Mutagenetix > Incidental Mutation

Incidental Mutation 'R7592:Vmn2r69'

587454

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r69

Ensembl Gene

ENSMUSG00000091006

Gene Name

vomeronasal 2, receptor 69

Synonyms

MMRRC Submission

045639-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

R7592 (G1)

Quality Score

138.467

Status

Validated

Chromosome

Chromosomal Location

85055584-85064884 bp(-) (GRCm39)

Type of Mutation

frame shift

DNA Base Change (assembly)

GAAAA to GAAAAA at 85060768 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000132726 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171213]

AlphaFold

G3XA45

Predicted Effect

probably null
Transcript: ENSMUST00000171213

SMART Domains

Protein: ENSMUSP00000132726
Gene: ENSMUSG00000091006

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	465	1.3e-28	PFAM
Pfam:NCD3G	507	559	1.8e-20	PFAM
Pfam:7tm_3	592	827	3.2e-54	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

98% (56/57)

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930562C15Rik	A	G	16: 4,667,138 (GRCm39)	T204A	unknown	Het
Abca12	T	C	1: 71,327,836 (GRCm39)	T1415A	probably benign	Het
Adamtsl3	A	G	7: 81,986,459 (GRCm39)	T24A	probably benign	Het
Ankrd13b	A	C	11: 77,367,327 (GRCm39)	V194G	probably benign	Het
Aurkc	C	T	7: 7,003,006 (GRCm39)	T167I	probably benign	Het
Capn1	T	C	19: 6,064,469 (GRCm39)	Y10C	probably benign	Het
Ccnk	T	C	12: 108,152,724 (GRCm39)	S14P	possibly damaging	Het
Cebpe	T	A	14: 54,949,298 (GRCm39)	I40F	probably damaging	Het
Cers3	G	A	7: 66,439,377 (GRCm39)	C296Y	probably damaging	Het
Cog8	A	T	8: 107,776,861 (GRCm39)	C505S	possibly damaging	Het
Col4a3	A	G	1: 82,626,338 (GRCm39)	I92V	unknown	Het
Col5a3	T	A	9: 20,708,689 (GRCm39)	H645L	unknown	Het
Crispld1	A	T	1: 17,798,990 (GRCm39)	E37V	possibly damaging	Het
Csmd2	A	G	4: 128,357,591 (GRCm39)	Y1684C		Het
Cstdc5	A	T	16: 36,187,862 (GRCm39)	M1K	probably null	Het
Dcst1	C	A	3: 89,260,599 (GRCm39)	S555I	probably benign	Het
Drc1	A	G	5: 30,499,060 (GRCm39)	S70G	possibly damaging	Het
Elavl2	A	T	4: 91,199,808 (GRCm39)		probably null	Het
Emc1	A	G	4: 139,087,877 (GRCm39)	H300R	probably benign	Het
Gcnt4	G	A	13: 97,083,669 (GRCm39)	V322I	probably benign	Het
