 |
95,815,029 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02264:Brwd1
|
APN |
16 |
95,820,656 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02679:Brwd1
|
APN |
16 |
95,804,023 (GRCm39) |
missense |
probably benign |
|
|
IGL02833:Brwd1
|
APN |
16 |
95,853,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02960:Brwd1
|
APN |
16 |
95,858,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03053:Brwd1
|
APN |
16 |
95,818,877 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL03074:Brwd1
|
APN |
16 |
95,813,050 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03135:Brwd1
|
APN |
16 |
95,822,458 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03168:Brwd1
|
APN |
16 |
95,818,877 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL03214:Brwd1
|
APN |
16 |
95,839,100 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL03328:Brwd1
|
APN |
16 |
95,803,925 (GRCm39) |
missense |
probably damaging |
0.99 |
|
bromide
|
UTSW |
16 |
95,866,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Embers
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Glowing
|
UTSW |
16 |
95,837,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Soporific
|
UTSW |
16 |
95,835,043 (GRCm39) |
nonsense |
probably null |
|
|
G1citation:Brwd1
|
UTSW |
16 |
95,842,474 (GRCm39) |
missense |
probably benign |
0.42 |
|
PIT4243001:Brwd1
|
UTSW |
16 |
95,803,871 (GRCm39) |
nonsense |
probably null |
|
|
R0012:Brwd1
|
UTSW |
16 |
95,860,852 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0012:Brwd1
|
UTSW |
16 |
95,860,852 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0030:Brwd1
|
UTSW |
16 |
95,822,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0135:Brwd1
|
UTSW |
16 |
95,848,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0366:Brwd1
|
UTSW |
16 |
95,839,164 (GRCm39) |
nonsense |
probably null |
|
|
R0551:Brwd1
|
UTSW |
16 |
95,837,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0586:Brwd1
|
UTSW |
16 |
95,844,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0865:Brwd1
|
UTSW |
16 |
95,869,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1226:Brwd1
|
UTSW |
16 |
95,832,748 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1329:Brwd1
|
UTSW |
16 |
95,804,434 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1378:Brwd1
|
UTSW |
16 |
95,842,570 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1420:Brwd1
|
UTSW |
16 |
95,837,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1441:Brwd1
|
UTSW |
16 |
95,867,351 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1484:Brwd1
|
UTSW |
16 |
95,829,491 (GRCm39) |
splice site |
probably null |
|
|
R1624:Brwd1
|
UTSW |
16 |
95,809,344 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1636:Brwd1
|
UTSW |
16 |
95,860,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1988:Brwd1
|
UTSW |
16 |
95,822,437 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1998:Brwd1
|
UTSW |
16 |
95,822,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2066:Brwd1
|
UTSW |
16 |
95,847,665 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2898:Brwd1
|
UTSW |
16 |
95,867,300 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2983:Brwd1
|
UTSW |
16 |
95,867,774 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3966:Brwd1
|
UTSW |
16 |
95,845,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4086:Brwd1
|
UTSW |
16 |
95,847,572 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4257:Brwd1
|
UTSW |
16 |
95,824,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4290:Brwd1
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4292:Brwd1
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4293:Brwd1
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4614:Brwd1
|
UTSW |
16 |
95,848,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Brwd1
|
UTSW |
16 |
95,804,518 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5025:Brwd1
|
UTSW |
16 |
95,855,172 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5155:Brwd1
|
UTSW |
16 |
95,803,993 (GRCm39) |
nonsense |
probably null |
|
|
R5229:Brwd1
|
UTSW |
16 |
95,803,409 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5246:Brwd1
|
UTSW |
16 |
95,803,757 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5668:Brwd1
|
UTSW |
16 |
95,817,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5763:Brwd1
|
UTSW |
16 |
95,835,043 (GRCm39) |
nonsense |
probably null |
|
|
R5782:Brwd1
|
UTSW |
16 |
95,844,243 (GRCm39) |
nonsense |
probably null |
|
|
R5831:Brwd1
|
UTSW |
16 |
95,820,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5836:Brwd1
|
UTSW |
16 |
95,865,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5906:Brwd1
|
UTSW |
16 |
95,859,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5995:Brwd1
|
UTSW |
16 |
95,865,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6143:Brwd1
|
UTSW |
16 |
95,804,156 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6241:Brwd1
|
UTSW |
16 |
95,815,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6313:Brwd1
|
UTSW |
16 |
95,809,141 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6362:Brwd1
|
UTSW |
16 |
95,803,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6551:Brwd1
|
UTSW |
16 |
95,795,162 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6736:Brwd1
|
UTSW |
16 |
95,869,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6822:Brwd1
|
UTSW |
16 |
95,842,474 (GRCm39) |
missense |
probably benign |
0.42 |
|
R7080:Brwd1
|
UTSW |
16 |
95,810,730 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7131:Brwd1
|
UTSW |
16 |
95,867,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7208:Brwd1
|
UTSW |
16 |
95,837,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7322:Brwd1
|
UTSW |
16 |
95,867,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7483:Brwd1
|
UTSW |
16 |
95,857,373 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7615:Brwd1
|
UTSW |
16 |
95,835,039 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7621:Brwd1
|
UTSW |
16 |
95,866,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7665:Brwd1
|
UTSW |
16 |
95,842,543 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7697:Brwd1
|
UTSW |
16 |
95,847,601 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7740:Brwd1
|
UTSW |
16 |
95,828,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8120:Brwd1
|
UTSW |
16 |
95,820,649 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8187:Brwd1
|
UTSW |
16 |
95,803,934 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8359:Brwd1
|
UTSW |
16 |
95,817,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8480:Brwd1
|
UTSW |
16 |
95,848,630 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8511:Brwd1
|
UTSW |
16 |
95,859,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9046:Brwd1
|
UTSW |
16 |
95,829,402 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9074:Brwd1
|
UTSW |
16 |
95,824,610 (GRCm39) |
missense |
|
|
|
R9102:Brwd1
|
UTSW |
16 |
95,869,725 (GRCm39) |
missense |
probably benign |
0.43 |
|
R9115:Brwd1
|
UTSW |
16 |
95,848,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9130:Brwd1
|
UTSW |
16 |
95,866,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9200:Brwd1
|
UTSW |
16 |
95,839,154 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9246:Brwd1
|
UTSW |
16 |
95,804,016 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9407:Brwd1
|
UTSW |
16 |
95,803,693 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R9444:Brwd1
|
UTSW |
16 |
95,855,180 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9451:Brwd1
|
UTSW |
16 |
95,845,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9751:Brwd1
|
UTSW |
16 |
95,795,015 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9753:Brwd1
|
UTSW |
16 |
95,825,028 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0017:Brwd1
|
UTSW |
16 |
95,845,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0028:Brwd1
|
UTSW |
16 |
95,813,123 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAGTGCATTCAATTCCTCACC -3'
(R):5'- TTGCAGTAACTATCCATGCCAG -3'
Sequencing Primer
(F):5'- GTGCATTCAATTCCTCACCAAACAG -3'
(R):5'- CCATGCCAGAATACTATTAGTTGTGC -3'
|
| Posted On |
2022-10-06 |
Incidental Mutation