Gsg1l2	A	G	11: 67,665,584 (GRCm39)	N51D	probably benign	Het
Gucy2e	A	T	11: 69,114,150 (GRCm39)		probably null	Het
Hip1r	A	G	5: 124,136,036 (GRCm39)	E579G	probably benign	Het
Hoxa4	T	C	6: 52,168,520 (GRCm39)	H50R	unknown	Het
Htr7	T	C	19: 36,034,292 (GRCm39)	Y121C	probably damaging	Het
Ift43	G	A	12: 86,207,964 (GRCm39)	D111N	probably damaging	Het
Itih3	A	G	14: 30,630,722 (GRCm39)	V863A	probably damaging	Het
Macf1	T	C	4: 123,304,686 (GRCm39)		probably benign	Het
Mgat3	A	G	15: 80,095,193 (GRCm39)	K7E	probably damaging	Het
Ndst4	T	A	3: 125,364,436 (GRCm39)	V371E	probably damaging	Het
Npr1	T	G	3: 90,372,323 (GRCm39)	D163A	possibly damaging	Het
Nudt12	T	C	17: 59,313,589 (GRCm39)	I330V	probably benign	Het
Or2a20	T	G	6: 43,194,179 (GRCm39)	C111G	probably damaging	Het
Or4k2	T	A	14: 50,424,020 (GRCm39)	Y219F	probably damaging	Het
Or51l4	C	A	7: 103,404,279 (GRCm39)	C171F	probably damaging	Het
Or7g32	C	A	9: 19,389,128 (GRCm39)	M139I	possibly damaging	Het
Poc1a	A	T	9: 106,226,967 (GRCm39)	R402S	probably benign	Het
Prex2	G	T	1: 11,193,437 (GRCm39)	V470L	probably damaging	Het
Prom1	T	C	5: 44,220,469 (GRCm39)	E93G	probably damaging	Het
Psma1	A	T	7: 113,868,961 (GRCm39)	M180K	probably benign	Het
Pudp	A	T	18: 50,701,053 (GRCm39)	F227I	probably damaging	Het
Rab15	T	A	12: 76,851,223 (GRCm39)	Q60L	probably damaging	Het
Scaf8	T	C	17: 3,221,497 (GRCm39)		probably null	Het
Septin9	T	A	11: 117,181,488 (GRCm39)	I96N	probably damaging	Het
Sez6	T	C	11: 77,868,876 (GRCm39)	S976P	probably damaging	Het
Slc2a12	A	G	10: 22,540,802 (GRCm39)	Y219C	probably damaging	Het
Slc38a9	T	A	13: 112,831,889 (GRCm39)	I213K	probably damaging	Het
Stil	T	A	4: 114,881,005 (GRCm39)	D516E	probably benign	Het
Supt20	A	G	3: 54,614,543 (GRCm39)	D184G	probably damaging	Het
Tars3	G	A	7: 65,308,619 (GRCm39)	S263N	probably benign	Het
Tmem181a	C	A	17: 6,339,295 (GRCm39)	T68K	probably benign	Het
Trav21-dv12	G	T	14: 54,113,997 (GRCm39)	C39F	probably damaging	Het
Tshz1	T	C	18: 84,032,173 (GRCm39)	E745G	probably damaging	Het
Ugt1a8	T	A	1: 88,015,904 (GRCm39)	F106I	probably benign	Het
Vmn1r39	C	A	6: 66,781,428 (GRCm39)	V297L	probably benign	Het
Vmn2r101	G	A	17: 19,811,443 (GRCm39)		probably null	Het

Other mutations in Vmn2r69

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01019:Vmn2r69	APN	7	85,055,739 (GRCm39)	missense	probably benign
IGL01457:Vmn2r69	APN	7	85,055,836 (GRCm39)	missense	possibly damaging	0.87
IGL01760:Vmn2r69	APN	7	85,056,072 (GRCm39)	missense	possibly damaging	0.90
IGL01834:Vmn2r69	APN	7	85,061,576 (GRCm39)	missense	probably damaging	1.00
IGL02001:Vmn2r69	APN	7	85,056,434 (GRCm39)	missense	probably benign	0.05
IGL02057:Vmn2r69	APN	7	85,060,990 (GRCm39)	missense	possibly damaging	0.93
IGL02289:Vmn2r69	APN	7	85,056,054 (GRCm39)	missense	probably damaging	1.00
IGL02472:Vmn2r69	APN	7	85,058,960 (GRCm39)	missense	probably benign	0.01
IGL02478:Vmn2r69	APN	7	85,055,889 (GRCm39)	missense	probably damaging	1.00
IGL02554:Vmn2r69	APN	7	85,059,014 (GRCm39)	missense	probably damaging	1.00
IGL02723:Vmn2r69	APN	7	85,059,416 (GRCm39)	missense	probably damaging	1.00
R0526:Vmn2r69	UTSW	7	85,060,711 (GRCm39)	missense	probably damaging	1.00
R0560:Vmn2r69	UTSW	7	85,058,922 (GRCm39)	critical splice donor site	probably null
R0909:Vmn2r69	UTSW	7	85,055,873 (GRCm39)	missense	probably benign	0.00
R0976:Vmn2r69	UTSW	7	85,056,108 (GRCm39)	missense	probably damaging	1.00
R1158:Vmn2r69	UTSW	7	85,059,058 (GRCm39)	splice site	probably benign
R1459:Vmn2r69	UTSW	7	85,055,908 (GRCm39)	nonsense	probably null
R1482:Vmn2r69	UTSW	7	85,056,082 (GRCm39)	missense	probably damaging	1.00
R1917:Vmn2r69	UTSW	7	85,060,891 (GRCm39)	missense	probably damaging	1.00
R2016:Vmn2r69	UTSW	7	85,056,493 (GRCm39)	missense	probably damaging	0.98
R2108:Vmn2r69	UTSW	7	85,059,404 (GRCm39)	missense	probably benign
R2571:Vmn2r69	UTSW	7	85,064,764 (GRCm39)	missense	probably benign
R2910:Vmn2r69	UTSW	7	85,055,918 (GRCm39)	missense	probably damaging	1.00
R2920:Vmn2r69	UTSW	7	85,060,973 (GRCm39)	missense	probably benign	0.08
R3708:Vmn2r69	UTSW	7	85,061,029 (GRCm39)	missense	probably damaging	0.98
R3710:Vmn2r69	UTSW	7	85,055,601 (GRCm39)	missense	probably benign
R4757:Vmn2r69	UTSW	7	85,061,575 (GRCm39)	missense	probably damaging	0.99
R4823:Vmn2r69	UTSW	7	85,060,508 (GRCm39)	missense	probably benign	0.21
R4870:Vmn2r69	UTSW	7	85,060,793 (GRCm39)	missense	possibly damaging	0.93
R4918:Vmn2r69	UTSW	7	85,055,967 (GRCm39)	missense	probably benign	0.06
R5022:Vmn2r69	UTSW	7	85,060,367 (GRCm39)	missense	possibly damaging	0.72
R5174:Vmn2r69	UTSW	7	85,064,739 (GRCm39)	missense	possibly damaging	0.92
R5200:Vmn2r69	UTSW	7	85,055,717 (GRCm39)	missense	probably damaging	1.00
R5278:Vmn2r69	UTSW	7	85,060,991 (GRCm39)	missense	probably benign	0.02
R5643:Vmn2r69	UTSW	7	85,056,404 (GRCm39)	missense	probably damaging	0.98
R5996:Vmn2r69	UTSW	7	85,061,117 (GRCm39)	splice site	probably null
R6083:Vmn2r69	UTSW	7	85,055,711 (GRCm39)	missense	probably damaging	1.00
R6140:Vmn2r69	UTSW	7	85,060,657 (GRCm39)	missense	probably damaging	0.99
R6306:Vmn2r69	UTSW	7	85,064,799 (GRCm39)	missense	probably benign	0.04
R6330:Vmn2r69	UTSW	7	85,060,835 (GRCm39)	missense	probably benign
R6380:Vmn2r69	UTSW	7	85,061,067 (GRCm39)	missense	probably benign
R6466:Vmn2r69	UTSW	7	85,056,378 (GRCm39)	missense	probably benign	0.01
R6542:Vmn2r69	UTSW	7	85,060,413 (GRCm39)	nonsense	probably null
R6583:Vmn2r69	UTSW	7	85,059,017 (GRCm39)	missense	probably benign
R6623:Vmn2r69	UTSW	7	85,056,309 (GRCm39)	missense	possibly damaging	0.84
R6709:Vmn2r69	UTSW	7	85,061,069 (GRCm39)	missense	probably benign	0.03
R6732:Vmn2r69	UTSW	7	85,060,351 (GRCm39)	missense	probably benign	0.00
R6741:Vmn2r69	UTSW	7	85,061,724 (GRCm39)	missense	probably benign	0.01
R7070:Vmn2r69	UTSW	7	85,060,688 (GRCm39)	missense	probably damaging	0.98
R7234:Vmn2r69	UTSW	7	85,056,315 (GRCm39)	missense	probably benign	0.22
R7323:Vmn2r69	UTSW	7	85,060,972 (GRCm39)	missense	possibly damaging	0.95
R7427:Vmn2r69	UTSW	7	85,060,467 (GRCm39)	missense	probably benign	0.28
R7428:Vmn2r69	UTSW	7	85,060,467 (GRCm39)	missense	probably benign	0.28
R7453:Vmn2r69	UTSW	7	85,060,768 (GRCm39)	frame shift	probably null
R7532:Vmn2r69	UTSW	7	85,059,622 (GRCm39)	missense	probably benign	0.36
R7556:Vmn2r69	UTSW	7	85,060,768 (GRCm39)	frame shift	probably null
R7562:Vmn2r69	UTSW	7	85,056,420 (GRCm39)	missense	probably benign
R7708:Vmn2r69	UTSW	7	85,061,755 (GRCm39)	missense	possibly damaging	0.87
R7803:Vmn2r69	UTSW	7	85,056,324 (GRCm39)	missense	probably benign	0.00
R7960:Vmn2r69	UTSW	7	85,055,973 (GRCm39)	missense	probably benign
R7966:Vmn2r69	UTSW	7	85,060,762 (GRCm39)	missense	possibly damaging	0.81
R8071:Vmn2r69	UTSW	7	85,055,713 (GRCm39)	nonsense	probably null
R8237:Vmn2r69	UTSW	7	85,060,340 (GRCm39)	missense	probably benign	0.02
R8347:Vmn2r69	UTSW	7	85,064,838 (GRCm39)	missense	probably benign	0.00
R8737:Vmn2r69	UTSW	7	85,055,783 (GRCm39)	missense	probably damaging	1.00
R8795:Vmn2r69	UTSW	7	85,064,883 (GRCm39)	start codon destroyed	probably null	0.94
R8831:Vmn2r69	UTSW	7	85,059,018 (GRCm39)	nonsense	probably null
R8856:Vmn2r69	UTSW	7	85,061,663 (GRCm39)	missense	probably benign	0.00
R8998:Vmn2r69	UTSW	7	85,060,307 (GRCm39)	missense	probably benign	0.33
R8999:Vmn2r69	UTSW	7	85,060,307 (GRCm39)	missense	probably benign	0.33
R9161:Vmn2r69	UTSW	7	85,056,177 (GRCm39)	missense	possibly damaging	0.88
R9228:Vmn2r69	UTSW	7	85,064,697 (GRCm39)	missense	probably benign	0.01
R9494:Vmn2r69	UTSW	7	85,060,768 (GRCm39)	missense	probably damaging	1.00
R9494:Vmn2r69	UTSW	7	85,056,084 (GRCm39)	missense	probably benign	0.08
R9541:Vmn2r69	UTSW	7	85,056,209 (GRCm39)	missense	probably benign
R9620:Vmn2r69	UTSW	7	85,061,504 (GRCm39)	missense	probably benign	0.10
Z1176:Vmn2r69	UTSW	7	85,055,696 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCGATGGTGGCAATGAACATC -3'
(R):5'- GTGATTGTTACAAGTGATGACCAAGG -3'

Sequencing Primer
(F):5'- TGGCAAAGGAAAATTCACTACTG -3'
(R):5'- TGTTACAAGTGATGACCAAGGAATAC -3'

Posted On

2019-10-24